Design, synthesis, and biological evaluation of novel transrepression- selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11- methylene-6 H-dibenz[ b, e ]azepin-6-one skeleton

Journal of Medicinal Chemistry

Volumn 55, Issue 17, 2012, Pages 7360-7377

  Aoyama, Atsushi ^a   Endo Umeda, Kaori ^b   Kishida, Kenji ^c   Ohgane, Kenji ^a   Noguchi Yachide, Tomomi ^a   Aoyama, Hiroshi ^d   Ishikawa, Minoru ^a   Miyachi, Hiroyuki ^c   Makishima, Makoto ^b   Hashimoto, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1,1,1,3,3,3 HEXAFLUORO 2 HYDROXYPROPAN 2 YL) 5 METHYL 11 METHYLENE 6H DIBENZ[B,E]AZEPIN 6 ONE; 2 BROMO 4 ISOPROPYLANILINE; 2 IODO N (2 VINYLPHENYL)BENZAMIDE; 2 IODO N (4 ISOPROPYL 2 VINYLPHENYL) N METHYLBENZAMIDE; 2 IODO N (4 METHYL 2 VINYLPHENYL)BENZAMIDE; 2 IODO N METHYL N (4 METHYL 2 VINYLPHENYL)BENZAMIDE; 2 IODO N METHYL N (4 NITRO 2 VINYLPHENYL)BENZAMIDE; 2 VINYLANILINE; 4 ETHYL 2 VINYLANILINE; 4 HEXYL 2 VINYLANILINE; 4 ISOPROPYL 2 VINYLANILINE; 4 METHYL 2 VINYLANILINE; 4 TERT BUTYL 2 BROMOANILINE; 4 TERT BUTYL 2 VINYLANILINE; 5,11 DIHYDRO 2 (1 DODECYL) 5 METHYL 11 METHYLENE 6H DIBENZ[B,E]AZEPIN 6 ONE; 5,11 DIHYDRO 2 ETHYL 5 METHYL 11 METHYLENE 6H DIBENZ[B,E]AZEPIN 6 ONE; 5,11 DIHYDRO 2 HEYL 5 METHYL 11 METHYLENE 6H DIBENZ[B,E]AZEPIN 6 ONE; 5,11 DIHYDRO 2 HYDROXY 5 METHYL 11 METHYLENE 6H DIBENZ[B,E]AZEPIN 6 ONE; 5,11 DIHYDRO 2 TERT BUTYL 5 METHYL 11 METHYLENE 6H DIBENZ[B,E]AZEPIN 6 ONE; 5,11 DIHYDRO 2,5 METHYL 11 METHYLENE 6H DIBENZ[B,E]AZEPIN 6 ONE; 5,11 DIHYDRO 5 METHYL 11 METHYLENE 6H DIBENZ[B,E]AZEPIN 6 ONE; ETHYL 4 (2 IODO N METHYLBENZAMIDO) 3 VINYLBENZOATE; LIVER X RECEPTOR AGONIST; N (4 ACETYL 2 VINYLPHENYL) 2 IODOBENZAMIDE; N (4 DODECYL 2 VINYLPHENYL) 2 IODO N METHYLBENZAMIDE; N (4 ETHYL 2 VINYLPHENYL) 2 IODO N METHYLBENZAMIDE; N (4 ETHYL 2 VINYLPHENYL) 2 IODOBENZAMIDE; N (4 HEXYL 2 VINYLPHENYL) 2 IODO N METHYLBENZAMIDE; N (4 TERT BUTYL 2 VINYLPHENYL) 2 IODO N METHYLBENZAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE POLARIZATION; LIGAND BINDING; MACROPHAGE; MOLECULAR DOCKING; PROTON NUCLEAR MAGNETIC RESONANCE; WILD TYPE;

CRYSTALLOGRAPHY, X-RAY; DIBENZOXAZEPINES; DRUG DESIGN; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; ORPHAN NUCLEAR RECEPTORS; TRANSCRIPTION, GENETIC;

EID: 84866306958     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3002394     Document Type: Article

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