메뉴 건너뛰기




Volumn 40, Issue 3, 2012, Pages 724-741

Emerging anti-inflammatory strategies for COPD

Author keywords

Chronic obstructive pulmonary disease; Targeted therapy; Therapeutic interventions; Treatment of chronic obstructive pulmonary disease

Indexed keywords

4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; 4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; 5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; ABX CXCL8; ADALIMUMAB; ADENOSINE A2A RECEPTOR AGONIST; ANALGESIC, ANTIINFLAMMATORY, ANTIRHEUMATIC AND ANTIGOUT AGENTS; ANTIINFLAMMATORY AGENT; BIMOSIAMOSE; CERTOLIZUMAB PEGOL; CILOMILAST; DILMAPIMOD; ETANERCEPT; GOLIMUMAB; GSK 256066; GW 328267X; I KAPPA B; INFLIXIMAB; MACROLIDE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PGX 100; PH 797804; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PLACEBO; PROTEIN INHIBITOR; REGADENOSON; ROFLUMILAST; UK 432097; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84865823980     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00213711     Document Type: Review
Times cited : (89)

References (153)
  • 1
    • 80052706801 scopus 로고    scopus 로고
    • New insights into the immunology of chronic obstructive pulmonary disease
    • Brusselle GG, Joos GF, Bracke KR. New insights into the immunology of chronic obstructive pulmonary disease. Lancet 2011; 378: 1015-1026.
    • (2011) Lancet , vol.378 , pp. 1015-1026
    • Brusselle, G.G.1    Joos, G.F.2    Bracke, K.R.3
  • 2
    • 23044502066 scopus 로고    scopus 로고
    • Corticosteroid resistance in airway disease
    • Barnes PJ. Corticosteroid resistance in airway disease. Proc Am Thorac Soc 2004; 1: 264-268.
    • (2004) Proc Am Thorac Soc , vol.1 , pp. 264-268
    • Barnes, P.J.1
  • 3
    • 13344250392 scopus 로고    scopus 로고
    • New anti-inflammatory approaches in COPD
    • DOI 10.1016/j.ddstr.2004.11.013, PII S1740677304000762
    • Matera MG, Cazzola M. New anti-inflammatory approaches in COPD. Drug Discov Today: Ther Strat 2004; 1: 335-343. (Pubitemid 40197612)
    • (2004) Drug Discovery Today: Therapeutic Strategies , vol.1 , Issue.3 , pp. 335-343
    • Matera, M.G.1    Cazzola, M.2
  • 4
    • 0344513958 scopus 로고    scopus 로고
    • Phosphodiesterase-4 Inhibitors in the Treatment of Inflammatory Lung Disease
    • DOI 10.2165/00003495-200363230-00002
    • Spina D. Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease. Drugs 2003; 63: 2575-2594. (Pubitemid 37491561)
    • (2003) Drugs , vol.63 , Issue.23 , pp. 2575-2594
    • Spina, D.1
  • 6
    • 33646924049 scopus 로고    scopus 로고
    • Are phosphodiesterase 4 inhibitors just more theophylline?
    • DOI 10.1016/j.jaci.2006.02.045, PII S0091674906006348
    • Boswell-Smith V, Cazzola M, Page CP. Are phosphodiesterase 4 inhibitors just more theophylline? J Allergy Clin Immunol 2006; 117: 1237-1243. (Pubitemid 43795733)
    • (2006) Journal of Allergy and Clinical Immunology , vol.117 , Issue.6 , pp. 1237-1243
    • Boswell-Smith, V.1    Cazzola, M.2    Page, C.P.3
  • 7
    • 69149103642 scopus 로고    scopus 로고
    • Roflumilast in symptomatic chronic obstructive pulmonary disease: Two randomized clinical trials
    • Calverley PM, Rabe KF, Goehring UM, et al. Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomized clinical trials. Lancet 2009; 374: 684-695.
    • (2009) Lancet , vol.374 , pp. 684-695
    • Calverley, P.M.1    Rabe, K.F.2    Goehring, U.M.3
  • 8
    • 79956098321 scopus 로고    scopus 로고
    • PDE4-inhibitors: A novel, targeted therapy for obstructive airways disease
    • Diamant Z, Spina D. PDE4-inhibitors: a novel, targeted therapy for obstructive airways disease. Pulm Pharmacol Ther 2011; 24: 353-360.
    • (2011) Pulm Pharmacol Ther , vol.24 , pp. 353-360
    • Diamant, Z.1    Spina, D.2
  • 9
    • 79251588730 scopus 로고    scopus 로고
    • Reduction of exacerbations by the PDE4 inhibitor roflumilast - The importance of defining different subsets of patients with COPD
    • Rennard SI, Calverley PM, Goehring UM, et al. Reduction of exacerbations by the PDE4 inhibitor roflumilast - the importance of defining different subsets of patients with COPD. Respir Res 2011; 12: 18.
    • (2011) Respir Res , vol.12 , pp. 18
    • Rennard, S.I.1    Calverley, P.M.2    Goehring, U.M.3
  • 10
    • 79957513424 scopus 로고    scopus 로고
    • Roflumilast with long-acting β2-agonists for COPD: Influence of exacerbationhistory
    • Bateman ED, Rabe KF, Calverley PM, et al. Roflumilast with long-acting β2-agonists for COPD: influence of exacerbationhistory. Eur Respir J 2011; 38: 553-560.
    • (2011) Eur Respir J , vol.38 , pp. 553-560
    • Bateman, E.D.1    Rabe, K.F.2    Calverley, P.M.3
  • 13
    • 74049158987 scopus 로고    scopus 로고
    • Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
    • Burgin AB, Magnusson OT, Singh J, et al. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat Biotechnol 2010; 28: 63-70.
    • (2010) Nat Biotechnol , vol.28 , pp. 63-70
    • Burgin, A.B.1    Magnusson, O.T.2    Singh, J.3
  • 14
    • 35948942231 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, parallel group, six-week study of the efficacy and safety of tofimilast dry powder for inhalation (DPI) in adults with COPD
    • Danto S, Wei GC, Gill J. A randomized, double-blind, placebo-controlled, parallel group, six-week study of the efficacy and safety of tofimilast dry powder for inhalation (DPI) in adults with COPD. Am J Respir Crit Care Med 2007; 175: A131.
    • (2007) Am J Respir Crit Care Med , vol.175
    • Danto, S.1    Wei, G.C.2    Gill, J.3
  • 16
    • 66749187721 scopus 로고    scopus 로고
    • A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD
    • Vestbo J, Tan L, Atkinson G, et al. A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD. Eur Respir J 2009; 33: 1039-1044.
    • (2009) Eur Respir J , vol.33 , pp. 1039-1044
    • Vestbo, J.1    Tan, L.2    Atkinson, G.3
  • 17
    • 33745939122 scopus 로고    scopus 로고
    • The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(N-carbamoyl- 2- aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4H-pyrimido[6,1-a] isoquinolin-4-one]
    • DOI 10.1124/jpet.105.099192
    • Boswell-Smith V, Spina D, Oxford AW, et al. The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6- trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H- pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6- diisopropylphenoxy)-9,10- dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one]. J Pharmacol Exp Ther 2006; 318: 840-848. (Pubitemid 44061259)
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.318 , Issue.2 , pp. 840-848
    • Boswell-Smith, V.1    Spina, D.2    Oxford, A.W.3    Comer, M.B.4    Seeds, E.A.5    Page, C.P.6
  • 18
    • 70349338939 scopus 로고    scopus 로고
    • Emerging oligonucleotide therapies for asthma and chronic obstructive pulmonary disease
    • Séguin RM, Ferrari N. Emerging oligonucleotide therapies for asthma and chronic obstructive pulmonary disease. Expert Opin Investig Drugs 2009; 18: 1505-1517.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 1505-1517
    • Séguin, R.M.1    Ferrari, N.2
  • 19
    • 0347093665 scopus 로고    scopus 로고
    • 2A receptor agonists as anti-inflammatory agents
    • Sullivan GW. Adenosine A2A receptor agonists as anti-inflammatory agents. Curr Opin Investig Drugs 2003; 4: 1313-1319. (Pubitemid 38100576)
    • (2003) Current Opinion in Investigational Drugs , vol.4 , Issue.11 , pp. 1313-1319
    • Sullivan, G.W.1
  • 20
    • 51049101334 scopus 로고    scopus 로고
    • Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases
    • Haskó G, Linden J, Cronstein B, et al. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov 2008; 7: 759-770.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 759-770
    • Haskó, G.1    Linden, J.2    Cronstein, B.3
  • 22
    • 53849141812 scopus 로고    scopus 로고
    • Treating lung inflammation with agonists of the adenosine A2A receptor: Promises, problems and potential solutions
    • Trevethick MA, Mantell SJ, Stuart EF, et al. Treating lung inflammation with agonists of the adenosine A2A receptor: promises, problems and potential solutions. Br J Pharmacol 2008; 155: 463-474.
    • (2008) Br J Pharmacol , vol.155 , pp. 463-474
    • Trevethick, M.A.1    Mantell, S.J.2    Stuart, E.F.3
  • 23
    • 44149118607 scopus 로고    scopus 로고
    • Safety of regadenoson, a selective adenosine A2A agonist, in patients with chronic obstructive pulmonary disease: A randomized, double-blind, placebo-controlled trial (RegCOPD trial)
    • Thomas GS, Tammelin BR, Schiffman GL, et al. Safety of regadenoson, a selective adenosine A2A agonist, in patients with chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled trial (RegCOPD trial). J Nucl Cardiol 2008; 15: 319-328.
    • (2008) J Nucl Cardiol , vol.15 , pp. 319-328
    • Thomas, G.S.1    Tammelin, B.R.2    Schiffman, G.L.3
  • 24
    • 72249089979 scopus 로고    scopus 로고
    • Nucleoside-5′-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5′-nucleotidase
    • El-Tayeb A, Iqbal J, Behrenswerth A, et al. Nucleoside-5′- monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5′-nucleotidase. J Med Chem 2009; 52: 7669-7677.
    • (2009) J Med Chem , vol.52 , pp. 7669-7677
    • El-Tayeb, A.1    Iqbal, J.2    Behrenswerth, A.3
  • 25
    • 80051495803 scopus 로고    scopus 로고
    • Therapeutic potential of adenosine analogues and conjugates
    • Samsel M, Dzierzbicka K. Therapeutic potential of adenosine analogues and conjugates. Pharmacol Rep 2011; 63: 601-617.
    • (2011) Pharmacol Rep , vol.63 , pp. 601-617
    • Samsel, M.1    Dzierzbicka, K.2
  • 26
    • 0035375198 scopus 로고    scopus 로고
    • Directional migration of leukocytes: Their pathological roles in inflammation and strategies for development of anti-inflammatory therapies
    • Geng JG. Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of antiinflammatory therapies. Cell Res 2001; 11: 85-88. (Pubitemid 33677212)
    • (2001) Cell Research , vol.11 , Issue.2 , pp. 85-88
    • Geng, J.G.1
  • 27
    • 79951926461 scopus 로고    scopus 로고
    • Biophysics of selectin-ligand interactions in inflammation and cancer
    • Cheung LS, Raman PS, Balzer EM, et al. Biophysics of selectin-ligand interactions in inflammation and cancer. Phys Biol 2011; 8: 015013.
    • (2011) Phys Biol , vol.8 , pp. 015013
    • Cheung, L.S.1    Raman, P.S.2    Balzer, E.M.3
  • 28
    • 2342464897 scopus 로고    scopus 로고
    • COPD: Is there light at the end of the tunnel?
    • DOI 10.1016/j.coph.2004.03.001, PII S1471489204000517
    • Barnes PJ. COPD: is there light at the end of the tunnel? Curr Opin Pharmacol 2004; 4: 263-272. (Pubitemid 38585311)
    • (2004) Current Opinion in Pharmacology , vol.4 , Issue.3 , pp. 263-272
    • Barnes, P.J.1
  • 29
    • 0034048369 scopus 로고    scopus 로고
    • Inhibition of adhesion of human neutrophils and eosinophils to P- selectin by the sialyl Lewis(x) antagonist TBC1269: Preferential activity against neutrophil adhesion in vitro
    • Davenpeck KL, Berens KL, Dixon RA, et al. Inhibition of adhesion of human neutrophils and eosinophils to P-selectin by the sialyl Lewis antagonist TBC1269: preferential activity against neutrophil adhesion in vitro. J Allergy Clin Immunol 2000; 105: 769-775. (Pubitemid 30226452)
    • (2000) Journal of Allergy and Clinical Immunology , vol.105 , Issue.4 , pp. 769-775
    • Davenpeck, K.L.1    Berens, K.L.2    Dixon, R.A.F.3    Dupre, B.4    Bochner, B.S.5
  • 30
    • 0035143166 scopus 로고    scopus 로고
    • Effects of the synthetic selectin inhibitor TBC1269 on tissue damage during acute Mannheimia haemolytica-induced pneumonia in neonatal calves
    • Radi ZA, Caverly JM, Dixon RA, et al. Effects of the synthetic selectin inhibitor TBC1269 on tissue damage during acute Mannheimia haemolytica-induced pneumonia in neonatal calves. Am J Vet Res 2001; 62: 17-22. (Pubitemid 32098899)
    • (2001) American Journal of Veterinary Research , vol.62 , Issue.1 , pp. 17-22
    • Radi, Z.A.1    Caverly, J.M.2    Dixon, R.A.3    Brogden, K.A.4    Ackermann, M.R.5
  • 31
    • 84858994721 scopus 로고    scopus 로고
    • Safety and efficacy of the inhaled pan-selectin antagonist bimosiamose in patients with COPD
    • Bock D, Beeh K, Beier J, et al. Safety and efficacy of the inhaled pan-selectin antagonist bimosiamose in patients with COPD. Eur Respir J 2007; 30: Suppl. S1, 613s.
    • (2007) Eur Respir J , vol.30 , Issue.SUPPL. S1
    • Bock, D.1    Beeh, K.2    Beier, J.3
  • 32
    • 84873984530 scopus 로고    scopus 로고
    • Inhaled pan-selectin antagonist bimosiamose in COPD: A double-blind, randomized, placebo-controlled phase II study
    • Watz H, Bock D, Meyer M, et al. Inhaled pan-selectin antagonist bimosiamose in COPD: A double-blind, randomized, placebo-controlled phase II study. Eur Respir J 2011; 38: Suppl. S5, 818s-819s.
    • (2011) Eur Respir J , vol.38 , Issue.SUPPL. S5
    • Watz, H.1    Bock, D.2    Meyer, M.3
  • 33
    • 77952569435 scopus 로고    scopus 로고
    • Selectin inhibitors: A patent review
    • Bedard PW, Kaila N. Selectin inhibitors: a patent review. Expert Opin Ther Pat 2010; 20: 781-793.
    • (2010) Expert Opin Ther Pat , vol.20 , pp. 781-793
    • Bedard, P.W.1    Kaila, N.2
  • 34
    • 75749095929 scopus 로고    scopus 로고
    • TNF-α inhibitors in asthma and COPD: We must not throw the baby out with the bath water
    • Matera MG, Calzetta L, Cazzola M. TNF-α inhibitors in asthma and COPD: we must not throw the baby out with the bath water. Pulm Pharmacol Ther 2010; 23: 121-128.
    • (2010) Pulm Pharmacol Ther , vol.23 , pp. 121-128
    • Matera, M.G.1    Calzetta, L.2    Cazzola, M.3
  • 35
    • 23744498786 scopus 로고    scopus 로고
    • First study of infliximab treatment in patients with chronic obstructive pulmonary disease
    • van der Vaart H, Koeter GH, et al. First study of infliximab treatment in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005; 172: 465-469.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 465-469
    • Van Der Vaart, H.1    Koeter, G.H.2
  • 37
    • 52949120563 scopus 로고    scopus 로고
    • Effect of infliximab on local and systemic inflammation in chronic obstructive pulmonary disease: A pilot study
    • Dentener MA, Creutzberg EC, Pennings H-J, et al. Effect of infliximab on local and systemic inflammation in chronic obstructive pulmonary disease: a pilot study. Respiration 2008; 76: 275-282.
    • (2008) Respiration , vol.76 , pp. 275-282
    • Dentener, M.A.1    Creutzberg, E.C.2    Pennings, H.-J.3
  • 38
    • 38049057089 scopus 로고    scopus 로고
    • TNF-α antagonists and the prevention of hospitalisation for chronic obstructive pulmonary disease
    • Suissa S, Ernst P, Hudson M. TNF-α antagonists and the prevention of hospitalisation for chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2008; 21: 234-238.
    • (2008) Pulm Pharmacol Ther , vol.21 , pp. 234-238
    • Suissa, S.1    Ernst, P.2    Hudson, M.3
  • 39
    • 4544275759 scopus 로고    scopus 로고
    • Efficacy and safety of a monoclonal antibody recognizing lnterleukin-8 in COPD: A pilot study
    • DOI 10.1378/chest.126.3.926
    • Mahler DA, Huang S, Tabrizi M, et al. Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study. Chest 2004; 126: 926-934. (Pubitemid 39258050)
    • (2004) Chest , vol.126 , Issue.3 , pp. 926-934
    • Mahler, D.A.1    Huang, S.2    Tabrizi, M.3    Bell, G.M.4
  • 40
    • 0032822643 scopus 로고    scopus 로고
    • Fully human anti-interleukin-8 monoclonal antibodies: Potential therapeutics for the treatment of inflammatory disease states
    • Yang XD, Corvalan JR, Wang P, et al. Fully human anti-interleukin-8 monoclonal antibodies: potential therapeutics for the treatment of inflammatory disease states. J Leukoc Biol 1999; 66: 401-410. (Pubitemid 29439246)
    • (1999) Journal of Leukocyte Biology , vol.66 , Issue.3 , pp. 401-410
    • Yang, X.-D.1    Corvalan, J.R.F.2    Wang, P.3    Roy, C.M.-N.4    Davis, C.G.5
  • 42
    • 42549172436 scopus 로고    scopus 로고
    • Interfering with chemokines and chemokine receptors as potential new therapeutic strategies
    • D'Elios MM, Del Prete G, Amedei A. Interfering with chemokines and chemokine receptors as potential new therapeutic strategies. Expert Opin Ther Patents 2008; 18: 309-325.
    • (2008) Expert Opin Ther Patents , vol.18 , pp. 309-325
    • D'Elios, M.M.1    Del Prete, G.2    Amedei, A.3
  • 43
    • 0141961518 scopus 로고    scopus 로고
    • Therapy for chronic obstructive pulmonary disease in the 21st century
    • DOI 10.2165/00003495-200363190-00002
    • Donnelly LE, Rogers DF. Therapy for chronic obstructive pulmonary disease in the 21st century. Drugs 2003; 63: 1973-1998. (Pubitemid 37229086)
    • (2003) Drugs , vol.63 , Issue.19 , pp. 1973-1998
    • Donnelly, L.E.1    Rogers, D.F.2
  • 44
    • 70949091447 scopus 로고    scopus 로고
    • The cytokine network in chronic obstructive pulmonary disease
    • Barnes PJ. The cytokine network in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2009; 41: 631-638.
    • (2009) Am J Respir Cell Mol Biol , vol.41 , pp. 631-638
    • Barnes, P.J.1
  • 45
    • 83555164893 scopus 로고    scopus 로고
    • Targeting chemokine receptors in chronic inflammatory diseases: An extensive review
    • Koelink PJ, Overbeek SA, Braber S, et al. Targeting chemokine receptors in chronic inflammatory diseases: an extensive review. Pharmacol Ther 2012; 133: 1-18.
    • (2012) Pharmacol Ther , vol.133 , pp. 1-18
    • Koelink, P.J.1    Overbeek, S.A.2    Braber, S.3
  • 46
    • 77951165310 scopus 로고    scopus 로고
    • SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects
    • Holz O, Khalilieh S, Ludwig-Sengpiel A, et al. SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects. Eur Respir J 2010; 35: 564-570.
    • (2010) Eur Respir J , vol.35 , pp. 564-570
    • Holz, O.1    Khalilieh, S.2    Ludwig-Sengpiel, A.3
  • 47
    • 79959340752 scopus 로고    scopus 로고
    • SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans
    • Lazaar AL, Sweeney LE, MacDonald AJ, et al. SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. Br J Clin Pharmacol 2011; 72: 282-293.
    • (2011) Br J Clin Pharmacol , vol.72 , pp. 282-293
    • Lazaar, A.L.1    Sweeney, L.E.2    MacDonald, A.J.3
  • 48
    • 0042387838 scopus 로고    scopus 로고
    • The role of interleukin-8 and its receptors in inflammatory lung disease: Implications for therapy
    • Pease JE, Sabroe I. The role of interleukin-8 and its receptors in inflammatory lung disease. Implications for therapy. Am J Respir Med 2002; 1: 19-25. (Pubitemid 37038920)
    • (2002) American Journal of Respiratory Medicine , vol.1 , Issue.1 , pp. 19-25
    • Pease, J.E.1    Sabroe, I.2
  • 50
    • 77956646923 scopus 로고    scopus 로고
    • Role of the CX3CL1-CX3CR1 axis in chronic inflammatory lung diseases
    • Zhang J, Patel JM. Role of the CX3CL1-CX3CR1 axis in chronic inflammatory lung diseases. Int J Clin Exp Med 2010; 3: 233-244.
    • (2010) Int J Clin Exp Med , vol.3 , pp. 233-244
    • Zhang, J.1    Patel, J.M.2
  • 51
    • 53149090155 scopus 로고    scopus 로고
    • CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema
    • McComb JG, Ranganathan M, Liu XH, et al. CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. Am J Pathol 2008; 173: 949-961.
    • (2008) Am J Pathol , vol.173 , pp. 949-961
    • McComb, J.G.1    Ranganathan, M.2    Liu, X.H.3
  • 53
    • 78149360636 scopus 로고    scopus 로고
    • CXCR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung
    • Mionnet C, Buatois V, Kanda A, et al. CXCR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Nat Med 2010; 16: 1305-1313.
    • (2010) Nat Med , vol.16 , pp. 1305-1313
    • Mionnet, C.1    Buatois, V.2    Kanda, A.3
  • 54
    • 0034930435 scopus 로고    scopus 로고
    • Chemokine receptors in airway disease: Which receptors to target?
    • DOI 10.1006/pupt.2001.0281
    • Owen C. Chemokine receptors in airway disease: which receptors to target? Pulm Pharmacol Ther 2001; 14: 193-202. (Pubitemid 32619924)
    • (2001) Pulmonary Pharmacology and Therapeutics , vol.14 , Issue.3 , pp. 193-202
    • Owen, C.1
  • 55
    • 0037040835 scopus 로고    scopus 로고
    • Targeting CCR2 or CD18 inhibits experimental in-stent restenosis in primates: Inhibitory potential depends on type of injury and leukocytes targeted
    • DOI 10.1161/hh0402.105956
    • Horvath C, Welt FG, Nedelman M, et al. Targeting CCR2 or CD18 inhibits experimental in-stent restenosis in primates: inhibitory potential depends on type of injury and leukocytes targeted. Circ Res 2002; 90: 488-494. (Pubitemid 34633920)
    • (2002) Circulation Research , vol.90 , Issue.4 , pp. 488-494
    • Horvath, C.1    Welt, F.G.P.2    Nedelman, M.3    Rao, P.4    Rogers, C.5
  • 56
    • 67649400529 scopus 로고    scopus 로고
    • Recent developments in CCR2 antagonists
    • Xia M, Sui Z. Recent developments in CCR2 antagonists. Expert Opin Ther Pat 2009; 19: 295-303.
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 295-303
    • Xia, M.1    Sui, Z.2
  • 57
    • 57749105255 scopus 로고    scopus 로고
    • Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease
    • Edwards MR, Bartlett NW, Clarke D, et al. Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease. Pharmacol Ther 2009; 121: 1-13.
    • (2009) Pharmacol Ther , vol.121 , pp. 1-13
    • Edwards, M.R.1    Bartlett, N.W.2    Clarke, D.3
  • 58
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002; 109: S81-S96.
    • (2002) Cell , vol.109
    • Ghosh, S.1    Karin, M.2
  • 59
    • 0034720896 scopus 로고    scopus 로고
    • Kinase regulation in inflammatory response
    • Delhase M, Li N, Karin M. Kinase regulation in inflammatory response. Nature 2000; 406: 367-368.
    • (2000) Nature , vol.406 , pp. 367-368
    • Delhase, M.1    Li, N.2    Karin, M.3
  • 60
    • 79951654440 scopus 로고    scopus 로고
    • Novel IκB kinase inhibitors for treatment of nuclear factor-κB -related diseases
    • Suzuki J, Ogawa M, Muto S, et al. Novel IκB kinase inhibitors for treatment of nuclear factor-κB -related diseases. Expert Opin Investig Drugs 2011; 20: 395-405.
    • (2011) Expert Opin Investig Drugs , vol.20 , pp. 395-405
    • Suzuki, J.1    Ogawa, M.2    Muto, S.3
  • 61
    • 33846411054 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor-α-inducible inflammatory genes by interferon-γ is associated with altered nuclear factor-κB transactivation and enhanced histone deacetylase activity
    • DOI 10.1124/mol.106.030171
    • Keslacy S, Tliba O, Baidouri H, et al. Inhibition of tumor necrosis factor-α-inducible inflammatory genes by interferon-γ is associated with altered nuclear factor-κB transactivation and enhanced histone deacetylase activity. Mol Pharmacol 2007; 71: 609-618. (Pubitemid 46147925)
    • (2007) Molecular Pharmacology , vol.71 , Issue.2 , pp. 609-618
    • Keslacy, S.1    Tliba, O.2    Baidouri, H.3    Amrani, Y.4
  • 62
    • 62749177245 scopus 로고    scopus 로고
    • IL-13 induces translocation of NF-κB in cultured human bronchial smooth muscle cells
    • Goto K, Chiba Y, Misawa M. IL-13 induces translocation of NF-κB in cultured human bronchial smooth muscle cells. Cytokine 2009; 46: 96-99.
    • (2009) Cytokine , vol.46 , pp. 96-99
    • Goto, K.1    Chiba, Y.2    Misawa, M.3
  • 63
    • 33746217403 scopus 로고    scopus 로고
    • Validation of the anti-inflammatory properties of small-molecule IκB kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle
    • DOI 10.1124/mol.106.023150
    • Catley MC, Sukkar MB, Chung KF, et al. Validation of the anti-inflammatory properties of small-molecule IκB kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol Pharmacol 2006; 70: 697-705. (Pubitemid 44092330)
    • (2006) Molecular Pharmacology , vol.70 , Issue.2 , pp. 697-705
    • Catley, M.C.1    Sukkar, M.B.2    Chung, K.F.3    Jaffee, B.4    Liao, S.-M.5    Coyle, A.J.6    Haddad, E.-B.7    Barnes, P.J.8    Newton, R.9
  • 64
    • 0036011294 scopus 로고    scopus 로고
    • Effects of NFκB decoy oligonucleotides released from biodegradable polymer microparticles on a glioblastoma cell line
    • DOI 10.1016/S0142-9612(02)00013-3, PII S0142961202000133
    • Gill JS, Zhu X, Moore MJ, et al. Effects of NFκB decoy oligonucleotides released from biodegradable polymer microparticles on a glioblastoma cell line. Biomaterials 2002; 23: 2773-2781. (Pubitemid 34465737)
    • (2002) Biomaterials , vol.23 , Issue.13 , pp. 2773-2781
    • Gill, J.S.1    Zhu, X.2    Moore, M.J.3    Lu, L.4    Yaszemski, M.J.5    Windebank, A.J.6
  • 66
    • 44649153952 scopus 로고    scopus 로고
    • Increased activation of p38 MAPK in COPD
    • Renda T, Baraldo S, Pelaia G, et al. Increased activation of p38 MAPK in COPD. Eur Respir J 2008; 31: 62-69.
    • (2008) Eur Respir J , vol.31 , pp. 62-69
    • Renda, T.1    Baraldo, S.2    Pelaia, G.3
  • 67
    • 26944440532 scopus 로고    scopus 로고
    • Post-transcriptional and nongenomic effects of glucocorticoids
    • Stellato C. Post-transcriptional and nongenomic effects of glucocorticoids. Proc Am Thorac Soc 2004; 1: 255-263.
    • (2004) Proc Am Thorac Soc , vol.1 , pp. 255-263
    • Stellato, C.1
  • 68
    • 28444495436 scopus 로고    scopus 로고
    • Novel signal transduction modulators for the treatment of airway diseases
    • DOI 10.1016/j.pharmthera.2005.08.001, PII S0163725805001737
    • Barnes PJ. Novel signal transduction modulators for the treatment of airway diseases. Pharmacol Ther 2006; 109: 238-245. (Pubitemid 41740824)
    • (2006) Pharmacology and Therapeutics , vol.109 , Issue.1-2 , pp. 238-245
    • Barnes, P.J.1
  • 69
    • 27744496768 scopus 로고    scopus 로고
    • The biology of p38 kinase: A central role in inflammation
    • Shieven GL. The biology of p38 kinase: a central role in inflammation. Curr Top Med Chem 2005; 5: 921-928.
    • (2005) Curr Top Med Chem , vol.5 , pp. 921-928
    • Shieven, G.L.1
  • 70
    • 52949154357 scopus 로고    scopus 로고
    • Therapeutic potential of inhaled p38 mitogen-activated protein kinase inhibitors for inflammatory pulmonary diseases
    • Chopra P, Kanoje V, Semwal A, et al. Therapeutic potential of inhaled p38 mitogen-activated protein kinase inhibitors for inflammatory pulmonary diseases. Expert Opin Investig Drugs 2008; 17: 1411-1425.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1411-1425
    • Chopra, P.1    Kanoje, V.2    Semwal, A.3
  • 71
    • 79958710208 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase pathways in asthma and COPD
    • Chung KF. p38 mitogen-activated protein kinase pathways in asthma and COPD. Chest 2011; 139: 1470-1479.
    • (2011) Chest , vol.139 , pp. 1470-1479
    • Chung, K.F.1
  • 72
    • 58149190433 scopus 로고    scopus 로고
    • Small-molecule p38 MAP kinase inhibitors for the treatment of inflammatory diseases: Novel structures and developments during 2006-2008
    • Pettus LH, Wurz RP. Small-molecule p38 MAP kinase inhibitors for the treatment of inflammatory diseases: novel structures and developments during 2006-2008. Curr Top Med Chem 2008; 8: 1452-1467.
    • (2008) Curr Top Med Chem , vol.8 , pp. 1452-1467
    • Pettus, L.H.1    Wurz, R.P.2
  • 75
    • 72749121087 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients
    • Singh D, Smyth L, Borrill Z, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol 2010; 50: 94-100.
    • (2010) J Clin Pharmacol , vol.50 , pp. 94-100
    • Singh, D.1    Smyth, L.2    Borrill, Z.3
  • 76
    • 84858957212 scopus 로고    scopus 로고
    • The novel oral p38 inhibitor, PH-797804, inhibits inhaled lipopolysaccharide (LPS)-induced airway and systemic inflammatory markers in healthy subjects
    • Tan E, Jones I, Tweedy S, et al. The novel oral p38 inhibitor, PH-797804, inhibits inhaled lipopolysaccharide (LPS)-induced airway and systemic inflammatory markers in healthy subjects. Am J Respir Crit Care Med 2011; 183: A2554.
    • (2011) Am J Respir Crit Care Med , vol.183
    • Tan, E.1    Jones, I.2    Tweedy, S.3
  • 77
    • 79958705077 scopus 로고    scopus 로고
    • Evaluation of an oral p38 mitogen activated protein kinase (MAPK inhibitor) SB-681323 in COPD
    • Barnes N, Pavord I, Maden C, et al. Evaluation of an oral p38 mitogen activated protein kinase (MAPK inhibitor) SB-681323 in COPD. Eur Respir J 2009; 34: Suppl. S3, 648s.
    • (2009) Eur Respir J , vol.34 , Issue.SUPPL. S3
    • Barnes, N.1    Pavord, I.2    Maden, C.3
  • 78
    • 79958752502 scopus 로고    scopus 로고
    • Arandomised, placebo controlled trial of 6 weeks' treatmentwith a novel oral p38 inhibitor in patients with COPD
    • MacNee W, Allan R, Jones I, et al. Arandomised, placebo controlled trial of 6 weeks' treatmentwith a novel oral p38 inhibitor in patients with COPD. Eur Respir J 2010; 36: Suppl. S4, 718s.
    • (2010) Eur Respir J , vol.36 , Issue.SUPPL. S4
    • MacNee, W.1    Allan, R.2    Jones, I.3
  • 79
    • 34249331264 scopus 로고    scopus 로고
    • Novel strategies for inhibition of the p38 MAPK pathway
    • DOI 10.1016/j.tips.2007.04.008, PII S0165614707000879
    • Zhang J, Shen B, Lin A. Novel strategies for inhibition of the p38 MAPK pathway. Trends Pharmacol Sci 2007; 28: 286-295. (Pubitemid 46818466)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.6 , pp. 286-295
    • Zhang, J.1    Shen, B.2    Lin, A.3
  • 80
    • 67651083303 scopus 로고    scopus 로고
    • p38a MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses
    • Perry JJ, Harris RM, Moiani D, et al. p38a MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses. J Mol Biol 2009; 391: 1-11.
    • (2009) J Mol Biol , vol.391 , pp. 1-11
    • Perry, J.J.1    Harris, R.M.2    Moiani, D.3
  • 81
    • 81555218671 scopus 로고    scopus 로고
    • Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease
    • Millan DS, Bunnage ME, Burrows JL, et al. Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease. J Med Chem 2011; 54: 7797-7814.
    • (2011) J Med Chem , vol.54 , pp. 7797-7814
    • Millan, D.S.1    Bunnage, M.E.2    Burrows, J.L.3
  • 82
    • 63749083925 scopus 로고    scopus 로고
    • Targeting protein kinases for the development of anti-inflammatory drugs
    • Cohen P. Targeting protein kinases for the development of anti-inflammatory drugs. Curr Opin Cell Biol 2009; 21: 317-324.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 317-324
    • Cohen, P.1
  • 83
    • 48449083636 scopus 로고    scopus 로고
    • MK2: A novel molecular target for anti-inflammatory therapy
    • Duraisamy S, Bajpai M, Bughani U, et al. MK2: a novel molecular target for anti-inflammatory therapy. Expert Opin Ther Targets 2008; 12: 921-936.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 921-936
    • Duraisamy, S.1    Bajpai, M.2    Bughani, U.3
  • 84
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • DOI 10.1126/science.296.5573.1655
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655-1657. (Pubitemid 34579158)
    • (2002) Science , vol.296 , Issue.5573 , pp. 1655-1657
    • Cantley, L.C.1
  • 86
    • 79955487961 scopus 로고    scopus 로고
    • Behavioural and structural differences in migrating peripheral neutrophils from patients with COPD
    • Sapey E, Stockley JA, Greenwood H, et al. Behavioural and structural differences in migrating peripheral neutrophils from patients with COPD. Am J Respir Crit Care Med 2011; 183: 1176-1186.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1176-1186
    • Sapey, E.1    Stockley, J.A.2    Greenwood, H.3
  • 87
    • 76349087609 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease
    • Marwick JA, Chung KF, Adcock IM. Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease. Ther Adv Respir Dis 2010; 4: 19-34.
    • (2010) Ther Adv Respir Dis , vol.4 , pp. 19-34
    • Marwick, J.A.1    Chung, K.F.2    Adcock, I.M.3
  • 88
    • 79954517766 scopus 로고    scopus 로고
    • PI3Kβ plays a critical role in neutrophil activation by immune complexes
    • Kulkarni S, Sitaru C, Jakus Z, et al. PI3Kβ plays a critical role in neutrophil activation by immune complexes. Sci Signal 2011; 4: ra23.
    • (2011) Sci Signal , vol.4
    • Kulkarni, S.1    Sitaru, C.2    Jakus, Z.3
  • 89
    • 77649160181 scopus 로고    scopus 로고
    • PI3K inhibition in inflammation: Toward tailored therapies for specific diseases
    • Ghigo A, Damilano F, Braccini L, et al. PI3K inhibition in inflammation: toward tailored therapies for specific diseases. Bioessays 2010; 32: 185-196.
    • (2010) Bioessays , vol.32 , pp. 185-196
    • Ghigo, A.1    Damilano, F.2    Braccini, L.3
  • 90
    • 62449213953 scopus 로고    scopus 로고
    • Aerosolized phosphoinositide 3-kinase γ/δ inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl) pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease
    • Doukas J, Eide L, Stebbins K, et al. Aerosolized phosphoinositide 3-kinase γ/δ inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl) pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. J Pharmacol Exp Ther 2009; 328: 758-765.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 758-765
    • Doukas, J.1    Eide, L.2    Stebbins, K.3
  • 91
    • 77951961401 scopus 로고    scopus 로고
    • Phosphoinositide-3 kinase c required for LPS-induced transepithelial neutrophil trafficking in the lung
    • Reutershan J, Saprito MS, Wu D, et al. Phosphoinositide-3 kinase c required for LPS-induced transepithelial neutrophil trafficking in the lung. Eur Respir J 2010; 35: 1137-1147.
    • (2010) Eur Respir J , vol.35 , pp. 1137-1147
    • Reutershan, J.1    Saprito, M.S.2    Wu, D.3
  • 94
    • 39549095380 scopus 로고    scopus 로고
    • 4 receptor antagonists as therapeutics for inflammatory disease: Preclinical and clinical developments
    • DOI 10.1517/13543784.16.12.1909
    • Hicks A, Monkarsh SP, Hoffman AF, et al. Leukotriene B4 receptor antagonists as therapeutics for inflammatory disease: preclinical and clinical developments. Exp Opin Invest Drugs 2007; 16: 1909-1920. (Pubitemid 351403723)
    • (2007) Expert Opinion on Investigational Drugs , vol.16 , Issue.12 , pp. 1909-1920
    • Hicks, A.1    Monkarsh, S.P.2    Hoffman, A.F.3    Goodnow Jr., R.4
  • 95
    • 70350094552 scopus 로고    scopus 로고
    • LTB4 contributes to exhaled breath condensate and sputum neutrophil chemotaxis in COPD
    • Corhay JL, Henket M, Nguyen D, et al. LTB4 contributes to exhaled breath condensate and sputum neutrophil chemotaxis in COPD. Chest 2009; 136: 1047-1054.
    • (2009) Chest , vol.136 , pp. 1047-1054
    • Corhay, J.L.1    Henket, M.2    Nguyen, D.3
  • 96
    • 0033679541 scopus 로고    scopus 로고
    • 15(S)-HETE modulates LTB4production and neutrophil chemotaxis in chronic bronchitis
    • Profita M, Sala A, Riccobono L, et al. 15(S)-HETE modulates LTB4production and neutrophil chemotaxis in chronic bronchitis. Am J Physiol Cell Physiol 2000; 279: C1249-C1258.
    • (2000) Am J Physiol Cell Physiol , vol.279
    • Profita, M.1    Sala, A.2    Riccobono, L.3
  • 97
    • 0029661982 scopus 로고    scopus 로고
    • The PPARα-leukotriene B4 pathway to inflammation control
    • Devchand PR, Keller H, Peters JM, et al. The PPARα-leukotriene B4 pathway to inflammation control. Nature 1996; 384: 39-43.
    • (1996) Nature , vol.384 , pp. 39-43
    • Devchand, P.R.1    Keller, H.2    Peters, J.M.3
  • 98
    • 39749178346 scopus 로고    scopus 로고
    • Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease
    • Grönke L, Beeh KM, Cameron R, et al. Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2008; 21: 409-417.
    • (2008) Pulm Pharmacol Ther , vol.21 , pp. 409-417
    • Grönke, L.1    Beeh, K.M.2    Cameron, R.3
  • 99
    • 77952104701 scopus 로고    scopus 로고
    • Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and nonhuman primates
    • Hicks A, Goodnow R Jr, Cavallo G, et al. Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and nonhuman primates. Prostaglandins Other Lipid Mediat 2010; 92: 33-43.
    • (2010) Prostaglandins Other Lipid Mediat , vol.92 , pp. 33-43
    • Hicks, A.1    Goodnow Jr., R.2    Cavallo, G.3
  • 100
    • 0036257558 scopus 로고    scopus 로고
    • 5-Lipoxygenase inhibitors for the treatment of COPD
    • Kilfeather S. 5-Lipoxygenase inhibitors for the treatment of COPD. Chest 2002; 121: Suppl. S, 197S-200S.
    • (2002) Chest , vol.121 , Issue.SUPPL. S
    • Kilfeather, S.1
  • 101
    • 33947369029 scopus 로고    scopus 로고
    • Zileuton: Clinical implications of 5-Lipoxygenase inhibition in severe airway disease
    • DOI 10.1111/j.1742-1241.2007.01320.x
    • Berger W, De Chandt MT, Cairns CB. Zileuton: clinical implications of 5-lipoxygenase inhibition in severe airway disease. Int J Clin Pract 2007; 61: 663-676. (Pubitemid 46449830)
    • (2007) International Journal of Clinical Practice , vol.61 , Issue.4 , pp. 663-676
    • Berger, W.1    De Chandt, M.T.M.2    Cairns, C.B.3
  • 102
    • 0036308390 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of a leukotriene synthesis inhibitor in patients with COPD
    • DOI 10.1378/chest.122.1.289
    • Gompertz S, Stockley RA. A randomized, placebo-controlled trial of a leukotriene synthesis inhibitor in patients with COPD. Chest 2002; 122: 289-294. (Pubitemid 34754176)
    • (2002) Chest , vol.122 , Issue.1 , pp. 289-294
    • Gompertz, S.1    Stockley, R.A.2
  • 103
    • 79151482943 scopus 로고    scopus 로고
    • MK-0633, a potent 5-lipoxygenase inhibitor, in chronic obstructive pulmonary disease
    • Bernstein JA, Liu N, Knorr BA, et al. MK-0633, a potent 5-lipoxygenase inhibitor, in chronic obstructive pulmonary disease. Respir Med 2011; 105: 392-401.
    • (2011) Respir Med , vol.105 , pp. 392-401
    • Bernstein, J.A.1    Liu, N.2    Knorr, B.A.3
  • 104
    • 79851476200 scopus 로고    scopus 로고
    • Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization
    • Woodruff PG, Albert RK, Bailey WC, et al. Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization. COPD 2011; 8: 21-29.
    • (2011) COPD , vol.8 , pp. 21-29
    • Woodruff, P.G.1    Albert, R.K.2    Bailey, W.C.3
  • 105
    • 70350133800 scopus 로고    scopus 로고
    • Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease
    • Belvisi MG, Mitchell JA. Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease. Br J Pharmacol 2009; 158: 994-1003.
    • (2009) Br J Pharmacol , vol.158 , pp. 994-1003
    • Belvisi, M.G.1    Mitchell, J.A.2
  • 107
    • 77954570636 scopus 로고    scopus 로고
    • Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-α agonist
    • Narala VR, Adapala RK, Suresh MV, et al. Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-α agonist. J Biol Chem 2010; 285: 22067-22074.
    • (2010) J Biol Chem , vol.285 , pp. 22067-22074
    • Narala, V.R.1    Adapala, R.K.2    Suresh, M.V.3
  • 108
    • 33644748138 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation
    • DOI 10.1016/j.ejphar.2005.12.048, PII S0014299905013774, The Pharmacology of the Respiratory Tract
    • Belvisi MG, Hele DJ, Birrell MA. Peroxisome proliferator-activated receptor γ agonists as therapy for chronic airway inflammation. Eur J Pharmacol 2006; 533: 101-109. (Pubitemid 43340008)
    • (2006) European Journal of Pharmacology , vol.533 , Issue.1-3 , pp. 101-109
    • Belvisi, M.G.1    Hele, D.J.2    Birrell, M.A.3
  • 109
    • 45849149234 scopus 로고    scopus 로고
    • PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin induced pulmonary fibrosis
    • Milam JE, Keshamouni VG, Phan SH, et al. PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2008; 294: L891-L901.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294
    • Milam, J.E.1    Keshamouni, V.G.2    Phan, S.H.3
  • 110
    • 77955285732 scopus 로고    scopus 로고
    • Rosiglitazone revisited: An updated meta-analysis of risk for myocardial infarction and cardiovascular mortality
    • Nissen SE, Wolski K. Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch Intern Med 2010; 170: 1191-1201.
    • (2010) Arch Intern Med , vol.170 , pp. 1191-1201
    • Nissen, S.E.1    Wolski, K.2
  • 111
    • 84858975027 scopus 로고    scopus 로고
    • The non-thiazolidinedione PPARγ ligand, GW1929 displays anti-inflammatory in poly(I:C)-induced air-liquid interface human bronchial epithelial cells
    • Velayudhan J, Haran AC, Wright CD. The non-thiazolidinedione PPARγ ligand, GW1929 displays anti-inflammatory in poly(I:C)-induced air-liquid interface human bronchial epithelial cells. Am J Respir Crit Care Med 2011; 183: A2827.
    • (2011) Am J Respir Crit Care Med , vol.183
    • Velayudhan, J.1    Haran, A.C.2    Wright, C.D.3
  • 112
    • 66749141807 scopus 로고    scopus 로고
    • Systemic manifestations and comorbidities of COPD
    • Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009; 33: 1165-1185.
    • (2009) Eur Respir J , vol.33 , pp. 1165-1185
    • Barnes, P.J.1    Celli, B.R.2
  • 113
    • 76949093909 scopus 로고    scopus 로고
    • Macrolide antibiotics and the airway: Antibiotic or non-antibiotic effects?
    • Murphy DM, Forrest IA, Curran D, et al. Macrolide antibiotics and the airway: antibiotic or non-antibiotic effects? Expert Opin Investig Drugs 2010; 19: 401-414.
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 401-414
    • Murphy, D.M.1    Forrest, I.A.2    Curran, D.3
  • 115
    • 78650516237 scopus 로고    scopus 로고
    • Immunomodulatory effects of macrolide antibiotics - Part 1: Biological mechanisms
    • Altenburg J, de Graaff CS, van der Werf TS, et al. Immunomodulatory effects of macrolide antibiotics - part 1: biological mechanisms. Respiration 2011; 81: 67-74.
    • (2011) Respiration , vol.81 , pp. 67-74
    • Altenburg, J.1    De Graaff, C.S.2    Van Der Werf, T.S.3
  • 116
    • 2142700049 scopus 로고    scopus 로고
    • Molecular Mechanisms of Anti-Inflammatory Action of Erythromycin in Human Bronchial Epithelial Cells: Possible Role in the Signaling Pathway That Regulates Nuclear Factor-κB Activation
    • DOI 10.1128/AAC.48.5.1581-1585.2004
    • Desaki M, Okazaki H, Sunazuka T, et al. Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kB activation. Antimicrob Agents Chemother 2004; 48: 1581-1585. (Pubitemid 38544362)
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , Issue.5 , pp. 1581-1585
    • Desaki, M.1    Okazaki, H.2    Sunazuka, T.3    Omura, S.4    Yamamoto, K.5    Takizawa, H.6
  • 117
    • 30744451971 scopus 로고    scopus 로고
    • Effect of clarithromycin on rhinovirus-16 infection in A549 cells
    • DOI 10.1183/09031936.06.00008005
    • Jang YJ, Kwon HJ, Lee BJ. Effect of clarithromycin on rhinovirus-16 infection in A549 cells. Eur Respir J 2006; 27: 12-19. (Pubitemid 43092661)
    • (2006) European Respiratory Journal , vol.27 , Issue.1 , pp. 12-19
    • Jang, Y.J.1    Kwon, H.-J.2    Lee, B.-J.3
  • 119
    • 33747057193 scopus 로고    scopus 로고
    • Anti-inflammatory activity of azithromycin attenuates the effects of lipopolysaccharide administration in mice
    • Ivetić Tkalcević V, Bosnjak B, Hrvacić B, et al. Anti-inflammatory activity of azithromycin attenuates the effects of lipopolysaccharide administration in mice. Eur J Pharmacol 2006; 539: 131-138.
    • (2006) Eur J Pharmacol , vol.539 , pp. 131-138
    • Ivetić Tkalcević, V.1    Bosnjak, B.2    Hrvacić, B.3
  • 120
    • 60749133504 scopus 로고    scopus 로고
    • Clarithromycin prevents smoke-induced emphysema in mice
    • Nakanishi Y, Kobayashi D, Asano Y, et al. Clarithromycin prevents smoke-induced emphysema in mice. Am J Respir Crit Care Med 2009; 179: 271-278.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 271-278
    • Nakanishi, Y.1    Kobayashi, D.2    Asano, Y.3
  • 122
    • 79955484840 scopus 로고    scopus 로고
    • Macrolide antibiotics broadly and distinctively inhibit cytokine and chemokine production by COPD sputum cells in vitro
    • Marjanović N, Bosnar M, Michielin F, et al. Macrolide antibiotics broadly and distinctively inhibit cytokine and chemokine production by COPD sputum cells in vitro. Pharmacol Res 2011; 63: 389-397.
    • (2011) Pharmacol Res , vol.63 , pp. 389-397
    • Marjanović, N.1    Bosnar, M.2    Michielin, F.3
  • 123
    • 56749157688 scopus 로고    scopus 로고
    • Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations
    • Seemungal TA, Wilkinson TM, Hurst JR, et al. Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations. Am J Respir Crit Care Med 2008; 178: 1139-1147.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 1139-1147
    • Seemungal, T.A.1    Wilkinson, T.M.2    Hurst, J.R.3
  • 124
    • 80052157895 scopus 로고    scopus 로고
    • Azithromycin for prevention of exacerbations of COPD
    • Albert RK, Connett J, Bailey WC, et al. Azithromycin for prevention of exacerbations of COPD. N Engl J Med 2011; 365: 689-698.
    • (2011) N Engl J Med , vol.365 , pp. 689-698
    • Albert, R.K.1    Connett, J.2    Bailey, W.C.3
  • 125
    • 27844582217 scopus 로고    scopus 로고
    • Approaches to the synthesis of immunolides: Selective immunomodulatory macrolides for cystic fibrosis
    • Fecik RA, Nguyen PL, Venkatraman L. Approaches to the synthesis of immunolides: selective immunomodulatory macrolides for cystic fibrosis. Curr Opin Drug Discov Devel 2005; 8: 741-747. (Pubitemid 41659402)
    • (2005) Current Opinion in Drug Discovery and Development , vol.8 , Issue.6 , pp. 741-747
    • Fecik, R.A.1    Nguyen, P.L.2    Venkatraman, L.3
  • 126
    • 77951709095 scopus 로고    scopus 로고
    • Pleiotropic effects of statins. Basic research and clinical perspectives
    • Zhou Q, Liao JK. Pleiotropic effects of statins. Basic research and clinical perspectives. Circ J 2010; 74: 818-826.
    • (2010) Circ J , vol.74 , pp. 818-826
    • Zhou, Q.1    Liao, J.K.2
  • 127
    • 33747079023 scopus 로고    scopus 로고
    • Potential therapeutic role for statins in respiratory disease
    • DOI 10.1136/thx.2005.057976
    • Hothersall E, McSharry C, Thomson NC. Potential therapeutic role for statins in respiratory disease. Thorax 2006; 61: 729-734. (Pubitemid 44211783)
    • (2006) Thorax , vol.61 , Issue.8 , pp. 729-734
    • Hothersall, E.1    McSharry, C.2    Thomson, N.C.3
  • 128
    • 0037319739 scopus 로고    scopus 로고
    • Statin effects beyond lipid lowering - Are they clinically relevant?
    • DOI 10.1016/S0195-668X(02)00419-0
    • Bonetti PO, Lerman LO, Napoli C, et al. Statin effects beyond lipid lowering - are they clinically relevant? Eur Heart J 2003; 24: 225-248. (Pubitemid 36207079)
    • (2003) European Heart Journal , vol.24 , Issue.3 , pp. 225-248
    • Bonetti, P.O.1    Lerman, L.O.2    Napoli, C.3    Lerman, A.4
  • 129
    • 78650771315 scopus 로고    scopus 로고
    • Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling
    • Wright JL, Zhou S, Preobrazhenska O, et al. Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling. Am J Respir Crit Care Med 2011; 183: 50-58.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 50-58
    • Wright, J.L.1    Zhou, S.2    Preobrazhenska, O.3
  • 130
    • 37549021118 scopus 로고    scopus 로고
    • The use of statins and lung function in current and former smokers
    • Keddissi JI, Younis WG, Chbeir EA, et al. The use of statins and lung function in current and former smokers. Chest 2007; 132: 1764-1771.
    • (2007) Chest , vol.132 , pp. 1764-1771
    • Keddissi, J.I.1    Younis, W.G.2    Chbeir, E.A.3
  • 131
    • 68349104141 scopus 로고    scopus 로고
    • Associations between statins and COPD: A systematic review
    • Dobler CC, Wong KK, Marks GB. Associations between statins and COPD: a systematic review. BMC Pulm Med 2009; 9: 32.
    • (2009) BMC Pulm Med , vol.9 , pp. 32
    • Dobler, C.C.1    Wong, K.K.2    Marks, G.B.3
  • 132
    • 80052406894 scopus 로고    scopus 로고
    • Statins and outcome after hospitalization for COPD exacerbation: A prospective study
    • Bartziokas K, Papaioannou AI, Minas M, et al. Statins and outcome after hospitalization for COPD exacerbation: a prospective study. Pulm Pharmacol Ther 2011; 24: 625-631.
    • (2011) Pulm Pharmacol Ther , vol.24 , pp. 625-631
    • Bartziokas, K.1    Papaioannou, A.I.2    Minas, M.3
  • 133
    • 77952951084 scopus 로고    scopus 로고
    • Mechanisms and resistance in glucocorticoid control of inflammation
    • Barnes PJ. Mechanisms and resistance in glucocorticoid control of inflammation. J Steroid Biochem Mol Biol 2010; 120: 76-85.
    • (2010) J Steroid Biochem Mol Biol , vol.120 , pp. 76-85
    • Barnes, P.J.1
  • 134
    • 54949154139 scopus 로고    scopus 로고
    • Modulation of steroid activity in chronic inflammation: A novel anti-inflammatory role for curcumin
    • Biswas S, Rahman I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Mol Nutr Food Res 2008; 52: 987-994.
    • (2008) Mol Nutr Food Res , vol.52 , pp. 987-994
    • Biswas, S.1    Rahman, I.2
  • 135
    • 0036877355 scopus 로고    scopus 로고
    • Involvement of multidrug resistance proteins (MDR) in the modulation of glucocorticoid response
    • DOI 10.1016/S0960-0760(02)00227-3, PII S0960076002002273
    • Webster JI, Carlstedt-Duke J. Involvement of multidrug resistance proteins (MDR) in the modulation of glucocorticoid response. J Steroid Biochem Mol Biol 2002; 82: 277-288. (Pubitemid 36187398)
    • (2002) Journal of Steroid Biochemistry and Molecular Biology , vol.82 , Issue.4-5 , pp. 277-288
    • Webster, J.I.1    Carlstedt-Duke, J.2
  • 136
    • 33745746815 scopus 로고    scopus 로고
    • Pharmacological strategies for overcomingmultidrug resistance
    • Nobili S, Landini I, Giglioni B, et al. Pharmacological strategies for overcomingmultidrug resistance. Curr Drug Targets 2006; 7: 861-879.
    • (2006) Curr Drug Targets , vol.7 , pp. 861-879
    • Nobili, S.1    Landini, I.2    Giglioni, B.3
  • 137
    • 34648819347 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor: A therapeutic target across inflammatory diseases
    • DOI 10.2174/187152807781696455
    • Hoi AY, Iskander MN, Morand EF. Macrophage migration inhibitory factor: a therapeutic target across inflammatory diseases. Inflamm Allergy Drug Targets 2007; 6: 183-190. (Pubitemid 47455787)
    • (2007) Inflammation and Allergy - Drug Targets , vol.6 , Issue.3 , pp. 183-190
    • Hoi, A.Y.1    Iskander, M.N.2    Morand, E.F.3
  • 139
    • 0029887584 scopus 로고    scopus 로고
    • Effects of fenoterol on inspiratory effort sensation and fatigue during inspiratory threshold loading
    • Suzuki J, Suzuki S, Okubo T. Effects of fenoterol on inspiratory effort sensation and fatigue during inspiratory threshold loading. J Appl Physiol 1996; 80: 727-733. (Pubitemid 26087231)
    • (1996) Journal of Applied Physiology , vol.80 , Issue.3 , pp. 727-733
    • Suzuki, J.1    Suzuki, S.2    Okubo, T.3
  • 140
    • 17444447481 scopus 로고    scopus 로고
    • Does inhaled albuterol improve diaphragmatic contractility in patients with chronic obstructive pulmonary disease?
    • Hatipoǧlu U, Laghi F, Tobin MJ. Does inhaled albuterol improve diaphragmatic contractility in patients with chronic obstructive pulmonary disease? Am J Respir Crit Care Med 1999; 160: 1916-1921.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1916-1921
    • Hatipoǧlu, U.1    Laghi, F.2    Tobin, M.J.3
  • 143
    • 0019421857 scopus 로고
    • Aminophylline improves diaphragmatic contractility
    • Aubier M, De Troyer A, Sampson M, et al. Aminophylline improves diaphragmatic contractility. N Engl J Med 1981; 305: 249-252.
    • (1981) N Engl J Med , vol.305 , pp. 249-252
    • Aubier, M.1    De Troyer, A.2    Sampson, M.3
  • 145
    • 84858155375 scopus 로고    scopus 로고
    • Pharmacological antioxidant strategies as therapeutic interventions for COPD
    • Rahman I. Pharmacological antioxidant strategies as therapeutic interventions for COPD. Biochim Biophys Acta 2012; 1822: 714-728.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 714-728
    • Rahman, I.1
  • 146
    • 80055014103 scopus 로고    scopus 로고
    • Pathogenic triad in COPD: Oxidative stress, protease-antiprotease imbalance, and inflammation
    • Fischer BM, Pavlisko E, Voynow JA. Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation. Int J Chron Obstruct Pulmon Dis 2011; 6: 413-421.
    • (2011) Int J Chron Obstruct Pulmon Dis , vol.6 , pp. 413-421
    • Fischer, B.M.1    Pavlisko, E.2    Voynow, J.A.3
  • 147
    • 59849113942 scopus 로고    scopus 로고
    • Attacking the multitiered proteolytic pathology of COPD: New insights from basic and translational studies
    • Djekic UV, Gaggar A, Weathington NM. Attacking the multitiered proteolytic pathology of COPD: new insights from basic and translational studies. Pharmacol Ther 2009; 121: 132-146.
    • (2009) Pharmacol Ther , vol.121 , pp. 132-146
    • Djekic, U.V.1    Gaggar, A.2    Weathington, N.M.3
  • 148
    • 84876844793 scopus 로고    scopus 로고
    • Targeting COPD: Advances on low-molecular-weight inhibitors of human neutrophil elastase
    • Epub ahead of print DOI: 10.1002/med.20247
    • Lucas SD, Costa E, Guedes RC, et al. Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase. Med Res Rev 2011 [Epub ahead of print DOI: 10.1002/med.20247].
    • (2011) Med Res Rev
    • Lucas, S.D.1    Costa, E.2    Guedes, R.C.3
  • 150
    • 84857911015 scopus 로고    scopus 로고
    • AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD
    • Kuna P, Jenkins M, O'Brien CD, et al. AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD. Respir Med 2012; 106: 531-539.
    • (2012) Respir Med , vol.106 , pp. 531-539
    • Kuna, P.1    Jenkins, M.2    O'Brien, C.D.3
  • 153
    • 80052691591 scopus 로고    scopus 로고
    • The future of chronic obstructive pulmonary disease treatment - Difficulties of and barriers to drug development
    • Martinez FJ, Donohue JF, Rennard SI. The future of chronic obstructive pulmonary disease treatment - difficulties of and barriers to drug development. Lancet 2011; 378: 1027-1037.
    • (2011) Lancet , vol.378 , pp. 1027-1037
    • Martinez, F.J.1    Donohue, J.F.2    Rennard, S.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.