Altered disposition of acetaminophen in Nrf2-null and keap1-knockdown mice

Toxicological Sciences

Volumn 109, Issue 1, 2009, Pages 31-40

  Reisman, Scott A ^a   Csanaky, Ivaán I ^a   Aleksunes, Lauren M ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; Nrf2; Pharmacokinetics; Transporters

Indexed keywords

DRUG METABOLITE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 3; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; PARACETAMOL GLUCURONIDE; PARACETAMOL SULFATE; SULFOTRANSFERASE; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG SULFATION; DRUG TRANSFORMATION; ENZYME ACTIVITY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SINGLE DRUG DOSE;

ACETAMINOPHEN; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BILE; BIOTRANSFORMATION; CARRIER PROTEINS; CYTOSKELETAL PROTEINS; GENE KNOCKDOWN TECHNIQUES; GUINEA PIGS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MICROSOMES, LIVER; NADPH DEHYDROGENASE; NF-E2-RELATED FACTOR 2;

MUS;

EID: 65549114152     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp047     Document Type: Article

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