The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 6, 2008, Pages 1484-1490

  An, Lei ^a,b   Zhang, You Zhi ^a   Yu, Neng Jiang ^a   Liu, Xin Min ^b   Zhao, Nan ^a   Yuan, Li ^a   Chen, Hong Xia ^a   Li, Yun Feng ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

BDNF; Flavonoids; Hippocampus; Neurogenesis; pCREB; XBXT 2

Indexed keywords

BROXURIDINE; CELL MARKER; CHINESE DRUG; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FLAVONOID; GLIAL FIBRILLARY ACIDIC PROTEIN; IMIPRAMINE; NEURON SPECIFIC ENOLASE; NEUROTROPHIC FACTOR; XBXT 2; XIAOBUXIN TANG EXTRACT;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CHINESE HERB; CHRONIC STRESS; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; HIPPOCAMPUS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MOLECULAR MECHANICS; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NEUROMODULATION; NONHUMAN; PROTEIN EXPRESSION; RAT; SEROTONIN RELEASE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIMETABOLITES; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; BROMODEOXYURIDINE; CELL PROLIFERATION; CHRONIC DISEASE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEPRESSION; DRUGS, CHINESE HERBAL; FLAVONOIDS; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; NERVE GROWTH FACTORS; NEURONS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL; UP-REGULATION;

EID: 47749100014     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2008.05.005     Document Type: Article

References (56)

1. An L, Zhang YZ, Yu NJ, Liu XM, Zhao N, Yuan L, et al. Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang. Pharmacol Biochem Behav 2008;89(4):572-80.
2. Alfonso J., Frick L.R., Silberman D.M., Palumbo M.L., Genaro A.M., and Frasch A.C. Regulation of hippocampal gene expression is conserved in two species subjected to different stressors and antidepressant treatments. Biol Psychiatry 59 (2006) 244-251
3. Alonso R., Griebel G., Pavone G., Stemmelin J., Le Fur G., and Soubrié P. Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression. Mol Psychiatry 9 (2004) 278-286
4. Brezun J.M., and Daszuta A. Serotonin may stimulate granule cell proliferation in the adult hippocampus, as observed in rats grafted with foetal raphe neurons. Eur J Neurosci 12 (2000) 391-396
5. Cameron H.A., Woolley C.S., McEwen B.S., and Gould E. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience 56 (1993) 337-344
6. Cameron H.A., and McKay R.D. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol 435 (2001) 406-417
7. Castrén E., Võikar V., and Rantamäki T. Role of neurotrophic factors in depression. Curr Opin Pharmacol 7 (2007) 18-21
8. Chen A.C., Shirayama Y., Shin K.H., Neve R.L., and Duman R.S. Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect. Biol Psychiatry 49 (2001) 753-762
9. Dranovsky A., and Hen R. Hippocampal neurogenesis: regulation by stress and antidepressants. Biol Psychiatry 59 (2006) 1136-1143
10. Duman R.S., and Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59 (2006) 1116-1127
11. Ehninger D., and Kempermann G. Neurogenesis in the adult hippocampus. Cell Tissue Res 331 (2008) 243-250
12. Eriksson P.S., Perfilieva E., Björk-Eriksson T., Alborn A.M., Nordborg C., Peterson D.A., et al. Neurogenesis in the adult human hippocampus. Nat Med 4 (1998) 1313-1317
13. Fujioka T., Fujioka A., and Duman R.S. Activation of cAMP signalling facilitates the morphological maturation of newborn neurons in adult hippocampus. J Neurosci 24 (2004) 319-328
14. Gould E., Reeves A.J., Graziano M.S., and Gross C.G. Neurogenesis in the neocortex of adult primates. Science 286 (1999) 548-552
15. Grønli J., Murison R., Fiske E., Bjorvatn B., Sørensen E., Portas C.M., et al. Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions. Physiol Behav 84 (2005) 571-577
16. Hastings N.B., and Gould E. Rapid extension of axons into the CA3 region by adult-generated granule cells. J Comp Neurol 413 (1999) 146-154
17. Hastings N.B., Seth M.I., Tanapat P., Rydel T.A., and Gould E. Granule neurons generated during development extend divergent axon collaterals to hippocampal area CA3. J Comp Neurol 452 (2002) 324-333
18. Henn F.A., and Vollmayr B. Neurogenesis and depression: etiology or epiphenomenon?. Biol Psychiatry 56 (2004) 146-150
19. Hoshaw B.A., Malberg J.E., and Lucki I. Central administration of IGF-I and BDNF leads to long-lasting antidepressant effects. Brain Res 1037 (2005) 204-208
20. Kim S.H., Han J., Seog D.H., Chung J.Y., Kim N., Hong Park Y., et al. Antidepressant effect of Chaihu-Shugan-San extract and its constituents in rat models of depression. Life Sci 6 (2005) 1297-1306
21. Levan M., Latendresse J.R., Kodell R.L., et al. Evaluation of cell proliferation in rat tissues with BrdU, PCNA, Ki-67 Immunohistochemistry and in situ hybridization for histone mRNA. J Histochem Cytochem 51 (2003) 1681-1688
22. Li J.M., Kong L.D., Wang Y.M., Cheng C.H., Zhang W.Y., and Tan W.Z. Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction. Life Sci 74 (2003) 55-73
23. Li Y.F., Chen H.X., Liu Y., Zhang Y.Z., Liu Y.Q., and Li J. Agmatine increases proliferation of cultured hippocampal progenitor cells and hippocampal neurogenesis in chronically stressed mice. Acta Pharmacol Sin 27 (2006) 1395-1400
24. Lonze B.E., and Ginty D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 35 (2002) 605-623
25. Luo L., Nong Wang J., Kong L.D., Jiang Q.G., and Tan R.X. Antidepressant effects of Banxia Houpu decoction, a traditional Chinese medicinal empirical formula. J Ethnopharmacol 73 (2000) 277-281
26. Malberg J., Eisch A.J., Nestler E.J., and Duman R.S. Chronic antidepressant treatment increases neurogenesis in adult hippocampus. J Neurosci 20 (2000) 9104-9110
27. Mao J.Q., Mi H.M., and Lou Z.Y. Detection of isoflavones contents in Seme sojae preparatum by HPLC. Acad J Second Miliary Med Univ 21 (2002) 955-957
28. Mqller W.E. Current St. John's wort research from mode of action to clinical efficacy. Pharmacol Res 47 (2003) 101-109
29. Nakagawa S., Kim J.E., Lee R., Chen J., Fujioka T., Malberg J., et al. Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus. J Neurosci 22 (2002) 9868-9876
30. Nakagawa S., Kim J.E., Lee R., Malberg J.E., Chen J., Steffen C., et al. Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci 22 (2002) 3673-3682
31. Nair A., and Vaidya V.A. Cyclic AMP response element binding protein and brain-derived neurotrophic factor: molecules that modulate our mood?. J Biosci 31 (2006) 423-434
32. Oksuz S. Flavonoidal compounds of Inula viscosa part II. Planta Med 31 (1977) 270-273
33. Paxinos G., and Watson C. The Rat Brain-in Stereotaxic Coordinates. 5th ed. (2005), Elsevier Academic Press, San Diego
34. Paizanis E., Hamon M., and Lanfumey L. Hippocampal neurogenesis, depressive disorders, and antidepressant therapy. Neural Plast (2007) 73754-73761 2007
35. Pencea V., Bingaman K.D., Wiegand S.J., and Luskin M.B. Infusion of brain-derived neurotrophic factor into the lateral ventricles of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J Neurosc 21 (2001) 6706-6717
36. Pittenger C., and Duman R.S. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 33 (2008) 88-109
37. Santarelli L., Saxe M., Gross C., Surget A., Battaglia F., Dulawa S., et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301 (2003) 805-809
38. Sapolsky R.M. The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death. Biol Psychiatry 48 (2000) 755-765
39. Takahashi T., Nowakowski R.S., and Caviness V.S. BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone. J Neurocytol 21 (1992) 185-197
40. Tardito D., Perez J., Tiraboschi E., Musazzi L., Racagni G., and Popoli M. Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview. Pharmacol Rev 58 (2006) 115-134
41. Tata D.A., Marciano V.A., and Anderson B.J. Synapse loss from chronically elevated glucocorticoids: relationship to neuropil volume and cell number in hippocampal area CA3. J Comp Neurol 498 (2006) 363-374
42. Vaidya V.A., Fernandes K., and Jha S. Regulation of adult hippocampal neurogenesis: relevance to depression. Expert Rev Neurother 7 (2007) 853-864
43. Vaidya V.A., and Duman R.S. Depression - emerging insights from neurobiology. Br Med Bull 57 (2001) 61-79
44. Vollmayr B., Mahlstedt M.M., and Henn F.A. Neurogenesis and depression: what animal models tell us about the link. Eur Arch Psychiatry Clin Neurosci 257 (2007) 300-303
45. Warner-Schmidt J.L., and Duman R.S. Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. Hippocampus 16 (2006) 239-249
46. West A.E., Griffith E.C., and Greenberg M.E. Regulation of transcription factors by neuronal activity. Nature Rev Neurosci 3 (2002) 921-931
47. Willner P. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl) 134 (1997) 319-329
48. Willner P. Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52 (2005) 90-110
49. Xia X., Cheng G., Pan Y., Xia Z.H., and Kong L.D. Behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from Curcuma longa L. in the mouse forced swimming test. J Ethnopharmacol 110 (2007) 356-363
50. Xu G., Zhang H., and Hu J. Leaching method of flavone from Bamboo leaves. Chinese J Anal Chem 28 (2000) 857-859
51. Xu C., Luo L., and Tan R.X. Antidepressant effect of three traditional Chinese medicines in the learned helplessness model. J Ethnopharmacol 91 (2004) 345-349
52. Xu Y., Ku B., Cui L., Li X., Barish P.A., Foster T.C., et al. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Res 1162 (2007) 9-18
53. Yu N.J., Zhao Y.M., Zhang Y.Z., and Li Y.F. Japonicins A and B from the flowers of Inula japonica. J. Asian Nat. Prod. Res. 8 (2006) 385-390
54. Zhang Y.Z., Li Y.F., Yu N.J., Yuan L., Zhao Y.M., Xiao W.B., et al. Antidepressant-like effects of the ethanolic extract of Xiaobuxin-Tang, a traditional Chinese herbal prescription in animal models of depression. Chin Med J (Engl) 120 (2007) 1792-1796
55. Zhang Y.Z., Yu N.J., Yuan L., An L., Zhao Y.M., Xiao W.B., et al. Antidepressant-like effect of the total flavonoids extracted from Xiaobuxin-Tang in forced swimming tests and learned helplessness in rats and mice. Chin J Pharmacol Toxicol 22 (2008) 1-8
56. Zhang Z.X., Liu K., Wang S.Y., Yang S.S., Kang T.G., and Sha M. The research and development of flavone-metal complexes as potential drugs. Chinese Tradit Herb Drugs 27 (1996) 179-182