Pathogenic triad in COPD: Oxidative stress, protease-antiprotease imbalance, and inflammation

International Journal of COPD

Volumn 6, Issue 1, 2011, Pages 413-421

  Fischer, Bernard M ^a   Pavlisko, Elizabeth ^a   Voynow, Judith A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Bronchitis; Chronic obstructive pulmonary disease; Emphysema; Senescence

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; CYTOKINE; EXTRACELLULAR SUPEROXIDE DISMUTASE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HEME OXYGENASE 1; LEUKOCYTE ELASTASE; MALONALDEHYDE; PROTEIN P16; PROTEIN P21; PROTEINASE; PROTEINASE INHIBITOR; RANTES; TRANSFERRIN; BIOLOGICAL MARKER; REACTIVE OXYGEN METABOLITE;

CCL5 GENE; CELL AGING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; EMPHYSEMA; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEME OXYGENASE 1 GENE; HISTOPATHOLOGY; HUMAN; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; RESPIRATORY TRACT INFLAMMATION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SUPEROXIDE DISMUTASE 3 GENE; T LYMPHOCYTE ACTIVATION; AGING; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LUNG FUNCTION TEST; METABOLISM; PATHOLOGY; RESPIRATORY SYSTEM; RISK FACTOR; SMOKING;

AGING; BIOLOGICAL MARKERS; GENE-ENVIRONMENT INTERACTION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; OXIDATIVE STRESS; PROTEASE INHIBITORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REACTIVE OXYGEN SPECIES; RESPIRATORY FUNCTION TESTS; RESPIRATORY SYSTEM; RISK FACTORS; SMOKING;

EID: 80055014103     PISSN: 11769106     EISSN: 11782005     Source Type: Journal    
DOI: 10.2147/COPD.S10770     Document Type: Review

References (83)

1. Wright JL, Churg A. Pathologic features of chronic obstructive pulmonary disease: diagnostic criteria and differential diagnosis. In: Fishman A P, Elias JA, Fishman JA, Grippi MA, Senior RM, Pack AI, editors. Fishman's pulmonary diseases and disorders. Vol 1. 4th ed. New York: McGraw Hill; 2008:693-705.
2. Roggli V, Cagle P. Emphysema and chronic bronchitis. In: Tomashefski J, Cagle P, Farver C, Fraire A, editors. Dail and hammar's pulmonary pathology. 3rd ed. New York: Springer; 2008:866-885.
3. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1995;152(5 Pt 2):S77-S121.
4. Reid L. Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax. 1960;15:132-141.
5. Pratt P. Emphysema and chronic airways disease. In: Dail D, Hammar S, editors. Pulmonary pathology. 2nd ed. New York: Springer-Verlag; 1994: 847-865.
6. Thurlbeck W. Chronic airfow obstruction. In: Thurlbeck W, Churg A, editors. Pathology of the lung. 2nd ed. New York: Thieme Medical Publishers; 1995:739-825.
7. Green L. Emphysema and diseases of large airways. In: Zander D, Farver C, editors. Pulmonary pathology. Philadelphia, PA: Churchill Livingstone/Elsevier; 2008:416-433.
8. Hogg JC, Chu F, Utokaparch S, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med. 2004;350:2645-2653.
9. Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol. 2009;4:435-459.
10. Cagle P, Roggli V. Pathology of small airways. In: Tomashefski J, Farver C, Fraire A, Cagle P, editors. Dail and Hammar's pulmonary pathology. Vol 1. 3rd ed. New York: Springer; 2008:886-910.
11. Grydeland TB, Dirksen A, Coxson HO, et al. Quantitative computed tomography measures of emphysema and airway wall thickness are related to respiratory symptoms. Am J Respir Crit Care Med. 2010;181: 353-359.
12. Patel BD, Coxson HO, Pillai SG, et al. Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;178: 500-505.
13. Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J. 2006;28:219-242.
14. Rahman I, van Schadewijk AA, Crowther AJ, et al. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002;166:490-495.
15. Kluchova Z, Petrasova D, Joppa P, Dorkova Z, Tkacova R. The association between oxidative stress and obstructive lung impairment in patients with COPD. Physiol Res. 2007;56:51-56.
16. Montano M, Cisneros J, Ramirez-Venegas A, et al. Malondialdehyde and superoxide dismutase correlate with FEV(1) in patients with COPD associated with wood smoke exposure and tobacco smoking. Inhal Toxicol. 2010;22:868-874.
17. Ghio AJ, Hilborn ED, Stonehuerner JG, et al. Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect. Am J Respir Crit Care Med. 2008;178:1130-1138.
18. Fischer BM, Domowicz DA, Zheng S, et al. Neutrophil elastase increases airway epithelial nonheme iron levels. Clin Transl Sci. 2009;2:333-339.
19. Britigan BE, Hayek MB, Doebbeling BN, Fick RB Jr. Transferrin and lactoferrin undergo proteolytic cleavage in the Pseudomonas aeruginosa-infected lungs of patients with cystic fbrosis. Infect Immun. 1993;61:5049-5055.
20. Owen CA. Proteinases and oxidants as targets in the treatment of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005;2:373-385; discussion 394-375.
21. Britigan BE, Edeker BL. Pseudomonas and neutrophil products modify transferrin and lactoferrin to create conditions that favor hydroxyl radical formation. J Clin Invest. 1991;88:1092-1102.
22. Miller RA, Britigan BE. Protease-cleaved iron-transferrin augments oxidant-mediated endothelial cell injury via hydroxyl radical formation. J Clin Invest. 1995;95:2491-2500.
23. DeMeo DL, Mariani T, Bhattacharya S, et al. Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet. 2009;85:493-502.
24. Comandini A, Marzano V, Curradi G, et al. Markers of anti-oxidant response in tobacco smoke exposed subjects: a data-mining review. Pulm Pharmacol Ther. 2010;23:482-492.
25. Kensler T W, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2007;47:89-116.
26. Malhotra D, Thimmulappa R, Navas-Acien A, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med. 2008;178:592-604.
27. Kimpara T, Takeda A, Watanabe K, et al. Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease. Hum Genet. 1997;100:145-147.
28. Yamada N, Yamaya M, Okinaga S, et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet. 2000;66:187-195.
29. DeMeo DL, Hersh C P, Hoffman EA, et al. Genetic determinants of emphysema distribution in the national emphysema treatment trial. Am J Respir Crit Care Med. 2007;176:42-48.
30. Nelson ME, O'Brien-Ladner AR, Wesselius LJ. Regional variation in iron and iron-binding proteins within the lungs of smokers. Am J Respire Crit Care Med. 1996;153(4 Pt 1):1353-1358.
31. Young R P, Hopkins R, Black PN, et al. Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function. Thorax. 2006;61:394-399.
32. Juul K, Tybjaerg-Hansen A, Marklund S, Lange P, Nordestgaard BG. Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;173: 858-864.
33. Dahl M, Bowler R P, Juul K, et al. Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations. Am J Respir Crit Care Med. 2008;178:906-912.
34. Sorheim IC, DeMeo DL, Washko G, et al. Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD. COPD. 2010;7:262-268.
35. Deslee G, Woods JC, Moore C, et al. Oxidative damage to nucleic acids in severe emphysema. Chest. 2009;135:965-974.
36. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298-300.
37. Harman D. The free radical theory of aging. Antioxid Redox Signal. 2003;5:557-561.
38. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408:239-247.
39. Ito K, Barnes PJ. COPD as a disease of accelerated lung aging. Chest. 2009;135:173-180.
40. Aoshiba K, Nagai A. Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009;6:596-601.
41. MacNee W, Tuder RM. New paradigms in the pathogenesis of chronic obstructive pulmonary disease I. Proc Am Thorac Soc. 2009;6:527-531.
42. Nyunoya T, Monick MM, Klingelhutz A, et al. Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol. 2006;35:681-688.
43. Tsuji T, Aoshiba K, Nagai A. Cigarette smoke induces senescence in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2004;31:643-649.
44. Tsuji T, Aoshiba K, Nagai A. Alveolar cell senescence in patients with pulmonary emphysema. Am J Respir Crit Care Med. 2006;174: 886-893.
45. Savale L, Chaouat A, Bastuji-Garin S, et al. Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009;179:566-571.
46. Mangino M, Brouilette S, Braund P, et al. A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans. Hum Mol Genet. 2008;17:2518-2523.
47. Kong X, Cho MH, Anderson W, et al. Genome-wide association study identifes BICD1 as a susceptibility gene for emphysema. Am J Respir Crit Care Med. 2011;183:43-49.
48. Demedts IK, Demoor T, Bracke KR, Joos GF, Brusselle GG. Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir Res. 2006;7:53.
49. Morissette MC, Parent J, Milot J. Alveolar epithelial and endothelial cell apoptosis in emphysema: what we know and what we need to know. Int J Chron Obstruct Pulmon Dis. 2009;4:19-31.
50. Kasahara Y, Tuder RM, Cool CD, et al. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med. 2001;163(3 Pt 1):737-744.
51. Morissette MC, Vachon-Beaudoin G, Parent J, Chakir J, Milot J. Increased p53 level, Bax/Bcl-x(L) ratio, and TRAIL receptor expression in human emphysema. Am J Respir Crit Care Med. 2008;178:240-247.
52. Takabatake N, Toriyama S, Igarashi A, et al. A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD. Biochem Biophys Res Commun. 2009;381:554-559.
53. Kim H P, Wang X, Chen ZH, et al. Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1. Autophagy. 2008;4:887-895.
54. Chen ZH, Kim H P, Sciurba FC, et al. Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS One. 2008;3:e3316.
55. Karadag F, Karul AB, Cildag O, Yilmaz M, Ozcan H. Biomarkers of systemic inflammation in stable and exacerbation phases of COPD. Lung. 2008;186:403-409.
56. Barnes PJ, Chowdhury B, Kharitonov SA, et al. Pulmonary biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;174:6-14.
57. Hacievliyagil SS, Gunen H, Mutlu LC, Karabulut AB, Temel I. Association between cytokines in induced sputum and severity of chronic obstructive pulmonary disease. Respir Med. 2006;100:846-854.
58. O'Donnell R, Breen D, Wilson S, Djukanovic R. Infammatory cells in the airways in COPD. Thorax. 2006;61:448-454.
59. Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med. 2009;360:2445-2454.
60. O'Shaughnessy TC, Ansari T W, Barnes NC, Jeffery PK. Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1. Am J Respir Crit Care Med. 1997;155:852-857.
61. Saetta M, Baraldo S, Corbino L, et al. CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;160:711-717.
62. Saetta M, Di Stefano A, Turato G, et al. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157(3 Pt 1):822-826.
63. Saetta M, Mariani M, Panina-Bordignon P, et al. Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002;165:1404-1409.
64. Di Stefano A, Caramori G, Gnemmi I, et al. Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD. Thorax. 2009;64:968-975.
65. Hizawa N, Makita H, Nasuhara Y, et al. Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients. Eur Respir J. 2008;32:372-378.
66. Sethi S, Mallia P, Johnston SL. New paradigms in the pathogenesis of chronic obstructive pulmonary disease II. Proc Am Thorac Soc. 2009;6: 532-534.
67. Qiu Y, Zhu J, Bandi V, et al. Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2003;168: 968-975.
68. Takabatake N, Shibata Y, Abe S, et al. A single nucleotide polymorphism in the CCL1 gene predicts acute exacerbations in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;174:875-885.
69. Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007;8:729-740.
70. Tsuji T, Aoshiba K, Nagai A. Alveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease. Respiration. 2010;80:59-70.
71. Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I. SIRT1, an antiinfammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;177:861-870.
72. Churg A, Wright JL. Proteases and emphysema. Curr Opin Pulm Med. 2005;11:153-159.
73. Cavarra E, Lucattelli M, Gambelli F, et al. Human SLPI inactivation after cigarette smoke exposure in a new in vivo model of pulmonary oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2001;281:L412-L417.
74. Shapiro SD. Proteinases in chronic obstructive pulmonary disease. Biochem Soc Trans. 2002;30:98-102.
75. Hunninghake G W, Davidson JM, Rennard S, et al. Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema. Science. 1981;212:925-927.
76. Weathington NM, van Houwelingen AH, Noerager BD, et al. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med. 2006;12:317-323.
77. Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science. 1997;277:2002-2004.
78. Hunninghake GM, Cho MH, Tesfaigzi Y, et al. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009;361: 2599-2608.
79. Ito I, Nagai S, Handa T, et al. Matrix metalloproteinase-9 promoter polymorphism associated with upper lung dominant emphysema. Am J Respir Crit Care Med. 2005;172:1378-1382.
80. Minematsu N, Nakamura H, Tateno H, Nakajima T, Yamaguchi K. Genetic polymorphism in matrix metalloproteinase-9 and pulmonary emphysema. Biochem Biophys Res Commun. 2001;289:116-119.
81. Demeo DL, Mariani TJ, Lange C, et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006;78:253-264.
82. Zhu G, Warren L, Aponte J, et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Am J Respir Crit Care Med. 2007;176:167-173.
83. Suzuki T, Moraes TJ, Vachon E, et al. Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol. 2005;33:231-247.