Global gene expression changes including drug metabolism and disposition induced by three-dimensional culture of HepG2 cells-Involvement of microtubules

Biochemical and Biophysical Research Communications

Volumn 378, Issue 3, 2009, Pages 558-562

  Horiuchi, Shin ichiro ^a   Ishida, Seiichi ^a   Hongo, Tomokatsu ^b   Ishikawa, Youichi ^b   Miyajima, Atsuko ^a   Sawada, Jun ichi ^a   Ohno, Yasuo ^a   Nakazawa, Ken ^a   Ozawa, Shogo ^c  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Able Co Ltd   (Japan)

^c IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Cytoskeleton; Drug metabolism; GeneChip; HepG2; Microtubule; Three dimensional culture

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 17BETA HYDROXYSTEROID DEHYDROGENASE 2; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 4; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 1A1; AROMATASE; ARYLAMINE ACETYLTRANSFERASE; ARYLDIALKYLPHOSPHATASE 2; CYTOCHROME P450 1A1; CYTOCHROME P450 2B6; CYTOCHROME P450 2J2; CYTOCHROME P450 3A4; DOCETAXEL; DRUG METABOLIZING ENZYME; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FATTY ACID AMIDASE; FRUCTOSE BISPHOSPHATASE; FRUCTOSE BISPHOSPHATASE 1; GLUTAMATE DECARBOXYLASE 1; GLUTAMATE DECARBOXYLASE 65; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE PEROXIDASE 3; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE A3; GLUTATHIONE TRANSFERASE P1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LIPID HYDROPEROXIDE; METALLOTHIONEIN II; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG;

ABCC1 GENE; ALAD GENE; ARTICLE; ASNA1 GENE; CELL CULTURE; CHST1 GENE; CONTROLLED STUDY; DRUG DISPOSITION; DRUG METABOLISM; GENE; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; HEPATOMA CELL; HUMAN; HUMAN CELL; MICROTUBULE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ARYL HYDROCARBON HYDROXYLASES; CELL CULTURE TECHNIQUES; CYTOCHROME P-450 CYP3A; GENE EXPRESSION; HUMANS; MICROTUBULES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OXIDOREDUCTASES, N-DEMETHYLATING; PHARMACEUTICAL PREPARATIONS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TAXOIDS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 57749188894     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.11.088     Document Type: Article

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