Estrogen receptor antagonist ICI182,780 exacerbates ischemic injury in female mouse

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 1, 2000, Pages 112-118

  Sawada, Masahiko ^a   Alkayed, Nabil J ^a   Goto, Shozo ^a   Crain, Barbara ^a   Traystman, Richard J ^a   Shaivitz, Amanda ^a   Nelson, Randy J ^b   Hurn, Patricia D ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Cerebral ischemia; Estrogen; Estrogen receptor; ICI182,780; Stroke

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; IODOPHENAZONE C 14;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; FEMALE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

EID: 0033981785     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200001000-00015     Document Type: Article

References (49)

1. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hum PD (1998) Gender-linked brain injury in experimental stroke. Stroke 29:159-165
2. Alkayed NJ, Grain BJ, Traystman RJ, Hum PD (1999) Estrogenmediated neuroprotection in reproductively senescent rats [Abstract]. Stroke 30:274
3. Ayres S, Abplanalp W, Liu JH, Subbiah MR (1998) Mechanisms involved in the protective effect of estradiol-17 beta on lipid peroxidation and DNA damage. Am J Physiol 274:E1002-E1008
4. Carswell HV, Anderson NH, Clark JS, Graham D, Jeffs B, Dominiczak AF, Macrae IM (1999) Genetic and gender influences on sensitivity to focal cerebral ischemia in the stroke-prone spontaneously hypertensive rat. Hypertension 33:681-685
5. Colburn P, Buonassisi V (1978) Estrogen-binding sites in endothelial cultures. Science 201:817-819
6. Couse JF, Lindzey J, Grandien K, Gustafsson JA, Korach KS (1997) Tissue distribution and quantitative analysis of estrogen receptor-α (ERα) and estrogen receptor-β (ERβ) mesenger ribonucleic acid in the wild-type and ER knockout mouse. Endocrinology 138:4613-4621
7. Dubai DB, Kashon ML, Pettigrew LC, Ren JM, Finklestein SP, Rau SW, et al. (1998) Estradiol protects against ischemic injury. J Cereb Blood Flow Metab 18:1253-1258
8. Duckies SP, Krause DN, Miller VM (1996) Effects of gonadal steroids on vascular function. J Pharmacol Exp Ther 279:1-3
9. Eliason MJL, Sampei K, Mandir AS, Hum PD, Traystman RJ, Bao J, et al. (1997) Poly (ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 3:1089-1095
10. Finucane FF, Madans JH, Bush TL, Wolf PH, Kleinman JC (1993) Decreased risk of stroke among postmenopausal hormone users. Arch Intern Med 1993;153:73-79
11. Gibson MK, Nemmers LA, Beckman WC, et al. (1991) The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue. Endocrinology 129:2000-2010
12. Goldman H, Skelley EB, Sandman CA (1976) Hormones and regional brain blood flow. Pharmacol Biochem Behav 5:165-169
13. Green PS, Gordon K, Simpkins JW (1997) Phenolic A ring requirement for the neuroprotective effects of steroids. J Steroid Biochem Mol Biol 63:229-235
14. Hall ED, Pazara KE, Linseman KL (1991) Sex differences in postischemic neuronal necrosis in gerbils. J Cereb Blood Flow Metab 11:292-298
15. Harder DR, Coulson PB (1975) Estrogen receptors and effects of estrogen on membrane properties of coronary vascular smooth muscle. J Cell Physiol 100:375-382
16. Hata R, Mies G, Wiessner C, Fritze K, Hesselbarth D, Brinker G, et al. (1998) A reproducible model of middle cerebral artery occlusion in mice: hemodynamic, biochemical, and magnetic resonance imaging. J Cereb Blood Flow Metab 18:367-375
17. Hurn PD, Littleton-Kearney ML, Kirsch RC, Dharmarajan AM, Traystman RJ (1995) Post-ischemic cerebral blood flow recovery in the female: effect of 17β-estradiol. J Cereb Blood Flow Metab 15: 666-672
18. Hum PD, Alkayed NJ, Toung TJK, Traystman RJ, Crain BJ, Nelson RJ, et al. (1998) Female vs male: injury in experimental stroke. In: Pharmacology of cerebral ischemia (Krieglstein J, ed), Stuttgart: Medpharm Scientific Publishing, pp 379-386
19. 14C]iodoantipyrine in the mouse. J Cereb Blood Flow Metab 8:121-129
20. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, et al. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors β and β. Endocrinology 38:863-870
21. Li K, Futrell N, Tovar S, Wang LC, Wang DZ, Schultz LR (1996) Gender influences the magnitude of the inflammatory response within embolic cerebral infarcts in young rats. Stroke 27:498-503
22. MacGregor JI, Jordan VC (1998) Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev 50:151-196
23. Magness RR, Phernetton TM, Zheng J (1998) Systemic and uterine blood flow distribution during prolonged infusion of 17β-estradiol. Am J Physiol 275:H731-H743
24. Mendelsohn ME, Karas RH (1994) Estrogen and the blood vessel wall. Curr Opin Cardiol 9:619-626
25. Mendelsohn ME, Karas RH (1999) Protective effects of estrogen on the cardiovascular system. N Engl J Med 340:1801-1811
26. Mermelstein PG, Becker JB, Surmeier DJ (1996) Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci 16:595-604
27. Nelson RJ, Demas GE, Huang PL, Fishman MC, Dawson VL, Dawson TM, et al. (1995) Behavioral abnormalities in male mice lacking neuronal nitric oxide synthase. Nature 378:383-386
28. Osterlund M, Kuiper GG, Gustafsson IA, Hurn YL (1997) Distribution of estrogen receptor mRNA, alpha and beta subtypes, within the human brain. Soc Neurosci Abst 23:1496
29. Paganini-Hill A, Ross RK, Henderson BE (1988) Postmenopausal oestrogen treatment and stroke: a prospective study. Br Med J 297: 519-522
30. Parker MG, Arbuckle N, Dauvois S, Danielian P, White R (1993) Structure and function of the estrogen receptor. Ann NY Acad Sci 684:119-126
31. Pelligrino DA, Santizo R, Baughman VL, Wang Q (1998) Cerebral vasodilating capacity during forebrain ischemia: effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase. Neuroreport 9:3285-3291
32. Petitti DB, Sidney S, Quesenberry CP Jr, Bernstein A (1998) Ischemic stroke and use of estrogen and estrogen/progestogen as hormone replacement therapy. Stroke 29:23-28
33. Ross RL, Gu Q (1999) Estrogen: mechanisms for a rapid action in CA1 hippocampal neurons. Steroids 64:14-21
34. Rusa R, Alkayed NJ, Crain BJ, Traystman RJ, Kimes AS, London ED, et al. (1999) 17β-Estradiol reduces stroke injury in estrogen-deficient female animals. Stroke 30:1665-1670
35. Shi J, Panickar KS, Yang SH, Rabbani O, Day AL, Simpkins JW (1998) Estrogen attenuates over-expression of β-amyloid precursor protein messenger RNA in an animal model of focal ischemia. Brain Res 810:87-92
36. Shughrue PJ, Lane MV, Merchenthaler I (1997) Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J Comp Neurol 388:507-525
37. Simpkins JW, Rajakumar G, Zhang YQ, Simpkins CE, Greenwald D, Yu CJ, et al. (1997) Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg 87:724-730
38. Stumpf WE (1968) Estradiol concentrating neurons. Science 162: 1001-1003
39. Toung TJK, Traystman RJ, Hum PD (1998) Estrogen-mediated neu-roprotection after experimental stroke in males. Stroke 29:1666-1670
40. Venema RC, Nishida K, Alexander RW, Harrison DG, Murphy TJ (1994) Organization of the bovine gene encoding the endothelial nitric oxide synthase. Biochim Biophys Acta 1218:413-420
41. Wade GN, Powers JB, Bluestain JD, Green DE (1993a) ICI 182,780 antagonizes the effects of estradiol on estrous behavior and energy balance in Syrian hamsters. Am J Physiol 265:R1399-R1403
42. Wade GN, Bluestain JD, Gray JM, Meredith JM (1993b) ICI 182,780, a pure antiestrogen that affects behaviors and energy balance in rats without acting in the brain. Am J Physiol 265:R1392-R1398
43. Walensky LD, Shi ZQ, Hacksaw S, DeVries AC, Demas GE, Gascard P, et al. (1998) Neurobehavioral deficits in mice lacking the eryth-rocyte membrane cytoskeletal protein 4.1. Curr Biol 8:1269-1272
44. Wang Q, Santizo R, Baughman VL, Pelligrino DA (1999) Estrogen provides neuroprotection in transient forebrain ischemia through perfusion-independant mechanisms in rats. Stroke 30:630-637
45. Wenger NK, Speroff L, Packard B (1993) Cardiovascular health and disease in women. W Engl J Med 329:247-256
46. Wilson PWF, Garrison RJ, Castelli W (1985) Postmenopausal estrogen use, cigarette smoking, and cardiovascular morbidity in women over 50. N Engl J Med 313:1038-43
47. Woolley CS, McEwen BS (1992) Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci 12:2549-2554
48. Zhang YQ, Shi J, Rajakumar G, Day AL, Simpkins JW (1998) Effects of gender and estradiol treatment on focal brain ischemia. Brain Res 784:321-324
49. Zhou Y, Dorsa D (1994) Estrogen rapidly induces c-jun immunoreac-tivity in rat striatum. Horm Behav 28:376-382