Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus

Science

Volumn 312, Issue 5772, 2006, Pages 404-410

  Stevens, James ^a   Blixt, Ola ^a   Tumpey, Terrence M ^b   Taubenberger, Jeffery K ^c   Paulson, James C ^a   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES   (United States)

^c ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; HUMAN ENGINEERING; OPTICAL RESOLVING POWER; ORGANIC ACIDS; VIRUSES;

GLYCAN MICROARRAY ANALYSIS; INFLUENZA VIRUSES; MUTATIONS; SIALIC ACID;

GENETIC ENGINEERING;

GLYCAN DERIVATIVE; HEMAGGLUTININ; SIALIC ACID;

INFECTIOUS DISEASE; INFLUENZA; MUTATION; PATHOGEN; VIRUS;

ARTICLE; INFLUENZA VIRUS; MICROANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR SENSITIVITY; VIRUS STRAIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENIC VARIATION; BINDING SITES; BIRDS; CARBOHYDRATE CONFORMATION; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; GLYCOSYLATION; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; LUNG; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; POLYSACCHARIDES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, VIRUS; RESPIRATORY MUCOSA; SIALIC ACIDS; SPECIES SPECIFICITY; VIRULENCE;

ASIA; EURASIA; SOUTHEAST ASIA; VIET NAM;

AVES; ORTHOMYXOVIRIDAE;

EID: 33645981586     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1124513     Document Type: Article

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67. The work was supported in part by National Institute of Allergy and Infectious Diseases grant AI058113 (I.A.W., T.T., J.K.T.); National Institute of General Medical Sciences grants GM062116 (to J.C.P., I.A.W.) and GM060938 (to J.C.P.); and partial support from NIH grants to I.A.W. (CA55896 and AI42266). We thank P. Palese and L. Glaser (Mount Sinai School of Medicine, New York) for providing the full-length clone of A/Vietnam/1203/2004; the staff of the Advanced Light Source Beamline 8.2.2 for the beamline assistance; X. Dai, S. Ferguson, P. Carney, and J. Vanhnasy (The Scripps Research Institute) for expert technical assistance; and R. Stanfield and M. Elsliger (The Scripps Research Institute) for helpful discussions. This is publication 17916-MB from The Scripps Research Institute. Coordinates and structure factors have been deposited in the Protein Data Bank (code 2FK0) and will be released on publication.