Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue

FASEB Journal

Volumn 14, Issue 12, 2000, Pages 1793-1800

  Rossmeisl, M ^a   Syrovy, I ^a   Baumruk, F ^a   Flachs, P ^a   Janovska, P ^a   Kopecky, J ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

3T3 L1; C57BL 6J mice; Lipogenesis; Obesity; UCP

Indexed keywords

2,4 DINITROPHENOL; ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTIC ACID; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 1;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENERGY CONVERSION; ENERGY EXPENDITURE; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; LIPOGENESIS; MALE; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OBESITY; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WHITE ADIPOSE TISSUE;

ANIMALIA; MUS MUSCULUS;

EID: 0033823015     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.99-0965com     Document Type: Article

References (51)

1. Effect of carbohydrate intake on de novo lipogenesis in human adipose tissue
2. The effect of 2,4-dinitrophenol on adipose-tissue metabolism
3. Metabolism of pyruvate and malate by isolated fat-cell mitochondria
4. Carboxylation of pyruvate by isolated rat adipose tissue mitochondria
5. Octanoate affects 2,4-dinitrophenol uncoupling in intact isolated rat hepatocytes
6. Conversion of carbohydrate to fat in adipose tissue: An energy-yielding and, therefore, self-limiting process
7. + leak in mitochondria and its relevance to metabolic rate
8. Structure and function of the uncoupling proteins from brown adipose tissue
9. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
10. Cloning and characterization of an uncoupling protein homolog
11. Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
12. UCP3: An uncoupling homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
13. Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
14. Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
15. Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice
16. Uncoupling protein gene: Quantification of expression levels in adipose tissues of obese and non-obese humans
17. Uncoupling protein-2 gene: Reduced mRNA expression in intraperitoneal adipose tissue of obese humans
18. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
19. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
20. Reduction of dietary obesity in the aP2-Ucp transgenic mice: Physiology and adipose tissue distribution
21. Reduction of dietary obesity in the aP2-Ucp transgenic mice: Mechanism and adipose tissue morphology
22. Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice
23. Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential
24. Lipid metabolism in obesity resistant aP2-Ucp transgenic mice
25. Subline of mouse 3T3 cells that accumulate lipid
26. Identification of a potent adipocyte-specific enhancer: Involvement of an NF-1-like factor
27. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation
28. A simple, rapid, and sensitive DNA assay procedure
29. Mechanisms whereby prolactin modulates lipogenesis in sheep mammary gland
30. Acute effect in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats
31. Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells
32. Reversing adipocyte differentiation: Implications for treatment of obesity
33. Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells
34. ATP balance and the effect of 2,4-dinitrophenol on fatty acid synthesis
35. Transgenic mice overexpressing the betal-adrenergic receptor in adipose tissue are resistant to obesity
36. The energy balance of triacylglycerol metabolism in isolated rat adipocytes and the effect of insulin
37. Fasting-mediated alteration studies in insulin action on lipolysis and lipogenesis in obese women
38. Regulation of fatty acid synthesis and malonyl-CoA content in mouse brown adipose tissue in response to cold-exposure, starvation or re-feeding
39. Nutritional regulation of lipogenic enzyme gene expression in rat epididymal adipose tissue
40. Hepatic and adipose tissue lipogenic enzyme mRNA levels are suppressed by high fat diets in the rat
41. Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans
42. Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans
43. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity
44. Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes
45. Nicotine induced uncoupling protein i in white adipose tissue of obese mice
46. Beta3-adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers
47. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin
48. Lipogenesis in rat brown adipocytes
49. Enzymes related to lipogenesis in the adipose tissue of obese subject
50. Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes
51. Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating rat liver