The modification of siRNA with 3' cholesterol to increase nuclease protection and suppression of native mRNA by select siRNA polyplexes

Biomaterials

Volumn 32, Issue 5, 2011, Pages 1404-1411

  Ambardekar, Vishakha V ^b   Han, Huai Yun ^b   Varney, Michelle L ^c   Vinogradov, Serguei V ^a,b   Singh, Rakesh K ^a,c   Vetro, Joseph A ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

H 2Kb ts A58; Immortomouse; Mammary fat pad; PEGss; PEGylated cationic polymers; PPIB

Indexed keywords

CATIONIC POLYMERS; H-2KB-TS-A58; IMMORTOMOUSE; MAMMARY FAT PAD; PEGSS; PPIB;

BIODEGRADABLE POLYMERS; BLOCK COPOLYMERS; CHOLESTEROL; COPOLYMERIZATION; CROSSLINKING; ENDOTHELIAL CELLS; FUNCTIONAL POLYMERS; GRAFT COPOLYMERS; GRAFTING (CHEMICAL); POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYMERS;

RNA;

BIODEGRADABLE CROSS LINKED NANOGEL; CHOLESTEROL DERIVATIVE; COPOLYMER; HEPARIN; MESSENGER RNA; NUCLEASE; POLY LEVO LYSINE10 POLY(ETHYLENE)GLYCO; POLY LEVO LYSINE50 POLY(ETHYLENE)GLYCO; POLYETHYLENIMINE POLY(ETHYLENE)GLYCOL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME REPRESSION; HYDRODYNAMICS; PRIORITY JOURNAL; PROTEIN MODIFICATION;

ANIMALS; CELLS, CULTURED; CHOLESTEROL; FEMALE; MICE; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYMERS; RIBONUCLEASES; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 78649721547     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.10.019     Document Type: Article

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