Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins

Journal of the American Chemical Society

Volumn 133, Issue 42, 2011, Pages 16958-16969

  Sinha, Sharmistha ^a   Lopes, Dahabada H J ^a   Du, Zhenming ^c   Pang, Eric S ^a,b   Shanmugam, Akila ^a   Lomakin, Aleksey ^e   Talbiersky, Peter ^d   Tennstaedt, Annette ^d   McDaniel, Kirsten ^a   Bakshi, Reena ^a   Kuo, Pei Yi ^a   Ehrmann, Michael ^d   Benedek, George B ^e   Loo, Joseph A ^a,b   Klärner, Frank Gerrit ^d   Schrader, Thomas ^d   Wang, Chunyu ^c   Bitan, Gal ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEINS; ASSEMBLY PROCESS; ASSEMBLY REACTIONS; ATTRACTIVE STRATEGIES; FIBRIL ELONGATION; MOLECULAR TWEEZERS; PROTEIN AGGREGATION;

AMINO ACIDS; COMPLEXATION; DISEASE CONTROL; GLYCOPROTEINS; LEAD COMPOUNDS; MASS SPECTROMETRY; OLIGOMERIZATION; OLIGOMERS; PROTEIN FOLDING; SELF ASSEMBLY; TOXICITY;

PROTEINS;

AMYLOID BETA PROTEIN; CLR 01; LYSINE; OLIGOMER; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

AMYLOIDOSIS; ANIMAL CELL; ARTICLE; BINDING SITE; HYDROPHOBICITY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERIZATION; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; RAT; STATIC ELECTRICITY;

AMYLOID BETA-PEPTIDES; AMYLOIDOSIS; ANIMALS; BINDING SITES; LYSINE; PC12 CELLS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RATS;

EID: 80055020556     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja206279b     Document Type: Article

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