Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism and risk of cancer: Cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls

International Journal of Cancer

Volumn 128, Issue 3, 2011, Pages 644-652

  Zacho, Jeppe ^a   Yazdanyar, Shiva ^a   Bojesen, Stig E ^a,b   Tybjærg Hansen, Anne ^b,c   Nordestgaard, Børge G ^a,b  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b BISPEBJERG HOSPITAL   (Denmark)

^c Rigshospitalet   (Denmark)

Author keywords

cancer; homocysteine; meta analyses; MTHFR c.677C>T; prospective study

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

AGE; ARTICLE; BREAST CANCER; CANCER RISK; CENTRAL NERVOUS SYSTEM TUMOR; COLORECTAL ADENOMA; COLORECTAL CANCER; CROSS-SECTIONAL STUDY; DENMARK; ENDOMETRIUM CANCER; ESOPHAGUS CANCER; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HEAD AND NECK CANCER; HETEROZYGOTE; HODGKIN DISEASE; HOMOZYGOTE; HUMAN; HYPERHOMOCYSTEINEMIA; KIDNEY CANCER; LEUKEMIA; LIVER CANCER; LUNG CANCER; LYMPHOMA; MELANOMA; MOUTH CANCER; NONHODGKIN LYMPHOMA; OVARY CANCER; PANCREAS CANCER; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE CANCER; SARCOMA; STOMACH CANCER; THYROID CANCER; UTERINE CERVIX CANCER;

ADULT; AGED; AGED, 80 AND OVER; CROSS-SECTIONAL STUDIES; DENMARK; DNA; ESOPHAGEAL NEOPLASMS; FEMALE; HOMOZYGOTE; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; META-ANALYSIS AS TOPIC; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; NEOPLASMS; PATIENT SELECTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RISK ASSESSMENT; STOMACH NEOPLASMS;

EID: 78649831580     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25375     Document Type: Article

References (47)

1. Kim YI,. Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem 1999; 10: 66-88.
2. Jones PA,. Overview of cancer epigenetics. Semin Hematol 2005; 42: S3-8.
3. Herman JG, Baylin SB,. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003; 349: 2042-54.
4. Jacob RA, Gretz DM, Taylor PC, James SJ, Pogribny IP, Miller BJ, Henning SM, Swendseid ME,. Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr 1998; 128: 1204-12.
5. Duthie SJ, Narayanan S, Brand GM, Pirie L, Grant G,. Impact of folate deficiency on DNA stability. J Nutr 2002; 132: 2444S-9S.
6. McMullin MF, Young PB, Bailie KEM, Savage GA, Lappin TRJ, White R,. Homocysteine and methylmalonic acid as indicators of folate and vitamin B-12 deficiency in pregnancy. Clin Lab Haematol 2001; 23: 161-5.
7. Savage DG, Lindenbaum J, Stabler SP, Allen RH,. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med 1994; 96: 239-46.
8. Wagner C,. Biochemical role of folate in cellular metabolism. In:, Bailey LB, ed. Folate in health and in disease. New York, NY: Marcel Dekker, 1995. 23-42.
9. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP,. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-3.
10. Ulvik A, Evensen ET, Lien EA, Hoff G, Vollset SE, Majak BM, Ueland PM,. Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum. Am J Med Genet 2001; 101: 246-54.
11. Kawakami K, Ruszkiewicz A, Bennett G, Moore J, Watanabe G, Iacopetta B,. The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase. Clin Cancer Res 2003; 9: 5860-5.
12. Stern LL, Mason JB, Selhub J, Choi SW,. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev 2000; 9: 849-53.
13. Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, Olivieri O, Jacques PF, Rosenberg IH, Corrocher R, Selhub J,. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 2002; 99: 5606-11.
14. Lucock M,. Is folic acid the ultimate functional food component for disease prevention? Br Med J 2004; 328: 211-14.
15. Crott JW, Mashiyama ST, Ames BN, Fenech M,. The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiol Biomarkers Prev 2001; 10: 1089-96.
16. Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB, Ames BN,. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 1997; 94: 3290-5.
17. Dianov GL, Timchenko TV, Sinitsina OI, Kuzminov AV, Medvedev OA, Salganik RI,. Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation. Mol Gen Genet 1991; 225: 448-52.
18. Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG,. Integrin beta3 Leu33Pro homozygosity and risk of cancer. J Natl Cancer Inst 2003; 95: 1150-7.
19. Johansen JS, Bojesen SE, Mylin AK, Frikke-Schmidt R, Price PA, Nordestgaard BG,. Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population. J Clin Oncol 2009; 27: 572-8.
20. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A,. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007; 298: 299-308.
21. Zacho J, Tybjaerg-Hansen A, Jensen JS, Grande P, Sillesen H, Nordestgaard BG,. Genetically elevated C-reactive protein and ischemic vascular disease. N Engl J Med 2008; 359: 1897-1908.
22. Storm HH, Michelsen EV, Clemmensen IH, Pihl J,. The Danish Cancer Registry-history, content, quality and use. Dan Med Bull 1997; 44: 535-9.
23. Storm HH,. Completeness of cancer registration in Denmark 1943-1966 and efficacy of record linkage procedures. Int J Epidemiol 1988; 17: 44-9.
24. Bray F, Sankila R, Ferlay J, Parkin DM,. Estimates of cancer incidence and mortality in Europe in 1995. Eur J Cancer 2002; 38: 99-166. (Pubitemid 34031832)
25. Frederiksen J, Juul K, Grande P, Jensen GB, Schroeder TV, Tybjaerg-Hansen A, Nordestgaard BG,. Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study. Blood 2004; 104: 3046-51.
26. Kleinbaum DG, Klein K,. Competing risks survival analysis. Survival analysis, 2nd edn. New York: Springer, 2005. 391-461.
27. Higgins JP, Thompson SG, Deeks JJ, Altman DG,. Measuring inconsistency in meta-analyses. BMJ 2003; 327: 557-60.
28. Weinstein SJ, Albanes D, Selhub J, Graubard B, Lim U, Taylor PR, Virtamo J, Stolzenberg-Solomon R,. One-carbon metabolism biomarkers and risk of colon and rectal cancers. Cancer Epidemiol Biomarkers Prev 2008; 17: 3233-40.
29. van Guelpen B, Hultdin J, Johansson I, Hallmans G, Stenling R, Riboli E, Winkvist A, Palmqvist R,. Low folate levels may protect against colorectal cancer. Gut 2006; 55: 1461-6.
30. Larsson SC, Giovannucci E, Wolk A,. Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis. Gastroenterology 2006; 131: 1271-83.
31. Langevin SM, Lin D, Matsuo K, Gao CM, Takezaki T, Stolzenberg-Solomon RZ, Vasavi M, Hasan Q, Taioli E,. Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer. Toxicol Lett 2009; 184: 73-80.
32. Boccia S, Hung R, Ricciardi G, Gianfagna F, Ebert MP, Fang JY, Gao CM, Gotze T, Graziano F, Lacasana-Navarro M, Lin D, Lopez-Carrillo L, et al. Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. Am J Epidemiol 2008; 167: 505-16.
33. Zintzaras E,. Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis. J Hum Genet 2006; 51: 618-24.
34. Sun L, Sun YH, Wang B, Cao HY, Yu C,. Methylenetetrahydrofolate reductase polymorphisms and susceptibility to gastric cancer in Chinese populations: a meta-analysis. Eur J Cancer Prev 2008; 17: 446-52.
35. Houlston RS, Tomlinson IP,. Polymorphisms and colorectal tumor risk. Gastroenterology 2001; 121: 282-301.
36. Kono S, Chen K,. Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma. Cancer Sci 2005; 96: 535-42.
37. Hubner RA, Houlston RS,. MTHFR C677T and colorectal cancer risk: a meta-analysis of 25 populations. Int J Cancer 2007; 120: 1027-35.
38. Huang Y, Han S, Li Y, Mao Y, Xie Y,. Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis. J Hum Genet 2007; 52: 73-85.
39. Sun D, Wang X, Fang J,. Relevance of genetic polymorphism of methylene tetrahydrofolate reductase and susceptibility of colonic cancer: a meta-analysis. Chin J Gastroenterol 2006; 11: 516-21.
40. Chen K, Jiang QT, He HQ,. Relationship between metabolic enzyme polymorphism and colorectal cancer. World J Gastroenterol 2005; 11: 331-5.
41. Taioli E, Garza MA, Ahn YO, Bishop DT, Bost J, Budai B, Chen K, Gemignani F, Keku T, Lima CS, Le ML, Matsuo K, et al. Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review. Am J Epidemiol 2009; 170: 1207-21.
42. Palladino M, Chiusolo P, Reddiconto G, Marietti S, de Ritis D, Leone G, Sica S,. MTHFR polymorphisms involved in vitamin B12 deficiency associated with atrophic gastritis. Biochem Genet 2009; 47: 645-50.
43. Solomon PR, Selvam GS, Shanmugam G,. Polymorphism in ADH and MTHFR genes in oral squamous cell carcinoma of Indians. Oral Dis 2008; 14: 633-9.
44. Qin JM, Yang L, Chen B, Wang XM, Li F, Liao PH, He L,. Interaction of methylenetetrahydrofolate reductase C677T, cytochrome P4502E1 polymorphism and environment factors in esophageal cancer in Kazakh population. World J Gastroenterol 2008; 14: 6986-92.
45. Ueland PM, Hustad S, Schneede J, Refsum H, Vollset SE,. Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 2001; 22: 195-201.
46. Hooper CE,. Cell turnover in epithelial populations. J Histochem Cytochem 1956; 4: 531-40.
47. Dhonukshe-Rutten RA, de Vries JH, de Bree A, van der PN, van Staveren WA, de Groot LC,. Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations. Eur J Clin Nutr 2009; 63: 18-30.