Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites

Journal of Comparative Neurology

Volumn 429, Issue 3, 2001, Pages 355-371

  Milner, Teresa A ^a   McEwen, Bruce S ^b   Hayashi, Shinji ^c   Li, Chen J ^b   Reagan, Lawrence P ^b   Alves, Stephen E ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Dendritic spines; Glia; Hippocampal formation; Sex steroids; Terminals

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; CALCIUM; ESTROGEN; ESTROGEN RECEPTOR ALPHA; RECEPTOR ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; CALCIUM TRANSPORT; CELL MEMBRANE; CONTROLLED STUDY; DENDRITIC SPINE; ENDOSOME; FEMALE; GLIA; HIPPOCAMPUS; IMMUNOELECTRON MICROSCOPY; IMMUNOREACTIVITY; INTERNEURON; NERVE ENDING; NONHUMAN; POLYSOME; PRIORITY JOURNAL; PROESTRUS; PROTEIN LOCALIZATION; RAT; RNA TRANSLATION; SYNAPSE VESICLE; ULTRASTRUCTURE;

EID: 0035863873     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9861(20010115)429:3<355::aid-cne1>3.0.co;2-%23     Document Type: Article

References (101)

1. Immunocytochemical localization of nuclear estrogen receptors and progestin receptors within the rat dorsal raphe nucleus
2. Estrogen regulated progestin receptors are found in the midbrain raphe but not hippocampus of the αERKO mouse
3. Calcium elevation in astrocytes causes an NMDA receptor-dependent increase in the frequency of miniature synaptic currents in cultured hippocampal neurons
4. Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus
5. Neuroprotective effects of estradiol in the adult rat hippocampus: Interaction with insulin-like growth factor-I signalling
6. Direct effect of 17β-estradiol on striatum: Sex differences in dopamine release
7. Neuronal calcium signaling
8. New monoclonal antibodies to oestrogen and progesterone receptors effective for paraffin section immunohistochemistry
9. Cytoplasmic estrogen receptors in rat brain: Immunocytochemical evidence using three antibodies with distinct epitopes
10. Estrogen receptor immunoreactivity in rat brain: Rapid effects of estradiol injection
11. Estrogen receptors in dendrites and axon terminals in guinea pig hypothalamus
12. Estrogen receptor immunoreactivity in the adult primate brain: Neuronal distribution and association with p75, trkA, and choline acetyltransferase
13. Optimization of differential immunogold-silver and peroxidase labeling with maintenance of ultrastructure in brain sections before plastic embedding
14. Perimembrane localization of the estrogen receptor α protein in neuronal processes of cultured hippocampal neurons
15. Localization of delta opiate receptor immunoreactivity in interneurons and pyramidal cells in the rat hippocampus
16. Estrogen facilitates induction of long term potentiation in the hippocampus of awake rats
17. Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus
18. Neuroactive steroids regulate astroglia morphology in hippocampal cultures from adult rats
19. Neuroactive steroids modulate the reaction of astroglia to high extracellular potassium levels
20. Free postsynaptic densities in the hippocampus of the female rat
21. Distribution of estrogen receptor-immunoreactive cells in the forebrain of the female guinea pig
22. Mu opioid receptors are in somatodendritic and axonal compartments of GABAergic neurons in rat hippocampal formation
23. Interneurons of the hippocampus
24. Role of astroglia in estrogen regulation of synaptic plasticity and brain repair
25. Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus
26. Expression of estrogen receptor-like immunoreactivity by different subgroups of basal forebrain cholinergic neurons in gonadectomized male and female rats
27. Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood
28. Monoclonal antibodies to human estrogen receptor
29. Novel mechanism for nongenomic action of 17β-oestradiol on kainate-induced currents in isolated rat CA1 hippocampal neurones
30. Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
31. The epidemiology of estrogen replacement therapy and Alzheimer's disease
32. Brainstem catecholamine neurons are target sites for sex steroid hormones
33. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures
34. Effects of estradiol and progesterone on voltage-gated calcium and potassium conductances in rat CA1 hippocampal neurons
35. Synaptic transmission in the hippocampus: Critical role for glial cells
36. Astrocytic volume fluctuates in the hippocampal CA1 region across the estrous cycle
37. Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: Immunogold evidence from hippocampal slice cultures
38. Estrogen receptor-immunoreactive glia, endothelia and epdyma in guinea pig preoptic area and median eminence: Electron microscopy
39. Women and Alzheimer's disease
40. Autoradiographic localization of estradiol-binding neurons in the rat hippocampal formation and entorhinal cortex
41. Ionic changes and alterations in the size of the extracellular space during epileptic activity
42. Gonadal and adrenal steroids regulate neurochemical and structural plasticity of the hippocampus via cellular mechanisms involving NMDA receptors
43. Permanence of brain sex differences and structural plasticity of the adult brain
44. Estrogen actions in the central nervous system
45. Inhibition of dendritic spine induction on hippocampal CA1 pyramidal neurons by a nonsteroidal estrogen antagonist in female rats
46. Gonadal steroids regulate number of astrocytes immunostained for glial fibrillary acidic protein in mouse hippocampus
47. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor
48. Ultrastructural localization of neuropeptide Y-like immunoreactivity in the rat hippocampal formation
49. 2A-adrenergic receptors are located predominantly pre-synaptically but are also found post-synaptically and in selective astrocytes
50. Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites
51. Steroid-induced developmental plasticity in hypothalamic astrocytes: Implications for synaptic patterning
52. Neurotrophic effects of steroids on lesion-induced growth in the hippocampus
53. Estrogen: Mechanisms for a rapid action in CA1 hippocampal neurons
54. Estrogen receptor immunoreactivity within subregions of the rat forebrain: Neuronal distribution and association with perikarya containing choline acetyltransferase
55. Regulation of dendritic spine density in cultured rat hippocampal neurons by steroid hormones
56. Estradiol increases dendritic spine density by reducing GABA neurotransmission in hippocampal neurons
57. Glial responses to steroid as markers of brain aging
58. 3H-serotonin in rat brain synaptosomes
59. Estrogen receptor mRNA alterations in the developing rat hippocampus
60. Effects of ovariectomy and estradiol benzoate on high affinity choline uptake, ACh synthesis, and release from rat cerebral cortical synaptosomes
61. Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice
62. A polyclonal antibody to the rat oestrogen receptor expressed in E. coli: Characterization and application to immunohistochemistry
63. Estrogen receptor alpha, but not beta, is expressed in the interneurons of the hippocampus in prepubertal rats: An in situ hybridization study
64. Posttraining intrahippocampal estradiol injections enhance spatial memory in male rats: Interaction with cholinergic systems
65. 17β-estradiol attenuates CREB decline in the rat hippocampus following seizure
66. Membrane estrogen receptors identified by multiple antibody labeling and impeded-ligand binding
67. Connection matrix of the hippocampal formation. 1. The dentate gyrus
68. Estrogen-induced efflux of endogenous catecholamines from the hypothalamus in vitro
69. Mapping of estrogen receptor-producing cells in rat brain by in situ hybridization
70. Atlas of estradiol-concentrating cells in the central nervous system of the female rat
71. Hippocampal astrocytes in situ respond to glutamate released from synaptic terminals
72. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: Studies of ERα and ERβ expressed in Chinese hamster ovary cells
73. Analysis of temporal and dose-dependent effects of estrogen on monoamines in brain nuclei
74. Sex with knockout models: Behavioral studies of estrogen receptor α
75. Calcium regulation of gene expression
76. Estrogen receptor is expressed in different types of glial cells in culture
77. Rapid membrane effect of steroid hormones: An emerging concept in neuroendocrinology
78. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system
79. Estrogen is more than just a "sex hormone": Novel sites for estrogen action in the hippocampus and cerebral cortex
80. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: An in situ hybridization study
81. Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats
82. Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat
83. Selective localization of polyribosomes beneath developing synapses: A quantitative analysis of the relationships between polyribosomes and developing synapses in the hippocampus and dentate gyrus
84. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat
85. Estrogen regulation of dopamine release in the nucleus accumbens: Genomic- and nongenomic-mediated effects
86. Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain
87. 2A-adrenergic receptors in the visual cortex of neonatal and adult rats
88. Evidence for estrogen receptor in cell nuclei and axon terminals within the lateral habenula of the rat: Regulation during pregnancy
89. LTP varies across the estrous cycle: Enhanced synaptic plasticity in proestrus rats
90. Rapid actions of estrogens in GH3/B6 pituitary tumor cells via a plasma membrane version of estrogen receptor-alpha
91. Estradiol selectively regulates agonist binding sites on the N-methyl-D-asparate receptor complex in the CA1 region of the hippocampus
92. Distribution and hormone regulation of estrogen receptor immunoreactive cells in the hippocampus of male and female rats
93. Effects of estrogen in the CNS
94. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat
95. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat
96. Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism
97. Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons
98. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: Correlation with dendritic spine density
99. Postnatal development and sex difference in neurons containing estrogen receptor-alpha immunoreactivity in the preoptic brain, the diencephalon and the amygdala in the rat