Dendritic cells: Arbiters of immunity and immunological tolerance

Cold Spring Harbor Perspectives in Biology

Volumn 4, Issue 8, 2012, Pages

  Lewis, Kanako L ^a   Reizis, Boris ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR IMMUNITY; DENDRITIC CELL; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84865639341     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a007401     Document Type: Article

References (114)

1. + T lymphocyte responses. J Immunol 172: 3725-3735.
2. + dendritic cells. J Exp Med 207: 1273-1281.
3. + dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci 107: 14745-14750.
4. Bar-On L, Birnberg T, KimKW, Jung S. 2011. Dendritic cellrestricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation. Eur J Immunol 41: 291-298.
5. Bell SJ, Rigby R, English N, Mann SD, Knight SC, Kamm MA, Stagg AJ. 2001. Migration and maturation of human colonic dendritic cells. J Immunol 166: 4958-4967.
6. Belz GT, Nutt SL. 2012. Transcriptional programming of the dendritic cell network. Nat Rev Immunol 12: 101-113.
7. Bierly AL, Shufesky WJ, Sukhumavasi W, Morelli AE Denkers EY. 2008. Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection. J Immunol 181: 8485-8491.
8. Birnberg T, Bar-On L, Sapoznikov A, Caton ML, Cervantes-Barragan L, Makia D, Krauthgamer R, Brenner O, Ludewig B, BrockschniederD, et al. 2008. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 29: 986-997.
9. Bogunovic M, Ginhoux F, Helft J, Shang L, Hashimoto D, Greter M, Liu K, Jakubzick C, Ingersoll MA, Leboeuf M, et al. 2009. Origin of the lamina propria dendritic cell network. Immunity 31: 513-525.
10. Bonasio R, Scimone ML, Schaerli P, Grabie N, Lichtman AH, von Andrian UH. 2006. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 7: 1092-1100.
11. Cervantes-Barragan L, Zust R, Weber F, Spiegel M, Lang KS Akira S, Thiel V, Ludewig B. 2007. Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. Blood 109: 1131-1137.
12. Cervantes-Barragan L, Lewis KL, Firner S, ThielV, Hugues S Reith W, Ludewig B, Reizis B. 2012. Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc Natl Acad Sci 109: 3012-3017.
13. Chen M, Wang YH, Wang Y, Huang L, Sandoval H, Liu YJ Wang J. 2006. Dendritic cell apoptosis in the maintenance of immune tolerance. Science 311: 1160-1164.
14. Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, HolmbergD, Zweier C, den Hollander NS, Kant SG, et al. 2008. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 135: 37-48.
15. Collin M, Bigley V, Haniffa M, Hambleton S. 2011. Human dendritic cell deficiency: The missing ID? Nat Rev Immunol 11: 575-583.
16. Collins CB, Aherne CM, McNamee EN, Lebsack MD, Eltzschig H, Jedlicka P, Rivera-Nieves J. 2011. Flt3 ligand expands CD103{thorn} dendritic cells and FoxP3{thorn} Tregulatory cells, and attenuates Crohn's-like murine ileitis. Gut doi: 10.1136/gutjnl-2011-300820.
17. Crozat K, Guiton R, Contreras V, Feuillet V, Dutertre CA, Ventre E, VuManh TP, Baranek T, Storset AK, Marvel J, et al. 2010a. The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8a{thorn} dendritic cells. J Exp Med 207: 1283-1292.
18. Crozat K, Guiton R, Guilliams M, Henri S, Baranek T Schwartz-Cornil I, Malissen B, Dalod M. 2010b. Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets. Immunol Rev 234: 177-198.
19. Darrasse-Jeze G, Deroubaix S, Mouquet H, Victora GD, Eisenreich T, Yao KH, Masilamani RF, Dustin ML, Rudensky A, Liu K, et al. 2009. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med 206: 1853-1862.
20. den Haan JM, Lehar SM, Bevan MJ. 2000. CD8{thorn} but not CD82 dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med 192: 1685-1696.
21. Denning TL, Norris BA, Medina-Contreras O, Manicassamy S, Geem D, Madan R, Karp CL, Pulendran B. 2011. Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization. J Immunol 187: 733-747.
22. Diamond MS, Kinder M, Matsushita H, Mashayekhi M, Dunn GP, Archambault JM, Lee H, Arthur CD, White JM, Kalinke U, et al. 2011. Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med 208: 1989-2003.
23. Dudziak D, Kamphorst AO, Heidkamp GF, Buchholz VR, Trumpfheller C, Yamazaki S, Cheong C, Liu K, Lee HW Park CG, et al. 2007. Differential antigen processing by dendritic cell subsets in vivo. Science 315: 107-111.
24. Edelson BT, Kc W, Juang R, Kohyama M, Benoit LA, Klekotka PA, Moon C, Albring JC, IseW, Michael DG, et al. 2010. Peripheral CD103{thorn} dendritic cells form a unified subset developmentally related to CD8a{thorn} conventional dendritic cells. J Exp Med 207: 823-836.
25. Edelson BT, Bradstreet TR, Hildner K, Carrero JA, Frederick KE, Kc W, Belizaire R, Aoshi T, Schreiber RD, Miller MJ, et al. 2011. CD8a{thorn} dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes. Immunity 35: 236-248.
26. Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P Sorensen C, Werb Z, Egeblad M, Krummel MF. 2012. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell 21: 402-417.
27. FuertesMB, Kacha AK, Kline J, Woo SR, Kranz DM, Murphy KM, Gajewski TF. 2011. Host type I IFN signals are required for antitumor CD8{thorn} T cell responses through CD8a{thorn} dendritic cells. J Exp Med 208: 2005-2016.
28. Gallegos AM, Bevan MJ. 2004. Central tolerance to tissuespecific antigens mediated by direct and indirect antigen presentation. J Exp Med 200: 1039-1049.
29. Garbi N, Hammerling GJ, Probst HC, van den Broek M. 2010. Tonic T cell signalling and T cell tolerance as opposite effects of self-recognition on dendritic cells. Curr Opin Immunol 22: 601-608.
30. Gaspar M, May JS, Sukla S, Frederico B, Gill MB, Smith CM Belz GT, Stevenson PG. 2011. Murid herpesvirus-4 exploits dendritic cells to infect B cells. PLoS Pathog 7: e1002346.
31. Geissmann F, Manz MG, Jung S, Sieweke MH, MeradM, Ley K. 2010. Development of monocytes, macrophages, and dendritic cells. Science 327: 656-661.
32. Ghosh HS, Cisse B, Bunin A, Lewis KL, Reizis B. 2010. Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity 33: 905-916.
33. Hadeiba H, Sato T, Habtezion A, Oderup C, Pan J, Butcher EC. 2008. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versushost disease. Nat Immunol 9: 1253-1260.
34. Hadeiba H, Lahl K, Edalati A, Oderup C, Habtezion A, Pachynski R, Nguyen L, Ghodsi A, Adler S, Butcher EC. 2012. Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance. Immunity 36: 438-450.
35. Hambleton S, Salem S, Bustamante J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez L, Bacon CM, et al. 2011. IRF8 mutations and human dendritic-cell immunodeficiency. N Engl J Med 365: 127-138.
36. Hamme GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, et al. 2011. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol 12: 1184-1193.
37. Hawiger D, Inaba K, Dorsett Y, Guo M, Mahnke K, Rivera M, Ravetch JV, Steinman RM, Nussenzweig MC. 2001. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 194: 769-779.
38. Hawiger D, Masilamani RF, Bettelli E, Kuchroo VK, Nussenzweig MC. 2004. Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. Immunity 20: 695-705.
39. + dendritic cells in cytotoxic T cell immunity. Science 322: 1097-1100.
40. Hochweller K, Miloud T, Striegler J, Naik S, Hammerling GJ Garbi N. 2009. Homeostasis of dendritic cells in lymphoid organs is controlled by regulation of their precursors via a feedback loop. Blood 114: 4411-4421.
41. Hochweller K, Wabnitz GH, Samstag Y, Suffner J, Hammerling GJ, Garbi N. 2010. Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen. Proc Natl Acad Sci 107: 5931-5936.
42. Hubert FX, Kinkel SA, Davey GM, Phipson B, Mueller SN, Liston A, Proietto AI, Cannon PZ, Forehan S, Smyth GK, et al. 2011. Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood 118: 2462-2472.
43. Irla M, Kupfer N, Suter T, Lissilaa R, Benkhoucha M, Skupsky J, Lalive PH, Fontana A, Reith W, Hugues S. 2010. MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity. J Exp Med 207: 1891-1905.
44. + dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med 205: 2139-2149.
45. + dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. J Exp Med 207: 1247-1260.
46. Kasahara S, Clark EA. 2012. Dendritic cell-associated lectin 2 (DCAL2) defines a distinct CD8a-dendritic cell subset. J Leukoc Biol 91: 437-448.
47. Kim JM, Rasmussen JP, Rudensky AY. 2007. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 8: 191-197.
48. Kim SJ, Zou YR, Goldstein J, Reizis B, Diamond B. 2011. Tolerogenic function of Blimp-1 in dendritic cells. J Exp Med 208: 2193-2199.
49. Klein L, Hinterberger M, von Rohrscheidt J, Aichinger M. 2011. Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance. Trends Immunol 32: 188-193.
50. Knight SC, Balfour BM, O'Brien J, Buttifant L, Sumerska T Clarke J. 1982. Role of veiled cells in lymphocyte activation. Eur J Immunol 12: 1057-1060.
51. Kool M, van Loo G, WaelputW, De Prijck S, Muskens F, Sze M, van Praet J, Branco-Madeira F, Janssens S, Reizis B, et al. 2011. The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity. Immunity 35: 82-96.
52. + dendritic cells. Proc Natl Acad Sci 109: 3457-3462.
53. Lacy-Hulbert A, Smith AM, Tissire H, Barry M, Crowley D Bronson RT, Roes JT, Savill JS, Hynes RO. 2007. Ulcerative colitis and autoimmunity induced by loss of myeloid av integrins. Proc Natl Acad Sci 104: 15823-15828.
54. Lei Y, Ripen AM, Ishimaru N, Ohigashi I, Nagasawa T, Jeker LT, Bosl MR, Hollander GA, Hayashi Y, Malefyt RdeW, et al. 2011. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med 208: 383-394.
55. Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, NgD, Klinakis A, Charo IF, Jung S, Gommerman JL, et al. 2011. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity 35: 780-791.
56. Liu YJ. 2005. IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 23: 275-306.
57. Liu K, Nussenzweig MC. 2010. Origin and development of dendritic cells. Immunol Rev 234: 45-54.
58. Liu K, Victora GD, Schwickert TA, Guermonprez P, Meredith MM, Yao K, Chu FF, Randolph GJ, Rudensky AY Nussenzweig M. 2009. In vivo analysis of dendritic cell development and homeostasis. Science 324: 392-397.
59. Loschko J, Heink S, Hackl D, Dudziak D, ReindlW, Korn T Krug AB. 2011a. Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity. J Immunol 187: 6346-6356.
60. Loschko J, Schlitzer A, Dudziak D, Drexler I, Sandholzer N Bourquin C, ReindlW, Krug AB. 2011b. Antigen delivery to plasmacytoid dendritic cells via BST2 induces protective T cell-mediated immunity. J Immunol 186: 6718-6725.
61. MacDonald KP, Munster DJ, Clark GJ, Dzionek A, Schmitz J, Hart DN. 2002. Characterization of human blood dendritic cell subsets. Blood 100: 4512-4520.
62. Manicassamy S, Reizis B, Ravindran R, Nakaya H, Salazar-Gonzalez RM, Wang YC, Pulendran B. 2010. Activation of b-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 329: 849-853.
63. Martin-Gayo E, Sierra-Filardi E, Corbi AL, Toribio ML. 2010. Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development. Blood 115: 5366-5375.
64. + dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity 35: 249-259.
65. Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, Geboes L, Louagie E, Guire CM, Vereecke L, et al. 2011. A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet 43: 908-912.
66. + dendritic cells in the small intestine. Nature 483: 345-349.
67. Melillo JA, Song L, Bhagat G, Blazquez AB, Plumlee CR, Lee C, Berin C, Reizis B, Schindler C. 2010. Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function. J Immunol 184: 2638-2645.
68. Merad M, Manz MG. 2009. Dendritic cell homeostasis. Blood 113: 3418-3427.
69. Mittag D, Proietto AI, Loudovaris T, Mannering SI, Vremec D, Shortman K, Wu L, Harrison LC. 2011. Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status. J Immunol 186: 6207-6217.
70. Morelli AE, Thomson AW. 2007. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 7: 610-621.
71. Naik SH, Sathe P, Park HY, Metcalf D, Proietto AI, Dakic A Carotta S, O'Keeffe M, Bahlo M, Papenfuss A, et al. 2007. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol 8: 1217-1226.
72. Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, Vyas JM, Boes M, Ploegh HL, Fox JG, et al. 2005. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307: 254-258.
73. Ochando JC, Homma C, Yang Y, Hidalgo A, Garin A, Tacke F, Angeli V, Li Y, Boros P, Ding Y, et al. 2006. Alloantigenpresenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol 7: 652-662.
74. Ohnmacht C, Pullner A, King SB, Drexler I, Meier S, Brocker T, Voehringer D. 2009. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 206: 549-559.
75. O'Keeffe M, Hochrein H, Vremec D, Pooley J, Evans R Woulfe S, Shortman K. 2002. Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colonystimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice. Blood 99: 2122-2130.
76. + plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol 8: 1207-1216.
77. Palucka K, Banchereau J, Mellman I. 2010. Designing vaccines based on biology of human dendritic cell subsets. Immunity 33: 464-478.
78. Palucka K, Ueno H, Banchereau J. 2011. Recent developments in cancer vaccines. J Immunol 186: 1325-1331.
79. + dendritic cells. J Exp Med 207: 1261-1271.
80. Poulin LF, Reyal Y, Uronen-Hansson H, Schraml B, Sancho D, Murphy KM, Hakansson UK, Ferreira Moita L, Agace WW, Bonnet D, et al. 2012. DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and non-lymphoid tissues. Blood doi: 10.1182/blood-2012-01-406967.
81. + T cell tolerance. Immunity 18: 713-720.
82. + T cell tolerance through PD-1 and CTLA-4. Nat Immunol 6: 280-286.
83. Proietto AI, van Dommelen S, Zhou P, Rizzitelli A, D'Amico A, Steptoe RJ, Naik SH, Lahoud MH, Liu Y, Zheng P, et al. 2008. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci 105: 19869-19874.
84. Proietto AI, van Dommelen S, Wu L. 2009. The impact of circulating dendritic cells on the development and differentiation of thymocytes. Immunol Cell Biol 87: 39-45.
85. Reizis B, Bunin A, Ghosh HS, Lewis KL, Sisirak V. 2011. Plasmacytoid dendritic cells: Recent progress and open questions. Annu Rev Immunol 29: 163-183.
86. Sapoznikov A, Jung S. 2008. Probing in vivo dendritic cell functions by conditional cell ablation. Immunol Cell Biol 86: 409-415.
87. Sathaliyawala T, O'Gorman WE, Greter M, Bogunovic M, Konjufca V, Hou ZE, Nolan GP, Miller MJ, Merad M Reizis B. 2010. Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity 33: 597-606.
88. Scheinecker C, McHugh R, Shevach EM, Germain RN. 2002. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J Exp Med 196: 1079-1090.
89. + T-cell tolerance induced by steady-state dendritic cells. Proc Natl Acad Sci 107: 199-203.
90. +, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med 206: 3101-3114.
91. Segura E, Valladeau-Guilemond J, Donnadieu MH, Sastre-Garau X, Soumelis V, Amigorena S. 2012. Characterization of resident and migratory dendritic cells in human lymph nodes. J Exp Med 209: 653-660.
92. Sela U, Olds P, Park A, Schlesinger SJ, Steinman RM. 2011. Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice. J Exp Med 208: 2489-2496.
93. Shakhar G, Lindquist RL, Skokos D, Dudziak D, Huang JH Nussenzweig MC, Dustin ML. 2005. Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat Immunol 6: 707-714.
94. Steinman RM. 2007. Lasker Basic Medical Research Award. Dendritic cells: Versatile controllers of the immune system. Nat Med 13: 1155-1159.
95. Steinman RM. 2012. Decisions about dendritic cells: Past, present, and future. Annu Rev Immunol 30: 1-22.
96. Steinman RM, WitmerMD. 1978. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc Natl Acad Sci 75: 5132-5136.
97. Steinman RM, Hawiger D, Nussenzweig MC. 2003. Tolerogenic dendritic cells. Annu Rev Immunol 21: 685-711.
98. Stranges PB, Watson J, Cooper CJ, Choisy-Rossi CM, Stonebraker AC, Beighton RA, Hartig H, Sundberg JP, Servick S, Kaufmann G, et al. 2007. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity 26: 629-641.
99. + regulatory T cells in Foxp3. LuciDTR mice. J Immunol 184: 1810-1820.
100. Swee LK, Bosco N, Malissen B, Ceredig R, Rolink A. 2009. Expansion of peripheral naturally occurring Tregulatory cells by Fms-like tyrosine kinase 3 ligand treatment. Blood 113: 6277-6287.
101. Swiecki M, Colonna M. 2010. Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev 234: 142-162.
102. + T cell accrual. Immunity 33: 955-966.
103. Takagi H, Fukaya T, Eizumi K, Sato Y, Sato K, Shibazaki A Otsuka H, Hijikata A, Watanabe T, Ohara O, et al. 2011. Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo. Immunity 35: 958-971.
104. Takeda K, Clausen BE, Kaisho T, Tsujimura T, Terada N Forster I, Akira S. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10: 39-49.
105. + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med 199: 1467-1477.
106. Teichmann LL, Ols ML, Kashgarian M, Reizis B, Kaplan DH Shlomchik MJ. 2010. Dendritic cells in lupus are not required for activation of Tand B cells but promote their expansion, resulting in tissue damage. Immunity 33: 967-978.
107. Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, et al. 2007. Loss of integrin avb8 on dendritic cells causes autoimmunity and colitis in mice. Nature 449: 361-365.
108. Varol C, Vallon-Eberhard A, Elinav E, Aychek T, Shapira Y, Luche H, Fehling HJ, Hardt WD, Shakhar G, Jung S. 2009. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31: 502-512.
109. Varol C, Zigmond E, Jung S. 2010. Securing the immune tightrope:Mononuclear phagocytes in the intestinal lamina propria. Nat Rev Immunol 10: 415-426.
110. Villadangos JA, Young L. 2008. Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 29: 352-361.
111. Vollstedt S, O'Keeffe M, Odermatt B, Beat R, Glanzmann B Riesen M, Shortman K, Suter M. 2004. Treatment of neonatal mice with Flt3 ligand leads to changes in dendritic cell subpopulations associated with enhanced IL-12 and IFN-a production. Eur J Immunol 34: 1849-1860.
112. + regulatory T cells by antigen-processing dendritic cells. J Exp Med 198: 235-247.
113. + regulatory T cells. J Immunol 181: 6923-6933.
114. Zhang M, Tang H, Guo Z, An H, Zhu X, Song W, Guo J Huang X, Chen T, Wang J, et al. 2004. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol 5: 1124-1133.