Macrolide antibiotics broadly and distinctively inhibit cytokine and chemokine production by COPD sputum cells in vitro

Pharmacological Research

Volumn 63, Issue 5, 2011, Pages 389-397

  Marjanović, Nikola ^a   Bosnar, Martina ^a   Michielin, Francesca ^b   Willé, David R ^c   Anić Milić, Tatjana ^a   Čulić, Ognjen ^a   Popović Grle, Sanja ^d   Bogdan, Mile ^d   Parnham, Michael J ^a,e   Haber, Vesna Eraković ^a  

^a Galapagos Istraživački Centar Doo ^*  (Sri Lanka)

^b GSK   (Italy)

^c Glaxo Smith Kline   (United Kingdom)

^d University Hospital for Lung Diseases Jordanovac   (Croatia)

^e Croatia   (Croatia)

Author keywords

Chemokines; COPD; Cytokines; Macrolide antibiotics; Sputum

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AZITHROMYCIN; CLARITHROMYCIN; CXCL1 CHEMOKINE; DEXAMETHASONE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; ERYTHROMYCIN; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; PLASMINOGEN ACTIVATOR INHIBITOR 1; RANTES; ROFLUMILAST; ROXITHROMYCIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SPUTUM ANALYSIS;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINES; CLARITHROMYCIN; CYTOKINES; ERYTHROMYCIN; HUMANS; MACROLIDES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; ROXITHROMYCIN; SPUTUM;

EID: 79955484840     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.02.001     Document Type: Article

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