-
1
-
-
0032211830
-
The cell biology of β-amyloid precursor protein and presenilin in Alzheimers disease
-
Selkoe, D. J. (1998) The cell biology of β-amyloid precursor protein and presenilin in Alzheimers disease Trends Cell Biol. 8, 447-453
-
(1998)
Trends Cell Biol.
, vol.8
, pp. 447-453
-
-
Selkoe, D.J.1
-
2
-
-
0028919919
-
Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome
-
Iwatsubo, T., Mann, D. M., Odaka, A., Suzuki, N., and Ihara, Y. (1995) Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome Ann. Neurol. 37, 294-299
-
(1995)
Ann. Neurol.
, vol.37
, pp. 294-299
-
-
Iwatsubo, T.1
Mann, D.M.2
Odaka, A.3
Suzuki, N.4
Ihara, Y.5
-
3
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
-
DOI 10.1038/nrm2101, PII NRM2101
-
Haass, C. and Selkoe, D. J. (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimers amyloid β-peptide Nat. Rev. Mol. Cell Biol. 8, 101-112 (Pubitemid 46432529)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.2
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
4
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
-
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., Wals, P., Zhang, C., Finch, C. E., Krafft, G. A., and Klein, W. L. (1998) Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins Proc. Natl. Acad. Sci. U.S.A. 95, 6448-6453
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
5
-
-
0037041426
-
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
-
DOI 10.1038/416535a
-
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., and Selkoe, D. J. (2002) Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo Nature 416, 535-539 (Pubitemid 34288854)
-
(2002)
Nature
, vol.416
, Issue.6880
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
6
-
-
1642308134
-
Neurodegenerative diseases and oxidative stress
-
Barnham, K. J., Masters, C. L., and Bush, A. I. (2004) Neurodegenerative diseases and oxidative stress Nat. Rev. Drug Discovery 3, 205-214
-
(2004)
Nat. Rev. Drug Discovery
, vol.3
, pp. 205-214
-
-
Barnham, K.J.1
Masters, C.L.2
Bush, A.I.3
-
7
-
-
0344824654
-
Amyloid β-peptide [1-42]-assosiated free radical-induced oxidative stress and neurodegeneration in Alzheimer's disease brain: Mechanisms and consequences
-
DOI 10.2174/0929867033456422
-
Butterfield, D. A. (2003) Amyloid β-peptide [1-42]-associated free radical-induced oxidative stress and neurodegeneration in Alzheimers disease brain: mechanisms and consequences Curr. Med. Chem. 10, 2651-2659 (Pubitemid 37456035)
-
(2003)
Current Medicinal Chemistry
, vol.10
, Issue.24
, pp. 2651-2659
-
-
Butterfield, D.A.1
-
8
-
-
27544511750
-
Formation and stabilization model of the 42-mer Aβ radical: Implications for the long-lasting oxidative stress in Alzheimer's disease
-
DOI 10.1021/ja054041c
-
Murakami, K., Irie, K., Ohigashi, H., Hara, H., Nagao, M., Shimizu, T., and Shirasawa, T. (2005) Formation and stabilization model of the 42-mer Aβ radical: implications for the long-lasting oxidative stress in Alzheimers disease J. Am. Chem. Soc. 127, 15168-15174 (Pubitemid 41547384)
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.43
, pp. 15168-15174
-
-
Murakami, K.1
Irie, K.2
Ohigashi, H.3
Hara, H.4
Nagao, M.5
Shimizu, T.6
Shirasawa, T.7
-
9
-
-
60349121505
-
Identification of physiological and toxic conformations in Aβ42 aggregates
-
Masuda, Y., Uemura, S., Ohashi, R., Nakanishi, A., Takegoshi, K., Shimizu, T., Shirasawa, T., and Irie, K. (2009) Identification of physiological and toxic conformations in Aβ42 aggregates ChemBioChem 10, 287-295
-
(2009)
ChemBioChem
, vol.10
, pp. 287-295
-
-
Masuda, Y.1
Uemura, S.2
Ohashi, R.3
Nakanishi, A.4
Takegoshi, K.5
Shimizu, T.6
Shirasawa, T.7
Irie, K.8
-
10
-
-
35048818925
-
The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease
-
DOI 10.2174/138955707782110187
-
Irie, K., Murakami, K., Masuda, Y., Morimoto, A., Ohigashi, H., Hara, H., Ohashi, R., Takegoshi, K., Fukuda, H., Nagao, M., Shimizu, T., and Shirasawa, T. (2007) The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimers disease Mini-Rev. Med. Chem. 7, 1001-1008 (Pubitemid 47554768)
-
(2007)
Mini-Reviews in Medicinal Chemistry
, vol.7
, Issue.10
, pp. 1001-1008
-
-
Irie, K.1
Murakami, K.2
Masuda, Y.3
Morimoto, A.4
Ohigashi, H.5
Hara, H.6
Ohashi, R.7
Takegoshi, K.8
Fukuda, H.9
Nagao, M.10
Shimizu, T.11
Shirasawa, T.12
-
11
-
-
77954688012
-
The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: The emerging role in the pathogenesis of Alzheimers disease
-
Murakami, K., Masuda, Y., Shirasawa, T., Shimizu, T., and Irie, K. (2010) The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: the emerging role in the pathogenesis of Alzheimers disease Geriatr. Gerontol. Int. 10 (Suppl. 1) S169-S179
-
(2010)
Geriatr. Gerontol. Int.
, vol.10
, Issue.SUPPL. 1
-
-
Murakami, K.1
Masuda, Y.2
Shirasawa, T.3
Shimizu, T.4
Irie, K.5
-
12
-
-
78649474332
-
Monoclonal antibody against the turn of the 42-residue amyloid β protein at positions 22 and 23
-
Murakami, K., Horikoshi-Sakuraba, Y., Murata, N., Noda, Y., Masuda, Y., Kinoshita, N., Hatsuta, H., Murayama, S., Shirasawa, T., Shimizu, T., and Irie, K. (2010) Monoclonal antibody against the turn of the 42-residue amyloid β protein at positions 22 and 23 ACS Chem. Neurosci. 1, 747-756
-
(2010)
ACS Chem. Neurosci.
, vol.1
, pp. 747-756
-
-
Murakami, K.1
Horikoshi-Sakuraba, Y.2
Murata, N.3
Noda, Y.4
Masuda, Y.5
Kinoshita, N.6
Hatsuta, H.7
Murayama, S.8
Shirasawa, T.9
Shimizu, T.10
Irie, K.11
-
13
-
-
84455161651
-
SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease
-
Murakami, K., Murata, N., Noda, Y., Tahara, S., Kaneko, T., Kinoshita, N., Hatsuta, H., Murayama, S., Barnham, K. J., Irie, K., Shirasawa, T., and Shimizu, T. (2011) SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease J. Biol. Chem. 286, 44557-44568
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 44557-44568
-
-
Murakami, K.1
Murata, N.2
Noda, Y.3
Tahara, S.4
Kaneko, T.5
Kinoshita, N.6
Hatsuta, H.7
Murayama, S.8
Barnham, K.J.9
Irie, K.10
Shirasawa, T.11
Shimizu, T.12
-
14
-
-
0017709445
-
β-Turns in proteins
-
Chou, P. Y. and Fasman, G. D. (1977) β-Turns in proteins J. Mol. Biol. 115, 135-175
-
(1977)
J. Mol. Biol.
, vol.115
, pp. 135-175
-
-
Chou, P.Y.1
Fasman, G.D.2
-
15
-
-
0038176528
-
In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis
-
DOI 10.1074/jbc.M210207200
-
Stine, W. B., Jr., Dahlgren, K. N., Krafft, G. A., and LaDu, M. J. (2003) In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis J. Biol. Chem. 278, 11612-11622 (Pubitemid 36792723)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.13
, pp. 11612-11622
-
-
Stine Jr., W.B.1
Dahlgren, K.N.2
Krafft, G.A.3
LaDu, M.J.4
-
16
-
-
80055020556
-
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins
-
Sinha, S., Lopes, D. H., Du, Z., Pang, E. S., Shanmugam, A., Lomakin, A., Talbiersky, P., Tennstaedt, A., McDaniel, K., Bakshi, R., Kuo, P. Y., Ehrmann, M., Benedek, G. B., Loo, J. A., Klarner, F. G., Schrader, T., Wang, C., and Bitan, G. (2011) Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins J. Am. Chem. Soc. 133, 16958-16969
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 16958-16969
-
-
Sinha, S.1
Lopes, D.H.2
Du, Z.3
Pang, E.S.4
Shanmugam, A.5
Lomakin, A.6
Talbiersky, P.7
Tennstaedt, A.8
McDaniel, K.9
Bakshi, R.10
Kuo, P.Y.11
Ehrmann, M.12
Benedek, G.B.13
Loo, J.A.14
Klarner, F.G.15
Schrader, T.16
Wang, C.17
Bitan, G.18
-
17
-
-
84862851209
-
Comparison of three amyloid assembly inhibitors: The sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01
-
(Published Online Mar 7), [Online early access]. DOI: 10.1021/cn200133x
-
Sinha, S., Du, Z., Maiti, P., Klarner, F.-G., Schrader, T., Wang, C., and Bitan, G. Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. (Published Online Mar 7, 2012) ACS Chem. Neurosci., [Online early access]. DOI: 10.1021/cn200133x.
-
(2012)
ACS Chem. Neurosci.
-
-
Sinha, S.1
Du, Z.2
Maiti, P.3
Klärner, F.-G.4
Schrader, T.5
Wang, C.6
Bitan, G.7
-
18
-
-
33745173188
-
Anti-amyloidogenic effects of antioxidants: Implications for the prevention and therapeutics of Alzheimer's disease
-
DOI 10.1016/j.bbadis.2006.03.002, PII S0925443906000469
-
Ono, K., Hamaguchi, T., Naiki, H., and Yamada, M. (2006) Anti-amyloidogenic effects of antioxidants: implications for the prevention and therapeutics of Alzheimers disease Biochim. Biophys. Acta 1762, 575-586 (Pubitemid 43903118)
-
(2006)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1762
, Issue.6
, pp. 575-586
-
-
Ono, K.1
Hamaguchi, T.2
Naiki, H.3
Yamada, M.4
-
19
-
-
0031467313
-
Heparin-binding properties of the amyloidogenic peptides Aβ and amylin: Dependence on aggregation state and inhibition by Congo red
-
DOI 10.1074/jbc.272.50.31617
-
Watson, D. J., Lander, A. D., and Selkoe, D. J. (1997) Heparin-binding properties of the amyloidogenic peptides Aβ and amylin. Dependence on aggregation state and inhibition by Congo red J. Biol. Chem. 272, 31617-31624 (Pubitemid 28013306)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.50
, pp. 31617-31624
-
-
Watson, D.J.1
Lander, A.D.2
Selkoe, D.J.3
-
20
-
-
75949121583
-
Oxidative stress in the progression of Alzheimer disease in the frontal cortex
-
Ansari, M. A. and Scheff, S. W. (2010) Oxidative stress in the progression of Alzheimer disease in the frontal cortex J. Neuropathol. Exp. Neurol. 69, 155-167
-
(2010)
J. Neuropathol. Exp. Neurol.
, vol.69
, pp. 155-167
-
-
Ansari, M.A.1
Scheff, S.W.2
-
21
-
-
79957935719
-
NADPH-oxidase activation and cognition in Alzheimer disease progression
-
Ansari, M. A. and Scheff, S. W. (2011) NADPH-oxidase activation and cognition in Alzheimer disease progression Free Radical Biol. Med. 51, 171-178
-
(2011)
Free Radical Biol. Med.
, vol.51
, pp. 171-178
-
-
Ansari, M.A.1
Scheff, S.W.2
-
22
-
-
75949101857
-
Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease
-
Nunomura, A., Tamaoki, T., Tanaka, K., Motohashi, N., Nakamura, M., Hayashi, T., Yamaguchi, H., Shimohama, S., Lee, H. G., Zhu, X., Smith, M. A., and Perry, G. (2010) Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease Neurobiol. Dis. 37, 731-737
-
(2010)
Neurobiol. Dis.
, vol.37
, pp. 731-737
-
-
Nunomura, A.1
Tamaoki, T.2
Tanaka, K.3
Motohashi, N.4
Nakamura, M.5
Hayashi, T.6
Yamaguchi, H.7
Shimohama, S.8
Lee, H.G.9
Zhu, X.10
Smith, M.A.11
Perry, G.12
-
23
-
-
84863229362
-
The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons
-
Nunomura, A., Tamaoki, T., Motohashi, N., Nakamura, M., McKeel, D. W., Jr., Tabaton, M., Lee, H. G., Smith, M. A., Perry, G., and Zhu, X. (2012) The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons J. Neuropathol. Exp. Neurol. 71, 233-241
-
(2012)
J. Neuropathol. Exp. Neurol.
, vol.71
, pp. 233-241
-
-
Nunomura, A.1
Tamaoki, T.2
Motohashi, N.3
Nakamura, M.4
Mckeel Jr., D.W.5
Tabaton, M.6
Lee, H.G.7
Smith, M.A.8
Perry, G.9
Zhu, X.10
-
24
-
-
79952528559
-
Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation
-
Himeno, E., Ohyagi, Y., Ma, L., Nakamura, N., Miyoshi, K., Sakae, N., Motomura, K., Soejima, N., Yamasaki, R., Hashimoto, T., Tabira, T., LaFerla, F. M., and Kira, J. (2011) Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation Ann. Neurol. 69, 248-256
-
(2011)
Ann. Neurol.
, vol.69
, pp. 248-256
-
-
Himeno, E.1
Ohyagi, Y.2
Ma, L.3
Nakamura, N.4
Miyoshi, K.5
Sakae, N.6
Motomura, K.7
Soejima, N.8
Yamasaki, R.9
Hashimoto, T.10
Tabira, T.11
Laferla, F.M.12
Kira, J.13
-
25
-
-
0033622324
-
Intraneuronal Aβ42 accumulation in human brain
-
Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., Greengard, P., and Relkin, N. R. (2000) Intraneuronal Aβ42 accumulation in human brain Am. J. Pathol. 156, 15-20 (Pubitemid 30644433)
-
(2000)
American Journal of Pathology
, vol.156
, Issue.1
, pp. 15-20
-
-
Gouras, G.K.1
Tsai, J.2
Naslund, J.3
Vincent, B.4
Edgar, M.5
Checler, F.6
Greenfield, J.P.7
Haroutunian, V.8
Buxbaum, J.D.9
Xu, H.10
Greengard, P.11
Relkin, N.R.12
-
26
-
-
10944272619
-
Fibrillar amyloid-β peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase: Implications for Alzheimer's disease
-
DOI 10.1074/jbc.M404635200
-
Jana, A. and Pahan, K. (2004) Fibrillar amyloid-β peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimers disease J. Biol. Chem. 279, 51451-51459 (Pubitemid 40017893)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.49
, pp. 51451-51459
-
-
Jana, A.1
Pahan, K.2
-
27
-
-
51349110166
-
The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
-
Hansson Petersen, C. A., Alikhani, N., Behbahani, H., Wiehager, B., Pavlov, P. F., Alafuzoff, I., Leinonen, V., Ito, A., Winblad, B., Glaser, E., and Ankarcrona, M. (2008) The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae Proc. Natl. Acad. Sci. U.S.A. 105, 13145-13150
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 13145-13150
-
-
Hansson Petersen, C.A.1
Alikhani, N.2
Behbahani, H.3
Wiehager, B.4
Pavlov, P.F.5
Alafuzoff, I.6
Leinonen, V.7
Ito, A.8
Winblad, B.9
Glaser, E.10
Ankarcrona, M.11
-
28
-
-
39149122810
-
Amyloid β, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimers disease
-
Reddy, P. H. and Beal, M. F. (2008) Amyloid β, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimers disease Trends Mol. Med. 14, 45-53
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 45-53
-
-
Reddy, P.H.1
Beal, M.F.2
-
29
-
-
0026570528
-
β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
-
Mattson, M. P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I., and Rydel, R. E. (1992) β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity J. Neurosci. 12, 376-389
-
(1992)
J. Neurosci.
, vol.12
, pp. 376-389
-
-
Mattson, M.P.1
Cheng, B.2
Davis, D.3
Bryant, K.4
Lieberburg, I.5
Rydel, R.E.6
-
30
-
-
0036830947
-
Calcium dyshomeostasis and intracellular signalling in Alzheimers disease
-
LaFerla, F. M. (2002) Calcium dyshomeostasis and intracellular signalling in Alzheimers disease Nat. Rev. Neurosci. 3, 862-872
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 862-872
-
-
Laferla, F.M.1
-
31
-
-
48249157930
-
ER stress is involved in Aβ-induced GSK-3β activation and tau phosphorylation
-
Resende, R., Ferreiro, E., Pereira, C., and Oliveira, C. R. (2008) ER stress is involved in Aβ-induced GSK-3β activation and tau phosphorylation J. Neurosci. Res. 86, 2091-2099
-
(2008)
J. Neurosci. Res.
, vol.86
, pp. 2091-2099
-
-
Resende, R.1
Ferreiro, E.2
Pereira, C.3
Oliveira, C.R.4
-
32
-
-
7444250188
-
α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons
-
DOI 10.1016/j.neuropharm.2004.06.029, PII S0028390804001923
-
Osakada, F., Hashino, A., Kume, T., Katsuki, H., Kaneko, S., and Akaike, A. (2004) α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons Neuropharmacology 47, 904-915 (Pubitemid 39440984)
-
(2004)
Neuropharmacology
, vol.47
, Issue.6
, pp. 904-915
-
-
Osakada, F.1
Hashino, A.2
Kume, T.3
Katsuki, H.4
Kaneko, S.5
Akaike, A.6
-
33
-
-
0037178573
-
Dietary intake of antioxidants and risk of Alzheimer disease
-
Engelhart, M. J., Geerlings, M. I., Ruitenberg, A., van Swieten, J. C., Hofman, A., Witteman, J. C., and Breteler, M. M. (2002) Dietary intake of antioxidants and risk of Alzheimer disease JAMA, J. Am. Med. Assoc. 287, 3223-3229 (Pubitemid 34686103)
-
(2002)
Journal of the American Medical Association
, vol.287
, Issue.24
, pp. 3223-3229
-
-
Engelhart, M.J.1
Geerlings, M.I.2
Ruitenberg, A.3
Van Swieten, J.C.4
Hofman, A.5
Witteman, J.C.M.6
Breteler, M.M.B.7
-
34
-
-
1442314722
-
Early vitamin e supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimers disease
-
Sung, S., Yao, Y., Uryu, K., Yang, H., Lee, V. M., Trojanowski, J. Q., and Pratico, D. (2004) Early vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimers disease FASEB J. 18, 323-325
-
(2004)
FASEB J.
, vol.18
, pp. 323-325
-
-
Sung, S.1
Yao, Y.2
Uryu, K.3
Yang, H.4
Lee, V.M.5
Trojanowski, J.Q.6
Pratico, D.7
-
35
-
-
70450246963
-
Depletion of vitamin e increases amyloid β accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease
-
Nishida, Y., Ito, S., Ohtsuki, S., Yamamoto, N., Takahashi, T., Iwata, N., Jishage, K., Yamada, H., Sasaguri, H., Yokota, S., Piao, W., Tomimitsu, H., Saido, T. C., Yanagisawa, K., Terasaki, T., Mizusawa, H., and Yokota, T. (2009) Depletion of vitamin E increases amyloid β accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease J. Biol. Chem. 284, 33400-33408
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 33400-33408
-
-
Nishida, Y.1
Ito, S.2
Ohtsuki, S.3
Yamamoto, N.4
Takahashi, T.5
Iwata, N.6
Jishage, K.7
Yamada, H.8
Sasaguri, H.9
Yokota, S.10
Piao, W.11
Tomimitsu, H.12
Saido, T.C.13
Yanagisawa, K.14
Terasaki, T.15
Mizusawa, H.16
Yokota, T.17
-
36
-
-
58149268892
-
Retinoic acid attenuates β-amyloid deposition and rescues memory deficits in an Alzheimers disease transgenic mouse model
-
Ding, Y., Qiao, A., Wang, Z., Goodwin, J. S., Lee, E. S., Block, M. L., Allsbrook, M., McDonald, M. P., and Fan, G. H. (2008) Retinoic acid attenuates β-amyloid deposition and rescues memory deficits in an Alzheimers disease transgenic mouse model J. Neurosci. 28, 11622-11634
-
(2008)
J. Neurosci.
, vol.28
, pp. 11622-11634
-
-
Ding, Y.1
Qiao, A.2
Wang, Z.3
Goodwin, J.S.4
Lee, E.S.5
Block, M.L.6
Allsbrook, M.7
McDonald, M.P.8
Fan, G.H.9
-
37
-
-
79956193119
-
Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimers disease
-
Murakami, K., Murata, N., Ozawa, Y., Kinoshita, N., Irie, K., Shirasawa, T., and Shimizu, T. (2011) Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimers disease J. Alzheimer's Dis. 26, 7-18
-
(2011)
J. Alzheimer's Dis.
, vol.26
, pp. 7-18
-
-
Murakami, K.1
Murata, N.2
Ozawa, Y.3
Kinoshita, N.4
Irie, K.5
Shirasawa, T.6
Shimizu, T.7
-
38
-
-
59149093139
-
Fulminant hepatic failure following overdose of the vitamin A metabolite acitretin
-
Leithead, J. A., Simpson, K. J., and MacGilchrist, A. J. (2009) Fulminant hepatic failure following overdose of the vitamin A metabolite acitretin Eur. J. Gastroenterol. Hepatol. 21, 230-232
-
(2009)
Eur. J. Gastroenterol. Hepatol.
, vol.21
, pp. 230-232
-
-
Leithead, J.A.1
Simpson, K.J.2
MacGilchrist, A.J.3
-
39
-
-
41749096713
-
A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia
-
DOI 10.1002/ana.21321
-
Tomiyama, T., Nagata, T., Shimada, H., Teraoka, R., Fukushima, A., Kanemitsu, H., Takuma, H., Kuwano, R., Imagawa, M., Ataka, S., Wada, Y., Yoshioka, E., Nishizaki, T., Watanabe, Y., and Mori, H. (2008) A new amyloid β variant favoring oligomerization in Alzheimers-type dementia Ann. Neurol. 63, 377-387 (Pubitemid 351499867)
-
(2008)
Annals of Neurology
, vol.63
, Issue.3
, pp. 377-387
-
-
Tomiyama, T.1
Nagata, T.2
Shimada, H.3
Teraoka, R.4
Fukushima, A.5
Kanemitsu, H.6
Takuma, H.7
Kuwano, R.8
Imagawa, M.9
Ataka, S.10
Wada, Y.11
Yoshioka, E.12
Nishizaki, T.13
Watanabe, Y.14
Mori, H.15
-
40
-
-
79251553420
-
E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity
-
Suzuki, T., Murakami, K., Izuo, N., Kume, T., Akaike, A., Nagata, T., Nishizaki, T., Tomiyama, T., Takuma, H., Mori, H., and Irie, K. (2010) E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity Int. J. Alzheimer's Dis. 2011, 431320
-
(2010)
Int. J. Alzheimer's Dis.
, vol.2011
, pp. 431320
-
-
Suzuki, T.1
Murakami, K.2
Izuo, N.3
Kume, T.4
Akaike, A.5
Nagata, T.6
Nishizaki, T.7
Tomiyama, T.8
Takuma, H.9
Mori, H.10
Irie, K.11
-
41
-
-
79955601720
-
Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo
-
Umeda, T., Tomiyama, T., Sakama, N., Tanaka, S., Lambert, M. P., Klein, W. L., and Mori, H. (2011) Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo J. Neurosci. Res. 89, 1031-1042
-
(2011)
J. Neurosci. Res.
, vol.89
, pp. 1031-1042
-
-
Umeda, T.1
Tomiyama, T.2
Sakama, N.3
Tanaka, S.4
Lambert, M.P.5
Klein, W.L.6
Mori, H.7
-
42
-
-
17644438639
-
BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons
-
DOI 10.1016/S0006-8993(97)00195-9, PII S0006899397001959
-
Kume, T., Kouchiyama, H., Kaneko, S., Maeda, T., Akaike, A., Shimohama, S., Kihara, T., Kimura, J., Wada, K., and Koizumi, S. (1997) BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons Brain Res. 756, 200-204 (Pubitemid 27241627)
-
(1997)
Brain Research
, vol.756
, Issue.1-2
, pp. 200-204
-
-
Kume, T.1
Kouchiyama, H.2
Kaneko, S.3
Maeda, T.4
Kaneko, S.5
Akaike, A.6
Shimohama, S.7
Kihara, T.8
Kimura, J.9
Wada, K.10
Koizumi, S.11
-
43
-
-
0033987876
-
P75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures
-
DOI 10.1016/S0006-8993(99)02226-X, PII S000689939902226X
-
Kume, T., Nishikawa, H., Tomioka, H., Katsuki, H., Akaike, A., Kaneko, S., Maeda, T., Kihara, T., and Shimohama, S. (2000) p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures Brain Res. 852, 279-289 (Pubitemid 30035164)
-
(2000)
Brain Research
, vol.852
, Issue.2
, pp. 279-289
-
-
Kume, T.1
Nishikawa, H.2
Tomioka, H.3
Katsuki, H.4
Akaike, A.5
Kaneko, S.6
Maeda, T.7
Kihara, T.8
Shimohama, S.9
-
44
-
-
0242580170
-
Neurotoxicity and physicochemical properties of Aβ mutant peptides from cerebral amyloid angiopathy: Implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease
-
DOI 10.1074/jbc.M301874200
-
Murakami, K., Irie, K., Morimoto, A., Ohigashi, H., Shindo, M., Nagao, M., Shimizu, T., and Shirasawa, T. (2003) Neurotoxicity and physicochemical properties of Aβ mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimers disease J. Biol. Chem. 278, 46179-46187 (Pubitemid 37432769)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.46
, pp. 46179-46187
-
-
Murakami, K.1
Irie, K.2
Morimoto, A.3
Ohigashi, H.4
Shindo, M.5
Nagao, M.6
Shimizu, T.7
Shirasawa, T.8
-
45
-
-
0038167009
-
Pyruvate protection against β-amyloid-induced neuronal death: Role of mitochondrial redox state
-
DOI 10.1002/jnr.10648
-
Alvarez, G., Ramos, M., Ruiz, F., Satrustegui, J., and Bogonez, E. (2003) Pyruvate protection against β-amyloid-induced neuronal death: role of mitochondrial redox state J. Neurosci. Res. 73, 260-269 (Pubitemid 36835427)
-
(2003)
Journal of Neuroscience Research
, vol.73
, Issue.2
, pp. 260-269
-
-
Alvarez, G.1
Ramos, M.2
Ruiz, F.3
Satrustegui, J.4
Bogonez, E.5
|