Inhibition of tumor necrosis factor-α-inducible inflammatory genes by interferon-γ is associated with altered nuclear factor-κB transactivation and enhanced histone deacetylase activity

Molecular Pharmacology

Volumn 71, Issue 2, 2007, Pages 609-618

  Keslacy, Stefan ^a   Tliba, Omar ^a   Baidouri, Hasna ^a   Amrani, Yassine ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2' AMINOETHYL)AMINO 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; BMS 345541; EOTAXIN; GAMMA INTERFERON; HISTONE ACETYL TRANSFERASE; HISTONE DEACETYLASE; I KAPPA B; I KAPPA B KINASE BETA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LUCIFERASE; TRANSFERASE; TRICHOSTATIN A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

CELLS, CULTURED; CHEMOKINES, CC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HUMANS; INFLAMMATION; INTERFERON TYPE II; INTERLEUKIN-6; INTERLEUKIN-8; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; TRACHEA; TRANS-ACTIVATION (GENETICS); TUMOR NECROSIS FACTOR-ALPHA;

EID: 33846411054     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.030171     Document Type: Article

References (44)

1. Adam E, Quivy V, Bex F, Chariot A, Collette Y, Vanhulle C, Schoonbroodt S, Goffin V, Nguyen TL, Gloire G, Carrard G, Friguet B, De Launoit Y, Burny A, Bours V, Piette J, and Van Lint C (2003) Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha. Mol Cell Biol 23:6200-6209.
2. Ammit AJ, Lazaar AL, Irani C, O'Neill GM, Gordon ND, Amrani Y, Penn RB and Panettieri RA Jr (2002) Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists. Am J Respir Cell Mol Biol 26:465-474.
3. Amrani Y, Chen H, and Panettieri RA Jr (2000) Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma? Respir Res 1:49-53.
4. Amrani Y, Lazaar AL, and Panettieri RA Jr (1999) Up-regulation of ICAM-1 by cytokines in human tracheal smooth muscle cells involves an NF-kappa B-dependent signaling pathway that is only partially sensitive to dexamethasone. J Immunol 163:2128-2134.
5. Ashburner BP, Westerheide SD, and Baldwin AS Jr (2001) The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol Cell Biol 21:7065-7077.
6. Baldwin AS Jr (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649-683.
7. Barnes PJ, Adcock IM, and Ito K (2005) Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J 25:552-563.
8. Barnes PJ and Karin M (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071.
9. Berry MA, Hargadon B, Shelley M, Parker D, Shaw DE, Green RH, Bradding P, Brightling CE, Wardlaw AJ, and Pavord ID (2006) Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med 354:697-708.
10. Birrell MA, Hardaker E, Wong S, McCluskie K, Catley M, De Alba J, Newton R, Haj-Yahia S, Pun KT, Watts CJ, et al. (2005) Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. Am J Respir Crit Care Med 172:962-971.
11. Burke JR, Pattoli MA, Gregor KR, Brassil PJ, MacMaster JF, McIntyre KW, Yang X, Iotzova VS, Clarke W, Strnad J, et al. (2003) BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 278:1450-1456.
12. Das J, Chen CH, Yang L, Cohn L, Ray P, and Ray A (2001) A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol 2:45-50.
13. Fukuda K, Yamada N, Fujitsu Y, Kumagai N, and Nishida T (2002) Inhibition of eotaxin expression in human corneal fibroblasts by interferon-gamma. Int Arch Allergy Immunol 129:138-144.
14. Ganster RW, Guo Z, Shao L, and Geller DA (2005) Differential effects of TNF-alpha and IFN-gamma on gene transcription mediated by NF-kappaB-Stat1 interactions. J Interferon Cytokine Res 25:707-719.
15. Halayko AJ and Amrani Y (2003) Mechanisms of inflammation-mediated airway smooth muscle plasticity and airways remodeling in asthma. Respir Physiol Neurobiol 137:209-222.
16. Hardaker EL, Bacon AM, Carlson K, Roshak AK, Foley JJ, Schmidt DB, Buckley PT, Comegys M, Panettieri RA Jr, Sarau HM, et al. (2004) Regulation of TNF-alpha-and IFN-gamma-induced CXCL10 expression: participation of the airway smooth muscle in the pulmonary inflammatory response in chronic obstructive pulmonary disease. FASEB J 18:191-193.
17. Hoberg JE, Popko AE, Ramsey CS, and Mayo MW (2006) IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. Mol Cell Biol 26:457-471.
18. Issa R, Xie S, Lee KY, Stanbridge RD, Bhavsar P, Sukkar MB, and Chung KF (2006) GRO-alpha regulation in airway smooth muscle by IL-1beta and TNF-alpha: role of NF-kappaB and MAP kinases. Am J Physiol 291:L66-L74.
19. Ito K, Caramori G, Lim S, Oates T, Chung KF, Barnes PJ, and Adcock IM (2002) Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med 166:392-396.
20. John M, Hirst SJ, Jose PJ, Robichaud A, Berkman N, Witt C, Twort CH, Barnes PJ, and Chung KF (1997) Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids. J Immunol 158:1841-1847.
21. Kim J, McKinley L, Natarajan S, Bolgos GL, Siddiqui J, Copeland S, and Remick DG (2006) Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust. Clin Exp Allergy 36:122-132.
22. Lajoie-Kadoch S, Joubert P, Letuve S, Halayko AJ, Martin JG, Soussi-Gounni A, and Hamid Q (2006) TNF-alpha and IFN-gamma inversely modulate expression of the IL-17E receptor in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 290:L1238-1246.
23. Lalor DJ, Truong B, Henness S, Blake AE, Ge Q, Ammit AJ, Armour CL, and Hughes JM (2004) Mechanisms of serum potentiation of GM-CSF production by human airway smooth muscle cells. Am J Physiol 287:L1007-L1016.
24. Manna SK, Mukhopadhyay A, and Aggarwal BB (2000) IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis. J Immunol 165:4927-4934.
25. Matsukura S, Kokubu F, Kuga H, Kawaguchi M, Ieki K, Odaka M, Suzuki S, Watanabe S, Takeuchi H, Adachi M, et al. (2003) Differential regulation of eotaxin expression by IFN-gamma in airway epithelial cells. J Allergy Clin Immunol 111:1337-1344.
26. Miyamasu M, Yamaguchi M, Nakajima T, Misaki Y, Morita Y, Matsushima K, Yamamoto K, and Hirai K (1999) Th1-derived cytokine IFN-gamma is a potent inhibitor of eotaxin synthesis in vitro. Int Immunol 11:1001-1004.
27. Nie M, Corbett L, Knox AJ, and Pang L (2005) Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists. J Biol Chem 280:2550-2561.
28. Nusinzon I and Horvath CM (2003) Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc Natl Acad Sci USA 100:14742-14747.
29. Pang L and Knox AJ (2001) Regulation of TNF-alpha-induced eotaxin release from cultured human airway smooth muscle cells by beta2-agonists and corticosteroids. FASEB J 15:261-269.
30. Poynter ME, Irvin CG, and Janssen-Heininger YM (2002) Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation. Am J Pathol 160:1325-1334.
31. Rahman I, Marwick J, and Kirkham P (2004) Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. Biochem Pharmacol 68:1255-1267.
32. Renzetti LM, Paciorek PM, Tannu SA, Rinaldi NC, Tocker JE, Wasserman MA, and Gater PR (1996) Pharmacological evidence for tumor necrosis factor as a mediator of allergic inflammation in the airways. J Pharmacol Exp Ther 278:847-853.
33. Sanceau J, Boyd DD, Seiki M, and Bauvois B (2002) Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B. J Biol Chem 277:35766-35775.
34. Singer CA, Baker KJ, McCaffrey A, AuCoin DP, Dechert MA, and Gerthoffer WT (2003) p38 MAPK and NF-kappaB mediate COX-2 expression in human airway myocytes. Am J Physiol 285:L1087-L1098.
35. Suk K, Kim S, Kim YH, Kim KA, Chang I, Yagita H, Shong M, and Lee MS (2001) IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death. J Immunol 166:4481-4489.
36. Sukkar MB, Issa R, Xie S, Oltmanns U, Newton R, and Chung KF (2004) Fractalkine/CX3CL1 production by human airway smooth muscle cells: induction by IFN-gamma and TNF-alpha and regulation by TGF-beta and corticosteroids. Am J Physiol 287:L1230-L1240.
37. Tliba O, Cidlowski JA, and Amrani Y (2006) CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform. Mol Pharmacol 69:588-596.
38. Tliba O, Panettieri RA Jr, Tliba S, Walseth TF, and Amrani Y (2004) Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-β-dependent CD38 pathway. Mol Pharmacol 66:322-329.
39. Tliba O, Tliba S, Da Huang C, Hoffman RK, DeLong P, Panettieri RA Jr, and Amrani Y (2003) Tumor necrosis factor α modulates airway smooth muscle function via the autocrine action of interferon β. J Biol Chem 278:50615-50623.
40. van Wissen M, Snoek M, Smids B, Jansen HM, and Lutter R (2002) IFN-gamma amplifies IL-6 and IL-8 responses by airway epithelial-like cells via indoleamine 2,3-dioxygenase. J Immunol 169:7039-7044.
41. Wang Y, Wu TR, Cai S, Welte T, and Chin YE (2000) Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation. Mol Cell Biol 20:4505-4512.
42. Wen FQ, Liu X, Manda W, Terasaki Y, Kobayashi T, Abe S, Fang Q, Ertl R, Manouilova L, and Rennard SI (2003) TH2 Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroids. J Allergy Clin Immunol 111:1307-1318.
43. Wesemann DR and Benveniste EN (2003) STAT-1 alpha and IFN-gamma as modulators of TNF-alpha signaling in macrophages: regulation and functional implications of the TNF receptor 1:STAT-1 alpha complex. J Immunol 171: 5313-5319.
44. Zhu YM, Bradbury DA, Pang L, and Knox AJ (2003) Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-κB. J Biol Chem 278:29366-29375.