Evaluation of histamine H1-, H2-, and H 3-receptor ligands at the human histamine H4 receptor: Identification of 4-methylhistamine as the first potent and selective H 4 receptor agonist

Journal of Pharmacology and Experimental Therapeutics

Volumn 314, Issue 3, 2005, Pages 1310-1321

  Lim, Herman D ^a   Van Rijn, Richard M ^a   Ling, Ping ^b   Bakker, Remko A ^a   Thurmond, Robin L ^b   Leurs, Rob ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(5 CHLORO 1H INDOL 2 YL)CARBONYL] 4 METHYLPIPERAZINE; 4 METHYLHISTAMINE; AMOXAPINE; AMTHAMINE; ANTIBIOTIC G 418; ANTIHISTAMINIC AGENT; BURIMAMIDE; CIMETIDINE; CLOBENPROPIT; CLOZAPINE; DEXCHLORPHENIRAMINE MALEATE; DIMAPRIT; DIPHENHYDRAMINE; DOXEPIN; FAMOTIDINE; FORSKOLIN; HISTAMINE; HISTAMINE AGONIST; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR AGONIST; IMETIT; JNJ 7777120; KETOTIFEN FUMARATE; LISURIDE; MIRTAZAPINE; NORCLOZAPINE; PIPERAZINE DERIVATIVE; S [3 (4 IMIDAZOLYL)PROPYL]ISOTHIOUREA; THIOPERAMIDE; TRITIUM; UNCLASSIFIED DRUG; UNINDEXED DRUG; 1 ((5 CHLORO 1H INDOL 2 YL)CARBONYL) 4 METHYLPIPERAZINE; 1-((5-CHLORO-1H-INDOL-2-YL)CARBONYL)-4-METHYLPIPERAZINE; 4-METHYLHISTAMINE; DRUG DERIVATIVE; G PROTEIN COUPLED RECEPTOR; HISTAMINE DERIVATIVE; HISTAMINE RECEPTOR; HRH4 PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; IODOPHENPROPIT; LIGAND; THIOUREA DERIVATIVE;

ARTICLE; DRUG ANTAGONISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; MOLECULAR INTERACTION; PRIORITY JOURNAL; RECEPTOR AFFINITY; CELL LINE; DRUG POTENTIATION; HUMAN; METABOLISM; RADIOASSAY;

CELL LINE; HISTAMINE AGONISTS; HUMANS; IMIDAZOLES; INDOLES; ISOTHIURONIUM; LIGANDS; METHYLHISTAMINES; PIPERAZINES; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H1; RECEPTORS, HISTAMINE H2; RECEPTORS, HISTAMINE H3;

EID: 23944433719     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.105.087965     Document Type: Article

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