Localization of estrogen receptor β-immunoreactivity in astrocytes of the adult rat brain

GLIA

Volumn 26, Issue 3, 1999, Pages 260-267

  Azcoitia, Iñigo ^a   Sierra, Amanda ^a   Garcia Segura, Luis Miguel ^b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b INSTITUTO CAJAL   (Spain)

Author keywords

Astroglia; Estradiol; Estrogen receptor alpha; Estrogen receptor beta; GFAP; Glia; Hippocampus

Indexed keywords

BRAIN; CELL NUCLEUS; CLONED GENE; CONFOCAL LASER MICROSCOPY; ESTROGEN; ESTROGEN RECEPTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOLOGICAL TECHNIQUE; NERVE CELL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN LOCALIZATION; RAT; TRANSCRIPTION REGULATION;

EID: 0033135265     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(199905)26:3<260::AID-GLIA7>3.0.CO;2-R     Document Type: Article

References (59)

1. Alves SE, Lopez V, McEwen BS, Weiland NG. 1998. Differential colocalization of estrogen receptor β (ERβ) with oxytocin and vasopressin in the paraventricular and supraoptic nuclei of the female rat brain: an immunocytochemical study. Proc Natl Acad Sci USA 95:3281-3286.
2. Arnold AP, Gorski RA. 1984. Gonadal steroid induction of structural sex differences in the central nervous system. Annu Rev Neurosci 7:413-442.
3. Azcoitia I, Sierra A, Garcia-Segura LM. 1998. Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus. NeuroReport 9:3075-3079.
4. Balthazart J, Ball GF. 1998. New insights into the regulation and function of brain estrogen synthase (aromatase). Trends Neurosci 21:243-249.
5. Behl C, Skutella T, Lezoualc'h F, Post A, Widmann M, Newton CJ, Holsboer F. 1997. Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol Pharmacol 51:535-541.
6. Bettini E, Pollio G, Santagati S, Maggi A. 1992. Estrogen receptor in rat brain: presence in the hippocampal formation. Neuroendocrinol 56:502-508.
7. Beyer C, Epp B, Fassberg J, Reisert I, Pilgrim C. 1990. Region-and sex-related differences in maturation of astrocytes in dissociated cell cultures of embryonic rat brain. Glia 3:55-64.
8. 125I] iodoestradiol binding: Neuronal localization of estrogen-binding sites in the developing rat brain. Endocrinology 124:2074-2088.
9. Cambiasso MJ, Diaz H, Caceres A, Carrer HF. 1995. Neuritogenic effect of estradiol on rat ventromedial hypothalamic neurons co-cultured with homotopic or heterotopic glia. J Neurosci Res 42:700-709.
10. Chowen JA, Busiguina S, Garcia-Segura LM. 1995. Sexual dimorphism and sex steroid modulation of glial fibrillary acidic protein messenger RNA and immunoreactivity levels in the rat hypothalamus. Neuroscience 69:519-532.
11. Collado P, Beyer C, Hutchison JB, Holman SD. 1995. Hypothalamic distribution of astrocytes is gender-related in Mongolian gerbils. Neurosci Lett 184:86-89.
12. Day JR, Laping NJ, Lampert-Etchells M, Brown SA, O'Callaghan JP, McNeill TH, Finch CE. 1993. Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus. Neuroscience 55:435-443.
13. DonCarlos LL, Monroy E, Morrell JI. 1991. Distribution of estrogen receptor-immunoreactive cells in the forebrain of the female guinea pig. J Comp Neurol 305:591-602.
14. Garcia-Estrada J, Del Rio JA, Luquin S, Soriano E, Garcia-Segura LM. 1993. Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury. Brain Res 628:271-278.
15. Garcia-Segura LM, Suarez I, Segovia S, Tranque PA, Cales JM, Aguilera P, Olmos G, Guillamon A. 1988. The distribution of glial fibrillary acidic protein in the adult rat brain is influenced by the neonatal levels of sex steroids. Brain Res 456:357-363.
16. Garcia-Segura LM, Chowen JA, Parducz A, Naftolin F. 1994a. Gonadal hormones as promoters of structural synaptic plasticity: cellular mechanisms. Prog Neurobiol 44:279-307.
17. Garcia-Segura LM, Luquin S, Parducz A, Naftolin F. 1994b. Gonadal hormone regulation of glial fibrillary acidic protein immunoreactivity and glial ultrastructure in the rat neuroendocrine hypothalamus. Glia 10:59-69.
18. Garcia-Segura LM, Cañas B, Parducz A, Rougon G, Theodosis D, Naftolin F, Torres-Aleman I. 1995. Estradiol promotion of changes in the morphology of astroglia growing in culture depends on the expression of polysialic acid of neural membranes. Glia 13:209-216.
19. Garcia-Segura LM, Chowen JA, Naftolin F. 1996. Endocrine glia: Roles of glial cells in the brain actions of steroid and thyroid hormones and in the regulation of hormone secretion. Front Neuroendocrinol 17:180-211.
20. Hrabovszky E, Kalló I, Hajszán T, Shughrue PJ, Merchenthaler I, Liposits Z. 1998. Expression of estrogen receptor-β messenger ribonucleic acid in oxytocin and vasopressin neurons of the rat supraoptic and paraventricular nuclei. Endocrinology 139:2600-2604.
21. Jones KJ, Kinderman NB, Oblinger MM. 1997. Alterations in glial fibrillary acidic protein (GFAP) mRNA levels in the hamster facial motor nucleus: effects of axotomy and testosterone. Neurochem Res 22:1359-1366.
22. Kohama SG, Goss JR, McNeill TH, Finch CE. 1995. Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice. Neurosci Lett 183:164-166.
23. Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J-X. 1996. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925-5930.
24. Langub MC, Watson RE. 1992. Estrogen receptor-immunoreactive glia, endothelia, and ependyma in guinea pig preoptic area and median eminence: electron microscopy. Endocrinology 130:364-372.
25. Lephart ED. 1996. A review of brain aromatase cytochrome P450. Brain Res Rev 22:1-26.
26. Li X, Schwartz PE, Rissman EF. 1997. Distribution of estrogen receptor-β-like immunoreactivity in rat forebrain. Neuroendocrinology 66:63-67.
27. Lopez L, Brana M, Burgos P, Arias JL. 1994. Structural dimorphism in the mammillary bodies of the rat. Neurosci Lett 176:197-200.
28. Luquin S, Naftolin F, Garcia-Segura LM. 1993. Natural fluctuation and gonadal hormone regulation of astrocyte immunoreactivity in dentate gyrus. J Neurobiol 24:913-924.
29. Ma YJ, Junier M-P, Costa ME, Ojeda SR. 1992. Transforming growth factor-α gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation. Neuron 9:657-670.
30. Ma YJ, Berg-von der Emde K, Moholt-Siebert M, Hill DF, Ojeda SR. 1994. Region-specific regulation of transforming growth factor α (TGFα) gene expression in astrocytes of the neuroendocrine brain. J Neurosci 14:5644-5651.
31. Matsumoto A, Arai Y. 1981. Neuronal plasticity in the deafferented hypothalamic arcuate nucleus of adult female rats and its enhancement by treatment with estrogen. J Comp Neurol 197:197-205.
32. Miller DB, Ali SF, O'Callaghan JP, Laws SC. 1998. The impact of gender and estrogen on striatal dopaminergic neurotoxicity. Ann NY Acad Sci 844:153-165.
33. Mong JA, Kurzweil RL, Davis AM, Rocca MS, McCarthy MM. 1996. Evidence for sexual differentiation of glia in rat brain. Horm Behav 30:553-562.
34. Moss RL, Gu Q, Wong M. 1997. Estrogen: nontranscriptional signaling pathway. Recent Prog Horm Res 52:33-68.
35. Naftolin F. 1994. Brain aromatization of androgens. J Reprod Med 39:257-261.
36. Osterlund M, Kuiper GG, Gustafsson JA, Hurd YL. 1998. Differential distribution and regulation of estrogen receptor-α and-β mRNA within the female rat brain. Mol Brain Res 54:175-180.
37. Pace P, Taylor J, Suntharalingam S, Coombes RC, Ali S. 1997. Human estrogen receptor P binds DNA in a manner similar to and dimerizes with estrogen receptor α. J Biol Chem 272:25832-25838.
38. Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson J, Kushner PJ, Scanlan TS. 1997. Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 277:1508-1510.
39. Pettersson K, Grandien K, Kuiper GG, Gustafsson JA. 1997. Mouse estrogen receptor p forms estrogen response element-binding heterodimers with estrogen receptor α. Mol Endocrinol 11:1486-1496.
40. Pfaff D, Keiner M. 1973. Atlas of estradiol-concentrating cells in the central nervous system of the female rat. J Comp Neurol 151:121-158.
41. Phillips SM, Sherwin BB. 1992. Effects of estrogen on memory function in surgically menopausal women. Psychoneuroendocrinology 17:485-495.
42. Rabbani O, Panickar KS, Rajakumar G, King MA, Bodor N, Meyer EM, Simpkins JW. 1997. 17β-estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum. Exp Neurol 146:179-186.
43. Rage F, Lee BJ, Ma YJ, Ojeda SR. 1997. Estradiol enhances prostaglandin E2 receptor gene expression in luteinizing hormone-releasing hormone (LHRH) neurons and facilitates the LHRH response to PGE2 by activating a glia-to-neuron signaling pathway. J Neurosci 17:9145-9156.
44. Santagati S, Melcangi RC, Celotti F, Martini L, Maggi A. 1994. Estrogen receptor is expressed in different types of glial cells in culture. J Neurochem 63:2058-2064.
45. Shughrue PJ, Komm B, Merchenthaler I. 1996. The distribution of estrogen receptor-β mRNA in the rat hypothalamus. Steroids 61:678-681.
46. Shughrue PJ, Lane MV, Merchenthaler I. 1997. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J Comp Neurol 388:507-525.
47. Simonian SX, Herbison AE. 1997. Differential expression of estrogen receptor α and β immunoreactivity by oxytocin neurons of rat paraventricular nucleus. J Neuroendocrinol 9:803-806.
48. Simpkins JW, Green PS, Gridley KE, Singh M, de Fiebre NC, Rajakumar G. 1997. Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease. Am J Med 103:19S-25S.
49. Stone DJ, Rozovsky I, Morgan TE, Anderson CP, Hajian H, Finch CE. 1997. Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro. Exp Neurol 143:313-318.
50. Stone DJ, Song Y, Anderson CP, Krohn KK, Finch CE, Rozovsky I. 1998. Bidirectional transcription regulation of glial fibrillary acidic protein by estradiol in vivo and in vitro. Endocrinology 139:3202-3209.
51. Suarez I, Bodega G, Rubio M, Fernandez B. 1991. Sexual dimorphism in the distribution of glial fibrillary acidic protein in the supraoptic nucleus of the hamster. J Anat 178:79-82.
52. Suarez I, Bodega G, Rubio M, Fernandez B. 1992. Sexual dimorphism in the hamster cerebellum demonstrated by glial fibrillary acidic protein (GFAP) and vimentin immunoreactivity. Glia 5:10-16.
53. Tanzer L, Jones KJ. 1997. Gonadal steroid regulation of hamster facial nerve regeneration: effects of dihydrotestosterone and estradiol. Exp Neurol 146:258-264.
54. Toran-Allerand CD. 1984. On the genesis of sexual differentiation of the central nervous system. Morphogenetic consequences of steroidal exposure and possible role of α-fetoprotein. Prog Brain Res 61:63-98.
55. Toran-Allerand CD, Miranda RC, Hochberg RB, MacLusky NJ. 1992. Cellular variations in estrogen receptor mRNA translation in the developing brain: evidence from combined [125I]estrogen autoradiography and non-isotopic in situ hybridization histochemistry. Brain Res 576:25-41.
56. Torres-Aleman I, Rejas MT, Pons S, Garcia-Segura LM. 1992. Estradiol promotes cell shape changes and glial fibrillary acidic protein redistribution in hypothalamic astrocytes in vitro: a neuronal-mediated effect. Glia 6:180-187.
57. Tranque PA, Suarez I, Olmos G, Fernandez B, Garcia-Segura LM. 1987. Estradiol-induced redistribution of glial fibrillary acidic protein immunoreactivity in the rat brain. Brain Res 406:348-351
58. Weiland NG, Orikasa C, Hayashi S, McEwen BS. 1997. Distribution and hormone regulation of estrogen receptor immunoreactive cells in the hippocampus of male and female rats. J Comp Neurol 388:603-612.
59. Wickelgren I. 1997. Estrogen stakes claim to cognition. Science 276:675-678.