메뉴 건너뛰기




Volumn 133, Issue 10, 2010, Pages 2999-3016

Oestrogen receptor β ligand: A novel treatment to enhance endogenous functional remyelination

Author keywords

EAE; myelin sheath; neurodegeneration; neuroprotection; oligodendrocytes; remyelination

Indexed keywords

DIARYLPROPIONITRILE; ESTROGEN RECEPTOR BETA;

EID: 77957681466     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq237     Document Type: Article
Times cited : (118)

References (87)
  • 1
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. Lancet 1998; 352: 1498-504.
    • (1998) Lancet , vol.352 , pp. 1498-504
  • 2
    • 67649948190 scopus 로고    scopus 로고
    • 17beta-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice
    • Acs P, Kipp M, Norkute A, Johann S, Clarner T, Braun A, et al. 17beta-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice. Glia 2009; 57: 807-14.
    • (2009) Glia , vol.57 , pp. 807-14
    • Acs, P.1    Kipp, M.2    Norkute, A.3    Johann, S.4    Clarner, T.5    Braun, A.6
  • 3
    • 24744468983 scopus 로고    scopus 로고
    • Hyaluronan accumulates in demyelinated lesions and inhibits oligo-dendrocyte progenitor maturation
    • Back SA, Tuohy TM, Chen H, Wallingford N, Craig A, Struve J, et al. Hyaluronan accumulates in demyelinated lesions and inhibits oligo-dendrocyte progenitor maturation. Nat Med 2005; 11: 966-72.
    • (2005) Nat Med , vol.11 , pp. 966-72
    • Back, S.A.1    Tuohy, T.M.2    Chen, H.3    Wallingford, N.4    Craig, A.5    Struve, J.6
  • 4
    • 23444441299 scopus 로고    scopus 로고
    • Motor neuron pathology in experimental autoimmune enceph-alomyelitis: Studies in THY1-YFP transgenic mice
    • Bannerman PG, Hahn A, Ramirez S, Morley M, Bonnemann C, Yu S, et al. Motor neuron pathology in experimental autoimmune enceph-alomyelitis: studies in THY1-YFP transgenic mice. Brain 2005; 128: 1877-86.
    • (2005) Brain , vol.128 , pp. 1877-86
    • Bannerman, P.G.1    Hahn, A.2    Ramirez, S.3    Morley, M.4    Bonnemann, C.5    Yu, S.6
  • 5
    • 0042018741 scopus 로고    scopus 로고
    • Breast cancer and hormone-replacement therapy in the Million Women Study
    • Beral V. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 2003; 362: 419-27.
    • (2003) Lancet , vol.362 , pp. 419-27
    • Beral, V.1
  • 9
    • 25144511407 scopus 로고    scopus 로고
    • Investigative models for determining hormone therapy-induced outcomes in brain: Evidence in support of a healthy cell bias of oestrogen action
    • Brinton RD. Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of oestrogen action. Ann N Y Acad Sci 2005; 1052: 57-74.
    • (2005) Ann N y Acad Sci , vol.1052 , pp. 57-74
    • Brinton, R.D.1
  • 10
    • 34247108119 scopus 로고    scopus 로고
    • Time course and distribution of inflammatory and neurodegenerative events suggest structural bases for the pathogenesis of experimental autoimmune encephalomyelitis
    • Brown DA, Sawchenko PE. Time course and distribution of inflammatory and neurodegenerative events suggest structural bases for the pathogenesis of experimental autoimmune encephalomyelitis. J Comp Neurol 2007; 502: 236-60.
    • (2007) J Comp Neurol , vol.502 , pp. 236-60
    • Brown, D.A.1    Sawchenko, P.E.2
  • 11
    • 0036284982 scopus 로고    scopus 로고
    • LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival
    • Butzkueven H, Zhang JG, Soilu-Hanninen M, Hochrein H, Chionh F, Shipham KA, et al. LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival. Nat Med 2002; 8: 613-19.
    • (2002) Nat Med , vol.8 , pp. 613-19
    • Butzkueven, H.1    Zhang, J.G.2    Soilu-Hanninen, M.3    Hochrein, H.4    Chionh, F.5    Shipham, K.A.6
  • 12
    • 0037022609 scopus 로고    scopus 로고
    • Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis
    • Calza L, Fernandez M, Giuliani A, Aloe L, Giardino L. Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis. Proc Natl Acad Sci USA 2002; 99: 3258-63.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3258-63
    • Calza, L.1    Fernandez, M.2    Giuliani, A.3    Aloe, L.4    Giardino, L.5
  • 14
    • 0037122960 scopus 로고    scopus 로고
    • Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
    • Chang A, Tourtellotte WW, Rudick R, Trapp BD. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N Engl J Med 2002; 346: 165-73.
    • (2002) N Engl J Med , vol.346 , pp. 165-73
    • Chang, A.1    Tourtellotte, W.W.2    Rudick, R.3    Trapp, B.D.4
  • 16
    • 0742305831 scopus 로고    scopus 로고
    • Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE
    • Craner MJ, Hains BC, Lo AC, Black JA, Waxman SG. Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE. Brain 2004; 127: 294-303.
    • (2004) Brain , vol.127 , pp. 294-303
    • Craner, M.J.1    Hains, B.C.2    Lo, A.C.3    Black, J.A.4    Waxman, S.G.5
  • 17
    • 67650232943 scopus 로고    scopus 로고
    • Assaying the functional effects of demyelination and remyelination: Revisiting field potential recordings
    • Crawford DK, Mangiardi M, Tiwari-Woodruff SK. Assaying the functional effects of demyelination and remyelination: revisiting field potential recordings. J Neurosci Methods 2009a; 182: 25-33.
    • (2009) J Neurosci Methods , vol.182 , pp. 25-33
    • Crawford, D.K.1    Mangiardi, M.2    Tiwari-Woodruff, S.K.3
  • 19
    • 77249101481 scopus 로고    scopus 로고
    • Additive effects of combination treatment with anti-inflammatory and neuroprotective agents in experimental autoimmune encephalomyelitis
    • Du S, Sandoval F, Trinh P, Voskuhl RR. Additive effects of combination treatment with anti-inflammatory and neuroprotective agents in experimental autoimmune encephalomyelitis. J Neuroimmunol 219: 64-74.
    • J Neuroimmunol , vol.219 , pp. 64-74
    • Du, S.1    Sandoval, F.2    Trinh, P.3    Voskuhl, R.R.4
  • 20
    • 33646779843 scopus 로고    scopus 로고
    • Differential modulation of oestrogen receptors (ERs) in ischemic brain injury: A role for ERalpha in estradiol-mediated protection against delayed cell death
    • Dubal DB, Rau SW, Shughrue PJ, Zhu H, Yu J, Cashion AB, et al. Differential modulation of oestrogen receptors (ERs) in ischemic brain injury: a role for ERalpha in estradiol-mediated protection against delayed cell death. Endocrinology 2006; 147: 3076-84.
    • (2006) Endocrinology , vol.147 , pp. 3076-84
    • Dubal, D.B.1    Rau, S.W.2    Shughrue, P.J.3    Zhu, H.4    Yu, J.5    Cashion, A.B.6
  • 21
    • 33646738475 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination
    • Emery B, Cate HS, Marriott M, Merson T, Binder MD, Snell C, et al. Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination. Proc Natl Acad Sci USA 2006; 103: 7859-64.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7859-64
    • Emery, B.1    Cate, H.S.2    Marriott, M.3    Merson, T.4    Binder, M.D.5    Snell, C.6
  • 22
    • 9244242542 scopus 로고    scopus 로고
    • Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease
    • Fernandez M, Giuliani A, Pirondi S, D'Intino G, Giardino L, Aloe L, et al. Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease. Proc Natl Acad Sci USA 2004; 101: 16363-8.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16363-8
    • Fernandez, M.1    Giuliani, A.2    Pirondi, S.3    D'Intino, G.4    Giardino, L.5    Aloe, L.6
  • 23
    • 0036331333 scopus 로고    scopus 로고
    • Correlations between structural CNS damage and functional MRI changes in primary progressive MS
    • Filippi M, Rocca MA, Falini A, Caputo D, Ghezzi A, Colombo B, et al. Correlations between structural CNS damage and functional MRI changes in primary progressive MS. Neuroimage 2002; 15: 537-46.
    • (2002) Neuroimage , vol.15 , pp. 537-46
    • Filippi, M.1    Rocca, M.A.2    Falini, A.3    Caputo, D.4    Ghezzi, A.5    Colombo, B.6
  • 24
    • 47549088244 scopus 로고    scopus 로고
    • Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination
    • Franco PG, Silvestroff L, Soto EF, Pasquini JM. Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination. Exp Neurol 2008; 21: 458-67.
    • (2008) Exp Neurol , vol.21 , pp. 458-67
    • Franco, P.G.1    Silvestroff, L.2    Soto, E.F.3    Pasquini, J.M.4
  • 26
    • 54249124952 scopus 로고    scopus 로고
    • Remyelination in the CNS: From biology to therapy
    • Franklin RJ, Ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 2008; 9: 839-55.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 839-55
    • Franklin, R.J.1    Ffrench-Constant, C.2
  • 28
    • 0034852518 scopus 로고    scopus 로고
    • Normal CNS myelination in transgenic mice overexpressing MHC class i H-2L(d) in oligodendro-cytes
    • Fuss B, Afshari FS, Colello RJ, Macklin WB. Normal CNS myelination in transgenic mice overexpressing MHC class I H-2L(d) in oligodendro-cytes. Mol Cell Neurosci 2001; 18: 221-34.
    • (2001) Mol Cell Neurosci , vol.18 , pp. 221-34
    • Fuss, B.1    Afshari, F.S.2    Colello, R.J.3    MacKlin, W.B.4
  • 30
    • 74049120922 scopus 로고    scopus 로고
    • New oral drugs for multiple sclerosis
    • Gasperini C, Ruggieri S. New oral drugs for multiple sclerosis. Neurol Sci 2009; 30 (Suppl 2): S179-83.
    • (2009) Neurol Sci , vol.30 , Issue.SUPPL. 2
    • Gasperini, C.1    Ruggieri, S.2
  • 31
    • 34447544689 scopus 로고    scopus 로고
    • Estradiol attenuates hyperoxia-induced cell death in the developing white matter
    • Gerstner B, Sifringer M, Dzietko M, Schuller A, Lee J, Simons S, et al. Estradiol attenuates hyperoxia-induced cell death in the developing white matter. Ann Neurol 2007; 61: 562-73.
    • (2007) Ann Neurol , vol.61 , pp. 562-73
    • Gerstner, B.1    Sifringer, M.2    Dzietko, M.3    Schuller, A.4    Lee, J.5    Simons, S.6
  • 32
    • 70349559752 scopus 로고    scopus 로고
    • Oestrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through oestrogen receptor alpha (ERalpha)
    • Gold SM, Sasidhar MV, Morales LB, Du S, Sicotte NL, Tiwari-Woodruff SK, et al. Oestrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through oestrogen receptor alpha (ERalpha). Lab Invest 2009; 89: 1076-83.
    • (2009) Lab Invest , vol.89 , pp. 1076-83
    • Gold, S.M.1    Sasidhar, M.V.2    Morales, L.B.3    Du, S.4    Sicotte, N.L.5    Tiwari-Woodruff, S.K.6
  • 34
    • 58149375840 scopus 로고    scopus 로고
    • Recovery from chronic demyelination by thyroid hormone therapy: Myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging
    • Harsan LA, Steibel J, Zaremba A, Agin A, Sapin R, Poulet P, et al. Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging. J Neurosci 2008; 28: 14189-201.
    • (2008) J Neurosci , vol.28 , pp. 14189-201
    • Harsan, L.A.1    Steibel, J.2    Zaremba, A.3    Agin, A.4    Sapin, R.5    Poulet, P.6
  • 35
    • 2442645177 scopus 로고    scopus 로고
    • Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis
    • Hobom M, Storch MK, Weissert R, Maier K, Radhakrishnan A, Kramer B, et al. Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis. Brain Pathol 2004; 14: 148-57.
    • (2004) Brain Pathol , vol.14 , pp. 148-57
    • Hobom, M.1    Storch, M.K.2    Weissert, R.3    Maier, K.4    Radhakrishnan, A.5    Kramer, B.6
  • 37
    • 0032952297 scopus 로고    scopus 로고
    • Estriol ameliorates autoimmune demyelinating disease: Implications for multiple sclerosis
    • Kim S, Liva SM, Dalal MA, Verity MA, Voskuhl RR. Estriol ameliorates autoimmune demyelinating disease: implications for multiple sclerosis. Neurology 1999; 52: 1230-8.
    • (1999) Neurology , vol.52 , pp. 1230-8
    • Kim, S.1    Liva, S.M.2    Dalal, M.A.3    Verity, M.A.4    Voskuhl, R.R.5
  • 38
    • 67349245212 scopus 로고    scopus 로고
    • Impact of sex steroids on neuroinflammatory processes and experimental multiple sclerosis
    • Kipp M, Beyer C. Impact of sex steroids on neuroinflammatory processes and experimental multiple sclerosis. Front Neuroendocrinol 2009; 30: 188-200.
    • (2009) Front Neuroendocrinol , vol.30 , pp. 188-200
    • Kipp, M.1    Beyer, C.2
  • 39
    • 0033870097 scopus 로고    scopus 로고
    • Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions
    • Kornek B, Storch MK, Weissert R, Wallstroem E, Stefferl A, Olsson T, et al. Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 2000; 157: 267-76.
    • (2000) Am J Pathol , vol.157 , pp. 267-76
    • Kornek, B.1    Storch, M.K.2    Weissert, R.3    Wallstroem, E.4    Stefferl, A.5    Olsson, T.6
  • 40
    • 46849098585 scopus 로고    scopus 로고
    • Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis
    • Kuhlmann T, Miron V, Cui Q, Wegner C, Antel J, Bruck W. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 2008; 131: 1749-58.
    • (2008) Brain , vol.131 , pp. 1749-58
    • Kuhlmann, T.1    Miron, V.2    Cui, Q.3    Wegner, C.4    Antel, J.5    Bruck, W.6
  • 42
    • 33947509525 scopus 로고    scopus 로고
    • The immunopathology of multiple sclerosis: An overview
    • Lassmann H, Bruck W, Lucchinetti CF. The immunopathology of multiple sclerosis: an overview. Brain Pathol 2007; 17: 210-18.
    • (2007) Brain Pathol , vol.17 , pp. 210-18
    • Lassmann, H.1    Bruck, W.2    Lucchinetti, C.F.3
  • 43
    • 0026758968 scopus 로고
    • Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody
    • Linington C, Engelhardt B, Kapocs G, Lassman H. Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody. J Neuroimmunol 1992; 40: 219-24.
    • (1992) J Neuroimmunol , vol.40 , pp. 219-24
    • Linington, C.1    Engelhardt, B.2    Kapocs, G.3    Lassman, H.4
  • 44
    • 36849027688 scopus 로고    scopus 로고
    • Evaluation of corticospinal axon loss by fluorescent dye tracing in mice with experimental autoimmune encephalomyelitis
    • Liu Z, Li Y, Zhang J, Elias S, Chopp M. Evaluation of corticospinal axon loss by fluorescent dye tracing in mice with experimental autoimmune encephalomyelitis. J Neurosci Methods 2008; 167: 191-7.
    • (2008) J Neurosci Methods , vol.167 , pp. 191-7
    • Liu, Z.1    Li, Y.2    Zhang, J.3    Elias, S.4    Chopp, M.5
  • 46
    • 0036469299 scopus 로고    scopus 로고
    • Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development
    • Mallon BS, Shick HE, Kidd GJ, Macklin WB. Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development. J Neurosci 2002; 22: 876-85.
    • (2002) J Neurosci , vol.22 , pp. 876-85
    • Mallon, B.S.1    Shick, H.E.2    Kidd, G.J.3    MacKlin, W.B.4
  • 47
    • 33749371142 scopus 로고    scopus 로고
    • Loss of interhemispheric inhibition in patients with multiple sclerosis is related to corpus callosum atrophy
    • Manson SC, Palace J, Frank JA, Matthews PM. Loss of interhemispheric inhibition in patients with multiple sclerosis is related to corpus callosum atrophy. Exp Brain Res 2006; 174: 728-33.
    • (2006) Exp Brain Res , vol.174 , pp. 728-33
    • Manson, S.C.1    Palace, J.2    Frank, J.A.3    Matthews, P.M.4
  • 48
    • 42449128329 scopus 로고    scopus 로고
    • Impairment of movement-associated brain deactivation in multiple sclerosis: Further evidence for a functional pathology of inter-hemispheric neuronal inhibition
    • Manson SC, Wegner C, Filippi M, Barkhof F, Beckmann C, Ciccarelli O, et al. Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of inter-hemispheric neuronal inhibition. Exp Brain Res 2008; 187: 25-31.
    • (2008) Exp Brain Res , vol.187 , pp. 25-31
    • Manson, S.C.1    Wegner, C.2    Filippi, M.3    Barkhof, F.4    Beckmann, C.5    Ciccarelli, O.6
  • 49
    • 17444374900 scopus 로고    scopus 로고
    • Oligodendrocyte progenitor proliferation and maturation is differentially regulated by male and female sex steroid hormones
    • Marin-Husstege M, Muggironi M, Raban D, Skoff RP, Casaccia-Bonnefil P. Oligodendrocyte progenitor proliferation and maturation is differentially regulated by male and female sex steroid hormones. Dev Neurosci 2004; 26: 245-54.
    • (2004) Dev Neurosci , vol.26 , pp. 245-54
    • Marin-Husstege, M.1    Muggironi, M.2    Raban, D.3    Skoff, R.P.4    Casaccia-Bonnefil, P.5
  • 50
    • 0022462027 scopus 로고
    • Insulin-like growth factor I/somatomedin C: A potent inducer of oligodendrocyte development
    • McMorris FA, Smith TM, DeSalvo S, Furlanetto RW. Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development. Proc Natl Acad Sci USA 1986; 83: 822-6.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 822-6
    • McMorris, F.A.1    Smith, T.M.2    Desalvo, S.3    Furlanetto, R.W.4
  • 52
    • 0033759398 scopus 로고    scopus 로고
    • The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis
    • European Study Group on Interferon beta-1b in secondary progressive multiple sclerosis
    • Molyneux PD, Kappos L, Polman C, Pozzilli C, Barkhof F, Filippi M, et al. The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis. European Study Group on Interferon beta-1b in secondary progressive multiple sclerosis. Brain 2000; 123 (Pt 11): 2256-63.
    • (2000) Brain , vol.123 , Issue.PART 11 , pp. 2256-63
    • Molyneux, P.D.1    Kappos, L.2    Polman, C.3    Pozzilli, C.4    Barkhof, F.5    Filippi, M.6
  • 53
    • 33745773543 scopus 로고    scopus 로고
    • Treatment with an oestrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis
    • Morales LB, Loo KK, Liu HB, Peterson C, Tiwari-Woodruff S, Voskuhl RR. Treatment with an oestrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis. J Neurosci 2006; 26: 6823-33.
    • (2006) J Neurosci , vol.26 , pp. 6823-33
    • Morales, L.B.1    Loo, K.K.2    Liu, H.B.3    Peterson, C.4    Tiwari-Woodruff, S.5    Voskuhl, R.R.6
  • 54
    • 66149190566 scopus 로고    scopus 로고
    • Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination
    • Narayanan SP, Flores AI, Wang F, Macklin WB. Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination. J Neurosci 2009; 29: 6860-70.
    • (2009) J Neurosci , vol.29 , pp. 6860-70
    • Narayanan, S.P.1    Flores, A.I.2    Wang, F.3    MacKlin, W.B.4
  • 56
    • 29444434481 scopus 로고    scopus 로고
    • Regional brain atrophy evolves differently in patients with multiple sclerosis according to clinical phenotype
    • Pagani E, Rocca MA, Gallo A, Rovaris M, Martinelli V, Comi G, et al. Regional brain atrophy evolves differently in patients with multiple sclerosis according to clinical phenotype. AJNR Am J Neuroradiol 2005; 26: 341-6.
    • (2005) AJNR Am J Neuroradiol , vol.26 , pp. 341-6
    • Pagani, E.1    Rocca, M.A.2    Gallo, A.3    Rovaris, M.4    Martinelli, V.5    Comi, G.6
  • 57
    • 34547645231 scopus 로고    scopus 로고
    • IGF-1 protects oligodendrocyte progenitors against TNFalpha-induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathway
    • Pang Y, Zheng B, Fan LW, Rhodes PG, Cai Z. IGF-1 protects oligodendrocyte progenitors against TNFalpha-induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathway. Glia 2007; 55: 1099-107.
    • (2007) Glia , vol.55 , pp. 1099-107
    • Pang, Y.1    Zheng, B.2    Fan, L.W.3    Rhodes, P.G.4    Cai, Z.5
  • 59
    • 0035174447 scopus 로고    scopus 로고
    • A longitudinal study of callosal atrophy and interhemispheric dysfunction in relapsing-remitting multiple sclerosis
    • Pelletier J, Suchet L, Witjas T, Habib M, Guttmann CR, Salamon G, et al. A longitudinal study of callosal atrophy and interhemispheric dysfunction in relapsing-remitting multiple sclerosis. Arch Neurol 2001; 58: 105-11.
    • (2001) Arch Neurol , vol.58 , pp. 105-11
    • Pelletier, J.1    Suchet, L.2    Witjas, T.3    Habib, M.4    Guttmann, C.R.5    Salamon, G.6
  • 60
    • 0018410045 scopus 로고
    • Remyelination in multiple sclerosis
    • Prineas JW, Connell F. Remyelination in multiple sclerosis. Ann Neurol 1979; 5: 22-31.
    • (1979) Ann Neurol , vol.5 , pp. 22-31
    • Prineas, J.W.1    Connell, F.2
  • 61
    • 41549156954 scopus 로고    scopus 로고
    • PI3 kinase/Akt activation mediates oestrogen and IGF-1 nigral da neuronal neuroprotection against a unilateral rat model of Parkinson's disease
    • Quesada A, Lee BY, Micevych PE. PI3 kinase/Akt activation mediates oestrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease. Dev Neurobiol 2008; 68: 632-44.
    • (2008) Dev Neurobiol , vol.68 , pp. 632-44
    • Quesada, A.1    Lee, B.Y.2    Micevych, P.E.3
  • 62
    • 35649010838 scopus 로고    scopus 로고
    • Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing-remitting experimental autoimmune encephalo-myelitis
    • Rasmussen S, Wang Y, Kivisakk P, Bronson RT, Meyer M, Imitola J, et al. Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing-remitting experimental autoimmune encephalo-myelitis. Brain 2007; 130: 2816-29.
    • (2007) Brain , vol.130 , pp. 2816-29
    • Rasmussen, S.1    Wang, Y.2    Kivisakk, P.3    Bronson, R.T.4    Meyer, M.5    Imitola, J.6
  • 63
    • 26244455133 scopus 로고    scopus 로고
    • Myelinated and unmyelinated axons of the corpus callosum differ in vulnerability and functional recovery following traumatic brain injury
    • Reeves TM, Phillips LL, Povlishock JT. Myelinated and unmyelinated axons of the corpus callosum differ in vulnerability and functional recovery following traumatic brain injury. Exp Neurol 2005; 196: 126-37.
    • (2005) Exp Neurol , vol.196 , pp. 126-37
    • Reeves, T.M.1    Phillips, L.L.2    Povlishock, J.T.3
  • 64
    • 0035784003 scopus 로고    scopus 로고
    • The response of adult oligodendrocyte progenitors to demyelination in EAE
    • Reynolds R, Cenci di Bello I, Dawson M, Levine J. The response of adult oligodendrocyte progenitors to demyelination in EAE. Prog Brain Res 2001; 132: 165-74.
    • (2001) Prog Brain Res , vol.132 , pp. 165-74
    • Reynolds, R.1    Cenci Di Bello, I.2    Dawson, M.3    Levine, J.4
  • 65
    • 70449447753 scopus 로고    scopus 로고
    • Insulin-like growth factor-I-stimulated Akt phosphorylation and oligodendrocyte progenitor cell survival require cholesterol-enriched membranes
    • Romanelli RJ, Mahajan KR, Fulmer CG, Wood TL. Insulin-like growth factor-I-stimulated Akt phosphorylation and oligodendrocyte progenitor cell survival require cholesterol-enriched membranes. J Neurosci Res 2009; 87: 3369-77.
    • (2009) J Neurosci Res , vol.87 , pp. 3369-77
    • Romanelli, R.J.1    Mahajan, K.R.2    Fulmer, C.G.3    Wood, T.L.4
  • 66
    • 0028200295 scopus 로고
    • Postmenopausal oestrogen and the risk of breast cancer. The need for randomized trials
    • Rossouw JE, Harlan WR. Postmenopausal oestrogen and the risk of breast cancer. The need for randomized trials. Ann Epidemiol 1994; 4: 255-6.
    • (1994) Ann Epidemiol , vol.4 , pp. 255-6
    • Rossouw, J.E.1    Harlan, W.R.2
  • 67
    • 0028832656 scopus 로고
    • Development and plasticity of cortical processing architectures
    • Singer W. Development and plasticity of cortical processing architectures. Science 1995; 270: 758-64.
    • (1995) Science , vol.270 , pp. 758-64
    • Singer, W.1
  • 68
    • 77950516252 scopus 로고    scopus 로고
    • CNs-targeted lif expression improves therapeutic efficacy and limits autoimmune-mediated demyelination in a model of multiple sclerosis
    • Slaets H, Hendriks JJ, van den Haute C, Coun F, Baekelandt V, Stinissen P, et al. CNs-targeted lif expression improves therapeutic efficacy and limits autoimmune-mediated demyelination in a model of multiple sclerosis. Mol Ther 2010; 18: 684-91.
    • (2010) Mol Ther , vol.18 , pp. 684-91
    • Slaets, H.1    Hendriks, J.J.2    Van Den Haute, C.3    Coun, F.4    Baekelandt, V.5    Stinissen, P.6
  • 69
    • 27844597182 scopus 로고    scopus 로고
    • Oestrogen attenuated markers of inflammation and decreased lesion volume in acute spinal cord injury in rats
    • Sribnick EA, Wingrave JM, Matzelle DD, Wilford GG, Ray SK, Banik NL. Oestrogen attenuated markers of inflammation and decreased lesion volume in acute spinal cord injury in rats. J Neurosci Res 2005; 82: 283-93.
    • (2005) J Neurosci Res , vol.82 , pp. 283-93
    • Sribnick, E.A.1    Wingrave, J.M.2    Matzelle, D.D.3    Wilford, G.G.4    Ray, S.K.5    Banik, N.L.6
  • 70
    • 33745728404 scopus 로고    scopus 로고
    • How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • Steinman L, Zamvil SS. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol 2006; 60: 12-21.
    • (2006) Ann Neurol , vol.60 , pp. 12-21
    • Steinman, L.1    Zamvil, S.S.2
  • 71
    • 2042454987 scopus 로고    scopus 로고
    • 17beta-estradiol protects oligodendrocytes from cytotoxicity induced cell death
    • Takao T, Flint N, Lee L, Ying X, Merrill J, Chandross KJ. 17beta-estradiol protects oligodendrocytes from cytotoxicity induced cell death. J Neurochem 2004; 89: 660-73.
    • (2004) J Neurochem , vol.89 , pp. 660-73
    • Takao, T.1    Flint, N.2    Lee, L.3    Ying, X.4    Merrill, J.5    Chandross, K.J.6
  • 72
    • 35548975206 scopus 로고    scopus 로고
    • Differential neuro-protective and antiinflammatory effects of oestrogen receptor (ER)alpha and ERbeta ligand treatment
    • Tiwari-Woodruff S, Morales LB, Lee R, Voskuhl RR. Differential neuro-protective and antiinflammatory effects of oestrogen receptor (ER)alpha and ERbeta ligand treatment. Proc Natl Acad Sci\USA 2007; 104: 14813-18.
    • (2007) Proc Natl Acad Sci\USA , vol.104 , pp. 14813-18
    • Tiwari-Woodruff, S.1    Morales, L.B.2    Lee, R.3    Voskuhl, R.R.4
  • 73
    • 70349778705 scopus 로고    scopus 로고
    • Neuroprotective and anti-inflammatory effects of oestrogen receptor ligand treatment in mice
    • Tiwari-Woodruff S, Voskuhl RR. Neuroprotective and anti-inflammatory effects of oestrogen receptor ligand treatment in mice. J Neurol Sci 2009; 286: 81-5.
    • (2009) J Neurol Sci , vol.286 , pp. 81-5
    • Tiwari-Woodruff, S.1    Voskuhl, R.R.2
  • 74
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: An immune or neurodegenerative disorder?
    • Trapp BD, Nave KA. Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 2008; 31: 247-69.
    • (2008) Annu Rev Neurosci , vol.31 , pp. 247-69
    • Trapp, B.D.1    Nave, K.A.2
  • 75
    • 33749118113 scopus 로고    scopus 로고
    • The Italian Multiple Sclerosis Database Network (MSDN): The risk of worsening according to IFNbeta exposure in multiple sclerosis
    • Trojano M, Russo P, Fuiani A, Paolicelli D, Di Monte E, Granieri E, et al. The Italian Multiple Sclerosis Database Network (MSDN): the risk of worsening according to IFNbeta exposure in multiple sclerosis. Mult Scler 2006; 12: 578-85.
    • (2006) Mult Scler , vol.12 , pp. 578-85
    • Trojano, M.1    Russo, P.2    Fuiani, A.3    Paolicelli, D.4    Di Monte, E.5    Granieri, E.6
  • 76
    • 66049119030 scopus 로고    scopus 로고
    • Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation
    • Tyler WA, Gangoli N, Gokina P, Kim HA, Covey M, Levison SW, et al. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. J Neurosci 2009; 29: 6367-78.
    • (2009) J Neurosci , vol.29 , pp. 6367-78
    • Tyler, W.A.1    Gangoli, N.2    Gokina, P.3    Kim, H.A.4    Covey, M.5    Levison, S.W.6
  • 78
    • 65949097056 scopus 로고    scopus 로고
    • Oestrogen receptor beta mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia
    • Wang M, Wang Y, Weil B, Abarbanell A, Herrmann J, Tan J, et al. Oestrogen receptor beta mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia. Am J Physiol Regul Integr Comp Physiol 2009; 296: R972-8.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296
    • Wang, M.1    Wang, Y.2    Weil, B.3    Abarbanell, A.4    Herrmann, J.5    Tan, J.6
  • 79
    • 48849098294 scopus 로고    scopus 로고
    • Callosal function in MS patients with mild and severe callosal damage as reflected by diffusion tensor imaging
    • Warlop NP, Fieremans E, Achten E, Debruyne J, Vingerhoets G. Callosal function in MS patients with mild and severe callosal damage as reflected by diffusion tensor imaging. Brain Res 2008; 1226: 218-25.
    • (2008) Brain Res , vol.1226 , pp. 218-25
    • Warlop, N.P.1    Fieremans, E.2    Achten, E.3    Debruyne, J.4    Vingerhoets, G.5
  • 80
    • 33751180140 scopus 로고    scopus 로고
    • Axonal conduction and injury in multiple sclerosis: The role of sodium channels
    • Waxman SG. Axonal conduction and injury in multiple sclerosis: the role of sodium channels. Nat Rev Neurosci 2006; 7: 932-41.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 932-41
    • Waxman, S.G.1
  • 81
    • 12444329705 scopus 로고    scopus 로고
    • IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis
    • Wensky AK, Furtado GC, Marcondes MC, Chen S, Manfra D, Lira SA, et al. IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis. J Immunol 2005; 174: 1416-23.
    • (2005) J Immunol , vol.174 , pp. 1416-23
    • Wensky, A.K.1    Furtado, G.C.2    Marcondes, M.C.3    Chen, S.4    Manfra, D.5    Lira, S.A.6
  • 83
    • 32544436383 scopus 로고    scopus 로고
    • Oestrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    • Xu K, Xu Y, Brown-Jermyn D, Chen JF, Ascherio A, Dluzen DE, et al. Oestrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine model of Parkinson's disease. J Neurosci 2006; 26: 535-41.
    • (2006) J Neurosci , vol.26 , pp. 535-41
    • Xu, K.1    Xu, Y.2    Brown-Jermyn, D.3    Chen, J.F.4    Ascherio, A.5    Dluzen, D.E.6
  • 84
    • 30044438885 scopus 로고    scopus 로고
    • Brain oestrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model
    • Yue X, Lu M, Lancaster T, Cao P, Honda S, Staufenbiel M, et al. Brain oestrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model. Proc Natl Acad Sci USA 2005; 102: 19198-203.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 19198-203
    • Yue, X.1    Lu, M.2    Lancaster, T.3    Cao, P.4    Honda, S.5    Staufenbiel, M.6
  • 85
    • 2042463364 scopus 로고    scopus 로고
    • Comparison of in vivo and in vitro subcellular localization of oestrogen receptors alpha and beta in oligodendrocytes
    • Zhang Z, Cerghet M, Mullins C, Williamson M, Bessert D, Skoff R. Comparison of in vivo and in vitro subcellular localization of oestrogen receptors alpha and beta in oligodendrocytes. J Neurochem 2004; 89: 674-84.
    • (2004) J Neurochem , vol.89 , pp. 674-84
    • Zhang, Z.1    Cerghet, M.2    Mullins, C.3    Williamson, M.4    Bessert, D.5    Skoff, R.6
  • 86
    • 41649104063 scopus 로고    scopus 로고
    • Neuroprotection and enhancement of remyelination by estradiol and dexamethasone in cocultures of rat DRG neurons and Schwann cells
    • Zhu TS, Glaser M. Neuroprotection and enhancement of remyelination by estradiol and dexamethasone in cocultures of rat DRG neurons and Schwann cells. Brain Res 2008; 1206: 20-32.
    • (2008) Brain Res , vol.1206 , pp. 20-32
    • Zhu, T.S.1    Glaser, M.2
  • 87
    • 77951792412 scopus 로고    scopus 로고
    • Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune en-cephalomyelitis EAE
    • Ziehn MO, Avedisian AA, Tiwari-Woodruff S, Voskuhl RR. Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune en-cephalomyelitis, EAE. Lab Invest 2010; 90: 774-86.
    • (2010) Lab Invest , vol.90 , pp. 774-86
    • Ziehn, M.O.1    Avedisian, A.A.2    Tiwari-Woodruff, S.3    Voskuhl, R.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.