15(S)-HETE modulates LTB4 production and neutrophil chemotaxis in chronic bronchitis

American Journal of Physiology - Cell Physiology

Volumn 279, Issue 4 48-4, 2000, Pages

  Profita, Mirella ^a   Sala, Angelo ^b,d   Riccobono, Loredana ^a   Pace, Elisabetta ^a   Paternò, Alessandra ^a   Zarini, Simona ^b   Siena, Liboria ^a   Mirabella, Angela ^c   Bonsignore, Giovanni ^a,c   Vignola, Antonio M ^a  

^a CNR   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d Ctr for Cardiopulmonary Pharmacol   (Italy)

Author keywords

15 Lipoxygenase; 5 Lipoxygenase

Indexed keywords

15 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; LEUKOTRIENE B4; MESSENGER RNA;

ADULT; AGED; ARTICLE; CHRONIC BRONCHITIS; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION FUNCTION; HUMAN; HUMAN CELL; MACROPHAGE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PATHOGENESIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; SPUTUM ANALYSIS; SPUTUM LEVEL;

SIGANUS;

EID: 0033679541     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2000.279.4.c1249     Document Type: Article

References (35)

1. Human tracheal epithelial cells selectively incorporate 15-hydroxyeicosatetraenoic acid into phosphatidylinositol
2. Ozone exposure of human tracheal epithelial cells inactivates cyclooxygenase and increases 15-HETE production
3. Definitions and classifications of chronic bronchitis, asthma and emphysema
4. Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: Agonist-induced deacylation and transformation of stored hydroxyeicosanoids
5. Neutrophils from subjects with chronic obstructive lung disease show enhanced chemotaxis and extracellular proteolysis
6. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase
7. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes)
8. Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects
9. Identification of 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) as a major metabolite of arachidonic acid in human lung
10. 15-Hydroxyeicosatetraenoic acid is a potent inflammatory mediator and agonist of canine tracheal mucus secretion
11. Fast one-step procedure for the detection of nucleic acids in situ by primer-induced sequence-specific labeling with fluorescein-12-dUTP
12. 15(S)-hydroxyeicosatetraenoic acid is the major arachidonic acid metabolite in human bronchi: Association with airway epithelium
13. Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease
14. Effect of 15-(s)-hydroxyeicosatetraenoic acid on allergen-induced asthmatic responses
15. 4 and N-formyl-L-methionyl-L-leucyl-L-phenylalanine
16. Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway
17. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins
18. Cigarette smoking causes accumulation of polymorphonuclear leukocytes in alveolar septum
19. 4 synthase
20. Human airway monohydroxyeicosatetraenoic acid generation and mucus release
21. The effects of chronic bronchitis and chronic air-flow obstruction on lung cell populations recovered by bronchoalveolar lavage
22. 2 into human airways during acute antigen challenge
23. Interleukin-8 induces lymphocyte chemotaxis into the pleural space. Role of pleural macrophages
24. The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,SZ,11Z,13E)-eicosatetraenoic acid: Structure-activity relationship and mechanism of action
25. Interleukin-4 enhances 15-lipoxygenase activity and incorporation of 15(S)-HETE into cellular phospholipids in cultured pulmonary epithelial cells
26. 4 from human polymorphonuclear leukocytes
27. 4-synthase
28. Differential metabolism of endogenous vs. exogenous arachidonic acid in human neutrophils
29. An elucidation of the arachidonic acid cascade Discovery of prostaglandins, thromboxane and leukotrienes
30. Eicosanoids in bronchoalveolar lavage fluid of aspirin-intolerant patients with asthma after aspirin challenge
31. Arachidonic acid and 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid modulate human polymorphonuclear neutrophil activation by monocyte derived neutrophil activating factor
32. 15-Hydroxyeicosatetraenoic acid inhibits neutrophil migration across cytokine-activated endothelium
33. Role of the 15-lipoxygenase in the immune system
34. Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid
35. Increased levels of elastase and alpha1-antitrypsin in sputum of asthmatic patients