Splitomicin inhibits fMLP-induced superoxide anion production in human neutrophils by activate cAMP/PKA signaling inhibition of ERK pathway

European Journal of Pharmacology

Volumn 688, Issue 1-3, 2012, Pages 68-75

  Liu, Fu Chao ^a,b   Day, Yuan Ji ^a,b   Liou, Jiin Tarng ^a,b   Yu, Huang Ping ^a,b   Liao, Hsiang Ruei ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

cAMP (3 5 cyclic adenosine monophosphate); ERK (extracellular signal regulated kinase); Neutrophil; Splitomicin; Superoxide anion

Indexed keywords

CALCIUM; CYCLIC AMP; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FORMYLPEPTIDE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE A2; PROTEIN INHIBITOR; PROTEIN KINASE; PROTEIN P42; PROTEIN P44; SILENT INFORMATION REGULATOR PROTEIN 2; SILENT INFORMATION REGULATOR PROTEIN 2 INHIBITOR; SPLITOMICIN; SUPEROXIDE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; MALE; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ADULT; ALPROSTADIL; ANTI-INFLAMMATORY AGENTS; CALCIUM SIGNALING; CELL SURVIVAL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIMETHYL SULFOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; INTRACELLULAR SPACE; MALE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NAPHTHALENES; NEUTROPHILS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRONES; SIGNAL TRANSDUCTION; SUPEROXIDES; YOUNG ADULT;

EID: 84863517148     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.05.006     Document Type: Article

References (40)

1. 2 + influx J. Biol. Chem. 270 1995 23816 23822
2. H. Ali, R.M. Richardson, B. Haribabu, and R. Snyderman Chemoattractant receptor cross-desensitization J. Biol. Chem. 274 1999 6027 6030
3. M. Alvarado-Kristensson, and T. Andersson Protein phosphatase 2A regulates apoptosis in neutrophils by dephosphorylating both p38 MAPK and its substrate caspase 3 J. Biol. Chem. 280 2005 6238 6244
4. S. Brechard, and E.J. Tschirhart Regulation of superoxide production in neutrophils: role of calcium influx J. Leukoc. Biol. 84 2008 1223 1237
5. B.M. Burgering, G.J. Pronk, P.C. van Weeren, P. Chardin, and J.L. Bos cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor EMBO J. 12 1993 4211 4220
6. S.J. Cook, and F. McCormick Inhibition by cAMP of Ras-dependent activation of Raf Science 262 1993 1069 1072
7. P.Y. Coxon, M.J. Rane, S. Uriarte, D.W. Powell, S. Singh, W. Butt, Q. Chen, and K.R. McLeish MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils Cell. Signal. 15 2003 993 1001
8. L.V. Dekker, M. Leitges, G. Altschuler, N. Mistry, A. McDermott, J. Roes, and A.W. Segal Protein kinase C-beta contributes to NADPH oxidase activation in neutrophils Biochem. J. 347 Pt 1 2000 285 289
9. G. Endemann, Y. Feng, C.M. Bryant, G.S. Hamilton, J. Perumattam, R.E. Mewshaw, and D.Y. Liu Novel anti-inflammatory compounds prevent CD11b/CD18, alpha M beta 2 (Mac-1)-dependent neutrophil adhesion without blocking activation-induced changes in Mac-1 J. Pharmacol. Exp. Ther. 276 1996 5 12
10. 2 + Biochim. Biophys. Acta 1359 1997 233 240
11. M.E. Ferretti, M. Nalli, C. Biondi, M.L. Colamussi, B. Pavan, S. Traniello, and S. Spisani Modulation of neutrophil phospholipase C activity and cyclic AMP levels by fMLP-OMe analogues Cell. Signal. 13 2001 233 240
12. C. gis-Garber, and N. Gruener Protein kinase A downregulates the phosphorylation of p47 phox in human neutrophils: a possible pathway for inhibition of the respiratory burst Cell. Signal. 8 1996 291 296
13. Y.J. Huang, I.S. Chen, C.P. Tseng, Y.J. Day, Y.C. Lin, and C.H. Liao (2R,3R)-2-(3′,4′-dihydroxybenzyl)-3-(3″,4″- dimethoxybenzyl)butyrolactone suppresses fMLP-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils Biochem. Pharmacol. 75 2008 688 697
14. T.L. Hwang, Y.C. Wu, S.H. Yeh, and R.Y. Kuo Suppression of respiratory burst in human neutrophils by new synthetic pyrrolo-benzylisoquinolines Biochem. Pharmacol. 69 2005 65 71
15. T.L. Hwang, S.H. Yeh, Y.L. Leu, C.Y. Chern, and H.C. Hsu Inhibition of superoxide anion and elastase release in human neutrophils by 3′-isopropoxychalcone via a cAMP-dependent pathway Br. J. Pharmacol. 148 2006 78 87
16. T.L. Hwang, G.L. Li, Y.H. Lan, Y.C. Chia, P.W. Hsieh, Y.H. Wu, and Y.C. Wu Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii Free Radic. Biol. Med. 46 2009 520 528
17. S.L. Jones Protein kinase A regulates beta2 integrin avidity in neutrophils J. Leukoc. Biol. 71 2002 1042 1048
18. S. Kausalya, and J. Nath Interactive role of nitric oxide and superoxide anion in neutrophil-mediated endothelial cell injury J. Leukoc. Biol. 64 1998 185 191
19. T. Kyoi, K. Noda, M. Oka, and Y. Ukai Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils Life Sci. 76 2004 71 83
20. K. Lang, H. Hatt, B. Niggemann, K.S. Zaenker, and F. Entschladen A novel function for chemokines: downregulation of neutrophil migration Scand. J. Immunol. 57 2003 350 361
21. K. Lehmann, J.P. Muller, B. Schlott, P. Skroblin, D. Barz, J. Norgauer, and R. Wetzker PI3Kgamma controls oxidative bursts in neutrophils via interactions with PKCalpha and p47phox Biochem. J. 419 2009 603 610
22. C.H. Liao, S.Z. Lin, C.P. Tseng, Y.J. Day, C.S. Chang, Y.H. Chang, and S.C. Kuo A benzodiazepines derived compound, 4-(3-chlorophenyl)-1,3- dihydronaphtho [2,3-b][1,4]diazepin-2-one (ND700C), inhibits fMLP-induced superoxide anion release by activating protein phosphatase 2A in human neutrophils Biochem. Pharmacol. 76 2008 1728 1739
23. P. Lin, E.J. Welch, X.P. Gao, A.B. Malik, and R.D. Ye Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP J. Immunol. 174 2005 2981 2989
24. ++ release Thromb. Res. 124 2009 199 207
25. J. Meshki, F. Tuluc, O. Bredetean, A. Garcia, and S.P. Kunapuli Signaling pathways downstream of P2 receptors in human neutrophils Purinergic. Signal. 2 2006 537 544
26. A. Mocsai, Z. Jakus, T. Vantus, G. Berton, C.A. Lowell, and E. Ligeti Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases J. Immunol. 164 2000 4321 4331
27. V. Niggli Signaling to migration in neutrophils: importance of localized pathways Int. J. Biochem. Cell Biol. 35 2003 1619 1638
28. T. Okada, L. Sakuma, Y. Fukui, O. Hazeki, and M. Ui Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase J. Biol. Chem. 269 1994 3563 3567
29. C.A. Parkos, S.P. Colgan, and J.L. Madara Interactions of neutrophils with epithelial cells: lessons from the intestine J. Am. Soc. Nephrol. 5 1994 138 152
30. M.H. Pillinger, A.S. Feoktistov, C. Capodici, B. Solitar, J. Levy, T.T. Oei, and M.R. Philips Mitogen-activated protein kinase in neutrophils and enucleate neutrophil cytoplasts: evidence for regulation of cell-cell adhesion J. Biol. Chem. 271 1996 12049 12056
31. J. Posakony, M. Hirao, S. Stevens, J.A. Simon, and A. Bedalov Inhibitors of Sir2: evaluation of splitomicin analogues J. Med. Chem. 47 2004 2635 2644
32. K.B. Pryzwansky, and V.J. Madden Type 4A cAMP-specific phosphodiesterase is stored in granules of human neutrophils and eosinophils Cell Tissue Res. 312 2003 301 311
33. F. Rossi The O2- -forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function Biochim. Biophys. Acta 853 1986 65 89
34. R. Seifert, and G. Schultz The superoxide-forming NADPH oxidase of phagocytes. An enzyme system regulated by multiple mechanisms Rev. Physiol. Biochem. Pharmacol. 117 1991 1 338
35. R. Selvatici, S. Falzarano, S. Traniello, Z.G. Pagani, and S. Spisani Formylpeptides trigger selective molecular pathways that are required in the physiological functions of human neutrophils Cell. Signal. 15 2003 377 383
36. R. Selvatici, S. Falzarano, A. Mollica, and S. Spisani Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils Eur. J. Pharmacol. 534 2006 1 11
37. S. Spisani, M.C. Pareschi, M. Buzzi, M.L. Colamussi, C. Biondi, S. Traniello, Z.G. Pagani, P.M. Paglialunga, I. Torrini, and M.E. Ferretti Effect of cyclic AMP level reduction on human neutrophil responses to formylated peptides Cell. Signal. 8 1996 269 277
38. G.R. Tintinger, A.J. Theron, R. Anderson, and J.A. Ker The anti-inflammatory interactions of epinephrine with human neutrophils in vitro are achieved by cyclic AMP-mediated accelerated resequestration of cytosolic calcium Biochem. Pharmacol. 61 2001 1319 1328
39. V. Witko-Sarsat, P. Rieu, B. Descamps-Latscha, P. Lesavre, and L. Halbwachs-Mecarelli Neutrophils: molecules, functions and pathophysiological aspects Lab. Invest. 80 2000 617 653
40. H.P. Yu, P.W. Hsieh, Y.J. Chang, P.J. Chung, L.M. Kuo, and T.L. Hwang DSM-RX78, a new phosphodiesterase inhibitor, suppresses superoxide anion production in activated human neutrophils and attenuates hemorrhagic shock-induced lung injury in rats Biochem. Pharmacol. 78 2009 983 992