-
1
-
-
0038054341
-
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha, V. K., Lindgren, C. M., Eriksson, K. F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E. et al. (2003) PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34, 267-273
-
(2003)
Nat. Genet
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
Puigserver, P.7
Carlsson, E.8
Ridderstråle, M.9
Laurila, E.10
-
2
-
-
0037477855
-
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
-
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R. et al. (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. U.S.A. 100, 8466-8471
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 8466-8471
-
-
Patti, M.E.1
Butte, A.J.2
Crunkhorn, S.3
Cusi, K.4
Berria, R.5
Kashyap, S.6
Miyazaki, Y.7
Kohane, I.8
Costello, M.9
Saccone, R.10
-
3
-
-
1642377274
-
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
-
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R. and Shulman, G. I. (2004) Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J Med. 350, 664-671
-
(2004)
N. Engl. J Med
, vol.350
, pp. 664-671
-
-
Petersen, K.F.1
Dufour, S.2
Befroy, D.3
Garcia, R.4
Shulman, G.I.5
-
4
-
-
19944431011
-
Cardiovascular risk factors emerge after artificial selection for low aerobic capacity
-
Wisløff, U., Najjar, S. M., Ellingsen, O., Haram, P. M., Swoap, S., Al-Share, Q., Fernström, M., Rezaei, K., Lee, S. J., Koch, L. G. and Britton, S. L. (2005) Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science 307, 334-335
-
(2005)
Science
, vol.307
, pp. 334-335
-
-
Wisløff, U.1
Najjar, S.M.2
Ellingsen, O.3
Haram, P.M.4
Swoap, S.5
Al-Share, Q.6
Fernström, M.7
Rezaei, K.8
Lee, S.J.9
Koch, L.G.10
Britton, S.L.11
-
5
-
-
76849100843
-
-
Mishra, S. K. and Misra, V. (2003) Muscle sarcopenia: an overview. Acta Myol. 22, 43-47 6 Balasubramanian, V. P. and Varkey, B. (2006) Chronic obstructive pulmonary disease: effects beyond the lungs. Curr. Opin. Pulm. Med. 12, 106-112
-
Mishra, S. K. and Misra, V. (2003) Muscle sarcopenia: an overview. Acta Myol. 22, 43-47 6 Balasubramanian, V. P. and Varkey, B. (2006) Chronic obstructive pulmonary disease: effects beyond the lungs. Curr. Opin. Pulm. Med. 12, 106-112
-
-
-
-
6
-
-
57649155915
-
Dysfunction of mitochondria and sarcoplasmic reticulum in the pathogenesis of collagen VI muscular dystrophies
-
Bernardi, P. and Bonaldo, P. (2008) Dysfunction of mitochondria and sarcoplasmic reticulum in the pathogenesis of collagen VI muscular dystrophies. Ann. N.Y. Acad. Sci. 1147, 303-311
-
(2008)
Ann. N.Y. Acad. Sci
, vol.1147
, pp. 303-311
-
-
Bernardi, P.1
Bonaldo, P.2
-
7
-
-
34147100819
-
Control of gene expression and mitochondrial biogenesis in the muscular adaptation to endurance exercise
-
Joseph, A. M., Pilegaard, H., Litvintsev, A., Leick, L. and Hood, D. A. (2006) Control of gene expression and mitochondrial biogenesis in the muscular adaptation to endurance exercise. Essays Biochem. 42, 13-29
-
(2006)
Essays Biochem
, vol.42
, pp. 13-29
-
-
Joseph, A.M.1
Pilegaard, H.2
Litvintsev, A.3
Leick, L.4
Hood, D.A.5
-
8
-
-
33947710793
-
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
-
Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R. and Ravussin, E. (2007) Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 4, e76
-
(2007)
PLoS Med
, vol.4
-
-
Civitarese, A.E.1
Carling, S.2
Heilbronn, L.K.3
Hulver, M.H.4
Ukropcova, B.5
Deutsch, W.A.6
Smith, S.R.7
Ravussin, E.8
-
9
-
-
33745225026
-
AMP-activated protein kinase: Development of the energy sensor concept
-
Hardie, D. G., Hawley, S. A. and Scott, J. W. (2006) AMP-activated protein kinase: development of the energy sensor concept. J. Physiol. 574, 7-15
-
(2006)
J. Physiol
, vol.574
, pp. 7-15
-
-
Hardie, D.G.1
Hawley, S.A.2
Scott, J.W.3
-
10
-
-
67650914230
-
AMPK in health and disease
-
Steinberg, G. R. and Kemp, B. E. (2009) AMPK in health and disease. Physiol. Rev. 89, 1025-1078
-
(2009)
Physiol. Rev
, vol.89
, pp. 1025-1078
-
-
Steinberg, G.R.1
Kemp, B.E.2
-
11
-
-
17844400342
-
5′ AMPK activated protein kinase in human skeletal muscle: Effects of strength training and type 2 diabetes
-
Wojtaszewski, J. P., Birk, J. B., Frosig, C., Holten, M., Pilegaard, H. and Dela, F. (2005) 5′ AMPK activated protein kinase in human skeletal muscle: effects of strength training and type 2 diabetes. J. Physiol. 564, 563-573
-
(2005)
J. Physiol
, vol.564
, pp. 563-573
-
-
Wojtaszewski, J.P.1
Birk, J.B.2
Frosig, C.3
Holten, M.4
Pilegaard, H.5
Dela, F.6
-
12
-
-
0037799908
-
AMPKβ subunit targets metabolic stress sensing to glycogen
-
Polekhina, G., Gupta, A., Michell, B. J., van Denderen. B., Murthy, S., Feil, S.C., Jennings, I.G., Campbell, D. J., Witters, L.A, Parker M.W. et al. (2003) AMPKβ subunit targets metabolic stress sensing to glycogen. Curr. Biol. 13, 867-871
-
(2003)
Curr. Biol
, vol.13
, pp. 867-871
-
-
Polekhina, G.1
Gupta, A.2
Michell, B.J.3
van Denderen, B.4
Murthy, S.5
Feil, S.C.6
Jennings, I.G.7
Campbell, D.J.8
Witters, L.A.9
Parker, M.W.10
-
13
-
-
33846955046
-
Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the γ subunit
-
Scott, J. W., Ross, F. A., Liu, J. K. and Hardie, D. G. (2007) Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the γ subunit. EMBO J. 26, 806-815
-
(2007)
EMBO J
, vol.26
, pp. 806-815
-
-
Scott, J.W.1
Ross, F.A.2
Liu, J.K.3
Hardie, D.G.4
-
14
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD α/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley, S. A., Boudeau, J., Reid, J. L., Mustard, K. J., Udd, L., Makela, T. P., Alessi, D. R. and Hardie, D. G. (2003) Complexes between the LKB1 tumor suppressor, STRAD α/β and MO25 α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2, 28
-
(2003)
J. Biol
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Makela, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
15
-
-
0041305909
-
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
-
Hong, S. P., Leiper, F. C., Woods, A., Carling, D. and Carlson, M. (2003) Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc. Natl. Acad. Sci. U.S.A. 100, 8839-8843
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 8839-8843
-
-
Hong, S.P.1
Leiper, F.C.2
Woods, A.3
Carling, D.4
Carlson, M.5
-
16
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M. and Carling, D. (2003) LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 13, 2004-2008
-
(2003)
Curr. Biol
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
17
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
-
Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G. and Hardie D.G. (2005) Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2, 9-19
-
(2005)
Cell Metab
, vol.2
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
Ross, L.4
Bain, J.5
Edelman, A.M.6
Frenguelli, B.G.7
Hardie, D.G.8
-
19
-
-
33748747706
-
Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro
-
Momcilovic, M., Hong, S. P. and Carlson, M. (2006) Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J. Biol. Chem. 281, 25336-25343
-
(2006)
J. Biol. Chem
, vol.281
, pp. 25336-25343
-
-
Momcilovic, M.1
Hong, S.P.2
Carlson, M.3
-
20
-
-
23044437445
-
2+/ calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells
-
2+/ calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2, 21-33
-
(2005)
Cell Metab
, vol.2
, pp. 21-33
-
-
Woods, A.1
Dickerson, K.2
Heath, R.3
Hong, S.P.4
Momcilovic, M.5
Johnstone, S.R.6
Carlson, M.7
Carling, D.8
-
21
-
-
33751552452
-
Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
-
Steinberg, G. R., Michell, B. J., van Denderen, B. J., Watt, M. J., Carey, A. L., Fam, B. C., Andrikopoulos, S., Proietto, J., Gorgun, C. Z., Carling, D. et al. (2006) Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab. 4, 465-474
-
(2006)
Cell Metab
, vol.4
, pp. 465-474
-
-
Steinberg, G.R.1
Michell, B.J.2
van Denderen, B.J.3
Watt, M.J.4
Carey, A.L.5
Fam, B.C.6
Andrikopoulos, S.7
Proietto, J.8
Gorgun, C.Z.9
Carling, D.10
-
22
-
-
0041319433
-
Effect of exercise intensity on skeletal muscle AMPK signalling in humans
-
Chen, Z. P., Stephens, T. J., Murthy, S., Canny, B. J., Hargreaves, M., Witters, L. A., Kemp, B. E. and McConell, G. K. (2003) Effect of exercise intensity on skeletal muscle AMPK signalling in humans. Diabetes 52, 2205-2212
-
(2003)
Diabetes
, vol.52
, pp. 2205-2212
-
-
Chen, Z.P.1
Stephens, T.J.2
Murthy, S.3
Canny, B.J.4
Hargreaves, M.5
Witters, L.A.6
Kemp, B.E.7
McConell, G.K.8
-
23
-
-
33749351995
-
Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle
-
Dreyer, H. C., Fujita, S., Cadenas, J. G., Chinkes, D. L., Volpi, E. and Rasmussen, B. B. (2006) Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J. Physiol. 576, 613-624
-
(2006)
J. Physiol
, vol.576
, pp. 613-624
-
-
Dreyer, H.C.1
Fujita, S.2
Cadenas, J.G.3
Chinkes, D.L.4
Volpi, E.5
Rasmussen, B.B.6
-
24
-
-
33845332346
-
Predominant α2/β2 /γ3 AMPK activation during exercise in human skeletal muscle
-
Birk, J. B. and Wojtaszewski, J. P. (2006) Predominant α2/β2 /γ3 AMPK activation during exercise in human skeletal muscle. J. Physiol. 577, 1021-1032
-
(2006)
J. Physiol
, vol.577
, pp. 1021-1032
-
-
Birk, J.B.1
Wojtaszewski, J.P.2
-
25
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
Tamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K. et al. (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8, 1288-1295
-
(2002)
Nat. Med
, vol.8
, pp. 1288-1295
-
-
Tamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
Ito, Y.4
Waki, H.5
Uchida, S.6
Yamashita, S.7
Noda, M.8
Kita, S.9
Ueki, K.10
-
26
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
-
Minokoshi, Y., Kim, Y. B., Peroni, O. D., Fryer, L. G., Müller, C., Carling, D. and Kahn, B. B. (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415, 339-343
-
(2002)
Nature
, vol.415
, pp. 339-343
-
-
Minokoshi, Y.1
Kim, Y.B.2
Peroni, O.D.3
Fryer, L.G.4
Müller, C.5
Carling, D.6
Kahn, B.B.7
-
27
-
-
33750859187
-
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
-
Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E. et al. (2006) Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 55, 2688-2697
-
(2006)
Diabetes
, vol.55
, pp. 2688-2697
-
-
Carey, A.L.1
Steinberg, G.R.2
Macaulay, S.L.3
Thomas, W.G.4
Holmes, A.G.5
Ramm, G.6
Prelovsek, O.7
Hohnen-Behrens, C.8
Watt, M.J.9
James, D.E.10
-
28
-
-
0034675354
-
q-coupled receptors
-
q-coupled receptors. Biochem. Biophys. Res. Commun. 276, 16-22
-
(2000)
Biochem. Biophys. Res. Commun
, vol.276
, pp. 16-22
-
-
Kishi, K.1
Yuasa, T.2
Minami, A.3
Yamada, M.4
Hagi, A.5
Hayashi, H.6
Kemp, B.E.7
Witters, L.A.8
Ebina, Y.9
-
29
-
-
37249044362
-
Absence of humoral mediated 5′ AMP-activated protein kinase activation in human skeletal muscle and adipose tissue during exercise
-
Kristensen, J. M., Johnsen, A. B., Birk, J. B., Nielsen, J. N., Jensen, B. R., Hellsten, Y., Richter, E. A. and Wojtaszewski, J. F. (2007) Absence of humoral mediated 5′ AMP-activated protein kinase activation in human skeletal muscle and adipose tissue during exercise. J. Physiol. 585, 897-909
-
(2007)
J. Physiol
, vol.585
, pp. 897-909
-
-
Kristensen, J.M.1
Johnsen, A.B.2
Birk, J.B.3
Nielsen, J.N.4
Jensen, B.R.5
Hellsten, Y.6
Richter, E.A.7
Wojtaszewski, J.F.8
-
30
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N. et al. (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108, 1167-1174
-
(2001)
J. Clin. Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
Wu, M.7
Ventre, J.8
Doebber, T.9
Fujii, N.10
-
31
-
-
0036299982
-
Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes
-
Musi, N., Hirshman, M. F., Nygren, J., Svanfeldt, M., Bavenholm, P., Rooyackers, O., Zhou, G., Williamson, J. M., Ljunqvist, O., Efendic, S. et al. (2002) Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 51, 2074-2081
-
(2002)
Diabetes
, vol.51
, pp. 2074-2081
-
-
Musi, N.1
Hirshman, M.F.2
Nygren, J.3
Svanfeldt, M.4
Bavenholm, P.5
Rooyackers, O.6
Zhou, G.7
Williamson, J.M.8
Ljunqvist, O.9
Efendic, S.10
-
32
-
-
85047689953
-
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
-
Corton, J., Gillespie, J., Hawley, S. and Hardie, D.G. (1995) 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur. J. Biochem. 229, 558-565
-
(1995)
Eur. J. Biochem
, vol.229
, pp. 558-565
-
-
Corton, J.1
Gillespie, J.2
Hawley, S.3
Hardie, D.G.4
-
33
-
-
51249103805
-
Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients
-
Boon, H., Bosselaar, M., Praet, S. F., Blaak, E. E., Saris, W. H., Wagenmakers, A. J., McGee, S. L., Tack, C. J., Smits, P., Hargreaves, M. and van Loon, L. J. (2008) Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients. Diabetologia 51, 1893-1900
-
(2008)
Diabetologia
, vol.51
, pp. 1893-1900
-
-
Boon, H.1
Bosselaar, M.2
Praet, S.F.3
Blaak, E.E.4
Saris, W.H.5
Wagenmakers, A.J.6
McGee, S.L.7
Tack, C.J.8
Smits, P.9
Hargreaves, M.10
van Loon, L.J.11
-
34
-
-
33744514139
-
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
-
Cool, B., Zinker, B., Chiou, W., Kifle, L., Cao, N., Perham, M., Dickinson, R., Adler, A., Gagne, G., Iyengar, R. et al. (2006) Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 3, 403-416
-
(2006)
Cell Metab
, vol.3
, pp. 403-416
-
-
Cool, B.1
Zinker, B.2
Chiou, W.3
Kifle, L.4
Cao, N.5
Perham, M.6
Dickinson, R.7
Adler, A.8
Gagne, G.9
Iyengar, R.10
-
35
-
-
56049112796
-
Thienopyridone drugs are selective activators of AMP-activated protein kinase β1-containing complexes
-
Scott, J. W., van Denderen, B. J., Jorgensen, S. B., Honeyman, J. E., Steinberg, G. R., Oakhill, J. S., Iseli, T. J., Koay, A., Gooley, P. R., Stapleton, D. and Kemp, B. E. (2008) Thienopyridone drugs are selective activators of AMP-activated protein kinase β1-containing complexes. Chem. Biol. 15, 1220-1230
-
(2008)
Chem. Biol
, vol.15
, pp. 1220-1230
-
-
Scott, J.W.1
van Denderen, B.J.2
Jorgensen, S.B.3
Honeyman, J.E.4
Steinberg, G.R.5
Oakhill, J.S.6
Iseli, T.J.7
Koay, A.8
Gooley, P.R.9
Stapleton, D.10
Kemp, B.E.11
-
36
-
-
36348998521
-
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
-
Göransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. and Sakamoto, K. (2007) Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J. Biol. Chem. 282, 32549-32560
-
(2007)
J. Biol. Chem
, vol.282
, pp. 32549-32560
-
-
Göransson, O.1
McBride, A.2
Hawley, S.A.3
Ross, F.A.4
Shpiro, N.5
Foretz, M.6
Viollet, B.7
Hardie, D.G.8
Sakamoto, K.9
-
37
-
-
70349921265
-
A-769662 activates AMPKβ1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle
-
a
-
a Treebak, J. T., Birk, J. B., Hansen, B. F., Olsen, G. S. and Wojtaszewski, J. F. (2009) A-769662 activates AMPKβ1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle. Am. J. Physiol. Cell Physiol. 297, C1041-C1052
-
(2009)
Am. J. Physiol. Cell Physiol
, vol.297
-
-
Treebak, J.T.1
Birk, J.B.2
Hansen, B.F.3
Olsen, G.S.4
Wojtaszewski, J.F.5
-
38
-
-
4544287365
-
AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females
-
Steinberg, G. R., Smith, A. C., van Denderen, B. J. W., Chen, Z. P., Murthy, S., Campbell, D. J., Heigenhauser, G. J. F, Dyck, D. J. and Kemp, B. E. (2004) AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females. J Clin. Endocinol. Metab. 89, 4575-4580
-
(2004)
J Clin. Endocinol. Metab
, vol.89
, pp. 4575-4580
-
-
Steinberg, G.R.1
Smith, A.C.2
van Denderen, B.J.W.3
Chen, Z.P.4
Murthy, S.5
Campbell, D.J.6
Heigenhauser, G.J.F.7
Dyck, D.J.8
Kemp, B.E.9
-
39
-
-
0023740043
-
Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases
-
Munday, M. R., Carling, D. and Hardie, D. G. (1988) Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases. FEBS Lett. 223, 217-222
-
(1988)
FEBS Lett
, vol.223
, pp. 217-222
-
-
Munday, M.R.1
Carling, D.2
Hardie, D.G.3
-
40
-
-
0031425839
-
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
-
Merrill, G. F., Kurth, E. J., Hardie, D. G. and Winder, W. W. (1997) AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am. J. Physiol. 273, E1107-E1112
-
(1997)
Am. J. Physiol
, vol.273
-
-
Merrill, G.F.1
Kurth, E.J.2
Hardie, D.G.3
Winder, W.W.4
-
41
-
-
44049087531
-
Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation
-
Chavez, J. A., Roach, W. G., Keller, S. R., Lane, W. S. and Lienhard, G. E. (2008) Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J. Biol. Chem. 283, 9187-9195
-
(2008)
J. Biol. Chem
, vol.283
, pp. 9187-9195
-
-
Chavez, J.A.1
Roach, W.G.2
Keller, S.R.3
Lane, W.S.4
Lienhard, G.E.5
-
42
-
-
0034687210
-
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
-
Marsin, A. S., Bertrand, L., Rider, M. H., Deprez, J., Beauloye, C., Vincent, M. F., Van den Berghe, G., Carling, D. and Hue, L. (2000) Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr. Biol. 10, 1247-1255
-
(2000)
Curr. Biol
, vol.10
, pp. 1247-1255
-
-
Marsin, A.S.1
Bertrand, L.2
Rider, M.H.3
Deprez, J.4
Beauloye, C.5
Vincent, M.F.6
Van den Berghe, G.7
Carling, D.8
Hue, L.9
-
43
-
-
61949165795
-
AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase ser633
-
Chen, Z., Chen Peng, I., Sun, W., Su, M. I., Hsu, P. H., Fu, Y., Zhu, Y., DeFea, K., Pan, S., Tsai, M. D. and Shyy, J. Y. J. (2009) AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase ser633. Circ. Res. 104, 496-505
-
(2009)
Circ. Res
, vol.104
, pp. 496-505
-
-
Chen, Z.1
Chen Peng, I.2
Sun, W.3
Su, M.I.4
Hsu, P.H.5
Fu, Y.6
Zhu, Y.7
DeFea, K.8
Pan, S.9
Tsai, M.D.10
Shyy, J.Y.J.11
-
44
-
-
57649180479
-
AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
-
Zwetsloot, K. A., Westerkamp, L. M., Holmes, B. F. and Gavin, T. P. (2008) AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise. J. Physiol. 586, 6021-6035
-
(2008)
J. Physiol
, vol.586
, pp. 6021-6035
-
-
Zwetsloot, K.A.1
Westerkamp, L.M.2
Holmes, B.F.3
Gavin, T.P.4
-
45
-
-
0034863102
-
Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase
-
Zheng, D., MacLean, P. S., Pohnert, S. C., Knight, J. B., Olson, A. L., Winder, W. W. and Dohm, G. L. (2001) Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase. J. Appl. Physiol. 91, 1073-1083
-
(2001)
J. Appl. Physiol
, vol.91
, pp. 1073-1083
-
-
Zheng, D.1
MacLean, P.S.2
Pohnert, S.C.3
Knight, J.B.4
Olson, A.L.5
Winder, W.W.6
Dohm, G.L.7
-
46
-
-
0036889017
-
AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle
-
Stoppani, J., Hildebrandt, A. L., Sakamoto, K., Cameron-Smith, D., Goodyear, L. J. and Neufer, P. D. (2002) AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 283, E1239-E1248
-
(2002)
Am. J. Physiol. Endocrinol. Metab
, vol.283
-
-
Stoppani, J.1
Hildebrandt, A.L.2
Sakamoto, K.3
Cameron-Smith, D.4
Goodyear, L.J.5
Neufer, P.D.6
-
47
-
-
33745717084
-
Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts
-
Chabowski, A., Momken, I., Coort, S. L., Calles-Escandon, J., Tandon, N. N., Glatz, J. F., Luiken, J. J. and Bonen, A. (2006) Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts. Mol. Cell. Biochem. 288, 201-212
-
(2006)
Mol. Cell. Biochem
, vol.288
, pp. 201-212
-
-
Chabowski, A.1
Momken, I.2
Coort, S.L.3
Calles-Escandon, J.4
Tandon, N.N.5
Glatz, J.F.6
Luiken, J.J.7
Bonen, A.8
-
48
-
-
33644701630
-
Changes in exercise-induced gene expression in 5′-AMP-activated protein kinase γ3-null and γ3 R225Q transgenic mice
-
Barnes, B. R., Long, Y. C., Steiler, T. L., Leng, Y., Galuska, D., Wojtaszewski, J. F., Andersson, L. and Zierath, J. R. (2005) Changes in exercise-induced gene expression in 5′-AMP-activated protein kinase γ3-null and γ3 R225Q transgenic mice. Diabetes 54, 3484-3489
-
(2005)
Diabetes
, vol.54
, pp. 3484-3489
-
-
Barnes, B.R.1
Long, Y.C.2
Steiler, T.L.3
Leng, Y.4
Galuska, D.5
Wojtaszewski, J.F.6
Andersson, L.7
Zierath, J.R.8
-
49
-
-
21744463063
-
Effects of α-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle
-
Jorgensen, S. B.,Wojtaszewski, J. F., Viollet, B., Andreelli, F., Birk, J. B., Hellsten, Y., Schjerling, P., Vaulont, S., Neufer, P. D., Richter, E. A. and Pilegaard, H. (2005) Effects of α-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle. FASEB J. 19, 1146-1148
-
(2005)
FASEB J
, vol.19
, pp. 1146-1148
-
-
Jorgensen, S.B.1
Wojtaszewski, J.F.2
Viollet, B.3
Andreelli, F.4
Birk, J.B.5
Hellsten, Y.6
Schjerling, P.7
Vaulont, S.8
Neufer, P.D.9
Richter, E.A.10
Pilegaard, H.11
-
50
-
-
33846012164
-
Role of AMPKα2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle
-
Jorgensen, S. B., Treebak, J. T., Viollet, B., Schjerling, P., Vaulont, S., Wojtaszewski, J. F. and Richter, E. A. (2007) Role of AMPKα2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle. Am. J. Physiol. Endocrinol. Metab. 292, E331-E339
-
(2007)
Am. J. Physiol. Endocrinol. Metab
, vol.292
-
-
Jorgensen, S.B.1
Treebak, J.T.2
Viollet, B.3
Schjerling, P.4
Vaulont, S.5
Wojtaszewski, J.F.6
Richter, E.A.7
-
51
-
-
58149099037
-
Gain-of-function R225Q mutation in AMP-activated protein kinase γ3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle
-
Garcia-Roves, P. M., Osler, M. E., Holmström, M. H. and Zierath, J. R. (2008) Gain-of-function R225Q mutation in AMP-activated protein kinase γ3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle. J. Biol. Chem. 283, 35724-35734
-
(2008)
J. Biol. Chem
, vol.283
, pp. 35724-35734
-
-
Garcia-Roves, P.M.1
Osler, M.E.2
Holmström, M.H.3
Zierath, J.R.4
-
52
-
-
33845596500
-
Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism
-
Handschin, C. and Spiegelman, B. M. (2006) Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr. Rev. 27, 728-735
-
(2006)
Endocr. Rev
, vol.27
, pp. 728-735
-
-
Handschin, C.1
Spiegelman, B.M.2
-
53
-
-
0037102256
-
Transcriptional co-activator PGC-1 α drives the formation of slow-twitch muscle fibres
-
Lin, J., Wu, H., Tarr, P. T., Zhang, C. Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N. et al. (2002) Transcriptional co-activator PGC-1 α drives the formation of slow-twitch muscle fibres. Nature 418, 797-801
-
(2002)
Nature
, vol.418
, pp. 797-801
-
-
Lin, J.1
Wu, H.2
Tarr, P.T.3
Zhang, C.Y.4
Wu, Z.5
Boss, O.6
Michael, L.F.7
Puigserver, P.8
Isotani, E.9
Olson, E.N.10
-
54
-
-
33847656213
-
Mitochondrial transcription factor A (TFAM): Roles in maintenance of mtDNA and cellular functions
-
Kang, D., Kim, S. H. and Hamasaki, N. (2007) Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions. Mitochondrion 7, 39-44
-
(2007)
Mitochondrion
, vol.7
, pp. 39-44
-
-
Kang, D.1
Kim, S.H.2
Hamasaki, N.3
-
55
-
-
4644309036
-
The 5′-AMP-activated protein kinase γ3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle
-
Barnes, B. R., Marklund, S., Steiler, T. L., Walter, M., Hjalm, G., Amerger, V., Mahlapuu, M., Leng, Y., Johansson, C., Galuska, D. et al. (2004) The 5′-AMP-activated protein kinase γ3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J. Biol. Chem. 279, 38441-38447
-
(2004)
J. Biol. Chem
, vol.279
, pp. 38441-38447
-
-
Barnes, B.R.1
Marklund, S.2
Steiler, T.L.3
Walter, M.4
Hjalm, G.5
Amerger, V.6
Mahlapuu, M.7
Leng, Y.8
Johansson, C.9
Galuska, D.10
-
56
-
-
48449094498
-
AMPK and PPARδ agonists are exercise mimetics
-
Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y. X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H. et al. (2008) AMPK and PPARδ agonists are exercise mimetics. Cell 134, 405-415
-
(2008)
Cell
, vol.134
, pp. 405-415
-
-
Narkar, V.A.1
Downes, M.2
Yu, R.T.3
Embler, E.4
Wang, Y.X.5
Banayo, E.6
Mihaylova, M.M.7
Nelson, M.C.8
Zou, Y.9
Juguilon, H.10
-
57
-
-
0041854190
-
AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions
-
Putman, C. T., Kiricsi, M., Pearcey, J., MacLean, I. M., Bamford, J. A., Murdoch, G. K., Dixon, W. T. and Pette, D. (2003) AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions. J. Physiol. 551, 169-178
-
(2003)
J. Physiol
, vol.551
, pp. 169-178
-
-
Putman, C.T.1
Kiricsi, M.2
Pearcey, J.3
MacLean, I.M.4
Bamford, J.A.5
Murdoch, G.K.6
Dixon, W.T.7
Pette, D.8
-
58
-
-
34547610976
-
Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift
-
Röckl, K. S., Hirshman, M. F., Brandauer, J., Fujii, N., Witters, L. A. and Goodyear, L. J. (2007) Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift. Diabetes 56, 2062-2069
-
(2007)
Diabetes
, vol.56
, pp. 2062-2069
-
-
Röckl, K.S.1
Hirshman, M.F.2
Brandauer, J.3
Fujii, N.4
Witters, L.A.5
Goodyear, L.J.6
-
59
-
-
4544386858
-
AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle
-
Holmes, B. F., Lang, D. B., Birnbaum, M. J., Mu, J. and Dohm, G. L. (2004) AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 287, E739-E743
-
(2004)
Am. J. Physiol. Endocrinol. Metab
, vol.287
-
-
Holmes, B.F.1
Lang, D.B.2
Birnbaum, M.J.3
Mu, J.4
Dohm, G.L.5
-
60
-
-
69949129312
-
Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo
-
Lee-Young, R. S., Griffee, S. R., Lynes, S. E., Bracy, D. P., Ayala, J. E., McGuinness, O. P. and Wasserman, D. H. (2009) Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo. J. Biol. Chem. 284, 23925-23934
-
(2009)
J. Biol. Chem
, vol.284
, pp. 23925-23934
-
-
Lee-Young, R.S.1
Griffee, S.R.2
Lynes, S.E.3
Bracy, D.P.4
Ayala, J.E.5
McGuinness, O.P.6
Wasserman, D.H.7
-
61
-
-
34547731363
-
Role of AMP-activated protein kinase in exercise capacity, whole body glucose homeostasis, and glucose transport in skeletal muscle: Insight from analysis of a transgenic mouse model
-
Fujii, N., Seifert, M. M., Kane, E. M., Peter, L. E., Ho, R. C., Winstead, S., Hirshman, M. F. and Goodyear, L. J. (2007) Role of AMP-activated protein kinase in exercise capacity, whole body glucose homeostasis, and glucose transport in skeletal muscle: insight from analysis of a transgenic mouse model. Diabetes Res. Clin. Pract. 77, (Suppl. 1), S92-S98
-
(2007)
Diabetes Res. Clin. Pract
, vol.77
, Issue.SUPPL. 1
-
-
Fujii, N.1
Seifert, M.M.2
Kane, E.M.3
Peter, L.E.4
Ho, R.C.5
Winstead, S.6
Hirshman, M.F.7
Goodyear, L.J.8
-
62
-
-
70349631803
-
Genetic impairment of α2-AMPK signaling does not reduce muscle glucose uptake during treadmill exercise in mice
-
Maarbjerg, S. J., Jorgensen, S. B., Rose, A. J., Jeppesen, J., Jensen, T. E., Treebak, J. T., Birk, J. B., Schjerling, P., Wojtaszewski, J. F. and Richter, E. A. (2009) Genetic impairment of α2-AMPK signaling does not reduce muscle glucose uptake during treadmill exercise in mice. Am. J. Physiol. Endocrinol. Metab. 297, E924-E934
-
(2009)
Am. J. Physiol. Endocrinol. Metab
, vol.297
-
-
Maarbjerg, S.J.1
Jorgensen, S.B.2
Rose, A.J.3
Jeppesen, J.4
Jensen, T.E.5
Treebak, J.T.6
Birk, J.B.7
Schjerling, P.8
Wojtaszewski, J.F.9
Richter, E.A.10
-
63
-
-
58149348480
-
Ablation of AMP-activated protein kinase α2 activity exacerbates insulin resistance induced by high-fat feeding of mice
-
Fujii, N., Ho, R. C., Manabe, Y., Jessen, N., Toyoda, T., Holland, W. L., Summers, S. A., Hirshman, M. F. and Goodyear, L. J. (2008) Ablation of AMP-activated protein kinase α2 activity exacerbates insulin resistance induced by high-fat feeding of mice. Diabetes 57, 2958-2966
-
(2008)
Diabetes
, vol.57
, pp. 2958-2966
-
-
Fujii, N.1
Ho, R.C.2
Manabe, Y.3
Jessen, N.4
Toyoda, T.5
Holland, W.L.6
Summers, S.A.7
Hirshman, M.F.8
Goodyear, L.J.9
-
64
-
-
70349886560
-
Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity
-
Jørgensen, S. B., O'Neill, H. M., Hewitt, K., Kemp, B. E. and Steinberg, G. R. (2009) Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity. Diabetologia 52, 2395-2404
-
(2009)
Diabetologia
, vol.52
, pp. 2395-2404
-
-
Jørgensen, S.B.1
O'Neill, H.M.2
Hewitt, K.3
Kemp, B.E.4
Steinberg, G.R.5
-
65
-
-
57049097476
-
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation
-
Dzamko, N., Schertzer, J. D., Ryall, J. G., Steel, R., Macaulay, S. L., Wee, S., Chen, Z. P., Michell, B. J., Oakhill, J. S., Watt, M. J. et al. (2008) AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. J. Physiol. 586, 5819-5831
-
(2008)
J. Physiol
, vol.586
, pp. 5819-5831
-
-
Dzamko, N.1
Schertzer, J.D.2
Ryall, J.G.3
Steel, R.4
Macaulay, S.L.5
Wee, S.6
Chen, Z.P.7
Michell, B.J.8
Oakhill, J.S.9
Watt, M.J.10
-
66
-
-
69949102948
-
Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle
-
Murgia, M., Jensen, T. E., Cusinato, M., Garcia, M., Richter, E. A. and Schiaffino, S. (2009) Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle. J. Physiol. 587, 4319-4327
-
(2009)
J. Physiol
, vol.587
, pp. 4319-4327
-
-
Murgia, M.1
Jensen, T.E.2
Cusinato, M.3
Garcia, M.4
Richter, E.A.5
Schiaffino, S.6
-
67
-
-
0034676455
-
Surfing the p53 network
-
Vogelstein, B., Lane, D. and Levine, A. J. (2000) Surfing the p53 network. Nature 408, 307-310
-
(2000)
Nature
, vol.408
, pp. 307-310
-
-
Vogelstein, B.1
Lane, D.2
Levine, A.J.3
-
68
-
-
33745149291
-
p53 regulates mitochondrial respiration
-
Matoba, S., Kang, J. G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F. and Hwang, P. M. (2006) p53 regulates mitochondrial respiration. Science 312, 1650-1653
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
69
-
-
66249089036
-
Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle
-
Saleem, A., Adhihetty, P. J. and Hood, D. A. (2009) Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle. Physiol. Genomics 37, 58-66
-
(2009)
Physiol. Genomics
, vol.37
, pp. 58-66
-
-
Saleem, A.1
Adhihetty, P.J.2
Hood, D.A.3
-
70
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J. and Thompson, C. B. (2005) AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol. Cell 18, 283-293
-
(2005)
Mol. Cell
, vol.18
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
Buzzai, M.4
Mu, J.5
Xu, Y.6
Birnbaum, M.J.7
Thompson, C.B.8
-
71
-
-
0035929359
-
Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, in a human hepatocellular carcinoma cell line
-
Imamura, K., Ogura, T., Kishimoto, A., Kaminishi, M. and Esumi, H. (2001) Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem. Biophys. Res. Commun. 287, 562-567
-
(2001)
Biochem. Biophys. Res. Commun
, vol.287
, pp. 562-567
-
-
Imamura, K.1
Ogura, T.2
Kishimoto, A.3
Kaminishi, M.4
Esumi, H.5
-
72
-
-
57749170458
-
The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
-
Haberland, M., Montgomery, R. L. and Olson, E. N. (2009) The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat. Rev. Genet. 10, 32-42
-
(2009)
Nat. Rev. Genet
, vol.10
, pp. 32-42
-
-
Haberland, M.1
Montgomery, R.L.2
Olson, E.N.3
-
73
-
-
0034685893
-
mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity
-
Lemercier, C., Verdel, A., Galloo, B., Curtet, S., Brocard, M. P. and Khochbin, S. (2000) mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity. J. Biol. Chem. 275, 15594-15599
-
(2000)
J. Biol. Chem
, vol.275
, pp. 15594-15599
-
-
Lemercier, C.1
Verdel, A.2
Galloo, B.3
Curtet, S.4
Brocard, M.P.5
Khochbin, S.6
-
74
-
-
0037452677
-
Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5
-
Czubryt, M. P., McAnally, J., Fishman, G. I. and Olson, E. N. (2003) Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5. Proc. Natl. Acad. Sci. U.S.A. 100, 1711-1716
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 1711-1716
-
-
Czubryt, M.P.1
McAnally, J.2
Fishman, G.I.3
Olson, E.N.4
-
75
-
-
42449161465
-
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5
-
McGee, S. L., van Denderen, B. J., Howlett, K. F., Mollica, J., Schertzer, J. D., Kemp, B. E. and Hargreaves, M. (2008) AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes 57, 860-867
-
(2008)
Diabetes
, vol.57
, pp. 860-867
-
-
McGee, S.L.1
van Denderen, B.J.2
Howlett, K.F.3
Mollica, J.4
Schertzer, J.D.5
Kemp, B.E.6
Hargreaves, M.7
-
76
-
-
0034597816
-
Signal-dependent nuclear export of a histone deactylase regulates muscle differentiation
-
McKinsey, T., Zhang, C. and Olson, E. N. (2000) Signal-dependent nuclear export of a histone deactylase regulates muscle differentiation. Nature 408, 106-111
-
(2000)
Nature
, vol.408
, pp. 106-111
-
-
McKinsey, T.1
Zhang, C.2
Olson, E.N.3
-
77
-
-
67049145833
-
HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells
-
Urbich, C., Rössig, L., Kaluza, D., Potente, M., Boeckel, J. N., Knau, A., Diehl, F., Geng, J. G., Hofmann, W. K., Zeiher, A. M. and Dimmeler, S. (2009) HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood 113, 5669-5679
-
(2009)
Blood
, vol.113
, pp. 5669-5679
-
-
Urbich, C.1
Rössig, L.2
Kaluza, D.3
Potente, M.4
Boeckel, J.N.5
Knau, A.6
Diehl, F.7
Geng, J.G.8
Hofmann, W.K.9
Zeiher, A.M.10
Dimmeler, S.11
-
78
-
-
33746228132
-
Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10
-
Chang, S., Young, B. D., Li, S., Qi, X., Richardson, J. A. and Olson, E. N. (2006) Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell 126, 321-334
-
(2006)
Cell
, vol.126
, pp. 321-334
-
-
Chang, S.1
Young, B.D.2
Li, S.3
Qi, X.4
Richardson, J.A.5
Olson, E.N.6
-
79
-
-
20444420893
-
An expression screen reveals modulators of class II histone deacetylase phosphorylation
-
Chang, S., Bezprozvannaya, S., Li, S. and Olson, E. N. (2005) An expression screen reveals modulators of class II histone deacetylase phosphorylation. Proc. Natl. Acad. Sci. U.S.A. 102, 8120-8125
-
(2005)
Proc. Natl. Acad. Sci. U.S.A
, vol.102
, pp. 8120-8125
-
-
Chang, S.1
Bezprozvannaya, S.2
Li, S.3
Olson, E.N.4
-
80
-
-
58149401189
-
Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
-
Choi, C. S., Befroy, D. E., Codella, R., Kim, S., Reznick, R. M., Hwang, Y. J., Liu, Z. X., Lee, H. Y., Distefano, A., Samuel, V. T. et al. (2008) Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc. Natl. Acad. Sci. U.S.A. 105, 19926-19931
-
(2008)
Proc. Natl. Acad. Sci. U.S.A
, vol.105
, pp. 19926-19931
-
-
Choi, C.S.1
Befroy, D.E.2
Codella, R.3
Kim, S.4
Reznick, R.M.5
Hwang, Y.J.6
Liu, Z.X.7
Lee, H.Y.8
Distefano, A.9
Samuel, V.T.10
-
81
-
-
42949083922
-
Modest PGC-1α overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria
-
Benton, C. R., Nickerson, J. G., Lally, J., Han, X. X., Holloway, G. P., Glatz, J. F., Luiken, J. J., Graham, T. E., Heikkila, J. J. and Bonen, A. (2008) Modest PGC-1α overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria. J. Biol. Chem. 283, 4228-4240
-
(2008)
J. Biol. Chem
, vol.283
, pp. 4228-4240
-
-
Benton, C.R.1
Nickerson, J.G.2
Lally, J.3
Han, X.X.4
Holloway, G.P.5
Glatz, J.F.6
Luiken, J.J.7
Graham, T.E.8
Heikkila, J.J.9
Bonen, A.10
-
82
-
-
34547545892
-
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
-
Jäger, S., Handschin, C., St-Pierre, J. and Spiegelman, B. M. (2007) AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proc. Natl. Acad. Sci. U.S.A. 104, 12017-12022
-
(2007)
Proc. Natl. Acad. Sci. U.S.A
, vol.104
, pp. 12017-12022
-
-
Jäger, S.1
Handschin, C.2
St-Pierre, J.3
Spiegelman, B.M.4
-
83
-
-
0035859836
-
Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor
-
Knutti, D., Kressler, D. and Kralli, A. (2001) Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proc. Natl. Acad. Sci. U.S.A. 98, 9713-9718
-
(2001)
Proc. Natl. Acad. Sci. U.S.A
, vol.98
, pp. 9713-9718
-
-
Knutti, D.1
Kressler, D.2
Kralli, A.3
-
84
-
-
0038810035
-
-
Handschin, C., Rhee, J., Lin, J., Tarr, P. T. ad Spiegelman and B.M. (2003) An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle. Proc. Natl. Acad. Sci. U.S.A. 100, 7111-7116
-
Handschin, C., Rhee, J., Lin, J., Tarr, P. T. ad Spiegelman and B.M. (2003) An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle. Proc. Natl. Acad. Sci. U.S.A. 100, 7111-7116
-
-
-
-
85
-
-
38949196761
-
PGC-1α is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle
-
Leick, L., Wojtaszewski, J. F., Johansen, S. T., Kiilerich, K., Comes, G., Hellsten, Y., Hidalgo, J. and Pilegaard, H. (2008) PGC-1α is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 294, E463-E474
-
(2008)
Am. J. Physiol. Endocrinol. Metab
, vol.294
-
-
Leick, L.1
Wojtaszewski, J.F.2
Johansen, S.T.3
Kiilerich, K.4
Comes, G.5
Hellsten, Y.6
Hidalgo, J.7
Pilegaard, H.8
-
86
-
-
62649165344
-
Identification and characterization of an alternative promoter of the human PGC-1α gene
-
Yoshioka, T., Inagaki, K., Noguchi, T., Sakai, M., Ogawa, W., Hosooka, T., Iguchi, H., Watanabe, E., Matsuki, Y., Hiramatsu, R. and Kasuga, M. (2009) Identification and characterization of an alternative promoter of the human PGC-1α gene. Biochem. Biophys. Res. Commun. 381, 537-543
-
(2009)
Biochem. Biophys. Res. Commun
, vol.381
, pp. 537-543
-
-
Yoshioka, T.1
Inagaki, K.2
Noguchi, T.3
Sakai, M.4
Ogawa, W.5
Hosooka, T.6
Iguchi, H.7
Watanabe, E.8
Matsuki, Y.9
Hiramatsu, R.10
Kasuga, M.11
-
87
-
-
38949119766
-
AMP-activated protein kinase phosphorylates transcription factors of the CREB family
-
Thomson, D. M., Herway, S. T., Fillmore, N., Kim, H., Brown, J. D., Barrow, J. R. and Winder, W.W. (2008) AMP-activated protein kinase phosphorylates transcription factors of the CREB family. J. Appl. Physiol. 104, 429-438
-
(2008)
J. Appl. Physiol
, vol.104
, pp. 429-438
-
-
Thomson, D.M.1
Herway, S.T.2
Fillmore, N.3
Kim, H.4
Brown, J.D.5
Barrow, J.R.6
Winder, W.W.7
-
88
-
-
0035855905
-
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
-
Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P. et al. (2001) CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413, 179-183
-
(2001)
Nature
, vol.413
, pp. 179-183
-
-
Herzig, S.1
Long, F.2
Jhala, U.S.3
Hedrick, S.4
Quinn, R.5
Bauer, A.6
Rudolph, D.7
Schutz, G.8
Yoon, C.9
Puigserver, P.10
-
89
-
-
34249664888
-
SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes
-
Berdeaux, R., Goebel, N., Banaszynski, L., Takemori, H., Wandless, T., Shelton, G. D. and Montminy, M. (2007) SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat. Med. 13, 597-603
-
(2007)
Nat. Med
, vol.13
, pp. 597-603
-
-
Berdeaux, R.1
Goebel, N.2
Banaszynski, L.3
Takemori, H.4
Wandless, T.5
Shelton, G.D.6
Montminy, M.7
-
90
-
-
33846003474
-
Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice
-
Thomson, D. M., Porter, B. B., Tall, J. H., Kim, H. J., Barrow, J. R. and Winder, W. W. (2007) Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice. Am. J. Physiol. Endocrinol. Metab. 292, E196-E202
-
(2007)
Am. J. Physiol. Endocrinol. Metab
, vol.292
-
-
Thomson, D.M.1
Porter, B.B.2
Tall, J.H.3
Kim, H.J.4
Barrow, J.R.5
Winder, W.W.6
-
91
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
-
Koo, S. H., Flechner, L., Qi, L., Zhang, X., Screaton, R. A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P. et al. (2005) The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437, 1109-1111
-
(2005)
Nature
, vol.437
, pp. 1109-1111
-
-
Koo, S.H.1
Flechner, L.2
Qi, L.3
Zhang, X.4
Screaton, R.A.5
Jeffries, S.6
Hedrick, S.7
Xu, W.8
Boussouar, F.9
Brindle, P.10
-
92
-
-
33749247065
-
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells
-
Wu, Z., Huang, X., Feng, Y., Handschin, C., Feng, Y., Gullicksen, P. S., Bare, O., Labow, M., Spiegelman, B. M. and Stevenson, S. C. (2006) Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells. Proc. Natl. Acad. Sci. U.S.A. 103, 14379-14384
-
(2006)
Proc. Natl. Acad. Sci. U.S.A
, vol.103
, pp. 14379-14384
-
-
Wu, Z.1
Huang, X.2
Feng, Y.3
Handschin, C.4
Feng, Y.5
Gullicksen, P.S.6
Bare, O.7
Labow, M.8
Spiegelman, B.M.9
Stevenson, S.C.10
-
93
-
-
34848861463
-
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
-
Greer, E. L., Oskoui, P. R., Banko, M. R., Maniar, J. M., Gygi, M. P., Gygi, S. P. and Brunet, A. (2007) The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J. Biol. Chem. 282, 30107-30119
-
(2007)
J. Biol. Chem
, vol.282
, pp. 30107-30119
-
-
Greer, E.L.1
Oskoui, P.R.2
Banko, M.R.3
Maniar, J.M.4
Gygi, M.P.5
Gygi, S.P.6
Brunet, A.7
-
94
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y. et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015
-
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
Lin, Y.6
Tran, H.7
Ross, S.E.8
Mostoslavsky, R.9
Cohen, H.Y.10
-
95
-
-
4544358547
-
Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control
-
Kamei, Y., Miura, S., Suzuki, M., Kai, Y., Mizukami, J., Taniguchi, T., Mochida, K., Hata, T., Matsuda, J., Aburatani, H. et al. (2004) Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J. Biol. Chem. 279, 41114-41123
-
(2004)
J. Biol. Chem
, vol.279
, pp. 41114-41123
-
-
Kamei, Y.1
Miura, S.2
Suzuki, M.3
Kai, Y.4
Mizukami, J.5
Taniguchi, T.6
Mochida, K.7
Hata, T.8
Matsuda, J.9
Aburatani, H.10
-
96
-
-
0036320801
-
Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase
-
Barthel, A., Schmoll, D., Kruger, K. D., Roth, R. A. and Joost, H. G. (2002) Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase. Endocrinology 143, 3183-3186
-
(2002)
Endocrinology
, vol.143
, pp. 3183-3186
-
-
Barthel, A.1
Schmoll, D.2
Kruger, K.D.3
Roth, R.A.4
Joost, H.G.5
-
97
-
-
0035665594
-
Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis
-
Bergeron, R., Ren, J. M., Cadman, K. S., Moore, I. K., Perret, P., Pypaert, M., Young, L. H., Semenkovich, C. F. and Shulman, G. I. (2001) Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. Am. J. Physiol. Endocrinol. Metab. 281, E1340-E1346
-
(2001)
Am. J. Physiol. Endocrinol. Metab
, vol.281
-
-
Bergeron, R.1
Ren, J.M.2
Cadman, K.S.3
Moore, I.K.4
Perret, P.5
Pypaert, M.6
Young, L.H.7
Semenkovich, C.F.8
Shulman, G.I.9
-
98
-
-
0034604547
-
Identification of a 30-base pair regulatory element and novel DNA binding protein that regulates the human GLUT4 promoter in transgenic mice
-
Oshel, K., Knight, J., Cao, K., Thai, M. and Olson, A. L. (2000) Identification of a 30-base pair regulatory element and novel DNA binding protein that regulates the human GLUT4 promoter in transgenic mice. J. Biol. Chem. 275, 23666-23673
-
(2000)
J. Biol. Chem
, vol.275
, pp. 23666-23673
-
-
Oshel, K.1
Knight, J.2
Cao, K.3
Thai, M.4
Olson, A.L.5
-
99
-
-
33644695373
-
Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase
-
Holmes, B. F., Sparling, D. P., Olson, A. L., Winder, W. W. and Dohm, G. L. (2005) Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase. Am. J. Physiol. Endocrinol. Metab. 289, E1071-E1076
-
(2005)
Am. J. Physiol. Endocrinol. Metab
, vol.289
-
-
Holmes, B.F.1
Sparling, D.P.2
Olson, A.L.3
Winder, W.W.4
Dohm, G.L.5
-
100
-
-
67349276169
-
+ metabolism and SIRT1 activity
-
+ metabolism and SIRT1 activity. Nature 458, 1056-1060
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Cantó, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
Milne, J.C.6
Elliott, P.J.7
Puigserver, P.8
Auwerx, J.9
-
101
-
-
0035913911
-
Negative control of p53 by Sir2α promotes cell survival under stress
-
Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L. and Gu, W. (2001) Negative control of p53 by Sir2α promotes cell survival under stress. Cell 107, 137-148
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
|