메뉴 건너뛰기




Volumn 7, Issue 3, 2012, Pages 369-386

Augmenting energy expenditure by mitochondrial uncoupling: A role of AMP-activated protein kinase

Author keywords

Adipose tissue; Insulin sensitivity; Mitochondria; Obesity; Skeletal muscle; Transgenic mice; Uncoupling protein

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SIRTUIN 1; UNCOUPLING PROTEIN 1;

EID: 84865714732     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-011-0260-8     Document Type: Review
Times cited : (31)

References (121)
  • 3
    • 55549085230 scopus 로고    scopus 로고
    • Inactivation of UCP1 and the glycerol phosphate cycle synergistically increases energy expenditure to resist diet-induced obesity
    • Anunciado-Koza R, Ukropec J, Koza RA, Kozak LP (2008) Inactivation of UCP1 and the glycerol phosphate cycle synergistically increases energy expenditure to resist diet-induced obesity. J Biol Chem 283:27688-27697
    • (2008) J Biol Chem , vol.283 , pp. 27688-27697
    • Anunciado-Koza, R.1    Ukropec, J.2    Koza, R.A.3    Kozak, L.P.4
  • 4
    • 0033000588 scopus 로고    scopus 로고
    • Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential
    • DOI 10.1016/S0014-5793(99)00053-8, PII S0014579399000538
    • Baumruk F, Flachs P, Horakova M, Floryk D, Kopecky J (1999) Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential. FEBS Lett 444:206-210 (Pubitemid 29092803)
    • (1999) FEBS Letters , vol.444 , Issue.2-3 , pp. 206-210
    • Baumruk, F.1    Flachs, P.2    Horakova, M.3    Floryk, D.4    Kopecky, J.5
  • 8
    • 0024268799 scopus 로고
    • The gene for rat Uncoupling Protein: Complete sequence, structure of primary transcript and evolutionary relationship between exons
    • DOI 10.1016/S0006-291X(88)80318-8
    • Bouillaud F, Raimbault S, Ricquier D (1988) The gene for rat uncoupling protein: complete sequence, structure of primary transcript and evolutionary relationship between exons. Biochem Biophys Res Commun 157:783-792 (Pubitemid 19021248)
    • (1988) Biochemical and Biophysical Research Communications , vol.157 , Issue.2 , pp. 783-792
    • Bouillaud, F.1    Raimbault, S.2    Ricquier, D.3
  • 9
    • 77949268951 scopus 로고    scopus 로고
    • Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase
    • Bourron O, Daval M, Hainault I, Hajduch E, Servant JM, Gautier JF, Ferre P, Foufelle F (2010) Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase. Diabetologia 53:768-778
    • (2010) Diabetologia , vol.53 , pp. 768-778
    • Bourron, O.1    Daval, M.2    Hainault, I.3    Hajduch, E.4    Servant, J.M.5    Gautier, J.F.6    Ferre, P.7    Foufelle, F.8
  • 10
    • 47349099980 scopus 로고    scopus 로고
    • Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity
    • DOI 10.1111/j.1474-9726.2008.00407.x
    • Caldeira da Silva CC, Cerqueira FM, Barbosa LF, Medeiros MH, Kowaltowski AJ (2008) Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity. Aging Cell 7:552-560 (Pubitemid 351998615)
    • (2008) Aging Cell , vol.7 , Issue.4 , pp. 552-560
    • Caldeira Da Silva, C.C.1    Cerqueira, F.M.2    Barbosa, L.F.3    Medeiros, M.H.G.4    Kowaltowski, A.J.5
  • 12
    • 0027300035 scopus 로고
    • Tissue-specific and β-adrenergic regulation of the mitochondrial uncoupling protein gene: Control by cis-acting elements in the 5'-flanking region
    • DOI 10.1210/me.7.4.497
    • Cassard-Doulcier A-M, Gelly C, Fox N, Schrementi J, Raimbault S, Klaus S, Forest C, Bouillaud F, Ricquier D (1993) Tissuespecific and beta-adrenergic regulation of the mitochondrial uncoupling protein gene: control by cis-acting elements in the 50-flanking region. Mol Endocrinol 7:497-506 (Pubitemid 23138159)
    • (1993) Molecular Endocrinology , vol.7 , Issue.4 , pp. 497-506
    • Cassard-Doulcier, A.-M.1    Gelly, C.2    Fox, N.3    Schrementi, J.4    Raimbault, S.5    Klaus, S.6    Forest, C.7    Bouillaud, F.8    Ricquier, D.9
  • 13
    • 28244447306 scopus 로고
    • Sur les effets produits par l'ingestion et l'infusion intra-veineuse de trois colorants jaunes, derives de la houille
    • Cazeneuve P, Lépine R (1885) Sur les effets produits par l'ingestion et l'infusion intra-veineuse de trois colorants jaunes, derives de la houille. Compt Rend Soc Biol 101:1167-1169
    • (1885) Compt Rend Soc Biol , vol.101 , pp. 1167-1169
    • Cazeneuve, P.1    Lépine, R.2
  • 14
    • 0036862318 scopus 로고    scopus 로고
    • Adipocyte differentiation and transdifferentiation: Plasticity of the adipose organ
    • Cinti S (2002) Adipocyte differentiation and transdifferentiation: plasticity of the adipose organ. J Endocrinol Invest 25:823-835 (Pubitemid 35446350)
    • (2002) Journal of Endocrinological Investigation , vol.25 , Issue.10 , pp. 823-835
    • Cinti, S.1
  • 15
    • 0031025546 scopus 로고    scopus 로고
    • 3-adrenergic receptor agonist treatment of diet-induced obesity in mice
    • DOI 10.1210/en.138.1.405
    • Collins S, Daniel KW, Petro AE, Surwit RS (1997) Strain-specific response to beta3-adrenergic receptor agonist treatment of dietinduced obesity in mice. Endocrinology 138:405-413 (Pubitemid 27009450)
    • (1997) Endocrinology , vol.138 , Issue.1 , pp. 405-413
    • Collins, S.1    Daniel, K.W.2    Petro, A.E.3    Surwit, R.S.4
  • 19
    • 33745183847 scopus 로고    scopus 로고
    • Functions of AMP-activated protein kinase in adipose tissue
    • DOI 10.1113/jphysiol.2006.111484
    • Daval M, Foufelle F, Ferre P (2006) Functions of AMP-activated protein kinase in adipose tissue. J Physiol 574:55-62 (Pubitemid 43905796)
    • (2006) Journal of Physiology , vol.574 , Issue.1 , pp. 55-62
    • Daval, M.1    Foufelle, F.2    Ferre, P.3
  • 20
    • 0015730193 scopus 로고
    • Minimal O2 consumption as an index of thyroid status: Standardization of method
    • Denckla WD, Marcum E (1973) Minimal O2 consumption as an index of thyroid status: standardization of method. Endocrinology 93:61-73
    • (1973) Endocrinology , vol.93 , pp. 61-73
    • Denckla, W.D.1    Marcum, E.2
  • 22
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann HM, Golozoubova V, Cannon B, Nedergaard J (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9:203-209
    • (2009) Cell Metab , vol.9 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 23
    • 0036606567 scopus 로고    scopus 로고
    • Impaired noradrenaline-induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels
    • DOI 10.1042/BJ20011438
    • Flachs P, Novotny J, Baumruk F, Bardova K, Bourova L, Miksik I, Sponarova J, Svoboda P, Kopecky J (2002) Impaired noradrenaline- induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels. Biochem J 364:369-376 (Pubitemid 34620796)
    • (2002) Biochemical Journal , vol.364 , Issue.2 , pp. 369-376
    • Flachs, P.1    Novotny, J.2    Baumruk, F.3    Bardova, K.4    Bourova, L.5    Miksik, I.6    Sponarova, J.7    Svoboda, P.8    Kopecky, J.9
  • 27
    • 0028972025 scopus 로고
    • 15-deoxy-delta12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARgamma
    • DOI 10.1016/0092-8674(95)90193-0
    • Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM (1995) 15-Deoxy-delta12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARgama. Cell 83:803-812 (Pubitemid 3006324)
    • (1995) Cell , vol.83 , Issue.5 , pp. 803-812
    • Forman, B.M.1    Tontonoz, P.2    Chen, J.3    Brun, R.P.4    Spiegelman, B.M.5    Evans, R.M.6
  • 29
    • 47749085114 scopus 로고    scopus 로고
    • AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: Potential mechanism and physiological relevance
    • Gauthier MS, Miyoshi H, Souza SC, Cacicedo JM, Saha AK, Greenberg AS, Ruderman NB (2008) AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J Biol Chem 283:16514-16524
    • (2008) J Biol Chem , vol.283 , pp. 16514-16524
    • Gauthier, M.S.1    Miyoshi, H.2    Souza, S.C.3    Cacicedo, J.M.4    Saha, A.K.5    Greenberg, A.S.6    Ruderman, N.B.7
  • 30
    • 0242577899 scopus 로고
    • Mammalian thermogenesis: An introduction
    • Girardier L, Stock MJ (eds), Chapman and Hall, London, NewYork
    • Girardier L, Stock MJ (1983) Mammalian thermogenesis: an introduction. In: Girardier L, Stock MJ (eds) Mammalian thermogenesis. Chapman and Hall, London, NewYork, pp 1-7
    • (1983) Mammalian Thermogenesis. , pp. 1-7
    • Girardier, L.1    Stock, M.J.2
  • 31
    • 33748612432 scopus 로고    scopus 로고
    • AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model
    • Giri S, Rattan R, Haq E, Khan M, Yasmin R, Won JS, Key L, Singh AK, Singh I (2006) AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model. Nutr Metab Lond 3:31
    • (2006) Nutr Metab Lond , vol.3 , pp. 31
    • Giri, S.1    Rattan, R.2    Haq, E.3    Khan, M.4    Yasmin, R.5    Won, J.S.6    Key, L.7    Singh, A.K.8    Singh, I.9
  • 33
    • 33746752252 scopus 로고    scopus 로고
    • Reduction in energy efficiency induced by expression of the uncoupling protein, UCP1, in mouse liver mitochondria
    • Gonzalez-Muniesa P, Milagro FI, Campion J, Martinez JA (2006) Reduction in energy efficiency induced by expression of the uncoupling protein, UCP1, in mouse liver mitochondria. Int J Mol Med 17:591-597
    • (2006) Int J Mol Med , vol.17 , pp. 591-597
    • Gonzalez-Muniesa, P.1    Milagro, F.I.2    Campion, J.3    Martinez, J.A.4
  • 35
    • 0032528169 scopus 로고    scopus 로고
    • Emergence of brown adipocytes in white fat in mice is under genetic control effects on body weight and adiposity
    • Guerra C, Koza RA, Yamashita H, King KW, Kozak LP (1998) Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest 102:412-420 (Pubitemid 28335201)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.2 , pp. 412-420
    • Guerra, C.1    Koza, R.A.2    Yamashita, H.3    Walsh, K.4    Kozak, L.P.5
  • 37
    • 50049091255 scopus 로고    scopus 로고
    • AMPK: A key regulator of energy balance in the single cell and the whole organism
    • Hardie DG (2008) AMPK: a key regulator of energy balance in the single cell and the whole organism. Int J Obes (Lond) 32(Suppl 4):S7-S12
    • (2008) Int J Obes (Lond) , vol.32 , Issue.SUPPL. 4
    • Hardie, D.G.1
  • 38
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • DOI 10.1146/annurev.biochem.67.1.821
    • Hardie DG, Carling D, Carlson M (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67:821-855 (Pubitemid 28411146)
    • (1998) Annual Review of Biochemistry , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 39
    • 84866008199 scopus 로고
    • Role of thermogenesis in brown adipose tissue in the regulation of energy balance
    • Hollenberg CH, Roncardi DAK (eds), Raven Press, New York
    • Himms-Hagen J (1983) Role of thermogenesis in brown adipose tissue in the regulation of energy balance. In: Hollenberg CH, Roncardi DAK (eds) The adipose and obesity: cellular and molecular mechanisms. Raven Press, New York, pp 259-270
    • (1983) The Adipose and Obesity: Cellular and Molecular Mechanisms , pp. 259-270
    • Himms-Hagen, J.1
  • 42
    • 27744502778 scopus 로고    scopus 로고
    • β-Adrenoceptors, but not α-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1
    • DOI 10.1007/s00125-005-1936-7
    • Hutchinson DS, Chernogubova E, Dallner OS, Cannon B, Bengtsson T (2005) Beta-adrenoceptors, but not alpha-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1. Diabetologia 48:2386-2395 (Pubitemid 41618931)
    • (2005) Diabetologia , vol.48 , Issue.11 , pp. 2386-2395
    • Hutchinson, D.S.1    Chernogubova, E.2    Dallner, O.S.3    Cannon, B.4    Bengtsson, T.5
  • 43
    • 17844363526 scopus 로고    scopus 로고
    • Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue
    • DOI 10.2337/diabetes.54.5.1385
    • Inokuma K, Ogura-Okamatsu Y, Toda C, Kimura K, Yamashita H, Saito M (2005) Uncoupling protein 1 is necessary for norepinephrine- induced glucose utilization in brown adipose tissue. Diabetes 54:1385-1391 (Pubitemid 40586668)
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1385-1391
    • Inokuma, K.-I.1    Ogura-Okamatsu, Y.2    Toda, C.3    Kimura, K.4    Yamashita, H.5    Saito, M.6
  • 44
    • 58349118928 scopus 로고    scopus 로고
    • Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cells
    • Irrcher I, Ljubicic V, Hood DA (2009) Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cells. Am J Physiol Cell Physiol 296:C116-C123
    • (2009) Am J Physiol Cell Physiol , vol.296
    • Irrcher, I.1    Ljubicic, V.2    Hood, D.A.3
  • 49
    • 70350668791 scopus 로고    scopus 로고
    • The 50 adenosine monophosphateactivated protein kinase: Regulating the ebb and flow of cellular energetics
    • Karagounis LG, Hawley JA (2009) The 50 adenosine monophosphateactivated protein kinase: regulating the ebb and flow of cellular energetics. Int J Biochem Cell Biol 41:2360-2363
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 2360-2363
    • Karagounis, L.G.1    Hawley, J.A.2
  • 50
    • 40149106348 scopus 로고    scopus 로고
    • Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1
    • DOI 10.1152/physiolgenomics.00194.2007
    • Katterle Y, Keipert S, Hof J, Klaus S (2008) Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1. Physiol Genomics 32:352-359 (Pubitemid 351328558)
    • (2008) Physiological Genomics , vol.32 , Issue.3 , pp. 352-359
    • Katterle, Y.1    Keipert, S.2    Hof, J.3    Klaus, S.4
  • 51
    • 73549125253 scopus 로고    scopus 로고
    • UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production
    • Keipert S, Klaus S, Heldmaier G, Jastroch M (2010) UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production. Biochim Biophys Acta 1797:324-330
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 324-330
    • Keipert, S.1    Klaus, S.2    Heldmaier, G.3    Jastroch, M.4
  • 52
    • 78651269800 scopus 로고    scopus 로고
    • Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice
    • Keipert S, Voigt A, Klaus S (2011) Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice. Aging Cell 10:122-136
    • (2011) Aging Cell , vol.10 , pp. 122-136
    • Keipert, S.1    Voigt, A.2    Klaus, S.3
  • 53
    • 0347965985 scopus 로고    scopus 로고
    • Adipose tissue as a regulator of energy balance
    • DOI 10.2174/1389450043490523
    • Klaus S (2004) Adipose tissue as a regulator of energy balance. Curr Drug Targets 5:241-250 (Pubitemid 38372310)
    • (2004) Current Drug Targets , vol.5 , Issue.3 , pp. 241-250
    • Klaus, S.1
  • 54
    • 0025861442 scopus 로고
    • The uncoupling protein UCP: A membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue
    • Klaus S, Casteilla L, Bouillaud F, Ricquier D (1991) The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue. Int J Biochem 23:791-801
    • (1991) Int J Biochem , vol.23 , pp. 791-801
    • Klaus, S.1    Casteilla, L.2    Bouillaud, F.3    Ricquier, D.4
  • 55
    • 21244480070 scopus 로고    scopus 로고
    • Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation
    • DOI 10.1152/physiolgenomics.00299.2004
    • Klaus S, Rudolph B, Dohrmann C, Wehr R (2005) Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation. Physiol Genomics 21:193-200 (Pubitemid 40898479)
    • (2005) Physiological Genomics , vol.21 , pp. 193-200
    • Klaus, S.1    Rudolph, B.2    Dohrmann, C.3    Wehr, R.4
  • 56
    • 0028972026 scopus 로고
    • A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation
    • DOI 10.1016/0092-8674(95)90194-9
    • Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83:813-819 (Pubitemid 3006325)
    • (1995) Cell , vol.83 , Issue.5 , pp. 813-819
    • Kliewer, S.A.1    Lenhard, J.M.2    Willson, T.M.3    Patel, I.4    Morris, D.C.5    Lehmann, J.M.6
  • 57
    • 0021271252 scopus 로고
    • Molecular mechanism of uncoupling in brown adipose tissue mitochondria. The non-identity of proton and chloride conducting pathways
    • DOI 10.1016/0014-5793(84)81396-4
    • Kopecky J, Guerrieri F, Jezek P, Drahota Z, Houstek J (1984) Molecular mechanism of uncoupling in brown adipose tissue mitochondria. The non-identity of proton and chloride conducting pathways. FEBS Lett 170:186-190 (Pubitemid 14105145)
    • (1984) FEBS Letters , vol.170 , Issue.1 , pp. 186-190
    • Kopecky, J.1    Guerrieri, F.2    Jezek, P.3
  • 58
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak LP (1995) Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 96:2914-2923
    • (1995) J Clin Invest , vol.96 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerback, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 60
    • 0029894407 scopus 로고    scopus 로고
    • Reduction of dietary obesity in the aP2-Ucp transgenic mice: Mechanism and adipose tissue morphology
    • Kopecky J, Rossmeisl M, Hodny Z, Syrovy I, Horakova M, Kolarova P (1996b) Reduction of dietary obesity in the aP2-Ucp transgenic mice: mechanism and adipose tissue morphology. Am J Physiol 270:E776-E786
    • (1996) Am J Physiol , vol.270
    • Kopecky, J.1    Rossmeisl, M.2    Hodny, Z.3    Syrovy, I.4    Horakova, M.5    Kolarova, P.6
  • 64
    • 0028153698 scopus 로고
    • An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene
    • Kozak UC, Kopecky J, Teisinger J, Enerback S, Boyer B, Kozak LP (1994) An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol Cell Biol 14:59-67
    • (1994) Mol Cell Biol , vol.14 , pp. 59-67
    • Kozak, U.C.1    Kopecky, J.2    Teisinger, J.3    Enerback, S.4    Boyer, B.5    Kozak, L.P.6
  • 65
    • 33845523156 scopus 로고    scopus 로고
    • Adiponectin-dependent and -independent pathways in insulin-sensitizing and antidiabetic actions of thiazolidinediones
    • DOI 10.2337/db06-S005
    • Kubota N, Yamauchi T, Tobe K, Kadowaki T (2006) Adiponectindependent and -independent pathways in insulin-sensitizing and antidiabetic actions of thiazolidinediones. Diabetes 55(Suppl 2):S32-S38 (Pubitemid 44927030)
    • (2006) Diabetes , vol.55 , Issue.SUPPL. 2
    • Kubota, N.1    Yamauchi, T.2    Tobe, K.3    Kadowaki, T.4
  • 69
    • 0033787068 scopus 로고    scopus 로고
    • Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
    • Li B, Nolte LA, Ju JS, Han DH, Coleman T, Holloszy JO, Semenkovich CF (2000) Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat Med 6:1115-1120
    • (2000) Nat Med , vol.6 , pp. 1115-1120
    • Li, B.1    Nolte, L.A.2    Ju, J.S.3    Han, D.H.4    Coleman, T.5    Holloszy, J.O.6    Semenkovich, C.F.7
  • 71
    • 75749104187 scopus 로고    scopus 로고
    • AMPK as a mediator of hormonal signalling
    • Lim CT, Kola B, Korbonits M (2010) AMPK as a mediator of hormonal signalling. J Mol Endocrinol 44:87-97
    • (2010) J Mol Endocrinol , vol.44 , pp. 87-97
    • Lim, C.T.1    Kola, B.2    Korbonits, M.3
  • 72
    • 0020477476 scopus 로고
    • Characterization of the isolated purine nucleotide binding protein from brown fat mitochondria
    • Lin C-S, Klingenberg M (1982) Characterization of the isolated purine nucleotide binding protein from brown fat mitochondria. Biochemistry 21:2950-2956
    • (1982) Biochemistry , vol.21 , pp. 2950-2956
    • Lin, C.-S.1    Klingenberg, M.2
  • 73
    • 34548504082 scopus 로고    scopus 로고
    • Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: A new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus
    • DOI 10.1007/s00125-007-0776-z
    • Maassen JA, Romijn JA, Heine RJ (2007) Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus. Diabetologia 50:2036-2041 (Pubitemid 47373858)
    • (2007) Diabetologia , vol.50 , Issue.10 , pp. 2036-2041
    • Maassen, J.A.1    Romijn, J.A.2    Heine, R.J.3
  • 74
    • 3042593895 scopus 로고    scopus 로고
    • Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat
    • DOI 10.1016/j.febslet.2004.06.002, PII S0014579304007124
    • Matejkova O, Mustard KJ, Sponarova J, Flachs P, Rossmeisl M, Miksik I, Thomason-Hughes M, Hardie DG, Kopecky J (2004) Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat. FEBS Lett 569:245-248 (Pubitemid 38844626)
    • (2004) FEBS Letters , vol.569 , Issue.1-3 , pp. 245-248
    • Matejkova, O.1    Mustard, K.J.2    Sponarova, J.3    Flachs, P.4    Rossmeisl, M.5    Miksik, I.6    Thomason-Hughes, M.7    Grahame Hardie, D.8    Kopecky, J.9
  • 75
    • 76849083600 scopus 로고    scopus 로고
    • AMPK-mediated regulation of transcription in skeletal muscle
    • McGee SL, Hargreaves M (2010) AMPK-mediated regulation of transcription in skeletal muscle. Clin Sci 118:507-518
    • (2010) Clin Sci , vol.118 , pp. 507-518
    • McGee, S.L.1    Hargreaves, M.2
  • 76
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • DOI 10.1038/415339a
    • Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Carling D, Kahn BB (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415:339-343 (Pubitemid 34087557)
    • (2002) Nature , vol.415 , Issue.6869 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.-B.2    Peroni, O.D.3    Fryer, L.G.D.4    Muller, C.5    Carling, D.6    Kahn, B.B.7
  • 77
    • 34147128194 scopus 로고    scopus 로고
    • Upregulation of AMPK during cold exposure occurs via distinct mechanisms in brown and white adipose tissue of the mouse
    • DOI 10.1113/jphysiol.2007.128652
    • Mulligan JD, Gonzalez AA, Stewart AM, Carey HV, Saupe KW (2007) Upregulation of AMPK during cold exposure occurs via distinct mechanism in brown and white adipose tissue. J Physiol 580:677-684 (Pubitemid 46564191)
    • (2007) Journal of Physiology , vol.580 , Issue.2 , pp. 677-684
    • Mulligan, J.D.1    Gonzalez, A.A.2    Stewart, A.M.3    Carey, H.V.4    Saupe, K.W.5
  • 78
    • 77950237717 scopus 로고    scopus 로고
    • The changed metabolic world with human brown adipose tissue: Therapeutic visions
    • Nedergaard J, Cannon B (2010) The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab 11:268-272
    • (2010) Cell Metab , vol.11 , pp. 268-272
    • Nedergaard, J.1    Cannon, B.2
  • 79
    • 27344449065 scopus 로고    scopus 로고
    • Uncoupling proteins: Current status and therapeutic prospects
    • DOI 10.1038/sj.embor.7400532, PII 7400532
    • Nedergaard J, Ricquier D, Kozak LP (2005) Uncoupling proteins: current status and therapeutic prospects. EMBO Rep 6:917-921 (Pubitemid 41521944)
    • (2005) EMBO Reports , vol.6 , Issue.10 , pp. 917-921
    • Nedergaard, J.1    Ricquier, D.2    Kozak, L.P.3
  • 80
    • 45549106810 scopus 로고    scopus 로고
    • Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo
    • DOI 10.1152/physiolgenomics.00226.2007
    • Neschen S, Katterle Y, Richter J, Augustin R, Scherneck S, Mirhashemi F, Schurmann A, Joost HG, Klaus S (2008) Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo. Physiol Genomics 33:333-340 (Pubitemid 352755735)
    • (2008) Physiological Genomics , vol.33 , Issue.3 , pp. 333-340
    • Neschen, S.1    Katterle, Y.2    Richter, J.3    Augustin, R.4    Scherneck, S.5    Mirhashemi, F.6    Schurmann, A.7    Joost, H.-G.8    Klaus, S.9
  • 81
    • 0015899581 scopus 로고
    • Brown adipose-tissue mitochondria - Influence of albumin and nucleotides on passive ion premeabilities
    • Nicholls DG, Lindberg O (1973) Brown adipose-tissue mitochondria - influence of albumin and nucleotides on passive ion premeabilities. Eur J Biochem 37:523-530
    • (1973) Eur J Biochem , vol.37 , pp. 523-530
    • Nicholls, D.G.1    Lindberg, O.2
  • 82
    • 0021322138 scopus 로고
    • Thermogenic mechanisms in brown fat
    • Nicholls DG, Locke RM (1984) Thermogenic mechanisms in brown fat. Physiol Rev 64:1-64 (Pubitemid 14139945)
    • (1984) Physiological Reviews , vol.64 , Issue.1 , pp. 1-64
    • Nicholls, D.G.1    Locke, R.M.2
  • 84
    • 0016271265 scopus 로고
    • Dinitrophenol and bioenergetics: An historical perspective
    • Parascandola J (1974) Dinitrophenol and bioenergetics: an historical perspective. Mol Cell Biochem 5:69-77
    • (1974) Mol Cell Biochem , vol.5 , pp. 69-77
    • Parascandola, J.1
  • 85
    • 0037031840 scopus 로고    scopus 로고
    • Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3- phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
    • DOI 10.1074/jbc.M201692200
    • Park H, Kaushik VK, Constant S, Prentki M, Przybytkowski E, Ruderman NB, Saha AK (2002) Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3- phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem 277:32571-32577 (Pubitemid 34984761)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.36 , pp. 32571-32577
    • Park, H.1    Kaushik, V.K.2    Constant, S.3    Prentki, M.4    Przybytkowski, E.5    Ruderman, N.6    Saha, A.K.7
  • 86
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B, Nedergaard J (2010) Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem 285:7153-7164
    • (2010) J Biol Chem , vol.285 , pp. 7153-7164
    • Petrovic, N.1    Walden, T.B.2    Shabalina, I.G.3    Timmons, J.A.4    Cannon, B.5    Nedergaard, J.6
  • 88
    • 44649099112 scopus 로고    scopus 로고
    • Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue
    • DOI 10.1038/emboj.2008.92, PII EMBOJ200892
    • Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P (2008) Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J 27:1537-1548 (Pubitemid 351794037)
    • (2008) EMBO Journal , vol.27 , Issue.11 , pp. 1537-1548
    • Qi, J.1    Gong, J.2    Zhao, T.3    Zhao, J.4    Lam, P.5    Ye, J.6    Li, J.Z.7    Wu, J.8    Zhou, H.-M.9    Li, P.10
  • 89
    • 0028853383 scopus 로고
    • Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene
    • Rabelo R, Schifman A, Rubio A, Sheng X, Silva JE (1995) Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene. Endocrinology 136:1003-1013
    • (1995) Endocrinology , vol.136 , pp. 1003-1013
    • Rabelo, R.1    Schifman, A.2    Rubio, A.3    Sheng, X.4    Silva, J.E.5
  • 90
    • 33745215883 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in mitochondrial biogenesis
    • DOI 10.1113/jphysiol.2006.109512
    • Reznick RM, Shulman GI (2006) The role of AMP-activated protein kinase in mitochondrial biogenesis. J Physiol 574:33-39 (Pubitemid 43905794)
    • (2006) Journal of Physiology , vol.574 , Issue.1 , pp. 33-39
    • Reznick, R.M.1    Shulman, G.I.2
  • 92
    • 0017124215 scopus 로고
    • Mitochondrial protein alteration in active brown fat: A sodium dodecyl sulfate-polyacrylamide gel electrophoretic study
    • Ricquier D, Kader J-C (1976) Mitochondrial protein alteration in active brown fat: a sodium dodecyl sulfate-polyacrylamide gel electrophoretic study. Biochem Biophys Res Commun 73:577-583
    • (1976) Biochem Biophys Res Commun , vol.73 , pp. 577-583
    • Ricquier, D.1    Kader, J.-C.2
  • 93
    • 0033823015 scopus 로고    scopus 로고
    • Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue
    • Rossmeisl M, Syrový I, Baumruk F, Flachs P, Janovská P, Kopecký J (2000) Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue. FASEB J 14:1793-1800
    • (2000) FASEB J , vol.14 , pp. 1793-1800
    • Rossmeisl, M.1    Syrový, I.2    Baumruk, F.3    Flachs, P.4    Janovská, P.5    Kopecký, J.6
  • 97
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in diet-induced thermogenesis
    • DOI 10.1038/281031a0
    • Rothwell NJ, Stock MJ (1979) A role for brown adipose tissue in dietinduced thermogenesis. Nature 281:31-35 (Pubitemid 9247988)
    • (1979) Nature , vol.281 , Issue.5726 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 98
    • 36849076271 scopus 로고    scopus 로고
    • Effect of uncoupling protein-1 expression on 3T3-L1 adipocyte gene expression
    • DOI 10.1016/j.febslet.2007.11.064, PII S0014579307012185
    • Senocak FS, Si Y, Moya C, RussellWK, Russell DH, Lee K, Jayaraman A (2007) Effect of uncoupling protein-1 expression on 3T3-L1 adipocyte gene expression. FEBS Lett 581:5865-5871 (Pubitemid 50009356)
    • (2007) FEBS Letters , vol.581 , Issue.30 , pp. 5865-5871
    • Senocak, F.S.1    Si, Y.2    Moya, C.3    Russell, W.K.4    Russell, D.H.5    Lee, K.6    Jayaraman, A.7
  • 99
    • 34147147434 scopus 로고    scopus 로고
    • Effects of forced uncoupling protein 1 expression in 3T3-L1 cells on mitochondrial function and lipid metabolism
    • DOI 10.1194/jlr.M600343-JLR200
    • Si Y, Palani S, Jayaraman A, Lee K (2007) Effects of forced uncoupling protein 1 expression in 3T3-L1 cells on mitochondrial function and lipid metabolism. J Lipid Res 48:826-836 (Pubitemid 46557887)
    • (2007) Journal of Lipid Research , vol.48 , Issue.4 , pp. 826-836
    • Si, Y.1    Palani, S.2    Jayaraman, A.3    Lee, K.4
  • 100
    • 70349165556 scopus 로고    scopus 로고
    • Metabolic flux analysis of mitochondrial uncoupling in 3T3-L1 adipocytes
    • Si Y, Shi H, Lee K (2009) Metabolic flux analysis of mitochondrial uncoupling in 3T3-L1 adipocytes. PLoS One 4:e7000
    • (2009) PLoS One , vol.4
    • Si, Y.1    Shi, H.2    Lee, K.3
  • 103
    • 40449137038 scopus 로고    scopus 로고
    • Thrifty metabolism that favors fat storage after caloric restriction: A role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase
    • DOI 10.1096/fj.07-8972com
    • Summermatter S, Mainieri D, Russell AP, Seydoux J, Montani JP, Buchala A, Solinas G, Dulloo AG (2008) Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase. FASEB J 22:774-785 (Pubitemid 351348130)
    • (2008) FASEB Journal , vol.22 , Issue.3 , pp. 774-785
    • Summermatter, S.1    Mainieri, D.2    Russell, A.P.3    Seydoux, J.4    Montani, J.P.5    Buchala, A.6    Solinas, G.7    Dulloo, A.G.8
  • 104
    • 0028879326 scopus 로고
    • Variability in metabolic rate: Biological sites of regulation
    • Tataranni PA, Ravussin E (1995) Variability in metabolic rate: biological sites of regulation. Int J Obes 19:S102-S105
    • (1995) Int J Obes , vol.19
    • Tataranni, P.A.1    Ravussin, E.2
  • 108
    • 77149154335 scopus 로고    scopus 로고
    • Adenosine 50-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation
    • Vila-Bedmar R, Lorenzo M, Fernandez-Veledo S (2010) Adenosine 50-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation. Endocrinology 151:980-992
    • (2010) Endocrinology , vol.151 , pp. 980-992
    • Vila-Bedmar, R.1    Lorenzo, M.2    Fernandez-Veledo, S.3
  • 111
    • 0041314066 scopus 로고    scopus 로고
    • Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice
    • DOI 10.1210/en.2002-0036
    • Voshol PJ, Haemmerle G, Ouwens DM, Zimmermann R, Zechner R, Teusink B, Maassen JA, Havekes LM, Romijn JA (2003) Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology 144:3456-3462 (Pubitemid 36904422)
    • (2003) Endocrinology , vol.144 , Issue.8 , pp. 3456-3462
    • Voshol, P.J.1    Haemmerle, G.2    Ouwens, D.M.3    Zimmermann, R.4    Zechner, R.5    Teusink, B.6    Maassen, J.A.7    Havekes, L.M.8    Romijn, J.A.9
  • 113
    • 78851468865 scopus 로고    scopus 로고
    • The economic burden of obesity worldwide: A systematic review of the direct costs of obesity
    • Withrow D, Alter DA (2010) The economic burden of obesity worldwide: a systematic review of the direct costs of obesity. Obes Rev 12:131-241
    • (2010) Obes Rev , vol.12 , pp. 131-241
    • Withrow, D.1    Alter, D.A.2
  • 114
    • 0037983775 scopus 로고    scopus 로고
    • Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes
    • DOI 10.2337/diabetes.52.6.1355
    • Wu X, Motoshima H, Mahadev K, Stalker TJ, Scalia R, Goldstein BJ (2003) Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 52:1355-1363 (Pubitemid 36666188)
    • (2003) Diabetes , vol.52 , Issue.6 , pp. 1355-1363
    • Wu, X.1    Motoshima, H.2    Mahadev, K.3    Stalker, T.J.4    Scalia, R.5    Goldstein, B.J.6
  • 117
    • 33750880400 scopus 로고    scopus 로고
    • Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats
    • DOI 10.2337/db05-1315
    • Ye JM, Dzamko N, Hoy AJ, Iglesias MA, Kemp B, Kraegen E (2006) Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats. Diabetes 55:2797-2804 (Pubitemid 44923679)
    • (2006) Diabetes , vol.55 , Issue.10 , pp. 2797-2804
    • Ye, J.-M.1    Dzamko, N.2    Hoy, A.J.3    Iglesias, M.A.4    Kemp, B.5    Kraegen, E.6
  • 118
    • 77957562729 scopus 로고    scopus 로고
    • Acute stimulation of white adipocyte respiration by PKAinduced lipolysis
    • Yehuda-Shnaidman E, Buehrer B, Pi J, Kumar N, Collins S (2010) Acute stimulation of white adipocyte respiration by PKAinduced lipolysis. Diabetes 59:2474-2483
    • (2010) Diabetes , vol.59 , pp. 2474-2483
    • Yehuda-Shnaidman, E.1    Buehrer, B.2    Pi, J.3    Kumar, N.4    Collins, S.5
  • 119
    • 65349177200 scopus 로고    scopus 로고
    • AMPK: An emerging drug target for diabetes and the metabolic syndrome
    • Zhang BB, Zhou G, Li C (2009) AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab 9:407-416
    • (2009) Cell Metab , vol.9 , pp. 407-416
    • Zhang, B.B.1    Zhou, G.2    Li, C.3
  • 121
    • 70349334680 scopus 로고    scopus 로고
    • The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
    • Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, Cannon B, Nedergaard J, Cinti S (2009) The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 23:3113-3120
    • (2009) FASEB J , vol.23 , pp. 3113-3120
    • Zingaretti, M.C.1    Crosta, F.2    Vitali, A.3    Guerrieri, M.4    Frontini, A.5    Cannon, B.6    Nedergaard, J.7    Cinti, S.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.