Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts

Nature Immunology

Volumn 7, Issue 6, 2006, Pages 652-662

  Ochando, Jordi C ^a   Homma, Chiho ^a   Yang, Yu ^a   Hidalgo, Andres ^a   Garin, Alexandre ^a   Tacke, Frank ^a   Angeli, Veronique ^a   Li, Yansui ^a   Boros, Peter ^a   Ding, Yaozhong ^a   Jessberger, Rolf ^a,b   Trinchieri, Giorgio ^c   Lira, Sergio A ^a   Randolph, Gwendalyn J ^a   Bromberg, Jonathan S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR4; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE TRANSFER; ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; BLOOD; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; LYMPH NODE; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PHAGOCYTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; AORTA; DENDRITIC CELLS; GRAFT SURVIVAL; HEART TRANSPLANTATION; ISOANTIGENS; LYMPH NODES; MICE; MICE, INBRED STRAINS; PHAGOCYTOSIS; PULMONARY ARTERY; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION TOLERANCE;

EID: 33744479421     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1333     Document Type: Article

References (56)

1. + cells are essential for allorejection. J. Exp. Med. 184, 2013-2018 (1996).
2. + TCR transgenic mouse. Am. J. Transplant. 3, 381-389 (2003).
3. Yamada, A. et al. Further analysis of the T-cell subsets and pathways of murine cardiac allograft rejection. Am. J. Transplant. 3, 23-27 (2003).
4. He, C. & Heeger, P.S. CD8 T cells can reject major histocompatibility complex class I-deficient skin allografts. Am. J. Transplant. 4, 698-704 (2004).
5. Hancock, W.W. Chemokine receptor-dependent alloresponses. Immunol. Rev. 196, 37-50 (2003).
6. Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245-252 (1998).
7. Sallusto, F. et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur. J. Immunol. 28, 2760-2769 (1998).
8. Miyasaka, M. & Tanaka, T. Lymphocyte trafficking across high endothelial venules: Dogmas and enigmas. Nat. Rev. Immunol. 4, 360-370 (2004).
9. + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6, 345-352 (2005).
10. + T cells. J. Immunol. 174, 3741-3748 (2005).
11. Hara, M. et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 166, 3789-3796 (2001).
12. + precursors in a thymus-independent process. J. Immunol. 172, 923-928 (2004).
13. + regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J. Immunol. 172, 6003-6010 (2004).
14. Abe, M., Wang, Z., de Creus, A. & Thomson, A.W. Plasmacytoid dendritic cell precursors induce allogeneic T-cell hyporesponsiveness and prolong heart graft survival. Am. J. Transplant. 5, 1808-1819 (2005).
15. Bai, Y. et al. L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance. J. Immunol. 168, 1579-1589 (2002).
16. + regulatory T cells. J. Immunol. 174, 6993-7005 (2005).
17. Quezada, S.A. et al. Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: The interplay of clonal anergy and immune regulation. J. Immunol. 175, 771-779 (2005).
18. Murphy, D.B. et al. A novel MHC class II epitope expressed in thymic medulla but not cortex. Nature 338, 765-768 (1989).
19. + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194, 1171-1178 (2001).
20. Grouard, G. et al. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J. Exp. Med. 185, 1101-1111 (1997).
21. 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. J. Immunol. 161, 952-956 (1998).
22. Rosen, S.D. Endothelial ligands for L-selectin: From lymphocyte recirculation to allograft rejection. Am. J. Pathol. 155, 1013-1020 (1999).
23. Berg, E.L., McEvoy, L.M., Berlin, C., Bargatze, R.F. & Butcher, E.C. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Nature 366, 695-698 (1993).
24. Stamper, H.B., Jr & Woodruff, J.J. Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules. J. Exp. Med. 144, 828-833 (1976).
25. Yoneyama, H, et al. Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules. Int. Immunol. 16, 915-928 (2004).
26. Bajenoff, M., Granjeaud, S. & Guerder, S. The strategy of T cell antigen-presenting cell encounter in antigen-draining lymph nodes revealed by imaging of initial T cell activation. J. Exp. Med. 198, 715-724 (2003).
27. Alferink, J. et al. Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J. Exp. Med. 197, 585-599 (2003).
28. + regulatory T cells. J. Exp. Med. 194, 847-853 (2001).
29. Shinohara, M. et al. SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling. Nature 416, 759-763 (2002).
30. Sivalenka, R.R. & Jessberger, R. SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration. Mol. Cell. Biol. 24, 10277-10288 (2004).
31. Asselin-Paturel, C., Brizard, G., Pin, J.J., Briere, F. & Trinchieri, G. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J. Immunol. 171, 6466-6477 (2003).
32. H1 polarization. Nat. Immunol. 1, 305-310 (2000).
33. high) dendritic cells in human nasal allergy. J. Immunol. 165, 4062-4068 (2000).
34. Salio, M., Palmowski, M.J., Atzberger, A., Hermans, I.F. & Cerundolo, V. CpG-matured murine plasmacytoid dendritic cells are capable of in vivo priming of functional CD8 T cell responses to endogenous but not exogenous antigens. J. Exp. Med. 199, 567-579 (2004).
35. Dzionek, A. et al. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon α/β induction. J. Exp. Med. 194, 1823-1834 (2001).
36. Lakkis, F.G., Arakelov, A., Konieczny, B.T. & Inoue, Y. Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat. Med. 6, 686-688 (2000).
37. + T cells through the indirect presentation pathway in vivo. J. Immunol. 171, 6510-6518 (2003).
38. Reed, A.J. et al. Alloreactive CD4 T cell activation in vivo: An autonomous function of the indirect pathway of alloantigen presentation. J. Immunol. 171, 6502-6509 (2003).
39. + T cells by TGF-β1 through a p38 mitogen-activated protein kinase-dependent pathway. J. Immunol. 165, 5011-5016 (2000).
40. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
41. Corbascio, M. et al. CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely. Transpl. Immunol. 10, 55-61 (2002).
42. + T cells is required for optimal antigen-dependent activation in vivo. J. Immunol. 173, 4443-4451 (2004).
43. Brandt, M., Steinmann, J., Steinhoff, G. & Haverich, A. Treatment with monoclonal antibodies to ICAM-1 and LFA-1 in rat heart allograft rejection. Transpl. Int. 10, 141-144 (1997).
44. Liu, Y.J., Oldfield, S. & MacLennan, I.C. Memory B cells in T cell-dependent antibody responses colonize the splenic marginal zones. Eur. J. Immunol. 18, 355-362 (1988).
45. Ellyard, J.I. et al. Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow. Blood 103, 3805-3812 (2004).
46. Shapiro-Shelef, M. & Calame, K. Regulation of plasma-cell development. Nat. Rev. Immunol. 5, 230-242 (2005).
47. Crowley, M., Inaba, K. & Steinman, R.M. Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. J. Exp. Med. 172, 383-386 (1990).
48. Josien, R., Heslan, M., Brouard, S., Soulillou, J.P. & Cuturi, M.C. Critical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion. Blood 92, 4539-4544 (1998).
49. Baldwin, W.M., III, Rhoton, K. & Sanfilippo, F. IgM and IgG alloantibody production by splenocytes and deposition in rat renal allografts are decreased by donor-specific blood transfusion. Transplantation 51, 481-485 (1991).
50. Han, S. et al. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155, 556-567 (1995).
51. de Heer, H.J. et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J. Exp. Med. 200, 89-98 (2004).
52. Itano, A.A. et al. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 19, 47-57 (2003).
53. + regulatory T cells. J. Immunol. 173, 4433-4442 (2004).
54. Kretschmer, K. et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6, 1219-1227 (2005).
55. Fontenot, J.D. et al. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 22, 329-341 (2005).
56. Corry, R.J., Winn, H.J. & Russell, P.S. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 16, 343-350 (1973).