Upregulation of AMPK during cold exposure occurs via distinct mechanisms in brown and white adipose tissue of the mouse

Journal of Physiology

Volumn 580, Issue 2, 2007, Pages 677-684

  Mulligan, Jacob D ^a   Gonzalez, Asensio A ^b   Stewart, Annette M ^a   Carey, Hannah V ^c   Saupe, Kurt W ^a,d,e  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b BELFAST CITY HOSPITAL   (United Kingdom)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; ADENYLATE KINASE; ALPHA1 ADENYLATE KINASE; ISOENZYME; NORADRENALIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

ADRENERGIC STIMULATION; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; COLD EXPOSURE; CONTROLLED STUDY; ENZYME ACTIVITY; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THERMOGENESIS; UPREGULATION; WHITE ADIPOSE TISSUE; ANIMAL EXPERIMENT; PROTEIN ANALYSIS; PROTEIN CONTENT;

ACCLIMATIZATION; ACETYL-COA CARBOXYLASE; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ADRENERGIC AGENTS; ANIMALS; COLD; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTEIN KINASES; UP-REGULATION;

EID: 34147128194     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.128652     Document Type: Article

References (37)

1. Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D & Small CJ (2004). AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 279, 12005-12008.
2. Arad M, Benson DW, Perez-Atayde AR, McKenna WJ, Sparks EA, Kanter RJ, McGarry K, Seidman JG & Seidman CE (2002). Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. J Clin Invest 109, 357-362.
3. Asakura H (2004). Fetal and neonatal thermoregulation. J Nippon Med Sch 71, 360-370.
4. 2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: Evidence for the central role of energy compromise in disease pathogenesis. Hum Mol Genet 10, 1215-1220.
5. Cannon B & Nedergaard J (2004). Brown adipose tissue: Function and physiological significance. Physiol Rev 84, 277-359.
6. Carling D (2004). The AMP-activated protein kinase cascade - a unifying system for energy control. Trends Biochem Sci 29, 18-24.
7. Carneheim C, Cannon B & Nedergaard J (1989). Rare fatty acids in brown fat are substrates for thermogenesis during arousal from hibernation. Am J Physiol Regul Integr Comp Physiol 256, R146-R154.
8. Davies SP, Carling D & Hardie DG (1989). Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Eur J Biochem 186, 123-128.
9. Gollob MH, Seger JJ, Gollob TN, Tapscott T, Gonzales O, Bachinski L & Roberts R (2001). Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy. Circulation 104, 3030-3033.
10. Golozoubova V, Hohtola E, Matthias A, Jacobsson A, Cannon B & Nedergaard J (2001). Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J 15, 2048-2050.
11. Gonzalez AA, Kumar R, Mulligan JD, Davis AJ & Saupe KW (2004 a). Effects of aging on cardiac and skeletal muscle AMPK activity: Basal activity, allosteric activation, and response to in vivo hypoxemia in mice. Am J Physiol Regul Integr Comp Physiol 287, R1270-R1275.
12. Gonzalez AA, Kumar R, Mulligan JD, Davis AJ, Weindruch R & Saupe KW (2004 b). Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity. Am J Physiol Endocrinol Metab 287, E1032-E1037.
13. Guerra C, Koza RA, Walsh K, Kurtz DM, Wood PA & Kozak LP (1998). Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation. J Clin Invest 102, 1724-1731.
14. Himms-Hagen J, Cui J, Danforth E Jr, Taatjes DJ, Lang SS, Waters BL & Claus TH (1994). Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats. Am J Physiol regul Integr Comp Physiol 266, R1371-R1382.
15. Himms-Hagen J, Melnyk A, Zingaretti MC, Ceresi E, Barbatelli G & Cinti S (2000). Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes. Am J Physiol Cell Physiol 279, C670-C681.
16. Hutchinson DS, Chernogubova E, Dallner OS, Cannon B & Bengtsson T (2005). beta-Adrenoceptors, but not alpha-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1. Diabetologia 48, 2386-2395.
17. Huttunen P, Hirvonen J & Kinnula V (1981). The occurrence of brown adipose tissue in outdoor workers. Eur J Appl Physiol Occup Physiol 46, 339-345.
18. Inokuma K, Ogura-Okamatsu Y, Toda C, Kimura K, Yamashita H & Saito M (2005). Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue. Diabetes 54, 1385-1391.
19. Joy RJ (1963). Responses of cold-acclimatized men to infused norepinephrine. J Appl Physiol 18, 1209-1212.
20. Kang BS, Han DS, Paik KS, Park YS, Kim JK, Kim CS, Rennie DW & Hong SK (1970). Calorgigenic action of norepinephrine in the Korean women divers. J Appl Physiol 29, 6-9.
21. Kishi K, Yuasa T, Minami A, Yamada M, Hagi A, Hayashi H, Kemp BE, Witters LA & Ebina Y (2000). AMP-Activated protein kinase is activated by the stimulations of G(q)-coupled receptors. Biochem Biophys Res Commun 276, 16-22.
22. Koska J, Ksinantova L, Sebokova E, Kvetnansky R, Klimes I, Chrousos G & Pacak K (2002). Endocrine regulation of subcutaneous fat metabolism during cold exposure in humans. Ann N Y Acad Sci 967, 500-505.
23. Lee WJ, Kim M, Park HS, Kim HS, Jeon MJ, Oh KS, Koh EH, Won JC, Kim MS, Oh GT, Yoon M, Lee KU & Park JY (2006). AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. Biochem Biophys Res Commun 340, 291-295.
24. Luo Z, Saha AK, Xiang X & Ruderman NB (2005). AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci 26, 69-76.
25. Martins R, Atgie C, Gineste L, Nibbelink M, Ambid L & Ricquier D (1991). Increased GDP binding and thermogenic activity in brown adipose tissue mitochondria during arousal of the hibernating garden dormouse (Eliomys quercinus L.). Comp Biochem Physiol A 98, 311-316.
26. Matejkova O, Mustard KJ, Sponarova J, Flachs P, Rossmeisl M, Miksik I, Thomason-Hughes M, Grahame Hardie D & Kopecky J (2004). Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat. FEBS Lett 569, 245-248.
27. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ, Stuck BJ & Kahn BB (2004). AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428, 569-574.
28. Moule SK & Denton RM (1998). The activation of p38 MAPK by the beta-adrenergic agonist isoproterenol in rat epididymal fat cells. FEBS Lett 439, 287-290.
29. Mulligan JD, Gonzalez AA, Kumar R, Davis AJ & Saupe KW (2005). Aging elevates basal AMPK activity and eliminates hypoxic activation of AMPK in mouse liver. J Gerontol A Biol Sci Med Sci 60, 21-27.
30. Rattan R, Giri S, Singh AK & Singh I (2005). 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase (AMPK). J Biol Chem 280, 29582-395893.
31. Rayner DV (2001). The sympathetic nervous system in white adipose tissue regulation. Proc Nutr Soc 60, 357-364.
32. Saha AK & Ruderman NB (2003). Malonyl-CoA and AMP-activated protein kinase: An expanding partnership. Mol Cell Biochem 253, 65-70.
33. Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D & Hardie DG (1998). AMP-activated protein kinase: Greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem J 334, 177-187.
34. Sponarova J, Mustard KJ, Horakova O, Flachs P, Rossmeisl M, Brauner P, Bardova K, Thomason-Hughes M, Braunerova R, Janovska P, Hardie DG & Kopecky J (2005). Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation. FEBS Lett 579, 6105-6110.
35. Suwa M, Nakano H & Kumagai S (2003). Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles. J Appl Physiol 95, 960-968.
36. Tiraby C & Langin D (2003). Conversion from white to brown adipocytes: A strategy for the control of fat mass? Trends Endocrinol Metab 14, 439-441.
37. Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ & Shulman GI (2002). AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A 99, 15983-15987.