Point mutations in the second extracellular loop of the histamine H 2 receptor do not affect the species-selective activity of guanidine-type agonists

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 376, Issue 4, 2007, Pages 253-264

  Preuss, Hendrik ^a   Ghorai, Prasanta ^a,b   Kraus, Anja ^a   Dove, Stefan ^a   Buschauer, Armin ^a   Seifert, Roland ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Fusion proteins; GPCR second extracellular loop; Histamine H 2 receptor; Species selectivity

Indexed keywords

AMTHAMINE; ARPROMIDINE; GUANIDINE DERIVATIVE; GUANOSINE TRIPHOSPHATASE; HISTAMINE; HISTAMINE H2 RECEPTOR; HISTAMINE H2 RECEPTOR AGONIST; HYBRID PROTEIN; IMPROMIDINE; ISOPROTEIN; MUTANT PROTEIN; TIOTIDINE; UNCLASSIFIED DRUG; URAK 57; URPG 123; URPG 126; URPG 136; URPG 215;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVITY; INSECT CELL CULTURE; POINT MUTATION; SPECIES DIFFERENCE; STEADY STATE; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DNA, COMPLEMENTARY; GTP PHOSPHOHYDROLASES; GUANIDINES; GUINEA PIGS; HISTAMINE AGONISTS; HUMANS; INSECTS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN CONFORMATION; RECEPTORS, HISTAMINE H2; RECOMBINANT PROTEINS;

EID: 36448938182     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-007-0204-4     Document Type: Article

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