Palmitic acid-conjugated 21-nucleotide siRNA enhances gene-silencing activity

Molecular Pharmaceutics

Volumn 8, Issue 6, 2011, Pages 2193-2203

  Kubo, Takanori ^a   Yanagihara, Kazuyoshi ^a   Takei, Yoshifumi ^b   Mihara, Keichiro ^c   Morita, Yasuhiro ^a   Seyama, Toshio ^a  

^a YASUDA WOMEN'S UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

gene silencing; intracellular delivery; inverted thymidine; long term RNAi potency; palmitic acid conjugates; siRNA

Indexed keywords

LIPOFECTAMINE; LIPOFECTAMINE 2000; LUCIFERASE; NUCLEASE; NUCLEOTIDE; PALMITIC ACID; SMALL INTERFERING RNA; THYMIDINE; UNCLASSIFIED DRUG; VASCULOTROPIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG POTENCY; ENZYME INHIBITION; ENZYME STABILITY; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; MAMMAL CELL; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RENILLA; RNA SEQUENCE; TECHNOLOGY;

BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; GENE SILENCING; HELA CELLS; HUMANS; LUCIFERASES, RENILLA; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PALMITIC ACID; RNA, SMALL INTERFERING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 82955229554     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200250f     Document Type: Article

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