Do polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene affect the risk of childhood acute lymphoblastic leukemia?

European Journal of Epidemiology

Volumn 21, Issue 12, 2006, Pages 885-886

  Pereira, Tiago Veiga ^a   Rudnicki, Martina ^a   Pereira, Alexandre Costa ^a   Pombo De Oliveira, Maria S ^b   Franco, Rendrik França ^c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^c Fleury   (Brazil)

Author keywords

Childhood; Leukemia; Meta analysis; MTHFR; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CLINICAL STUDY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; PUBLICATION; STATISTICAL ANALYSIS;

EID: 33846661727     PISSN: 03932990     EISSN: 15737284     Source Type: Journal    
DOI: 10.1007/s10654-006-9079-9     Document Type: Article

References (10)

1. Zintzaras E, Koufakis T, Ziakas PD, Rodopoulou P, Giannouli S, Voulgarelis M. A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. Eur J Epidemiol 2006; 21: 501-510.
2. Deligezer U, Akisik E, Dalay N. Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis. Mol Diagn 2003; 7: 181-185.
3. Gemmati D, Ongaro A, Scapoli GL, et al. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prev 2004; 13: 787-794.
4. Thirumaran RK, Gast A, Flohr T, et al. MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. Blood 2005; 106: 2590-2591.
5. Zanrosso CW, Hatagima A, Emerenciano M, et al. The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population. Leuk Res 2006; 30: 477-481.
6. Thakkinstian A, D'Este C, Eisman J, Nguyen T, Attia J. Meta-analysis of molecular association studies: Vitamin D receptor gene polymorphisms and BMD as a case study. J Bone Miner Res 2004; 19: 419-428.
7. Milne E, de Klerk NH, van Bookxmeer F, et al. Is there a folate-related gene-environment interaction in the etiology of childhood acute lymphoblastic leukemia? Int J Cancer 2006; 119: 229-232.
8. Pereira TV, Rudniki M, Pereira AC, Pombo-de-Oliveira MS, Franco RF. 5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: A meta-analysis. Cancer Epidemiol Biomarkers Prev 2006; 15: 1956-63.
9. Clarke M. Searching MEDLINE for randomised trials. Br Med J 1993; 307: 565.
10. Dickersin K, Scherer R, Lefebvre C. Identifying relevant studies for systematic reviews. Br Med J 1994; 309: 1286-1291.