Curcumin inhibits SK-Hep-1 hepatocellular carcinoma cell invasion in vitro and suppresses matrix metalloproteinase-9 secretion

Oncology

Volumn 55, Issue 4, 1998, Pages 349-353

  Lin, Liang In ^a,b   Ke, Yuh Fen ^a   Ko, Ya Chen ^a   Lin, Jen Kun ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Curcumin; Hepatocellular carcinoma cell; Invasion; Matrix metalloproteinase 9; Metastasis; Migration

Indexed keywords

CURCUMIN; GELATINASE B; MATRIGEL;

ARTICLE; CANCER INHIBITION; CANCER INVASION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME RELEASE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; COLLAGENASES; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; TUMOR CELLS, CULTURED;

EID: 0031813252     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000011876     Document Type: Article

References (32)

1. Fidler IJ, Gersten DM, Hart IR: The biology of cancer invasion and metastasis. Adv Cancer Res 1978;28:149-250.
2. Fieler IJ, Kripke ML: Metastasis results from preexisting variant cells within a malignant tumor. Science 1977;197:893-895.
3. Wattenberg LW: Inhibition of carcinogenesis by minor .anutrient constituents of the diet. Proc Nutr Soc 1990;49:173-183.
4. Huang M-T, Smart RC, Wong C-Q, Conney AH: Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 1988;48: 5941-5946.
5. Huang T-S, Lee S-C, Lin J-K: Suppression of c-Jun/AP1 activation by an inhibitor of tumor promotion in mouse fibroblast cells. Proc Natl Acad Sci USA 1991;88:5292-5296.
6. Srivastava R, Dikshit M, Srimal RC, Dhawan BN: Anti-thrombotic effect of curcumin. Throm Res 1985;40:413-417.
7. Srimal RC, Dharvan BN: Pharmacology of curcumin: A non-steroidal and anti-inflammatory agents. J Pharm Pharmacol 1973;25:447-452.
8. Mukhopadhyay A, Basu N, Ghatak N, Gujzal PK: Anti-inflammatory and irritant activities of curcumin analogues in rats. Agents Actions 1982;12:508-515.
9. Huang H-C, Jan T-R, Yeh S-F: Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur J Pharmacol 1992;221:381-384.
10. Sharma OP: Antioxidant activity of curcumin and related compounds. Biochem Pharmacol 1976;25:1811-1812.
11. Nagabhushan M, Amonkar AJ, Bhide SV: In vitro antimutagenicity of curcumin against environmental mutagens. Food Chem Toxicol 1987;25:545-547.
12. Polasa K, Raghuram TC, Krishna TP, Krishnaswamy K: Effect of turmeric on urinary mutagens in smokers. Mutagenesis 1992;7:107-109.
13. Rao DS, Sekhara NC, Satyanarayana MN, Srinivasan M: Effect of curcumin on serum and liver cholesterol levels in the rat. J Nutr 1970; 100:1307-1315.
14. Srinivasan M: Effect of curcumin on blood sugar as seen in a diabetic subject. Indian J Med Sci 1972;26:169-270.
15. Menon LG, Kuttan R, Kuttan G: Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds. Cancer Lett 1995;95:221-225.
16. Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson SA, Kozlowski JM, McEwan RN: A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 1987;47:3239-3245.
17. Stoner GD, Mukhtar H: Polyphenols as cancer chemopreventive agents. J Cell Biochem Suppl 1995;22:169-180.
18. Huang M-T, Robertson FM, Lysz T, Ferraro T, Wang ZY, Georgiadis CA, Laskin JD, Conney AH: Inhibitory effects of curcumin on carcinogenesis in mouse epidermis; in Huang M-T, Ho C-T, Lee CY (eds): Phenolic Compounds in Food and Their Effects on Health. II. Antioxidants and Cancer Prevention. Washington, American Chemical Society, 1992, pp 339-349.
19. Kunchandy E, Rao MNA: Oxygen radical scavenging activity of curcumin. Int J Pharm 1990; 58:237-240.
20. Huang M-T, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH: Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res 1991;51:813-819.
21. Rao CV, Simi B, Reddy BS: Inhibitory effect by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis 1993;14:2219-2225.
22. Azuine MA, Bhide SV: Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice. Nutr Cancer 1992;17:77-83.
23. Liu JY, Lin SJ, Lin JK: Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoylphorbol-13-acetate in NIH3T3 cells. Carcinogenesis 1993;14:857-861.
24. Shih CA, Lin JK: Inhibition of 8-hydroxydeoxy-guanosine formation by curcumin in mouse fibroblast cells. Carcinogenesis 1993;14:709-712.
25. Lin JK, Shih CA: Inhibitory effects of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NIH3T3 cells. Carcinogenesis 1994;15:1717-1721.
26. 2+ ion and cellular p53 protein by curcumin in colorectal carcinoma cells. Mol Carcinog 1996;17:224-234.
27. Kuo M-L, Huang T-Z, Lin J-K: Curcumin, an antioxidant and antitumor promoter, induces apoptosis in human leukemia cells. Biochim Biophys Acta 1996;1317:95-100.
28. Jiang M-C, Yang-Yen H-F, Yan JJ-Y, Lin J-K: Curcumin induces apoptosis in immortalized NIH3T3 and malignant cancer cell lines. Nutr Cancer 1996;26:111-120.
29. Mignatti P, Rifkin DB: Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 1993;73:161-195.
30. Juarez J, Clayman G, Nakajuma M, Tanabe KK, Saya H, Nicolson GL, Boyd D: Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in two invasive squamous-cell-carcinoma cell lines of the oral cavity. Int J Cancer 1993;55:10-18.
31. Sato H, Seiki M: Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 1993;8:395-405.
32. Singh S, Aggarwal BB: Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane). J Biol Chem 1995;270: 24995-25000.