Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: A study of cell viability, morphology and drug metabolism

Toxicology in Vitro

Volumn 24, Issue 4, 2010, Pages 1314-1323

  Lan, Shih Feng ^a   Safiejko Mroczka, Barbara ^a   Starly, Binil ^a,b  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b University of Oklahoma   (United States)

Author keywords

3D tissue models; Alginate; Cell encapsulation; CYP enzymes; Hydrogels

Indexed keywords

7 ETHOXY 4 TRIFLUOROMETHYL COUMARIN; 7 HYDROXY 4 TRIFLUOROMETHYL COUMARIN; ALGINIC ACID; COUMARIN DERIVATIVE; CYTOCHROME P450 1A1; CYTOCHROME P450 3A4; UNCLASSIFIED DRUG;

ARTICLE; CELL ENCAPSULATION; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL STRUCTURE; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG METABOLISM; DRUG SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYDROGEL; LIVER METABOLISM; METABOLIC RATE; MONOLAYER CULTURE; SCANNING ELECTRON MICROSCOPY;

ALGINATES; CELL CULTURE TECHNIQUES; CELL SURVIVAL; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE; HEP G2 CELLS; HYDROGELS; PRODRUGS; TOXICITY TESTS;

EID: 77952958460     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.02.015     Document Type: Article

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