α-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the erk signaling pathway in mcf-7 human breast adenocarcinoma cells

Journal of Food Science

Volumn 75, Issue 1, 2010, Pages

  Lee, Yuan Bing ^a   Ko, Kung Chung ^a   Shi, Ming Der ^a,b   Liao, Yi Chen ^c   Chiang, Tai An ^d   Wu, Pei Fen ^e   Shih, You Xin ^f   Shih, Yuan Wei ^d  

^a Yongkang Veterans Hospital   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c CHI MEI MEDICAL CENTER   (Taiwan)

^d CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^e TAJEN UNIVERSITY   (Taiwan)

^f Taipei Song Shan Primary School   (Taiwan)

Author keywords

mangostin; ERK1 2; Invasion; Migration; MMP 2; MMP 9; TPA

Indexed keywords

CARCINOGEN; DNA; GELATINASE A; GELATINASE B; MANGOSTIN; MITOGEN ACTIVATED PROTEIN KINASE 3; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE INHIBITOR; XANTHONE DERIVATIVE;

ADENOCARCINOMA; ARTICLE; BREAST TUMOR; CELL ADHESION; CELL SURVIVAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING; WOUND HEALING;

ADENOCARCINOMA; BLOTTING, WESTERN; BREAST NEOPLASMS; CARCINOGENS; CELL ADHESION; CELL LINE, TUMOR; CELL SURVIVAL; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRADECANOYLPHORBOL ACETATE; WOUND HEALING; XANTHONES;

EID: 74249113058     PISSN: 00221147     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2009.01407.x     Document Type: Article

References (38)

1. Bange J, Zwick E, Ullrich A. 2001. Molecular targets for breast cancer therapy and prevention. Nat Med 7 : 548 552.
2. Bernhard EJ, Gruber SB, Muschel RJ. 1994. Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci USA 91 : 4293 4297.
3. Brockman JA, Scherer DC, McKinsey TA, Hall SM, Qi X, Lee WY, Ballard DW. 1995. Coupling of a signal response domain in IkBa to multiple pathways for NF-kB activation. Mol Cell Biol 15 : 2809 2818.
4. Carpenter CL, Cantley LC. 1996. Phosphoinositide kinases. Curr Opin Cell Biol 8 : 153 158.
5. Chairungsrilerd N, Furukawa KI, Ohta T, Nozoe S, Ohizumi Y. 1996. Pharmacological properties of α-mangostin, a novel histamine H1 receptor antagonist. Eur J Pharmacol 314 : 351 356.
6. Chen PN, Hsieh YS, Chiou HL, Chu SC. 2005a. Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways. Chem Biol Interact 156 : 141 150.
7. Chen YC, Shen SC, Tsai SH. 2005b. Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species. Biochim Biophys Acta 1743 : 291 304.
8. Chu SC, Chiou HL, Chen PN, Yang SF, Hsieh YS. 2004. Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol Carcinog 40 : 143 149.
9. Chung TW, Lee YC, Kim CH. 2004. Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J 18 : 1123 1125.
10. Fu C, Loo AE, Chia FP, Huang D. 2007. Oligomeric proanthocyanidins from mangosteen pericarps. J Agric Food Chem 55 : 7689 7694.
11. Govindachari TRKP, Muthukumaraswamy N. 1971. Xanthones of Garcinia Mangostana Linn. Tetrahedron 27 : 3919 3926.
12. Huang Q, Shen HM, Ong CN. 2004. Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB. Biochem Pharmacol 68 : 361 371.
13. Huang SC, Ho CT, Lin-Shiau SY, Lin JK. 2005. Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-Jun. Biochem Pharmacol 69 : 221 232.
14. Hung SH, Shen KH, Wu CH, Liu CL, Shih YW. 2009. α-Mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase- plasminogen activator expression through the JNK signaling pathway. J Agric Food Chem 57 : 1291 1298.
15. Ho CK, Huang YL, Chen CC. 2002. Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta Med 68 : 975 979.
16. Hoppe-Seyler F, Butz K, Rittmuller C, von Knebel Doeberitz M. 1991. A rapid microscale procedure for the simultaneous preparation of cytoplasmic RNA, nuclear DNA binding proteins and enzymatically active luciferase extracts. Nucleic Acids Res 19 : 5080.
17. Jang BC, Park YK, Choi IH, Kim SP, Hwang JB, Baek WK, Suh MH, Mun KC, Suh SI. 2007. 12-O-tetradecanoyl phorbol 13-acetate induces the expression of B7-DC, -H1, -H2, and -H3 in K562 cells. Int J Oncol 31 : 1439 1447.
18. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. 2007. Cancer statistics. CA Cancer J Clin 57 : 43 66.
19. Jinsart W, Ternai B, Buddhasukh D, Polya GM. 1992. Inhibition of wheat embryo calcium-dependent protein kinase and other kinases by mangostin and γ-mangostin. Phytochemistry 31 : 3711 3713.
20. Jung HA, Su BN, Keller WJ, Mehta RG, Kinghorn AD. 2006. Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J Agric Food Chem 54 : 2077 2082.
21. Kleiner DE, Stetler-Stevenson WG. 1999. Matrix metalloproteinases and metastasis. Cancer Chemother. Pharmacol 43 : S42 51.
22. Kwon GT, Cho HJ, Chung WY, Park KK, Moon A, Park JH. 2009. Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. J Nutr Biochem 20 : 663 676.
23. Lee SJ, Park SS, Lee US, Kim WJ, Moon SK. 2008. Signaling pathway for TNF-alpha-induced MMP-9 expression: mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells. Int Immunopharmacol 8 : 1821 1826.
24. Ma W, Lim W, Gee K, Aucoin S, Nandan D, Kozlowski M, Diaz-Mitoma F, Kumar A. 2001. The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide stimulated human macrophages. J Biol Chem 276 : 13664 13674.
25. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and 1 survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65 : 55 63.
26. Moongkarndi P, Kosem N, Kaslungka S. 2004. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol 90 : 161 166.
27. Nagase H, Woessner Jr. JF. 1999. Matrix metalloproteinases. J Biol Chem 274 : 21491 21494.
28. Nakagawa Y, Iinuma M, Naoe T, Nozawa Y, Akao Y. 2007. Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells. Bioorg Med Chem 15 : 5620 5628.
29. Ochi Y, Atsumi S, Aoyagi T, Umezawa K. 1993. Inhibition of tumor cell invasion in the Boyden chamber assay by a mannosidase inhibitor, mannostatin A. Anticancer Res 13 : 1421 1424.
30. Peres V, Nagem TJ. 1997. Trioxygenated naturally occurring xanthones. Phytochemistry 44 : 191 214.
31. Peres V, Nagem TJ, Faustino de Oliveira F. 2000. Tetraoxygenated naturally occurring xantones. Phytochemistry 55 : 683 710.
32. Roy AM, Baliga MS, Katiyar SK. 2005. Epigallocatechin-3-gallate induces apoptosis in estrogen receptor-negative human breast carcinoma cells via modulation in protein expression of p53 and Bax and caspase-3 activation. Mol Cancer Ther 4 : 81 90.
33. Singh RP, Deep G, Chittezhath M, Kaur M, Dwyer-Nield LD, Malkinson AM, Agarwal R. 2006. Effect of silibinin on the growth and progression of primary lung tumors in mice. J Natl Cancer Inst 98 : 846 855.
34. Sliva D. 2004. Signaling pathways responsible for cancer cell invasion as targets for cancer therapy. Curr Cancer Drug Targets 4 : 327 336.
35. Sultanbawa MUS. 1980. Xanthonoids of tropical plants. Tetrahedron 36 : 1465 1506.
36. Vieira LM, Kijjoa A. 2005. Naturally-occurring xanthones: recent developments. Curr Med Chem 12 : 2413 2446.
37. Westermarck J, Kahari VM. 1999. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 13 : 781 792.
38. Yang SF, Lin CY, Yang PY, Chao SC, Ye YZ, Hu DN. 2009. Expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts is increased with disease progression and activation of protein kinase C. Invest Ophthalmol Vis Sci 50 : 4588 4596.