Significant anti-invasive activities of α-mangostin from the mangosteen pericarp on two human skin cancer cell lines

Anticancer Research

Volumn 32, Issue 9, 2012, Pages 3805-3816

  Wang, Jing J ^a,b   Sanderson, Barbara J S ^a   Zhang, Wei ^a,b  

^a FLINDERS UNIVERSITY   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

Author keywords

Mangostin; A 431; Akt1; Metastasis; MMPs; NF B; SK MEL 28 cells; Skin cancer

Indexed keywords

ALPHA MANGOSTIN; ANTIMETASTATIC AGENT; GELATINASE A; GELATINASE B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; HUMAN; HUMAN CELL; MELANOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN CANCER; SKIN CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; GARCINIA MANGOSTANA; GENE EXPRESSION; HUMANS; MELANOMA; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PLANT EXTRACTS; SKIN NEOPLASMS; XANTHONES;

EID: 84866988376     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Weigelt B, Peterse JL and van't Veer LJ: Breast cancer metastasis: markers and models. Nat Rev Cancer 5: 591-602, 2005. (Pubitemid 41081385)
2. Gupta S and Mukhtar H: Chemoprevention of skin cancer through natural agents. Skin Pharmacol Appl Skin Physiol 14: 373-385, 2001. (Pubitemid 34701809)
3. Nouri K, ed. Skin cancer. McGraw-Hill Medical: New York. 2008.
4. Mohapatra S, Coppola D, Riker AI and Pledger WJ: Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanoma. Mol Cancer Res 5: 145-151, 2007. (Pubitemid 46423995)
5. Autier P: Perspectives in melanoma prevention: the case of sunbeds. Eur J Cancer 40: 2367-2376, 2004.
6. Tarhini AA and Agarwala SS: Cutaneous melanoma: available therapy for metastatic disease. Dermatol Ther 19: 19-25, 2006.
7. Tsao H and Sober AJ: Melanoma treatment update. Dermatol Clin 23: 323-333, 2005.
8. Balch CM, Buzaid AC, Soong SJ, Atkins MB, Cascinelli N, Coit DG, Fleming ID, Gershenwald JE, Houghton A, Jr., Kirkwood JM, McMasters KM, Mihm MF, Morton DL, Reintgen DS, Ross MI, Sober A, Thompson JA and Thompson JF: Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 19: 3635-3648, 2001. (Pubitemid 32786276)
9. Kwa RE, Campana K and Moy RL: Biology of cutaneous squamous cell carcinoma. J Am Acad Dermatol 26: 1-26, 1992.
10. Miller SJ: Biology of basal cell carcinoma (Part I). J Am Acad Dermatol 24: 1-13, 1991.
11. Brohem CA, Sawada TC, Massaro RR, Almeida RL, Rivelli DP, Ropke CD, da Silva VV, de Lima TM, Curi R, Barros SB and Maria-Engler SS: Apoptosis induction by 4-nerolidylcatechol in melanoma cell lines. Toxicol In Vitro 23: 111-119, 2009.
12. Chang PN, Yap WN, Lee DT, Ling MT, Wong YC and Yap YL: Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells. Nutr Cancer 61: 357-366, 2009.
13. Banerji A, Chakrabarti J, Mitra A and Chatterjee A: Effect of curcumin on gelatinase A (MMP-2) activity in B16F10 melanoma cells. Cancer Lett 211: 235-242, 2004. (Pubitemid 38824637)
14. Lin LI, Ke YF, Ko YC and Lin JK: Curcumin inhibits SK-Hep-1 hepatocellular carcinoma cell invasion in vitro and suppresses matrix metalloproteinase-9 secretion. Oncology 55: 349-353, 1998.
15. Lee KJ, Kim JY, Choi JH, Kim HG, Chung YC, Roh SH and Jeong HG: Inhibition of tumor invasion and metastasis by aqueous extract of the radix of Platycodon grandiflorum. Food Chem Toxicol 44 : 1890-1896, 2006. (Pubitemid 44894149)
16. Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N and Neungton N: Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol 90: 161-166, 2004. (Pubitemid 38091702)
17. Ho CK, Huang YL and Chen CC: Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta Med 68: 975-979, 2002.
18. Nakagawa Y, Iinuma M, Naoe T, Nozawa Y and Akao Y: Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells. Bioorg Med Chem 15: 5620-5628, 2007. (Pubitemid 46962985)
19. Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M and Nozawa Y: Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. J Nat Prod 66: 1124-1127, 2003. (Pubitemid 37034054)
20. Suksamrarn S, Komutiban O, Ratananukul P, Chimnoi N, Lartpornmatulee N and Suksamrarn A: Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana. Chem Pharm Bull 54: 301-305, 2006.
21. Wang JJ, Sanderson BJS and Zhang W: Cytotoxic effect of xanthones from pericarp of the tropical fruit mangosteen (Garcinia mangostana Linn.) on human melanoma cells. Food Chem Toxicol 49: 2385-2391, 2011.
22. Hung SH, Shen KH, Wu CH, Liu CL and Shih YW: Alpha-mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen expression through the JNK signaling pathway. J Agric Food Chem 57 : 1291-1298, 2009.
23. Lee YB, Ko KC, Shi MD, Liao YC, Chiang TA, Wu PF, Shih YX and Shih YW: α-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells. J Food Sci 75: 13-23, 2010.
24. Shih YW, Chien ST, Chen PS, Lee JH, Wu SH and Yin LT: α- Mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via αvβ3 integrin/FAK/ERK and NFkB signaling pathway in human lung adenocarcinoma A549 cells. Cell Biochem Biophys 58: 31-44, 2010.
25. Shibata M-A, Iinuma M, Morimoto J, Kurose H, Akamatsu K, Okuno Y, Akao Y and Otsuki Y: alpha-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC Med 9: 69, 2011.
26. Doi H, Shibata MA, Shibata E, Morimoto J, Akao Y, Iinuma M, Tanigawa N and Otsuki Y: Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer. Anticancer Res 29: 2485-2495, 2009.
27. Lovey J, Fazekas K, Ladanyi A, Nemeth G and Timar J: Low-dose irradiation and short-exposure suboptimal-dose paclitaxel adversely modulate metastatic potential of squamous carcinoma cells. Strahlenther Onkol 179: 812-818, 2003. (Pubitemid 37509468)
28. Lu Z, Jiang G, Blume-Jensen P and Hunter T: Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol 21: 4016-4031, 2001. (Pubitemid 32476463)
29. Valster A, Tran NL, Nakada M, Berens ME, Chan AY and Symons M: Cell migration and invasion assays. Methods 37: 208-215, 2005. (Pubitemid 41587431)
30. Sakamoto H, Broekelmann T, Cheresh DA, Ramirez F, Rosenbloom J and Mecham RP: Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1. J Biol Chem 271: 4916-4922, 1996. (Pubitemid 26074980)
31. Wang J, Sanderson B and Zhang Z: Anti-skin cancer properties of phenolic-rich extract from the pericarp of mangosteen (Garcinia mangostana Linn.). Food Chem Toxicol 2012 (Article in Press). DOI: 10.1016/j.fct.2012.06. 003
32. Cavallaro U and Christofori G: Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough. Biochim Biophys Acta 1552: 39-45, 2001. (Pubitemid 34066627)
33. Kawaguchi T: Cancer metastasis: characterization and identification of the behavior of metastatic tumor cells and the cell adhesion molecules, including carbohydrates. Curr Drug Targets Cardiovasc Haematol Disord 5: 39-64, 2005.
34. Onn A and Herbst RS: Angiogenesis, metastasis, and lung cancer. An overview. Methods Mol Med 74: 329-348, 2003.
35. Barinaga M: Cancer research: designing therapies that target tumor blood vessels. Science 275: 482-484, 1997.
36. Muangman S, Thippornwong M and Tohtong R: Anti-metastatic effects of curcusone B, a diterpene from Jatropha curcas. In Vivo 19: 265-268, 2005. (Pubitemid 40450406)
37. Liotta LA, Stetler-Stevenson WG and Steeg PS: Cancer invasion and metastasis: positive and negative regulatory elements. Cancer Invest 9: 543-551, 1991.
38. van Muijen GN, Danen EH, de Vries TJ, Quax PH, Verheijen JH and Ruiter DJ: Properties of metastasizing and nonmetastasizing human melanoma cells. Recent Results Cancer Res 139: 105-122, 1995.
39. Bernhard EJ, Gruber SB and Muschel RJ: Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci USA 91: 4293-4297, 1994. (Pubitemid 24143419)
40. Itoh Y and Nagase H: Matrix metalloproteinases in cancer. Essays Biochem 38: 21-36, 2002. (Pubitemid 36589192)
41. Li A, Dubey S, Varney ML, Dave BJ and Singh RK: IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 170: 3369-3376, 2003. (Pubitemid 36302216)
42. Karin M, Cao Y, Greten FR and Li ZW: NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2: 301-310, 2002. (Pubitemid 37328783)
43. Huang S, Robinson JB, Deguzman A, Bucana CD and Fidler IJ: Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res 60: 5334-5339, 2000.
44. Surh YJ, Na HK, Lee JY and Keum YS: Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer. J Korean Med Sci 16: 38-41, 2001.
45. Bharti AC and Aggarwal BB: Nuclear factor-kappa B and cancer: its role in prevention and therapy. Biochem Pharmacol 64: 883-888, 2002. (Pubitemid 35238030)
46. Jenkins GJS, Harries K, Doak SH, Wilmes A, Griffiths AP, Baxter JN and Parry JM: The bile acid deoxycholic acid (DCA) at neutral pH activates NF-vB and induces IL-8 expression in oesophageal cells in vitro. Carcinogenesis 25: 317-323, 2004. (Pubitemid 38344397)
47. Eberle J, Kurbanov BM, Hossini AM, Trefzer U and Fecker LF: Overcoming apoptosis deficiency of melanoma-hope for new therapeutic approaches. Drug Resist Updat 10: 218-234, 2007. (Pubitemid 351163147)
48. Chau NM and Ashcroft M: Akt2: a role in breast cancer metastasis. Breast Cancer Res 6: 55-57, 2004.
49. Sun LC, Luo J, Mackey LV, Fuselier JA and Coy DH: A conjugate of camptothecin and a somatostatin analog against prostate cancer cell invasion via a possible signaling pathway involving PI3K/Akt, alphaVbeta3/alphaVbeta5 and MMP-2/-9. Cancer Lett 246: 157-166, 2007. (Pubitemid 44959389)
50. Robertson GP: Functional and therapeutic significance of Akt deregulation in malignant melanoma. Cancer Metastasis Rev 24: 273-285, 2005.
51. Neudauer CL and McCarthy JB: Insulin-like growth factor I-stimulated melanoma cell migration requires phosphoinositide 3-kinase but not extracellular-regulated kinase activation. Exp Cell Res 286: 128-137, 2003. (Pubitemid 36506865)
52. Shin DH, Kim OH, Jun HS and Kang MK: Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway. Exp Mol Med 40: 486-494, 2008.
53. Horst B, Gruvberger-Saal SK, Hopkins BD, Bordone L, Yang Y, Chernoff KA, Uzoma I, Schwipper V, Liebau J, Nowak NJ, Brunner G, Owens D, Rimm DL, Parsons R and Celebi JT: Gab2-mediated signaling promotes melanoma metastasis. Am J Pathol 174: 1524-1533, 2009.
54. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM and Donner DB: NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401: 82-85, 1999.
55. Romashkova JA and Makarov SS: NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401: 86-90, 1999.
56. Gygi SP, Rochon Y, Franza BR and Aebersold R: Correlation between Protein and mRNA Abundance in Yeast. Mol Cell Biol 19: 1720-1730, 1999. (Pubitemid 29098230)
57. Harford JB and Morris DR, Post-transcriptional gene regulation. New York, NY Wiley-Liss, Inc. 1997.
58. Urlinger S, Kuchler K, Meyer TH, Uebel S and Tampé R: Intracellular location, complex formation, and function of the transporter associated with antigen processing in yeast. Eur J Biochem 245: 266-272, 1997. (Pubitemid 27171246)
59. Varshavsky A: The N-end rule: functions, mysteries, uses. Proc Natl Acad Sci USA 93: 12142-12149, 1996.
60. Wilkins MR, Williams KL, Appel RD and Hochstrasser DF, Proteome research: new frontiers in functional genomics. Berlin, Germany: Springer-Verlag. 1997.
61. Odashiro AN, Pereira PR, Marshall J-C, Godeiro K and Burnier MN Jr.: Skin cancer models. Drug Discov Today Dis Models 2: 71-75, 2005. (Pubitemid 40932062)