SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

British Journal of Clinical Pharmacology

Volumn 72, Issue 2, 2011, Pages 282-293

  Lazaar, Aili L ^a   Sweeney, Lisa E ^a   Macdonald, Alexander J ^b   Alexis, Neil E ^c   Chen, Chao ^b   Tal Singer, Ruth ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

CD11b; Chemokine; CXCR2; Lung; Neutrophils; Ozone

Indexed keywords

CD11B ANTIGEN; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; MYELOPEROXIDASE; OZONE; PLACEBO; SB 656933; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DOSE ESCALATION; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; EX VIVO STUDY; FLOW CYTOMETRY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LEUKOCYTE ACTIVATION; MALE; MAXIMUM PLASMA CONCENTRATION; NEUTROPENIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFLAMMATION; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; SPUTUM; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTIGENS, CD11B; BRONCHITIS; CHEMOKINE CXCL1; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; NEUTROPHIL ACTIVATION; NEUTROPHILS; OZONE; PEROXIDASE; PHENYLUREA COMPOUNDS; RECEPTORS, INTERLEUKIN-8B; SINGLE-BLIND METHOD; SPUTUM; SULFONAMIDES; YOUNG ADULT;

EID: 79959340752     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2011.03968.x     Document Type: Article

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