Influenza Virology

Milestones in Drug Therapy

Volumn 36, Issue , 2012, Pages 1-29

  Klenk, Hans Dieter ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; AMANTADINE DERIVATIVE; INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; MATRIX PROTEIN; NONSTRUCTURAL PROTEIN 1; NUCLEOCAPSID PROTEIN; OSELTAMIVIR; RIMANTADINE; RNA DIRECTED RNA POLYMERASE; VIRUS SIALIDASE; ZANAMIVIR;

2009 H1N1 INFLUENZA; ANTIVIRAL RESISTANCE; ARTICLE; AVIAN INFLUENZA; EPIDEMIC; GENETIC REASSORTMENT; HONG KONG INFLUENZA; HOST RANGE; HUMAN; INFECTION PREVENTION; INFLUENZA A; INFLUENZA A (H1N1); INFLUENZA A (H2N2); INFLUENZA B; INFLUENZA VIRUS; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS C; MEMBRANE FUSION; NONHUMAN; PANDEMIC; PRIORITY JOURNAL; RECEPTOR BINDING; RNA REPLICATION; RNA TRANSCRIPTION; SEASONAL INFLUENZA; SPANISH INFLUENZA; VIRION; VIRUS CLASSIFICATION; VIRUS GENOME; VIRUS MORPHOLOGY; VIRUS PATHOGENESIS; VIRUS RELEASE; VIRUS REPLICATION; VIRUS TRANSMISSION; VIRUS VIRULENCE;

EID: 84866982437     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7643-8927-7_1     Document Type: Article

References (182)

1. Shope RE (1931) Swine influenza. 1. Experimental transmission and pathology. J Exp Med 54:349-360
2. Smith W, Andrewes CH, Laidlaw PP (1933) A virus obtained from influenza patients. Lancet 66-68
3. Centanni E (1902) Die Vogelpest. Beitrag zu dem durch Kerzen filtrierbaren Virus (Fowl plague. Report on the candle filterable virus). Centralblatt fur Bakteriologie. Parasitenkunde und Infektionskrankheiten I Abteilung: medizinische-hygienische Bakteriologie und tierische Parasitenkunde 31:145-152
4. Lode A, Gruber F (1901) Bakteriologische Studien uber die Aetiologie einer epidemischen Erkrankung der Huhner in Tirol. Centralblatt fur Bakteriologie, Parasitenkunde und Infektionskrankheiten I Abteilung: medizinische-hygienische Bakteriologie und tierische Parasitenkunde 30:593-604
5. Schaefer W (1955) Vergleichende sero-immunologische Untersuchungen uber die Viren der Influenza und klassischen Geflugelpest (Comparative sero-immunological investigations on the viruses of influenza and classical fowl plague). Z Naturforsch 10b:81-91
6. Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y (1992) Evolution and ecology of influenza A viruses. Microbiol Rev 56:152-179
7. Hirst GK (1941) The agglutination of red cells by allantoic fluid of chick embryos infected with influenza virus. Science 94:22-23
8. McClelland L, Hare R (1941) The adsorption of influenza virus by red cells and a new in vitro method of measuring antibodies for influenza virus. Can J Public Health 32:530-538
9. Burnet FM, Stone JD (1947) The receptor destroying enzyme of V. cholerae. Aust J Exp Biol Med Sci 25:227-233
10. Gottschalk A, Lind PE (1949) Product of interaction between influenza virus enzyme and ovomucin. Nature 164:232
11. Klenk E, Faillard H, Lempfrid H (1955) Uber die enzymatische Wirkung von Influenza Virus. Z Physiol Chem 301:235-246
12. Shaw ML, Palese P (2008) Orthomyxoviruses: molecular biology. In: Mahy BWJ, Van Regenmortel M (eds) Encyclopedia of virology, vol 3. Elsevier, Amsterdam, pp 483-489
13. Olsen B, Munster VJ, Wallensten A, Waldenstrom J, Osterhaus AD, Fouchier RA (2006) Global patterns of influenza a virus in wild birds. Science 312:384-388
14. Alexander DJ, Brown IH (2009) History of highly pathogenic avian influenza. Rev Sci Tech 28:19-38
15. Campitelli L, Mogavero E, De Marco MA, Delogu M, Puzelli S, Frezza F, Facchini M, Chiapponi C, Foni E, Cordioli P et al (2004) Interspecies transmission of an H7N3 influenza virus from wild birds to intensively reared domestic poultry in Italy. Virology 323:24-36
16. Roehm C, Horimoto T, Kawaoka Y, Suss J, Webster RG (1995) Do hemagglutinin genes of highly pathogenic avian influenza viruses constitute unique phylogenetic lineages? Virology 209:664-670
17. Chen H, Smith GJ, Li KS, Wang J, Fan XH, Rayner JM, Vijaykrishna D, Zhang JX, Zhang LJ, Guo CT et al (2006) Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc Natl Acad Sci USA 103:2845-2850
18. Matrosovich M, Zhou N, Kawaoka Y, Webster R (1999) The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties. J Virol 73:1146-1155
19. Matrosovich MN, Krauss S, Webster RG (2001) H9N2 Influenza A Viruses from Poultry in Asia Have Human Virus-like Receptor Specificity. Virology 281:156-162
20. Horimoto T, Kawaoka Y (2005) Influenza: lessons from past pandemics, warnings from current incidents. Nat Rev Microbiol 3:591-600
21. Gabriel G, Dauber B, Wolff T, Planz O, Klenk HD, Stech J (2005) The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc Natl Acad Sci USA 102:18590-18595
22. Ludwig S, Stitz L, Planz O, Van H, Fitch WM, Scholtissek C (1995) European swine virus as a possible source for the next influenza pandemic? Virology 212:555-561
23. Scholtissek C (1990) Pigs as "mixing vessels" for the creation of new pandemic influenza A viruses. Med Principles Pract 2:65-71
24. Taubenberger JK, Morens DM (2009) Pandemic influenza-including a risk assessment of H5N1. Rev Sci Tech 28:187-202
25. Taubenberger JK, Reid AH, Krafft AE, Bijwaard KE, Fanning TG (1997) Initial genetic characterization of the 1918 "Spanish" influenza virus. Science 275:1793-1796
26. Reid AH, Fanning TG, Hultin JV, Taubenberger JK (1999) Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin gene. Proc Natl Acad Sci USA 96:1651-1656
27. Tumpey TM, Basler CF, Aguilar PV, Zeng H, Solorzano A, Swayne DE, Cox NJ, Katz JM, Taubenberger JK, Palese P, Garcia-Sastre A (2005) Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 310:77-80
28. Kobasa D, Takada A, Shinya K, Hatta M, Halfmann P, Theriault S, Suzuki H, Nishimura H, Mitamura K, Sugaya N et al (2004) Enhanced virulence of influenza A viruses with the hemagglutinin of the 1918 pandemic virus. Nature 431:703-707
29. Tumpey TM, Garcia-Sastre A, Mikulasova A, Taubenberger JK, Swayne DE, Palese P, Basler CF (2002) Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus. Proc Natl Acad Sci USA 99:13849-13854
30. Tumpey TM, Garcia-Sastre A, Taubenberger JK, Palese P, Swayne DE, Basler CF (2004) Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus. Proc Natl Acad Sci USA 101:3166-3171
31. Van Hoeven N, Pappas C, Belser JA, Maines TR, Zeng H, Garcia-Sastre A, Sasisekharan R, Katz JM, Tumpey TM (2009) Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air. Proc Natl Acad Sci USA 106: 3366-3371
32. Watanabe T, Watanabe S, Shinya K, Kim JH, Hatta M, Kawaoka Y (2009) Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets. Proc Natl Acad Sci USA 106:588-592
33. Geiss GK, Salvatore M, Tumpey TM, Carter VS, Wang X, Basler CF, Taubenberger JK, Bumgarner RE, Palese P, Katze MG, Garcia-Sastre A (2002) Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proc Natl Acad Sci USA 99:10736-10741
34. McAuley JL, Hornung F, Boyd KL, Smith AM, McKeon R, Bennink J, Yewdell JW, McCullers JA (2007) Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe 2:240-249
35. Kash JC, Tumpey TM, Proll SC, Carter V, Perwitasari O, Thomas MJ, Basler CF, Palese P, Taubenberger JK, Garcia-Sastre A et al (2006) Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature 443:578-581
36. Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, Ebihara H, Hatta Y, Kim JH, Halfmann P, Hatta M et al (2007) Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445:319-323
37. Kawaoka Y, Krauss S, Webster RG (1989) Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics. J Virol 63:4603-4608
38. Scholtissek C, Rohde W, Von Hoyningen V, Rott R (1978) On the origin of the human influenza virus subtypes H2N2 and H3N2. Virology 87:13-20
39. Nakajima K, Desselberger U, Palese P (1978) Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950. Nature 274:334-339
40. Scholtissek C, von Hoyningen V, Rott R (1978) Genetic relatedness between the new 1977 epidemic strains (H1N1) of influenza and human influenza strains isolated between 1947 and 1957 (H1N1). Virology 89:613-617
41. Holmes EC, Ghedin E, Miller N, Taylor J, Bao Y, St George K, Grenfell BT, Salzberg SL, Fraser CM, Lipman DJ, Taubenberger JK (2005) Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses. PLoS Biol 3:e300
42. Kilbourne ED (1977) Influenza pandemics in perspective. JAMA 237:1225-1228
43. Pyle GF (1986) The diffusion of influenza: patterns and paradigms. Rowan & Littlefield, New Jersey
44. Noble GR (1982) Epidemiological and clinical aspects of influenza. In: Beare AS (ed) Basic and applied influenza research. CRC Press, Boca Raton, FL, pp 11-50
45. Kilbourne ED, Smith C, Brett I, Pokorny BA, Johansson B, Cox N (2002) The total influenza vaccine failure of 1947 revisited: major intrasubtypic antigenic change can explain failure of vaccine in a post-World War II epidemic. Proc Natl Acad Sci USA 99:10748-10752
46. Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, Sessions WM, Xu X, Skepner E, Deyde V et al (2009) Antigenic and genetic characteristics of swine-origin 2009 A (H1N1) influenza viruses circulating in humans. Science 325:197-201
47. Claas EC, Osterhaus AD, van Beek R, De Jong JC, Rimmelzwaan GF, Senne DA, Krauss S, Shortridge KF, Webster RG (1998) Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet 351:472-477
48. Subbarao K, Klimov A, Katz J, Regnery H, Lim W, Hall H, Perdue M, Swayne D, Bender C, Huang J et al (1998) Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279:393-396
49. Xu X, Subbarao CNJ, Guo Y (1999) Genetic characterization of the pathogenic influenza A/ Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong. Virology 261:15-19
50. Cauthen AN, Swayne DE, Schultz-Cherry S, Perdue ML, Suarez DL (2000) Continued circulation in China of highly pathogenic avian influenza viruses encoding the hemagglutinin gene associated with the 1997 H5N1 outbreak in poultry and humans. J Virol 74:6592-6599
51. Guan Y, Peiris JS, Lipatov AS, Ellis TM, Dyrting KC, Krauss S, Zhang LJ, Webster RG, Shortridge KF (2002) Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR. Proc Natl Acad Sci USA 99:8950-8955
52. World Health Organization (2003) WHO: disease alert: 10 December 2003. Influenza A (H9N2) in Hong Kong Special Administrative Region of China
53. Li KS, Guan Y, Wang J, Smith GJ, Xu KM, Duan L, Rahardjo AP, Puthavathana P, Buranathai C, Nguyen TD et al (2004) Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 430:209-213
54. Liu J, Xiao H, Lei F, Zhu Q, Qin K, Zhang XW, Zhang XL, Zhao D, Wang G, Feng Y et al (2005) Highly pathogenic H5N1 influenza virus infection in migratory birds. Science 309:1206
55. Kuiken T, Rimmelzwaan G, van Riel D, van Amerongen G, Baars M, Fouchier R, Osterhaus A (2004) Avian H5N1 influenza in cats. Science 306:241
56. Enserink M, Kaiser J (2004) Virology. Avian flu finds new mammal hosts. Science 305:1385
57. Weber S, Harder T, Starick E, Beer M, Werner O, Hoffmann B, Mettenleiter TC, Mundt E (2007) Molecular analysis of highly pathogenic avian influenza virus of subtype H5N1 isolated from wild birds and mammals in northern Germany. J Gen Virol 88:554-558
58. de Jong MD, Simmons CP, Thanh TT, Hien VM, Smith GJ, Chau TN, Hoang DM, Chau NV, Khanh TH, Dong VC et al (2006) Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med 12:1203-1207
59. Banks J, Speidel E, Alexander DJ (1998) Characterisation of an avian influenza A virus isolated from a human-is an intermediate host necessary for the emergence of pandemic influenza viruses? Arch Virol 143:781-787
60. Kurtz J, Manvell RJ, Banks J (1996) Avian influenza virus isolated from a woman with conjunctivitis. Lancet 348:901-902
61. Fouchier RA, Schneeberger PM, Rozendaal FW, Broekman JM, Kemink SA, Munster V, Kuiken T, Rimmelzwaan GF, Schutten M, Van Doornum GJ et al (2004) Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome. Proc Natl Acad Sci USA 101:1356-1361
62. Koopmans M, Vennema H, Heersma H, van Strien E, van Duynhoven Y, Brown D, Reacher M, Lopman B (2003) Early identification of common-source foodborne virus outbreaks in Europe. Emerg Infect Dis 9:1136-1142
63. van Kolfschooten F (2003) Dutch veterinarian becomes first victim of avian influenza. Lancet 361:1444
64. Bosman A (2004) Avian flu epidemic 2003. RIVM report
65. Guo YJ, Krauss S, Senne DA, Mo IP, Lo KS, Xiong XP, Norwood M, Shortridge KF, Webster RG, Guan Y (2000) Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in Asia. Virology 267:279-288
66. Peiris M, Yuen KY, Leung CW, Chan KH, Ip PL, Lai RW, Orr WK, Shortridge KF (1999) Human infection with influenza H9N2. Lancet 354:916-917
67. Lin YP, Shaw M, Gregory V, Cameron K, Lim W, Klimov A, Subbarao K, Guan Y, Krauss S, Shortridge K et al (2000) Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates. Proc Natl Acad Sci USA 97:9654-9658
68. Choi YK, Ozaki H, Webby RJ, Webster RG, Peiris JS, Poon L, Butt C, Leung YH, Guan Y (2004) Continuing evolution of H9N2 influenza viruses in Southeastern China. J Virol 78:8609-8614
69. Gratzl E, Koehler H (1968) Gefluegelpest Spezielle Pathologie und Therapie der Gefluegelk-rankheiten. Ferdinand Enke Verlag, Stuttgart, Germany
70. Narayan O, Thorsen J, Hulland TJ, Ankeli G, Joseph PG (1972) Pathogenesis of lethal influenza virus infection in turkeys. I. Extraneural phase of infection. J Comp Pathol 82:129-137
71. Van Campen H, Easterday BC, Hinshaw VS (1989) Virulent avian influenza A viruses: their effect on avian lymphocytes and macrophages in vivo and in vitro. J Gen Virol 70(Pt 11):2887-2895
72. Van Campen H, Easterday BC, Hinshaw VS (1989) Destruction of lymphocytes by a virulent avian influenza A virus. J Gen Virol 70(Pt 2):467-472
73. Kobayashi Y, Horimoto T, Kawaoka Y, Alexander DJ, Itakura C (1996) Pathological studies of chickens experimentally infected with two highly pathogenic avian influenza viruses. Avian Pathol 25:285-304
74. Feldmann A, Schafer MK, Garten W, Klenk HD (2000) Targeted infection of endothelial cells by avian influenza virus A/FPV/Rostock/34 (H7N1) in chicken embryos. J Virol 74:8018-8027
75. Area E, Martin-Benito J, Gastaminza P, Torreira E, Valpuesta JM, Carrascosa JL, Ortin J (2004)3D structure of the influenza virus polymerase complex: localization of subunit domains. Proc Natl Acad Sci USA 101:308-313
76. Fodor E, Smith M (2004) The PA subunit is required for efficient nuclear accumulation of the PB1 subunit of the influenza A virus RNA polymerase complex. J Virol 78:9144-9153
77. Deng T, Sharps JL, Brownlee GG (2006) Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication. J Gen Virol 87:3373-3377
78. Engelhardt OG, Smith M, Fodor E (2005) Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II. J Virol 79:5812-5818
79. Ye Q, Krug RM, Tao YJ (2006) The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA. Nature 444:1078-1082
80. Hay AJ, Lomniczi B, Bellamy AR, Skehel JJ (1977) Transcription of the influenza virus genome. Virology 83:337-355
81. Ulmanen I, Broni BA, Krug RM (1981) Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7G pppNm) on RNAs and in initiating viral RNA transcription. Proc Natl Acad Sci USA 78:7355-7359
82. Shi L, Summers DF, Peng Q, Galarz JM (1995) Influenza A virus RNA polymerase subunit PB2 is the endonuclease which cleaves host cell mRNA and functions only as the trimeric enzyme. Virology 208:38-47
83. Poon LL, Pritlove DC, Fodor E, Brownlee GG (1999) Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template. J Virol 73:3473-3476
84. Zheng H, Lee HA, Palese P, Garcia-Sastre A (1999) Influenza A virus RNA polymerase has the ability to stutter at the polyadenylation site of a viral RNA template during RNA replication. J Virol 73:5240-5243
85. Poon LL, Pritlove DC, Sharps J, Brownlee GG (1998) The RNA polymerase of influenza virus, bound to the 5' end of virion RNA, acts in cis to polyadenylate mRNA. J Virol 72:8214-8219
86. Hay AJ, Skehel JJ, McCauley J (1982) Characterization of influenza virus RNA complete transcripts. Virology 116:517-522
87. Castrucci MR, Kawaoka Y (1993) Biologic importance of neuraminidase stalk length in influenza A virus. J Virol 67:759-764
88. Deshpande KL, Naeve CW, Webster RG (1985) The neuraminidases of the virulent and avirulent A/Chicken/Pennsylvania/83 (H5N2) influenza A viruses: sequence and antigenic analyses. Virology 147:49-60
89. Els MC, Air GM, Murti KG, Webster RG, Laver WG (1985) An 18-amino acid deletion in an influenza neuraminidase. Virology 142:241-247
90. Luo G, Chung J, Palese P (1993) Alterations of the stalk of the influenza virus neuraminidase: deletions and insertions. Virus Res 29:141-153
91. Steuler H, Rohde W, Scholtissek C (1984) Sequence of the neuraminidase gene of an avian influenza A virus (A/parrot/ulster/73, H7N1). Virology 135:118-124
92. Khatchikian D, Orlich M, Rott R (1989) Increased viral pathogenicity after insertion of a 28S ribosomal RNA sequence into the hemagglutinin gene of an influenza virus. Nature 340:156-157
93. Orlich M, Khatchikian D, Teigler A, Rott R (1990) Structural variation occurring in the hemagglutinin of influenza virus A/turkey/Oregon/71 during adaptation to different cell types. Virology 176:531-538
94. Bergmann M, Garcia-Sastre A, Palese P (1992) Transfection-mediated recombination of influenza A virus. J Virol 66:7576-7580
95. Orlich M, Gottwald H, Rott R (1994) Nonhomologous recombination between the hemag-glutinin gene and the nucleoprotein gene of an influenza virus. Virology 204:462-465
96. Pasick J, Handel K, Robinson J, Copps J, Ridd D, Hills K, Kehler H, Cottam-Birt C, Neufeld J, Berhane Y, Czub S (2005) Intersegmental recombination between the hemagglutinin and matrix genes was responsible for the emergence of a highly pathogenic H7N3 avian influenza virus in British Columbia. J Gen Virol 86:727-731
97. Suarez DL, Senne DA, Banks J, Brown IH, Essen SC, Lee CW, Manvell RJ, Mathieu-Benson C, Moreno V, Pedersen JC et al (2004) Recombination resulting in virulence shift in avian influenza outbreak, Chile. Emerg Infect Dis 10:693-699
98. Subbarao EK, London W, Murphy BR (1993) A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J Virol 67:1761-1764
99. Massin P, van der WS, Naffakh N (2001) Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses. J Virol 75:5398-5404
100. Gao P, Watanabe S, Ito T, Goto H, Wells K, McGregor M, Cooley AJ, Kawaoka Y (1999) Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong. J Virol 73:3184-3189
101. Hatta M, Gao P, Halfmann P, Kawaoka Y (2001) Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 293:1840-1842
102. Salomon R, Franks J, Govorkova EA, Ilyushina NA, Yen HL, Hulse-Post DJ, Humberd J, Trichet M, Rehg JE, Webby RJ et al (2006) The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J Exp Med 203:689-697
103. Shinya K, Hamm S, Hatta M, Ito H, Ito T, Kawaoka Y (2004) PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology 320:258-266
104. Govorkova EA, Rehg JE, Krauss S, Yen HL, Guan Y, Peiris M, Nguyen TD, Hanh TH, Puthavathana P, Long HT et al (2005) Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol 79:2191-2198
105. Puthavathana P, Auewarakul P, Charoenying PC, Sangsiriwut K, Pooruk P, Boonnak K, Khanyok R, Thawachsupa P, Kijphati R, Sawanpanyalert P (2005) Molecular characterization of the complete genome of human influenza H5N1 virus isolates from Thailand. J Gen Virol 86:423-433
106. Taubenberger JK, Reid AH, Lourens RM, Wang R, Jin G, Fanning TG (2005) Characterization of the 1918 influenza virus polymerase genes. Nature 437:889-893
107. Li Z, Chen H, Jiao P, Deng G, Tian G, Li Y, Hoffmann E, Webster RG, Matsuoka Y, Yu K (2005) Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model. J Virol 79:12058-12064
108. Gabriel G, Abram M, Keiner B, Wagner R, Klenk HD, Stech J (2007) Differential polymerase activity in avian and mammalian cells determines host range of influenza virus. J Virol 81:9601-9604
109. Naffakh N, Massin P, Escriou N, Crescenzo-Chaigne B, van der WS (2000) Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses. J GenVirol 81:1283-1291
110. Gabriel G, Herwig A, Klenk HD (2008) Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus. PLoS Pathog 4:e11
111. Tarendeau F, Boudet J, Guilligay D, Mas PJ, Bougault CM, Boulo S, Baudin F, Ruigrok RW, Daigle N, Ellenberg J et al (2007) Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat Struct Mol Biol 14:229-233.
112. Tarendeau F, Crepin T, Guilligay D, Ruigrok RW, Cusack S, Hart DJ (2008) Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. PLoS Pathog 4:e1000136
113. Mayer D, Molawi K, Martinez-Sobrido L, Ghanem A, Thomas S, Baginsky S, Grossmann J, Garcia-Sastre A, Schwemmle M (2007) Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches. J Proteome Res 6:672-682
114. Chen W, Calvo PA, Malide D, Gibbs J, Schubert U, Bacik I, Basta S, O'Neill R, Schickli J, Palese P et al (2001) A novel influenza A virus mitochondrial protein that induces cell death. Nat Med 7:1306-1312
115. Chang S, Zhang J, Liao X, Zhu X, Wang D, Zhu J, Feng T, Zhu B, Gao GF, Wang J et al (2007) Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research. Nucleic Acids Res 35:D376-380
116. Russell RJ, Gamblin SJ, Haire LF, Stevens DJ, Xiao B, Ha Y, Skehel JJ (2004) H1 and H7 influenza hemagglutinin structures extend a structural classification of hemagglutinin subtypes. Virology 325:287-296
117. Stevens J, Corper AL, Basler CF, Taubenberger JK, Palese P, Wilson IA (2004) Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus. Science 303:1866-1870
118. Chen J, Lee KH, Steinhauer DA, Stevens DJ, Skehel JJ, Wiley DC (1998) Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation. Cell 95:409-417
119. Wilson IA, Skehel JJ, Wiley DC (1981) Structure of the hemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature 289:366-373
120. Ha Y, Stevens DJ, Skehel JJ, Wiley DC (2002) H5 avian and H9 swine influenza virus hemagglutinin structures: possible origin of influenza subtypes. Embo J 21:865-875
121. Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA (2006) Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science C 312:404-410
122. Eisen MB, Sabesan S, Skehel JJ, Wiley DC (1997) Binding of the influenza A virus to cellsurface receptors: structures of five hemagglutinin-sialyloligosaccharide complexes determined by X-ray crystallography. Virology 232:19-31
123. Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A et al (2004) The structure and receptor-binding properties of the 1918 influenza hemagglutinin. Science 303:1838-1842
124. Ha Y, Stevens DJ, Skehel JJ, Wiley DC (2001) X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs. Proc Natl Acad Sci USA 98:11181-11186
125. Ha Y, Stevens DJ, Skehel JJ, Wiley DC (2003) X-ray structure of the hemagglutinin of a potential H3 avian progenitor of the 1968 Hong Kong pandemic influenza virus. Virology 309:209-218
126. Skehel JJ, Wiley DC (2000) Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu Rev Biochem 69:531-569
127. Wang Q, Tian X, Chen X, Ma J (2007) Structural basis for receptor specificity of influenza B virus hemagglutinin. Proc Natl Acad Sci USA 104:16874-16879
128. Matrosovich MN, Klenk HD, Kawaoka Y (2006) Receptor specificity, host-range and pathogenicity of influenza viruses. In: Kawaoka Y (ed) Influenza virology: current topics. Horizon Press, Wymondham, pp 95-137
129. Rogers GN, Paulson JC (1983) Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin. Virology 127:361-373
130. Matrosovich M, Matrosovich T, Uhlendorff J, Garten W, Klenk HD (2007) Avian-virus-like receptor specificity of the hemagglutinin impedes influenza virus replication in cultures of human airway epithelium. Virology 361:384-390
131. Matrosovich MN, Matrosovich TY, Gray T, Roberts NA, Klenk HD (2004) Human and avian influenza viruses target different cell types in cultures of human airway epithelium. Proc Natl Acad Sci USA 101:4620-4624
132. Nicholls JM, Chan MC, Chan WY, Wong HK, Cheung CY, Kwong DL, Wong MP, Chui WH, Poon LL, Tsao SW et al (2007) Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract. Nat Med 13:147-149
133. Shinya K, Ebina M, Yamada S, Ono M, Kasai N, Kawaoka Y (2006) Avian flu: influenza virus receptors in the human airway. Nature 440:435-436
134. van Riel D, Munster VJ, de Wit E, Rimmelzwaan GF, Fouchier RA, Osterhaus AD, Kuiken T (2006) H5N1 virus attachment to lower respiratory tract. Science 312:399
135. van Riel D, Munster VJ, de Wit E, Rimmelzwaan GF, Fouchier RA, Osterhaus AD, Kuiken T (2007) Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals. Am J Pathol 171:1215-1223
136. Yao L, Korteweg C, Hsueh W, Gu J (2007) Avian influenza receptor expression in H5N1infected and noninfected human tissues. FASEB J. doi:DOI:10.1096/fj.1006-7880com
137. Matrosovich MN, Gambarian AS, Klenk HD (2008) Receptor specificity of influenza viruses and its alteration during interspecies transmission. In: Klenk HD, Matrosovich MN, Stech J (eds) Avian influenza, vol 27. Karger, Basel, pp 134-155
138. Matrosovich MN, Gambaryan AS, Teneberg S, Piskarev VE, Yamnikova SS, Lvov DK, Robertson JS, Karlsson KA (1997) Avian influenza A viruses differ from human viruses by recognition of sialyloligosaccharides and gangliosides and by a higher conservation of the HA receptor-binding site. Virology 233:224-234
139. Matrosovich M, Tuzikov A, Bovin N, Gambarian A, Klimov A, Cox N, Castrucci M, Donatelli I, Kawaoka Y (2000) Alterations of receptor-binding properties of H1, H2 and H3 avian influenza virus hemagglutinins upon introduction into mammals. J Virol 74:8502-8512
140. Klenk HD, Rott R, Orlich M, Blodorn J (1975) Activation of influenza A viruses by trypsin treatment. Virology 68:426-439
141. Lazarowitz SG, Choppin PW (1975) Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide. Virology 68:440-454
142. Bosch FX, Garten W, Klenk HD, Rott R (1981) Proteolytic cleavage of influenza virus hemagglutinins: primary structure of the connecting peptide between HA1 and HA2 determines proteolytic cleavability and pathogenicity of avian influenza viruses. Virology 113:725-735
143. Garten W, Bosch FX, Linder D, Rott R, Klenk HD (1981) Proteolytic activation of the influenza virus hemagglutinin: the structure of the cleavage site and the enzymes involved in cleavage. Virology 115:361-374
144. Garten W, Klenk HD (1983) Characterization of the carboxypeptidase involved in the proteolytic cleavage of the influenza hemagglutinin. J Gen Virol 64(Pt 10):2127-2137
145. Garten W, Linder D, Rott R, Klenk HD (1982) The cleavage site of the hemagglutinin of fowl plague virus. Virology 122:186-190
146. Garten W, Klenk HD (2008) Cleavage activation of the influenza virus hemagglutinin and its role in pathogenesis. In: Klenk HD, Matrosovich MN, Stech J (eds) Avian influenza, vol 27. Karger, Basel, pp 156-167
147. Klenk HD, Garten W (1994) Host cell proteases controlling virus pathogenicity. Trends Microbiol 2:39-43
148. Steinhauer DA (1999) Role of hemagglutinin cleavage for the pathogenicity of influenza virus. Virology 258:1-20
149. Guenther I, Glatthaar B, Doller G, Garten W (1993) A H1 hemagglutinin of a human influenza A virus with a carbohydrate-modulated receptor binding site and an unusual cleavage site. Virus Res 27:147-160
150. Kawaoka Y, Yamnikova S, Chambers TM, Lvov DK, Webster RG (1990) Molecular characterization of a new hemagglutinin, subtype H14, of influenza A virus. Virology 179:759-767
151. Boettcher E, Matrosovich T, Beyerle M, Klenk HD, Garten W, Matrosovich M (2006) Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. J Virol 80:9896-9898
152. Tashiro M, Ciborowski P, Klenk HD, Pulverer G, Rott R (1987) Role of Staphylococcus protease in the development of influenza pneumonia. Nature 325:536-537.
153. Stieneke-Groeber A, Vey M, Angliker H, Shaw E, Thomas G, Roberts C, Klenk HD, Garten W (1992) Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease. Embo J 11:2407-2414
154. Seidah NG, Chretien M (1999) Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res 848:45-62.
155. Hallenberger S, Bosch V, Angliker H, Shaw E, Klenk HD, Garten W (1992) Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160. Nature 360:358-361.
156. Horimoto T, Nakayama K, Smeekens SP, Kawaoka Y (1994) Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses. J Virol 68:6074-6078
157. Neumann G, Kawaoka Y (2006) Host range restriction and pathogenicity in the context of influenza pandemic. Emerg Infect Dis 12:881-886
158. Kawaoka Y, Webster RG (1989) Interplay between carbohydrate in the stalk and the length of the connecting peptide determines the cleavability of influenza virus hemagglutinin. J Virol 63:3296-3300
159. Kawaoka Y, Naeve CW, Webster RG (1984) Is virulence of H5N2 influenza viruses in chickens associated with loss of carbohydrate from the hemagglutinin? Virology 139: 303-316
160. Li SQ, Orlich M, Rott R (1990) Generation of seal influenza virus variants pathogenic for chickens, because of hemagglutinin cleavage site changes. J Virol 64:3297-3303.
161. Morsy J, Garten W, Rott R (1994) Activation of an influenza virus A/turkey/Oregon/71 HA insertion variant by the subtilisin-like endoprotease furin. Virology 202:988-991.
162. Garcia M, Crawford JM, Latimer JW, Rivera-Cruz E, Perdue ML (1996) Heterogeneity in the hemagglutinin gene and emergence of the highly pathogenic phenotype among recent H5N2 avian influenza viruses from Mexico. J Gen Virol 77(Pt 7):1493-1504
163. Perdue ML, Garcia M, Senne D, Fraire M (1997) Virulence-associated sequence duplication at the hemagglutinin cleavage site of avian influenza viruses. Virus Res 49:173-186.
164. Banks J, Speidel ES, Moore E, Plowright L, Piccirillo A, Capua I, Cordioli P, Fioretti A, Alexander DJ (2001) Changes in the hemagglutinin and the neuraminidase genes prior to the emergence of highly pathogenic H7N1 avian influenza viruses in Italy. Arch Virol 146:963-973
165. Varghese JN, Laver WG, Colman PM (1983) Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution. Nature 303:35-40
166. Blok J, Air GM (1982) Block deletions in the neuraminidase genes from some influenza A viruses of the N1 subtype. Virology 118:229-234
167. Colman PM, Varghese JN, Laver WG (1983) Structure of the catalytic and antigenic sites in influenza virus neuraminidase. Nature 303:41-44
168. Mitnaul LJ, Matrosovich MN, Castrucci MR, Tuzikov AB, Bovin NV, Kobasa D, Kawaoka Y (2000) Balanced hemagglutinin and neuraminidase activities are critical for efficient replication of influenza A virus. J Virol 74:6015-6020
169. Wagner R, Wolff T, Herwig A, Pleschka S, Klenk HD (2000) Interdependence of hemagglutinin glycosylation and neuraminidase as regulators of influenza virus growth: a study by reverse genetics. J Virol 74:6316-6323
170. Hausmann J, Kretzschmar E, Garten W, Klenk HD (1995) N1 neuraminidase of influenza virus A/FPV/Rostock/34 has haemadsorbing activity. J Gen Virol 76(Pt 7):1719-1728.
171. Kobasa D, Rodgers ME, Wells K, Kawaoka Y (1997) Neuraminidase hemadsorption activity, conserved in avian influenza A viruses, does not influence viral replication in ducks. J Virol 71:6706-6713
172. Laver WG, Colman PM, Webster RG, Hinshaw VS, Air GM (1984) Influenza virus neuraminidase with hemagglutinin activity. Virology 137:314-323
173. Nuss JM, Air GM (1991) Transfer of the hemagglutinin activity of influenza virus neuraminidase subtype N9 into an N2 neuraminidase background. Virology 183:496-504.
174. Varghese JN, Colman PM, van Donkelaar A, Blick TJ, Sahasrabudhe A, McKimm-Breschkin JL (1997) Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases. Proc Natl Acad Sci USA 94:11808-11812
175. Uhlendorff J, Matrosovich T, Klenk HD, Matrosovich M (2009) Functional significance of the hemadsorption activity of influenza virus neuraminidase and its alteration in pandemic viruses. Arch Virol 154:945-957
176. Matrosovich MN, Matrosovich TY, Gray T, Roberts NA, Klenk HD (2004) Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium. J Virol 78:12665-12667
177. Palese P, Tobita K, Ueda M, Compans RW (1974) Characterization of temperature sensitive influenza virus mutants defective in neuraminidase. Virology 61:397-410.
178. Herrler G, Rott R, Klenk HD, Muller HP, Shukla AK, Schauer R (1985) The receptordestroying enzyme of influenza C virus is neuraminate-O-acetylesterase. EMBO J 4:1503-1506
179. Rosenthal PB, Zhang X, Formanowski F, Fitz W, Wong CH, Meier-Ewert H, Skehel JJ, Wiley DC (1998) Structure of the hemagglutinin-esterase-fusion glycoprotein of influenza C virus. Nature 396:92-96
180. Hay AJ, Collins PJ, Russell RJ (2008) Antivirals and resistance. In: Klenk HD, Matrosovich MN, Stech J (eds) Avian influenza. Karger, Basel, pp 252-271
181. Haller O, Kochs G, Staeheli P (2008) Influenza a virus virulence and innate immunity: Recent insights from new mouse models. In: Klenk HD, Matrosovich MN, Stech J (eds) Avian influenza. Karger, Basel, pp 195-209
182. Neumann G, Noda T, Kawaoka Y (2009) Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 459:931-939