Lipid-conjugated 27-nucleotide double-stranded RNAs with dicer-substrate potency enhance RNAi-mediated gene silencing

Molecular Pharmaceutics

Volumn 9, Issue 5, 2012, Pages 1374-1383

  Kubo, Takanori ^a   Yanagihara, Kazuyoshi ^a   Takei, Yoshifumi ^b   Mihara, Keichiro ^c   Sato, Yuichiro ^a   Seyama, Toshio ^a  

^a YASUDA WOMEN'S UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

27 nt dsRNA; Dicer substrate; intracellular delivery; nuclease resistance; palmitic acid conjugates; potent gene silencing

Indexed keywords

CHOLESTEROL; DICER; DOUBLE STRANDED RNA; LIPID CONJUGATED 27 NUCLEOTIDE DOUBLE STRANDED RNA; LUCIFERASE; PALMITIC ACID; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; ENZYME STABILITY; ENZYME SUBSTRATE; ENZYME SYNTHESIS; FEMALE; GENE SILENCING; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; PRIORITY JOURNAL; RNA INTERFERENCE;

CELL LINE, TUMOR; GENE SILENCING; HELA CELLS; HUMANS; LIPIDS; PALMITIC ACID; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84860756787     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2006278     Document Type: Article

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