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Volumn 48, Issue 4, 2007, Pages 826-836

Effects of forced uncoupling protein 1 expression in 3T3-L1 cells on mitochondrial function and lipid metabolism

Author keywords

Adipocyte metabolic profile; Cellular ATP content; Glucose starvation

Indexed keywords

BIOLOGICAL MARKER; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; LEPTIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2;

EID: 34147147434     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600343-JLR200     Document Type: Article
Times cited : (44)

References (56)
  • 1
    • 0032577308 scopus 로고    scopus 로고
    • Obesity: How big a problem?
    • Wickelgren, I. 1998. Obesity: how big a problem? Science. 280: 1364-1367.
    • (1998) Science , vol.280 , pp. 1364-1367
    • Wickelgren, I.1
  • 2
    • 0033656405 scopus 로고    scopus 로고
    • From obesity to diabetes: Why, when and who?
    • Scheen, A. J. 2000. From obesity to diabetes: why, when and who? Acta Clin. Belg. 55: 9-15.
    • (2000) Acta Clin. Belg , vol.55 , pp. 9-15
    • Scheen, A.J.1
  • 3
    • 0035936763 scopus 로고    scopus 로고
    • New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
    • Saltiel, A. R. 2001. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell. 104: 517-529.
    • (2001) Cell , vol.104 , pp. 517-529
    • Saltiel, A.R.1
  • 5
    • 0028091785 scopus 로고
    • Regional adiposity and morbidity
    • Kissebah, A. H., and G. R. Krakower. 1994. Regional adiposity and morbidity. Physiol. Rev. 74: 761-811.
    • (1994) Physiol. Rev , vol.74 , pp. 761-811
    • Kissebah, A.H.1    Krakower, G.R.2
  • 8
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil, G. S., N. S. Shargill, and B. M. Spiegelman. 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 259: 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 9
    • 0030731621 scopus 로고    scopus 로고
    • NIDDM as a disease of the innate immune system: Association of acute-phase reactants and interleukin-6 with metabolic syndrome X
    • Pickup, J. C., M. B. Mattock, G. D. Chusney, and D. Burt. 1997. NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia. 40: 1286-1292.
    • (1997) Diabetologia , vol.40 , pp. 1286-1292
    • Pickup, J.C.1    Mattock, M.B.2    Chusney, G.D.3    Burt, D.4
  • 10
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden, G. 1997. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes. 46: 3-10.
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 11
    • 0030759095 scopus 로고    scopus 로고
    • The role of nonesterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: Results of the Paris Prospective Study
    • Charles, M. A., E. Eschwege, N. Thibult, J. R. Claude, J. M. Warnet, G. E. Rosselin, J. Girard, and B. Balkau. 1997. The role of nonesterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study. Diabetologia. 40: 1101-1106.
    • (1997) Diabetologia , vol.40 , pp. 1101-1106
    • Charles, M.A.1    Eschwege, E.2    Thibult, N.3    Claude, J.R.4    Warnet, J.M.5    Rosselin, G.E.6    Girard, J.7    Balkau, B.8
  • 12
    • 0029049346 scopus 로고
    • A high concentration of fasting plasma nonesterified fatty acids is a risk factor for the development of NIDDM
    • Paolisso, G., P. A. Tataranni, J. E. Foley, C. Bogardus, B. V. Howard, and E. Ravussin. 1995. A high concentration of fasting plasma nonesterified fatty acids is a risk factor for the development of NIDDM. Diabetologia. 38: 1213-1217.
    • (1995) Diabetologia , vol.38 , pp. 1213-1217
    • Paolisso, G.1    Tataranni, P.A.2    Foley, J.E.3    Bogardus, C.4    Howard, B.V.5    Ravussin, E.6
  • 13
    • 0346690101 scopus 로고    scopus 로고
    • NO-1886 inhibits size of adipocytes, suppresses plasma levels of tumor necrosis factor-[alpha] and free fatty acids, improves glucose metabolism in high-fat/high-sucrosefed miniature pigs
    • Yin, W., D. Liao, Z. Wang, S. Xi, K. Tsutsumi, T. Koike, J. Fan, G. Yi, Q. Zhang, Z. Yuan, et al. 2004. NO-1886 inhibits size of adipocytes, suppresses plasma levels of tumor necrosis factor-[alpha] and free fatty acids, improves glucose metabolism in high-fat/high-sucrosefed miniature pigs. Pharmacol. Res. 49: 199-206.
    • (2004) Pharmacol. Res , vol.49 , pp. 199-206
    • Yin, W.1    Liao, D.2    Wang, Z.3    Xi, S.4    Tsutsumi, K.5    Koike, T.6    Fan, J.7    Yi, G.8    Zhang, Q.9    Yuan, Z.10
  • 15
    • 0021322138 scopus 로고
    • Thermogenic mechanisms in brown fat
    • Nicholls, D. G., and R. M. Locke. 1984. Thermogenic mechanisms in brown fat. Physiol. Rev. 64: 1-64.
    • (1984) Physiol. Rev , vol.64 , pp. 1-64
    • Nicholls, D.G.1    Locke, R.M.2
  • 16
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky, J., G. Clarke, S. Enerback, B. Spiegelman, and L. P. Kozak. 1995. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Invest. 96: 2914-2923.
    • (1995) J. Clin. Invest , vol.96 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerback, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 20
    • 33646038669 scopus 로고    scopus 로고
    • Cultures of human adipose precursor cells
    • G. Ailhaud, editor. Humana Press, Totowa, NJ. xiii
    • Hauner, H., T. Skurk, and M. Wabitsch. 2001. Cultures of human adipose precursor cells. In Adipose Tissue Protocols. G. Ailhaud, editor. Humana Press, Totowa, NJ. xiii.
    • (2001) Adipose Tissue Protocols
    • Hauner, H.1    Skurk, T.2    Wabitsch, M.3
  • 21
    • 0034694128 scopus 로고    scopus 로고
    • Effect of experimental treatment on housekeeping gene expression: Validation by realtime, quantitative RT-PCR
    • Schmittgen, T. D., and B. A. Zakrajsek. 2000. Effect of experimental treatment on housekeeping gene expression: validation by realtime, quantitative RT-PCR. J. Biochem. Biophys. Methods. 46: 69-81.
    • (2000) J. Biochem. Biophys. Methods , vol.46 , pp. 69-81
    • Schmittgen, T.D.1    Zakrajsek, B.A.2
  • 22
    • 0035370048 scopus 로고    scopus 로고
    • A high-capacity screen for adipogenic differentiation
    • Sottile, V., and K. Seuwen. 2001. A high-capacity screen for adipogenic differentiation. Anal. Biochem. 293: 124-128.
    • (2001) Anal. Biochem , vol.293 , pp. 124-128
    • Sottile, V.1    Seuwen, K.2
  • 23
    • 0014478342 scopus 로고
    • Determination of blood glucose using an oxidaseperoxidase system with a non-carcinogenic chromogen
    • Trinder, P. 1969. Determination of blood glucose using an oxidaseperoxidase system with a non-carcinogenic chromogen. J. Clin. Pathol. 22: 158-161.
    • (1969) J. Clin. Pathol , vol.22 , pp. 158-161
    • Trinder, P.1
  • 24
    • 0000251344 scopus 로고
    • An enzymatic fluorometric method for the determination of lactic acid in serum
    • Loomis, M. E. 1961. An enzymatic fluorometric method for the determination of lactic acid in serum. J. Lab. Clin. Med. 57: 966-969.
    • (1961) J. Lab. Clin. Med , vol.57 , pp. 966-969
    • Loomis, M.E.1
  • 25
    • 2942596022 scopus 로고    scopus 로고
    • Method for determining oxygen consumption rates of static cultures from microplate measurements of pericellular dissolved oxygen concentration
    • Guarino, R. D., L. E. Dike, T. A. Haq, J. A. Rowley, J. B. Pitner, and M. R. Timmins. 2004. Method for determining oxygen consumption rates of static cultures from microplate measurements of pericellular dissolved oxygen concentration. Biotechnol. Bioeng. 86: 775-787.
    • (2004) Biotechnol. Bioeng , vol.86 , pp. 775-787
    • Guarino, R.D.1    Dike, L.E.2    Haq, T.A.3    Rowley, J.A.4    Pitner, J.B.5    Timmins, M.R.6
  • 26
    • 1442300762 scopus 로고    scopus 로고
    • Chronological changes in metabolism and functions of cultured adipocytes: A hypothesis for cell aging in mature adipocytes
    • Yu, Y. H., and H. Zhu. 2004. Chronological changes in metabolism and functions of cultured adipocytes: a hypothesis for cell aging in mature adipocytes. Am. J. Physiol. Endocrinol. Metab. 286: E402-E410.
    • (2004) Am. J. Physiol. Endocrinol. Metab , vol.286
    • Yu, Y.H.1    Zhu, H.2
  • 29
    • 0034650763 scopus 로고    scopus 로고
    • The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    • Ricquier, D., and F. Bouillaud. 2000. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem. J. 345: 161-179.
    • (2000) Biochem. J , vol.345 , pp. 161-179
    • Ricquier, D.1    Bouillaud, F.2
  • 30
    • 0030040740 scopus 로고    scopus 로고
    • Regulation of ob gene mRNA levels in cultured adipocytes
    • Rentsch, J., and M. Chiesi. 1996. Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett. 379: 55-59.
    • (1996) FEBS Lett , vol.379 , pp. 55-59
    • Rentsch, J.1    Chiesi, M.2
  • 31
    • 0016693548 scopus 로고
    • An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion
    • Green, H., and O. Kehinde. 1975. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell. 5: 19-27.
    • (1975) Cell , vol.5 , pp. 19-27
    • Green, H.1    Kehinde, O.2
  • 33
    • 0014471588 scopus 로고
    • The effect of 2,4-dinitrophenol on adipose-tissue metabolism
    • Rognstad, R., and J. Katz. 1969. The effect of 2,4-dinitrophenol on adipose-tissue metabolism. Biochem. J. 111: 431-444.
    • (1969) Biochem. J , vol.111 , pp. 431-444
    • Rognstad, R.1    Katz, J.2
  • 34
    • 0033823015 scopus 로고    scopus 로고
    • Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue
    • Rossmeisl, M., I. Syrovy, F. Baumruk, P. Flachs, P. Janovska, and J. Kopecky. 2000. Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue. FASEB J. 14: 1793-1800.
    • (2000) FASEB J , vol.14 , pp. 1793-1800
    • Rossmeisl, M.1    Syrovy, I.2    Baumruk, F.3    Flachs, P.4    Janovska, P.5    Kopecky, J.6
  • 36
    • 0034532010 scopus 로고    scopus 로고
    • The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat
    • Emilsson, V., J. O'Dowd, S. Wang, Y. L. Liu, M. Sennitt, R. Heyman, and M. A. Cawthorne. 2000. The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat. Metabolism. 49: 1610-1615.
    • (2000) Metabolism , vol.49 , pp. 1610-1615
    • Emilsson, V.1    O'Dowd, J.2    Wang, S.3    Liu, Y.L.4    Sennitt, M.5    Heyman, R.6    Cawthorne, M.A.7
  • 37
    • 0034085884 scopus 로고    scopus 로고
    • A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice
    • Fukui, Y., S. Masui, S. Osada, K. Umesono, and K. Motojima. 2000. A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes. 49: 759-767.
    • (2000) Diabetes , vol.49 , pp. 759-767
    • Fukui, Y.1    Masui, S.2    Osada, S.3    Umesono, K.4    Motojima, K.5
  • 38
    • 0031693322 scopus 로고    scopus 로고
    • Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes
    • Matsuda, J., K. Hosoda, H. Itoh, C. Son, K. Doi, I. Hanaoka, G. Inoue, H. Nishimura, Y. Yoshimasa, Y. Yamori, et al. 1998. Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes. Diabetes. 47: 1809-1814.
    • (1998) Diabetes , vol.47 , pp. 1809-1814
    • Matsuda, J.1    Hosoda, K.2    Itoh, H.3    Son, C.4    Doi, K.5    Hanaoka, I.6    Inoue, G.7    Nishimura, H.8    Yoshimasa, Y.9    Yamori, Y.10
  • 40
    • 0036606567 scopus 로고    scopus 로고
    • Impaired noradrenaline-induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels
    • Flachs, P., J. Novotny, F. Baumruk, K. Bardova, L. Bourova, I. Miksik, J. Sponarova, P. Svoboda, and J. Kopecky. 2002. Impaired noradrenaline-induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels. Biochem. J. 364: 369-376.
    • (2002) Biochem. J , vol.364 , pp. 369-376
    • Flachs, P.1    Novotny, J.2    Baumruk, F.3    Bardova, K.4    Bourova, L.5    Miksik, I.6    Sponarova, J.7    Svoboda, P.8    Kopecky, J.9
  • 41
    • 0029894407 scopus 로고    scopus 로고
    • Reduction of dietary obesity in aP2-Ucp transgenic mice: Mechanism and adipose tissue morphology
    • Kopecky, J., M. Rossmeisl, Z. Hodny, I. Syrovy, M. Horakova, and P. Kolarova. 1996. Reduction of dietary obesity in aP2-Ucp transgenic mice: mechanism and adipose tissue morphology. Am. J. Physiol. 270: E776-E786.
    • (1996) Am. J. Physiol , vol.270
    • Kopecky, J.1    Rossmeisl, M.2    Hodny, Z.3    Syrovy, I.4    Horakova, M.5    Kolarova, P.6
  • 42
    • 0033580852 scopus 로고    scopus 로고
    • Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells
    • Li, B., J. O. Holloszy, and C. F. Semenkovich. 1999. Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells. J. Biol. Chem. 274: 17534-17540.
    • (1999) J. Biol. Chem , vol.274 , pp. 17534-17540
    • Li, B.1    Holloszy, J.O.2    Semenkovich, C.F.3
  • 43
    • 0027532692 scopus 로고
    • Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells
    • Bashan, N., E. Burdett, A. Guma, R. Sargeant, L. Tumiati, Z. Liu, and A. Klip. 1993. Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells. Am. J. Physiol. 264: C430-C440.
    • (1993) Am. J. Physiol , vol.264
    • Bashan, N.1    Burdett, E.2    Guma, A.3    Sargeant, R.4    Tumiati, L.5    Liu, Z.6    Klip, A.7
  • 44
    • 0024318634 scopus 로고
    • Enhanced glucose transport in response to inhibition of respiration in Clone 9 cells
    • Mercado, C. L., J. N. Loeb, and F. Ismail-Beigi. 1989. Enhanced glucose transport in response to inhibition of respiration in Clone 9 cells. Am. J. Physiol. 257: C19-C28.
    • (1989) Am. J. Physiol , vol.257
    • Mercado, C.L.1    Loeb, J.N.2    Ismail-Beigi, F.3
  • 45
    • 0035023211 scopus 로고    scopus 로고
    • Effects of cellular ATP depletion on glucose transport and insulin signaling in 3T3-L1 adipocytes
    • Kang, J., E. Heart, and C. K. Sung. 2001. Effects of cellular ATP depletion on glucose transport and insulin signaling in 3T3-L1 adipocytes. Am. J. Physiol. Endocrinol. Metab. 280: E428-E435.
    • (2001) Am. J. Physiol. Endocrinol. Metab , vol.280
    • Kang, J.1    Heart, E.2    Sung, C.K.3
  • 47
  • 48
    • 0026341287 scopus 로고
    • Effect of inhibition of the mitochondrial ATPase on net myocardial ATP in total ischemia
    • Jennings, R. B., K. A. Reimer, and C. Steenbergen. 1991. Effect of inhibition of the mitochondrial ATPase on net myocardial ATP in total ischemia. J. Mol. Cell. Cardiol. 23: 1383-1395.
    • (1991) J. Mol. Cell. Cardiol , vol.23 , pp. 1383-1395
    • Jennings, R.B.1    Reimer, K.A.2    Steenbergen, C.3
  • 49
  • 50
    • 0033953115 scopus 로고    scopus 로고
    • Steady-state and pre-steady-state kinetics of the mitochondrial F(1)F(o) ATPase: Is ATP synthase a reversible molecular machine?
    • Vinogradov, A. D. 2000. Steady-state and pre-steady-state kinetics of the mitochondrial F(1)F(o) ATPase: is ATP synthase a reversible molecular machine? J. Exp. Biol. 203: 41-49.
    • (2000) J. Exp. Biol , vol.203 , pp. 41-49
    • Vinogradov, A.D.1
  • 51
    • 0142093596 scopus 로고    scopus 로고
    • Metabolic partitioning of endogenous fatty acid in adipocytes
    • Wang, T., Y. Zang, W. Ling, B. E. Corkey, and W. Guo. 2003. Metabolic partitioning of endogenous fatty acid in adipocytes. Obes. Res. 11: 880-887.
    • (2003) Obes. Res , vol.11 , pp. 880-887
    • Wang, T.1    Zang, Y.2    Ling, W.3    Corkey, B.E.4    Guo, W.5
  • 52
    • 0035917865 scopus 로고    scopus 로고
    • Cooperation and competition in the evolution of ATP-producing pathways
    • Pfeiffer, T., S. Schuster, and S. Bonhoeffer. 2001. Cooperation and competition in the evolution of ATP-producing pathways. Science. 292: 504-507.
    • (2001) Science , vol.292 , pp. 504-507
    • Pfeiffer, T.1    Schuster, S.2    Bonhoeffer, S.3
  • 53
    • 0141521643 scopus 로고    scopus 로고
    • New insights into the bioenergetics of mitochondrial disorders using intracellular ATP reporters
    • Gajewski, C. D., L. Yang, E. A. Schon, and G. Manfredi. 2003. New insights into the bioenergetics of mitochondrial disorders using intracellular ATP reporters. Mol. Biol. Cell. 14: 3628-3635.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 3628-3635
    • Gajewski, C.D.1    Yang, L.2    Schon, E.A.3    Manfredi, G.4
  • 54
    • 0028001390 scopus 로고
    • ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibition
    • Nieminen, A. L., A. K. Saylor, B. Herman, and J. J. Lemasters. 1994. ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibition. Am. J. Physiol. 267: C67-C74.
    • (1994) Am. J. Physiol , vol.267
    • Nieminen, A.L.1    Saylor, A.K.2    Herman, B.3    Lemasters, J.J.4
  • 55
    • 0027411294 scopus 로고
    • ATP synthase activity is required for fructose to protect cultured hepatocytes from the toxicity of cyanide
    • Snyder, J. W., J. G. Pastorino, A. P. Thomas, J. B. Hoek, and J. L. Farber. 1993. ATP synthase activity is required for fructose to protect cultured hepatocytes from the toxicity of cyanide. Am. J. Physiol. 264: C709-C714.
    • (1993) Am. J. Physiol , vol.264
    • Snyder, J.W.1    Pastorino, J.G.2    Thomas, A.P.3    Hoek, J.B.4    Farber, J.L.5
  • 56
    • 0028802746 scopus 로고
    • A hierarchy of ATP-consuming processes in mammalian cells
    • Buttgereit, F., and M. D. Brand. 1995. A hierarchy of ATP-consuming processes in mammalian cells. Biochem. J. 312: 163-167.
    • (1995) Biochem. J , vol.312 , pp. 163-167
    • Buttgereit, F.1    Brand, M.D.2


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