SiRNAs conjugated with aromatic compounds induce RISC-mediated antisense strand selection and strong gene-silencing activity

Biochemical and Biophysical Research Communications

Volumn 426, Issue 4, 2012, Pages 571-577

  Kubo, Takanori ^a   Yanagihara, Kazuyoshi ^a,b   Takei, Yoshifumi ^c   Mihara, Keichiro ^d   Sato, Yuichiro ^a   Seyama, Toshio ^a  

^a YASUDA WOMEN'S UNIVERSITY   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Intracellular delivery; Nuclease resistance; Potent gene silencing; SiRNA conjugates; Strand selection

Indexed keywords

AROMATIC COMPOUND; BENZENE DERIVATIVE; COMPLEMENTARY RNA; HYDROXPHENYL SMALL INTERFERING RNA; LOCKED NUCLEIC ACID; NAPHTHYL SMALL INTERFERING RNA; NUCLEASE; PHENYL SMALL INTERFERING RNA; PYRENYL SMALL INTERFERING RNA; RENILLA LUCIFERIN 2 MONOOXYGENASE; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONJUGATE; CONTROLLED STUDY; CYTOPLASM; ENZYME DEGRADATION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA INTERFERENCE; RNA STABILITY; THERMODYNAMICS; THERMOSTABILITY;

HELA CELLS; HUMANS; HYDROCARBONS, AROMATIC; LUCIFERASES, RENILLA; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA-INDUCED SILENCING COMPLEX;

MAMMALIA; RENILLA LUCIFERASE;

EID: 84867220502     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.08.128     Document Type: Article

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