The RNA polymerase of influenza virus, bound to the 5' end of virion RNA, acts in cis to polyadenylate mRNA

Journal of Virology

Volumn 72, Issue 10, 1998, Pages 8214-8219

  Poon, Leo L M ^a   Pritlove, David C ^a   Sharps, Jane ^a   Brownlee, George G ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; POLYADENYLATED RNA; RNA POLYMERASE; VIRUS RNA;

ARTICLE; BASE PAIRING; ENZYME BINDING; INFLUENZA VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; STEREOSPECIFICITY; TRANSCRIPTION INITIATION; VIRION; VIRUS TRANSCRIPTION;

EID: 0031667216     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.10.8214-8219.1998     Document Type: Article

References (30)

1. Beaton, A. R., and R. M. Krug. 1986. Transcription antitermination during influenza viral template RNA synthesis requires the nucleocapsid protein and the absence of a 5′ capped end. Proc. Natl. Acad. Sci. USA 83:6282-6286.
2. Cianci, C., L. Tiley, and M. Krystal. 1995. Differential activation of the influenza virus polymerase via template RNA binding. J. Virol. 69:3995-3999.
3. Desselberger, U., V. R. Racaniello, J. J. Zazra, and P. Palese. 1980. The 3′ and 5′ terminal sequences of influenza A, B and C virus RNA segments are highly conserved and show partial inverted complementarity. Gene 8:315-328.
4. Fodor, E., D. C. Pritlove, and G. G. Brownlee. 1994. The influenza virus panhandle is involved in the initiation of transcription. J. Virol. 68:4092-4096.
5. Fodor, E., D. C. Pritlove, and G. G. Brownlee. 1995. Characterization of the RNA-fork model of the virion RNA in the initiation of transcription in influenza A virus. J. Virol. 69:4012-4019.
6. Hagen, M., T. D. Y. Chung, J. A. Butcher, and M. Krystal. 1994. Recombinant influenza virus polymerase: requirement of both 5′ and 3′ viral ends for endonuclease activity. J. Virol. 68:1509-1515.
7. Hay, A, J., B. Lomnicza, A. R. Bellamy, and J. J. Skehel. 1977. Transcription of the influenza virus genome. Virology 83:337-355.
8. Honda, A., K. Ueda, K. Nagata, and A. Ishihama. 1988. RNA polymerase of influenza virus: role of NP on RNA chain elongation. J. Biochem. 104:1021-1026.
9. Hsu, M., J. D. Parvin, S. Gupta. M. Krystal, and P. Palese. 1987. Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle. Proc. Natl. Acad. Sci. USA 84: 8140-8144.
10. Huang, T. S., P. Palese, and M. Krystal. 1990. Determination of influenza virus proteins required for genome replication. J. Virol. 64:5669-5673.
11. Kimura, N., M. Nishida, K. Nagata, A. Ishihama, K. Oda, and S. Nakada. 1992. Transcription of a recombinant influenza virus RNA in cells that can express the influenza virus RNA polymerase and nucleoprotein genes. J. Gen. Virol, 73:1321-1328.
12. Klumpp, K., R. W. H. Ruigrok, and F. Baudin. 1997. Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structure. EMBO J. 16:1248-1257.
13. Krug, R. F., F. V. Alonso-Caplan, I. Julkunen, and M. G. Katze. 1989. Expression and replication of the influenza virus genome, p. 89-142. In R. M. Krug (ed.), The influenza viruses. Plenum Press, New York, N.Y.
14. Li, X., and P. Palese. 1994. Characterization of the polyadenylation signal of influenza virus RNA. J. Virol. 68:1245-1249.
15. Luo, G., W. Luytjes, M. Enami, and P. Palese. 1991. The polyadenylation signal of influenza virus RNA involves a stretch of uridines followed by the RNA duplex of the panhandle structure. J. Virol. 65:2861-2867.
16. Luytjes, W., M. Krystal, M. Enami, J. D. Parvin, and P. Palese. 1989. Amplification, expression, and packaging of a foreign gene by influenza virus. Cell 59:1107-1113.
17. Martin, J., C. Albo, J. Ortin, A. Melero, and A. Portela. 1992. In vitro reconstitution of active influenza virus ribonucleoprotein complexes using viral proteins purified from infected cells. J. Gen. Virol. 73:1855-1859.
18. Nagata, K., K. Takeuchi, and A. Ishihama. 1989. In vitro synthesis of influenza virus RNA: biochemical complementation assay of factors required for influenza virus replication. J. Biochem. 106:205-208.
19. Palese, P. 1977. The genes of influenza virus. Cell 10:1-10.
20. Parvin, J. D., P. Palese, A. Honda, A. Ishihama, and M. Krystal. 1989. Promoter analysis of the influenza virus RNA polymerase. J. Virol. 63:5142-5152.
21. 7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription. Cell 23:847-858.
22. Pritlove, D. C. Unpublished data.
23. Pritlove, D. C., L. L. M. Poon, E. Fodor, J. Sharps, and G. G. Brownlee. 1998. Polyadenylation of influenza virus mRNA transcribed in vitro from model virion RNA templates: requirement for 5′ conserved sequences. J. Virol. 72: 1280-1286.
24. Robertson, J. S. 1979. 5′ and 3′ Terminal nucleotide sequences of the RNA genome segments of influenza virus. Nucleic Acids Res. 6:3745-3757.
25. Robertson, J. S., M. Schubert, and R. A. Lazzarini. 1981. Polyadenylation sites for influenza virus mRNA. J. Virol. 38:157-163.
26. Seong, B. L., and G. G. Brownlee. 1992. A new method for reconstituting influenza polymerase and RNA in vitro: a study of the promoter elements for cRNA and vRNA synthesis in vitro and viral rescue in vivo. Virology 186: 247-260.
27. Seong, B. L., M. Kobayashi, K. Nagata, G. G. Brownlee, and A. Ishihama. 1992. Comparison of two reconstitution systems for in vitro transcription and replication of influenza virus. J. Biochem. 111:496-499.
28. Shapiro, G. I., and R. M. Krug. 1988. Influenza virus RNA replication in vitro: synthesis of viral template RNAs and virion RNAs in the absence of an added primer. J. Virol. 62:2285-2290.
29. Sharps, J., and G. G. Brownlee. Unpublished data.
30. Tiley, L. S., M. Hagen, J. T. Matthews, and M. Krystal. 1994. Sequencespecific binding of the influenza virus RNA polymerase to sequences located at the 5′ ends of the viral RNAs. J. Virol. 68:5108-5116.