Pyruvate protection against β-amyloid-induced neuronal death: Role of mitochondrial redox state

Journal of Neuroscience Research

Volumn 73, Issue 2, 2003, Pages 260-269

  Alvarez, Gema ^a   Ramos, Milagros ^a   Ruiz, Francisca ^a   Satrústegui, Jorgina ^a   Bogónez, Elena ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Alzheimer's disease; Mitochondria; Oxidative stress; Pyruvate

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALPHA CYANO 3 HYDROXYCINNAMIC ACID; AMYLOID BETA PROTEIN; ANTIOXIDANT; CASPASE 3; CINNAMIC ACID DERIVATIVE; DICHLOROFLUORESCEIN; FLUORESCEIN DERIVATIVE; GLUCOSE; MALIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; CULTURE MEDIUM; ENZYME ACTIVITY; FLUORESCENCE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RESPIRATORY CHAIN;

AMYLOID BETA-PROTEIN; ANIMALS; CELL DEATH; CELLS, CULTURED; CYTOPROTECTION; MITOCHONDRIA; NEURONS; OXIDATION-REDUCTION; PYRUVIC ACID; RATS;

EID: 0038167009     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10648     Document Type: Article

References (61)

1. Altman FP. 1976. Tetrazolium salts and formazans. Prog Histochem Cytochem 9:1-56.
2. Alvarez G, Muñoz-Montano JR, Satrústegui J, Avila J, Bogónez E, Diaz-Nido J. 1999. Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration. FEBS Lett 453:260-264.
3. Barkats M, Millecamps S, Abrioux P, Geoffroy MC, Mallet J. 2000. Overexpression of glutathione peroxidase increased the resistance of neuronal cells to Aβ-mediated neurotoxicity. J Neurochem 75:1438-1446.
4. Behl C, Davis JB, Lesley R, Schubert D. 1994. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77:817-827.
5. Bottenstein JE, Sato GH. 1979. Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc Natl Acad Sci USA 76:514-517.
6. Brewer GL, Cotman CW. 1989. Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Res 494:65-74.
7. Butterfield DA, Hensley K, Harris M, Mattson M, Carney J. 1994 β-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease. Biochem Biophys Res Commun 200:710-715.
8. Butterfield DA, Drake J, Pocernich C, Castegna A. 2001. Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide. Trends Mol Med 7:548-554.
9. Cai J, Jones DP. 1999. Mitochondrial redox signaling during apoptosis. J Bioenerg Biomembr 4:327-334.
10. Constantopoulus G, Barranger JA. 1984. Nonenzymatic decarboxylation of pyruvate. Anal Biochem 139:353-358.
11. Desagher S, Glowinski J, Prémont J. 1997. Pyruvate protects neurons against hydrogen peroxide-induced toxicity. J Neurosci 17:9060-9067.
12. 2+ after toxic NMDA-receptor activity. J Neurochem 65:739-743.
13. Facci L, Skaper SD, Varon S. 1985. Specific replacements of pyruvate for trophic support of central and peripheral nervous system neurons. J Neurochem 45:926-934.
14. Giovanni A, Keramaris E, Morris EJ, Hou ST, O'Hare M, Dyson N, Robertson GS, Slack RS, Park DS. 2000. E2F1 mediates death of β-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase-3. J Biol Chem 275:11553-11560.
15. Gjedde A, Marrett S. 2001. Glycolysis in neurons, not astrocytes, delays oxidative metabolism of human visual cortex during sustained checker-board stimulation in vivo. J Cereb Blood Flow Metab 21:1384-1392.
16. Gjedde A, Marrett S, Vafaee M. 2002. Oxidative and nonoxidative metabolism of excited neurons and astrocytes. J Cereb Blood Flow Metab 22:1-14.
17. Green DR, Reed JC. 1998. Mitochondria and apoptosis. Science 281:1309-1312.
18. Halestrap AP, Denton RM. 1975. The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by alpha-cyano-4-hydroxycinnamate and related compounds. Biochem J 148:97-106.
19. Hansen MB, Nielsen SB, Berg K. 1989. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119:203-210.
20. Hensley K, Karney JM, Mattson MP, Aksenova M, Harris M, Wu JF, Floyd RA, Butterfield DA. 1994. A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer's disease. Proc Natl Acad Sci USA 91:3270-3274.
21. Izumi Y, Benz AM, Zorumski CF, Olney JW. 1994. Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices. Neuroreport 5:617-620.
22. Izumi Y, Katsuki H, Zorumski CF. 1997. Monocarboxyates (pyruvate and lactate) as alternative energy substrates for the induction of long-term potentiation in rat hippocampal slices. Neurosci Lett 232:17-20.
23. 2+ pump revealed by fluorescent chelator dyes in human red blood cell ghosts. J Gen Physiol 99:41-62.
24. 2+ in pancreatic beta-cells. A possible role for pyruvate. J Biol Chem 269:14391-14395.
25. Kashiwaya Y, Takeshima T, Nozomi M, Nakashima K, Clarke K, Veech RL. 2000. D-β-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc Natl Acad Sci USA 97:5440-5444.
26. Keller JN, Kindy MS, Holtsberg FW, St. Clair DK, Yen HC, Germeyer A, Steiner SM, Bruce-Keller AJ, Hutchins JB, Mattson MP. 1998. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci 18:687-697.
27. Lee JY, Kim YH, Koh JY. 2001. Protection by pyruvate against transient forebrain ischemia in rats. J Neurosci 21:RC171(1-6).
28. Lenaz G. 2001. The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology. IUBMB Life 52:159-164.
29. Liu Y, Schubert D. 1997. Cytotoxic amyloid peptides inhibit cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction by enhancing MTT formazan exocytosis. J Neurochem 69:2285-2293.
30. 1-42-treated neuronal cell lines. J Neurochem 75:1977-1985.
31. Lorenzo A, Yankner BA. 1994. β-Amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc Natl Acad Sci USA 91:12243-12247.
32. Mark RJ, Pang Z, Geddes JV, Uchida K, Mattson MP. 1997. Amyloid β-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation. J Neurosci 17:1046-1054.
33. Mattson MP, Tomaselli KJ, Rydel EE. 1993. Calcium destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF. Brain Res 621:35-49.
34. Mattson MP, Barger SW, Begley JG, Mark RJ. 1995. Calcium, free radicals, and excitotoxic neuronal death in primary cell culture. Methods Cell Biol 46:187-216.
35. Mattson MP, Partin J, Begley JG. 1998. Amyloid β-peptide induces apoptosis-related events in synapses and dendrites. Brain Res 807:167-176.
36. May PC, Gitter BD, Waters DC, Simmons LK, Becker GW, Small JS, Robinson MP. 1992. β-Amyloid in vitro toxicity: lot-to-lot variability. Neurobiol Aging 13:605-607.
37. Miranda-Vizuete A, Damdimopoulos AE, Spyrou G. 2000. The mitochondrial thioredoxin system. Antiox Redox Signal 2:801-810.
38. Nomura K, Imai H, Koumura T, Kobayashi T, Nakagawa Y. 2000. Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglucaemia-induced apoptosis. Biochem J 351:183-193.
39. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. 1991. In vitro ageing of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res 563:311-314.
40. Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW. 1993. Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci 13:1676-1687.
41. Pike CJ, Ramezan-Arab N, Cotman CW. 1997. β-Amyloid neurotoxicity in vitro: evidence of oxidative stress but not protection by antioxidants. J Neurochem 69:1601-1611.
42. Praticì D, Delanty N. 2000. Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. Am J Med 109:577-585.
43. Reed LJ. 1981. Regulation of mammalian pyruvate dehydrogenase complex by a phosphorylation-dephosphorylation cycle. Curr Top Cell Regul 18:95-106.
44. Ruiz F, Alvarez G, Pereira R, Hernández M, Villalba M, Cruz F, Cerdán S, Bogónez E, Satrústegui J. 1998. Protection by pyruvate and malate against glutamate-mediated neurotoxicity. Neuroreport 9:1277-1282.
45. Ruiz F, Alvarez G, Ramos M, Hernández M, Bogónez E, Satrústegui J. 2000. Cyclosporin A targets involved in protection against glutamate excitotoxicity. Eur J Pharmacol 404:29-39.
46. Sagara Y, Dargusch R, Klier FG, Schubert D, Behl C. 1996. Increased antioxidant enzyme activity in amyloid β protein-resistant cells. J Neurosci 16:497-505.
47. Schubert D, Behl C, Lesley R, Brack A, Dargusch R, Sagara Y, Kimura H. 1995. Amyloid peptides are toxic via a common oxidative mechanism. Proc Natl Acad Sci USA 92:1989-1993.
48. Schurr A, West CA, Rigor BM. 1988. Lactate-supported synaptic function in the rat hippocampal slice preparation. Science 240:1326-1328.
49. Selak I, Skaper SD, Varon S. 1985. Pyruvate participation in the low molecular weight trophic activity for central nervous system neurons in glia-conditioned media. J Neurosci 5:23-28.
50. Selkoe DJ. 1999. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399(Suppl):A23-A31.
51. Selznick LA, Zheng TS, Flavell RA, Rakic P, Roth KA. 2000. Amyloid beta-induced neuronal death is bax-dependent but caspase-independent. J Neuropathol Exp Neurol 59:271-279.
52. Shearman MS, Ragan CI, Iversen LL. 1994. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death. Proc Natl Acad Sci USA 91:1470-1474.
53. + and inhibition of glycolysis. J Neurosci 20:3139-3146.
54. Sies H. 1993. Strategies of antioxidant defense. Eur J Biochem 215:213-219.
55. Slater TF, Sawyer B, Strauli U. 1963. Studies of succinate reductase systems. III. Points of coupling of four different tetrazolium salts. Biochim Biophys Acta 77:383-393.
56. Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML. 2000. Caspase-2 mediates neuronal cell death induced by β-amyloid. J Neurosci 20:1386-1392.
57. 2+ channels: a posible involvement of free radicals. J Neurochem 68:265-271.
58. Villalba M, Martínez-Serrano A, Gómez-Puertas P, Blanco P, Börner C, Casado M, Giménez C, Pereira R, Bogónez E, Pozzan T, Satrústegui J. 1994. The role of pyruvate in neuronal calcium homeostasis. Effects on intracellular calcium pools. J Biol Chem 269:2468-2476.
59. Wang CN, Chi CW, Lin YL, Chen CF, Shiao YJ. 2001. The neuroprotective effects of phytoestrogens on amyloid β protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. J Biol Chem 276:5287-5295.
60. Wang XF, Cynader MS. 2001. Pyruvate released by astrocytes protects neurons from copper-catalyzed cysteine neurotoxicity. J Neurosci 21:3322-3331.
61. Yankner BA. 1996. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16:921-932.