Structure-based design and synthesis of fluorescent PPARα/δ co-agonist and its application as a probe for fluorescent polarization assay of PPARδ ligands

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 9, 2008, Pages 1357-1359

  Araya, Yoko ^a   Kasuga, Jun Ichi ^a   Toyota, Kenji ^b   Hirakawa, Yuko ^b   Oyama, Takuji ^b   Makishima, Makoto ^c   Morikawa, Kosuke ^b   Hashimoto, Yuichi ^a   Miyachi, Hiroyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c NIHON UNIVERSITY   (Japan)

Author keywords

Fluorescent ligand; Fluorescent peroxisome proliferator activated receptor co agonist; Fluorescent polarization; Peroxisome proliferator activated receptor; Phenylpropanoic acid

Indexed keywords

2 [4 METHOXY 3 [(PYRENE 1 CARBOXAMIDO)METHYL]BENZYL]BUTANOIC ACID; FARGLITAZAR; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; TIPP 401; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; COMPLEX FORMATION; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE; FLUORESCENCE POLARIZATION; LIGAND BINDING; MOLECULAR PROBE; OPTICAL ROTATION; PROTEIN DOMAIN; RECEPTOR AFFINITY; STRUCTURE ANALYSIS; TECHNIQUE; X RAY CRYSTALLOGRAPHY;

BENZALDEHYDES; CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE POLARIZATION; FLUORESCENT DYES; HUMANS; INDICATORS AND REAGENTS; LIGANDS; MOLECULAR CONFORMATION; PPAR ALPHA; PPAR DELTA; PYRENES;

EID: 51349131065     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.1357     Document Type: Article

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