Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles (Review)

Experimental and Therapeutic Medicine

Volumn 4, Issue 4, 2012, Pages 551-561

  Magaye, Ruth ^a   Zhao, Jinshun ^a   Bowman, Linda ^b   Ding, Min ^b  

^a NINGBO UNIVERSITY   (China)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Carcinogenicity; Cobalt; Copper; Genotoxicity; Nanoparticles; Nickel

Indexed keywords

COBALT; COBALT NANOPARTICLE; COPPER; COPPER NANOPARTICLE; NANOPARTICLE; NICKEL; NICKEL NANOPARTICLE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOGENICITY; EPIGENETICS; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MAMMAL; MEDICAL LITERATURE; NANOTECHNOLOGY; NONHUMAN; OXIDATIVE STRESS;

EID: 84865375479     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.656     Document Type: Article

References (127)

1. Klapper M, Nenov S, Haschick R, MüllerK and MüllenK: Oil-in-oil emulsions: a unique tool for the formation of polymer nanoparticles. Acc Chem Res 41: 1190-1201, 2008.
2. Morimoto Y, Kobayashi N, Shinohara N, Myojo T, TanakaI and NakanishiJ: Hazard assessments of manufactured nanomaterials. J Occup Health 52: 325-334, 2010.
3. Scuri M, Chen BT, Castranova V, et al: Effects of titanium dioxide nanoparticle exposure on neuroimmune responses in rat airways. J Toxicol Environ Health A 73: 1353-1369, 2010.
4. Buffle J: The key role of environmental colloids/nanoparticles for the sustainability of life. Environ Chem 3: 155-158, 2006.
5. Ng C, Li JJ, Bay B and YungLL: Current studies into the genotoxic effects of nanomaterials. J Nucleic Acids 2010: 947859, 2010.
6. Rushton EK, Jiang J, Leonard SS, et al: Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. J Toxicol Environ HealthA 73: 445-461, 2010.
7. Buzea C, Pacheco II and RobbieK: Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2: MR17-MR71, 2007.
8. LeBlanc AJ, Cumpston JL, Chen BT, Frazer D, CastranovaV and NurkiewiczTR: Nanoparticle inhalation impairs endothelium-dependent vasodilation in subepicardial arterioles. J Toxicol Environ Health A 72: 1576-1584, 2009.
9. Oberdörster G: Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 74: 1-8, 2001.
10. Oberdörster G, FerinJ and LehnertBE: Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect 102 (Suppl 5): 173-179, 1994.
11. Liang G, Pu Y, YinL, et al: Influence of different sizes of titanium dioxide nanoparticles on hepatic and renal functions in rats with correlation to oxidative stress. J Toxicol Environ Health A 72: 740-745, 2009.
12. 2) nanoparticles induce JB6 cell apoptosis through activation of the caspase-8/Bid and mitochondrial pathways. J Toxicol Environ Health A 72: 1141-1149, 2009.
13. Gulumian M and VallyathanV: Nanoparticles and potential human health implications: past and future directions. Preface. J Toxicol Environ Health A 73: 339-340, 2010.
14. Huang YC, Karoly ED, DaileyLA, et al: Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter. J Toxicol Environ Health A 74: 296-312, 2011.
15. Valko M, Rhodes CJ, Moncol J, Izakovic M and MazurM: Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160: 1-40, 2006.
16. Ghio AJ, CarrawayMS and MaddenMC: Composition of air pollution particles and oxidative stress in cells, tissues, and living systems. J Toxicol Environ Health B Crit Rev 15: 1-21, 2012.
17. Shi X, Castranova V, HalliwellB and VallyathanV: Reactive oxygen species and silica-induced carcinogenesis. J Toxicol Environ Health B Crit Rev 1: 181-197, 1998.
18. Fahmy B and Cormier SA: Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells. Toxicol In Vitro 23: 1365-1371, 2009.
19. Lin W, Stayton I, Huang Y, Zhou XD and Ma Y: Cytotoxicity and cell membrane depolarization induced by aluminum oxide nanoparticles in human lung epithelial cells A549. Toxicol Environ Chem 90: 983-996, 2008.
20. Lin W, Xu Y, Huang CC, Ma Y, ShannonKB, ChenDR and HuangYW: Toxicity of nano-and micro-sized ZnO particles in human lung epithelial cells. J Nanoparticle Res 11:25-39, 2009.
21. Lin W, Huang YW, Zhou XD and MaY: In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol Appl Pharmacol 217: 252-259, 2006.
22. Lin W, Huang YW, Zhou XD and MaY: Toxicity of cerium oxide nanoparticles in human lung cancer cells. Int J Toxicol 25: 451-457, 2006.
23. Limbach LK, Wick P, Manser P, Grass RN, Bruinink A and Stark WJ: Exposure of engineered nanoparticles to human lung epithelial cells: Influence of chemical composition and catalytic activity on oxidative stress. Environ Sci Technol 41: 4158-4163, 2007.
24. Tabet L, Bussy C, Amara N, et al: Adverse effects of industrial multiwalled carbon nanotubes on human pulmonary cells. J Toxicol Environ Health A 72: 60-73, 2009.
25. Sohaebuddin SK, Thevenot PT, Baker D, EatonJW and TangL: Nanomaterial cytotoxicity is composition, size, and cell type dependent. Part Fibre Toxicol 7: 22, 2010.
26. ZhaoJ and CastranovaV: Toxicology of nanomaterials used in nanomedicine. J Toxicol Environ Health B Crit Rev 14: 593-632, 2011.
27. Bhattacharya K, Cramer H, AlbrechtC, et al: Vanadium pentoxide-coated ultrafine titanium dioxide particles induce cellular damage and micronucleus formation in V79 cells. J Toxicol Environ Health A 71: 976-980, 2008.
28. Wang K, Xu JJ and ChenHY: A novel glucose biosensor based on the nanoscaled cobalt phthalocyanine-glucose oxidase biocomposite. Biosens Bioelectron 20: 1388-1396, 2005.
29. Martens JWD and Peeters WL: Anisotropy in cobalt-ferrite thin films. J Magn Magn Mater 61: 21-23, 1986.
30. Bouchard LS, Anwar MS, Liu GL, Hann B, Xie ZH, Gray JW, Wang X, Pines A and Chen FF: Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles. Proc Natl Acad Sci USA 106: 4085-4089, 2009.
31. Seo WS, Lee JH, Sun X, Suzuki Y, Mann D, LiuZ, TerashimaM, YangPC, McConnel MV, Nishimura DG and DaiH: FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents. Nat Mater 5: 971-976, 2006.
32. Sadjadi MS, Pourahmad A, Sohrabnezhad Sh and Zare K: Formation of NiS and CoS semiconductor nanoparticles inside mordenite-type zeolite. Mater Lett 61: 2923-2926, 2006.
33. Florencio L, Field JA and LettingaG: Importance of cobalt for individual trophic groups in an anaerobic methanol-degrading consortium. Appl Environ Microbiol 60: 227-234, 1994.
34. Council INI: Wastewater treatment using semiconductor nanocomposites. http://www.nanowerk.com/news/newsid=11840.php. 2011.
35. Lison D, Lauwerys R, Demedts M and NemeryB: Experimental research into the pathogenesis of cobalt/hard metal lung disease. Eur Respir J 9: 1024-1028, 1996.
36. Lison D, De Boeck M, VerougstraeteV and Kirsch-VoldersM: Update on the genotoxicity and carcinogenicity of cobalt compounds. Occup Environ Med 58: 619-625, 2001.
37. Domingo JL: Metal-induced developmental toxicity in mammals: a review. J Toxicol Environ Health 42: 123-141, 1994.
38. Kuo CY, Wong RH, Lin JY, LaiJC and LeeH: Accumulation of chromium and nickel metals in lung tumors from lung cancer patients in Taiwan. J Toxicol Environ Health A 69: 1337-1344, 2006.
39. De Boeck M, Kirsch-Volders M and LisonD: Cobalt and antimony: genotoxicity and carcinogenicity. Mutat Res 533: 135-152, 2003.
40. Beyersmann D and HartwigA: The genetic toxicology of cobalt. Toxicol Appl Pharmacol 115: 137-145, 1992.
41. Ponti J, Sabbioni E, Munaro B, Broggi F, MarmoratoP, FranchiniF, ColognatoR and RossiF: Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride: an in vitro study in Balb/3T3 mouse fibroblasts. Mutagenesis 24: 439-445, 2009.
42. Colognato R, Bonelli A, Ponti J, Farina M, BergamaschiE, SabbioniE and MiglioreL: Comparative genotoxicity of cobalt nanoparticles and ions in human peripheral leukocytes in vitro. Mutagenesis 23: 377-382, 2008.
43. Kwon Y, Xia Z, Glyn-Jones S, Beard D, Gill HS and MurrayD: Dose-dependent cytotoxicity of clinically relevant cobalt nanoparticles and ions on macrophages in vitro. Biomed Mater 4: 025018, 2009.
44. Peters K, Unger RE, Gatti AM, Sabbioni E, TsarykR and KirkpatrickCJ: Metallic nanoparticles exhibit paradoxical effects on oxidative stress and pro-inflammatory response in endothelial cells in vitro. Int J Immunopathol Pharmacol 20: 685-695, 2007.
45. Papageorgiou I, Brown C, Schins R, Singh S, Newson R, Davis S, Fisher J, Ingham E and Case CP: The effect of nano-and micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitro. Biomaterials 28: 2946-2958, 2007.
46. Figgitt M, Newson R, Leslie IJ, Fisher J, InghamE and CaseCP: The genotoxicity of physiological concentrations of chromium (Cr(III) and Cr(VI) and cobalt (Co(II): an in vitro study. Mutat Res 688: 53-61, 2010.
47. 3) and metal (CoCr alloy) particles. Mutat Res 697: 1-9, 2010.
48. Bhabra G, Sood A, Fisher B, Cartwright L, SaundersM, EvansWH, Surprenant A, Lopez-Castejon G, Mann S, DavisSA, et al: Nanoparticles can cause DNA damage across a cellular barrier. Nat Nanotechnol 4: 876-883, 2009.
49. Parry MC, Bhabra G, Sood A, Machado F, CartwrightL, SaundersM, Ingham E, Newson R, Blom AW and CaseCP: Thresholds for indirect DNA damage across cellular barriers for orthoaedic biomaterials. Biomaterials 31: 4477-4483, 2010.
50. Grassian VH, Adamcakova-Dodd A, Pettibone JM, O'shaughnessyPT and ThornePS: Inflammatory response of mice to manufactured titanium dioxide nanoparticles: comparison of size effects through different exposure routes. Nanotoxicology 1: 211-226, 2007.
51. Monteiller C, Tran L, MacNee W, Faux S, Jones A, MillerB and DonaldsonK: The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area. Occup Environ Med 64: 609-615, 2007.
52. Sayes CM, Reed KL and Warheit DB: Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol Sci 97: 163-180, 2007.
53. Park E and ParkK: Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol Lett 184: 18-25, 2009.
54. Carlson C, Hussain SM, Schrand AM, Braydich-StolleLK, HessKL, Jones RL and SchlagerJJ: Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. J Phys Chem B 112: 13608-13619, 2008.
55. Guildford AL, Poletti T, OsbourneLH, Di CerboA, GattiAM and SantinM: Nanoparticles of a different source induce different patterns of activation in key biochemical and cellular components of the host response. J R Soc Interface 6: 1213-1221, 2009.
56. Singh N, Manshian B, Jenkins GJ, Griffiths SM, Williams PM, Maffeis TG, Wright CJ and DoakSH: NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. Biomaterials 30: 3891-3894, 2009.
57. WangH and ChoCH: Effect of NF-κB signaling on apoptosis in chronic inflammation-associated carcinogenesis. Curr Cancer Drug Targets 10: 593-599, 2010.
58. Papis E, Rossi F, Raspanti M, Dalle-Donne I, ColomboG, MilzaniA, BernadiniG and GornatiR: Engineered cobalt oxide nanoparticles readily enter cells. Toxicol Lett 189: 253-259, 2009.
59. Anard D, Kirsch-Volders M, ElhajoujiA, BelpaemeK and LisonD: In vitro genotoxic effects of hard metal particles assessed by alkaline single cell gel and elution assays. Carcinogenesis 18: 177-184, 1997.
60. Ding M, Kisin ER, Zhao J, Bowman L, Lu Y, Jiang B, LeonardS, VallyathanV, CastranovaV, MurrrayAR, et al: Size-dependent effects of tungsten carbide-cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells. Toxicol Appl Pharmacol 241: 260-268, 2009.
61. Busch W, Kühnel D, SchirmerK and ScholzS: Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes. BMC Genomics 11: 65, 2010.
62. Zhang XD, Zhao J, Bowman L, ShiX, CastranovaV and DingM: Tungsten carbide-cobalt particles activate Nrf2 and its downstream target genes in JB6 cells possibly by ROS generation. J Environ Pathol Toxicol Oncol 29: 31-40, 2010.
63. Pershina AG, Sazonov AE, Novikov DV, et al: Study of DNA interaction with cobalt ferrite nanoparticles. J Nanosci Nanotechnol 11: 2673-2677, 2011.
64. Hansen T, Clermont G, Alves A, EloyR, BrochhausenC, BoutrandJP, Gatti AM and Kirkpatrick CJ: Biological tolerance of different materials in bulk and nanoparticulate form in a rat model: sarcoma development by nanoparticles. J R Soc Interface 3: 767-775, 2006.
65. Ban I, Stergar J, Drofenik M, Ferk G and Makovec D: Synthesis of copper-nickel nanoparticles prepared by mechanical milling for use in magnetic hyperthermia. J Magn Magn Mater 323: 2254-2258, 2011.
66. Chou KS, Chang CS and Huang KC: Study on the characteristics of nanosized nickel particles using sodium borohydride to promote conve. AZojomo 3: 2007. doi:10.2240/azojomo0232.
67. Zhu FQ, Chern GW, Tchernyshyov O, Zhu XC, ZhuJG and ChienCL: Magnetic bistability and controllable reversal of asymmetric ferromagnetic nanorings. Phys Rev Lett 96: 027205, 2006.
68. Zhao J, Shi X, Castranova V and Ding M: Occupational toxicology of nickel and nickel compounds. J Environ Pathol Toxicol Oncol 28: 177-208, 2009.
69. Cameron KS, BuchnerV and TchounwouPB: Exploring the molecular mechanisms of nickel-induced genotoxicity and carcinogenicity: a literature review. Rev Environ Health 26: 81-92, 2011.
70. Kasprzak KS, Sunderman FW Jr and Salnikow K: Nickel carcinogenesis. Mutat Res 533: 67-97, 2003.
71. Kornick R and Zug KA: Nickel. Dermatitis 19: 3-8, 2008.
72. Tang X, Li C and Wu W: Research progress on carcinogenicity of nickel and its compounds. Chinese Journal of Industrial Medicine 4: 276-279, 2010 (In Chinese).
73. Oller AR: Respiratory carcinogenicity assessment of soluble nickel compounds. Environ Health Perspect 110 (Suppl 5): 841-844, 2002.
74. Seilkop SK and Oller AR: Respiratory cancer risks associated with low-level nickel exposure: an integrated assessment based on animal, epidemiological, and mechanistic data. Regul Toxicol Pharmacol 37: 173-190, 2003.
75. Grimsrud TK, Berge SR, ResmannF, NorsethT and AndersenA: Assessment of historical exposures in a nickel refinery in Norway. Scand J Work Environ Health 26: 338-345, 2000.
76. Goodman JE, Prueitt RL, Thakali S and OllerAR: The nickel ion bioavailability model of the carcinogenic potential of nickel-containing substances in the lung. Crit Rev Toxicol 41: 142-174, 2011.
77. Costa M, Yan Y, Zhao D and SainikowK: Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling. J Environ Monit 5: 222-223, 2003.
78. Zhang Q, Kusaka Y, ZhuX, et al: Comparative toxicity of standard nickel and ultrafine nickel in lung after intratracheal instillation. J Occup Health 45: 23-30, 2003.
79. Kyono H, Kusaka Y, Homma K, Kubota H and Endo-IchikawaY: Reversible lung lesions in rats due to short-term exposure to ultrafine cobalt particles. Ind Health 30: 103-118, 1992.
80. Maynard AD and KuempelED: Airborne nanostructured particles and occupational health. J Nanopart Res 7: 587-614, 2005.
81. NIPERA: Safe Use of Nickel in the Workplace-Incorporating European Nickel Risk Assessment Outcomes. A guide for Health Maintenance of Workers Exposed to Nickel, Its Compounds and Alloys-Health guide. 3rd edition. Nickel Producers Environmental Research Association, Durham, NC, USA, 2008.
82. Park S, Lee YK, Jung M, Kim KH, Chung N, Ahn EK, LimY and LeeKH: Cellular toxicity of various inhalable nanoparticles on human alveolar epithelial cells. Inhal Toxicol 19 (Suppl 1): 59-65, 2007.
83. Nagata S: Apoptotic DNA fragmentation. Exp Cell Res 256: 12-18, 2000.
84. Yang H, Liu C, Yang D, Zhang H and Xi Z: Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J Appl Toxicol 29: 69-78, 2009.
85. Pujalté I, Passagne I, Daculsi R, BrouillaudB, RémyM, TréguerM, DePortalC, Ohayon-Courtès C and L'Azou B: Toxicity and oxidative stress induced by metallic nanoparticles in renal cells. Proceeding of the Annual Meeting of the French Society of Toxicology 2010. Paris, 2010 (Available at: http://www.sftox.com/congres/sft2010/posters/index.html).
86. Zhao J, Bowman L, Zhang X, Shi X, Jiang B, Castranova V and Ding M: Metallic nickel nano-and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway. J Nanobiotechnology 7: 2, 2009.
87. Ryter SW, Kim HP, Hoetzel A, et al: Mechanisms of cell death in oxidative stress. Antioxid Redox Signal 9: 49-89, 2007.
88. Guo D, Wu C, Li X, Jiang H, Wang X and Chen B: In vitro cellular uptake and cytotoxic effect of functionalized nickel nanoparticles on leukemia cancer cells. J Nanosci Nanotechnol 8: 2301-2307, 2008.
89. Pietruska JR, Liu X, Smith A, McNeil K, Weston P, ZhitkovichA, HurtR and KaneAB: Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci 124: 138-148, 2011.
90. Ahamed M: Toxic response of nickel nanoparticles in human lung epithelial A549 cells. Toxicol In Vitro 25: 930-936, 2011.
91. Horie M, Fukui H, Nishio K, Endoh S, Kato H, FujitaK, MiyauchiA, Nakamura A, Shichiri M, Ishida N, et al: Evaluation of Acute Oxidative Stress Induced by NiO Nanoparticles In Vivo and In Vitro. J Occup Health 53: 64-74, 2011.
92. Cho WS, Duffin R, Poland CA, Howie SE, MacNee W, BradleyM, MegsonIL and DonaldsonK: Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing. Environ Health Perspect 118: 1699-1706, 2010.
93. Iannitti T, Capone S, Gatti A, Capitani F, Cetta F and PalmieriB: Intracellular heavy metal nanoparticle storage: progressive accumulation within lymph nodes with transformation from chronic inflammation to malignancy. Int J Nanomedicine 5: 955-960, 2010.
94. Phillip JI, Green FY, Davis JCA and MurrayJ: Pulmonary and systemic toxicity following exposure to nickel nanoparticles. Am J Ind Med 53: 763-767, 2010.
95. Gillespie PA, Kang GS, Elder A, Gelein R, Chen L, MoreiraAL, KobersteinJ, Tchou-Wong KM, Gordon T and Chen LC: Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: short and long-term studies in mice. Nanotoxicology 4: 106-119, 2010.
96. Morimoto Y, Ogami A, Todoroki M, YamamotoM, MurakamiM, Hirohashi M, Oyabu T, Myojo T, Nishi K, KadoyaC, et al: Expression of inflammation-related cytokines following intratracheal instillation of nickel oxide nanoparticles. Nanotoxicology 4: 161-176, 2010.
97. Morimoto Y, Hirohashi M, Ogami A, Oyabu T, MyojoT, HashibaM, Mizuquchi Y, Kambara T, Lee BW, Kuroda E and TanakaI: Pulmonary toxicity following an intratracheal instillation of nickel oxide nanoparticle agglomerates. J Occup Health 53: 293-295, 2011.
98. Nishi K, Morimoto Y, Ogami A, Murakami M, MyojoT, OyabuT, Kadoya C, Yamamoto M, Todoroki M, HirohashiM, et al: Expression of cytokine-induced neutrophil chemoattractant in rat lungs by intratracheal instillation of nickel oxide nanoparticles. Inhal Toxicol 21: 1030-1039, 2009.
99. Kang GS, Gillespie PA, Gunnison A, Rengifo H, KobersteinJ and Chen LC: Comparative pulmonary toxicity of inhaled nickel nanoparticles; role of deposited dose and solubility. Inhal Toxicol 23: 95-103, 2011.
100. Brown TJ, Bide T, Walters AS, Idoine NE, Shaw RA, HannisSD, LustyPAJ and Kendall R: World Mineral Production 2005-09. British Geological Survey, Nottingham, UK, 2011.
101. Olivares M and Uauy R: Copper as an essential nutrient. Am J Clin Nutr 63: 791S-796S, 1996.
102. Chambers A, Krewski D, BirkettN, et al: An exposure-response curve for copper excess and deficiency. J Toxicol Environ Health B Crit Rev 13: 546-578, 2010.
103. Stern BR, Solioz M, Krewski D, et al: Copper and human health: biochemistry, genetics, and strategies for modeling dose-response relationships. J Toxicol Environ Health B Crit Rev 10: 157-222, 2007.
104. Failla ML: Trace elemnts and host defense: recent advances and continuing challenges. J Nutr 133 (5 Suppl 1): 1443S-1447S, 2003.
105. Tapiero H, Townsend DM and Tew KD: Trace elements in the human physiology and pathology. Copper. Biomed Pharmacother 57: 386-398, 2003.
106. Chen Z, Meng H, Xing GM, Chen CY, Zhao YL, JiaG, Wang T, Yuan H, Ye C, Zhao F, et al: Acute toxicological effects of copper nanoparticles in vivo. Toxicol Lett 163: 109-120, 2006.
107. Kempson IM, Skinner WM and Kirkbride KP: The occurrence and incorporation of copper and zinc in hair and their potential role as bioindicators: a review. J Toxicol Environ Health B Crit Rev 10: 611-622, 2007.
108. Cioffi N, Ditaranto N, Torsi L, Picca RA, SabbatiniL, ValentiniA, Novello L, Tantillo G, Bleve-Zacheo T and ZamboninPG: Analytical characterization of bioactive fluoropolymer ultra-thin coatings modified by copper nanoparticles. Anal Bioanal Chem 381: 607-616, 2005.
109. Athanassiou EK, Grass RN and Stark WJ: Large-scale production of carbon-coated copper nanoparticles for sensor applications. Nanotechnology 17: 1668, 2006.
110. Hahn A, Günther S, Wagener P and Barcikowski S: Electro-chemistry-controlled metal ion release from silicone elastomer nanocomposites through combination of different metal nanoparticles. J Mater Chem 21: 10287-10289, 2011.
111. De Oliveira JV, Boufleur LA, Dos Santos CE, et al: Occupational genotoxicity among copper smelters. Toxicol Ind Health: Oct 31, 2011 (Epub ahead of print).
112. Bhunya SP and Jena GB: Clastogenic effects of copper sulphate in chick in vivo test system. Mutat Res 367: 57-63, 1996.
113. Agarwal K, Sharma A and Talukder G: Clastogenic effects of copper sulphate on the bone marrow chromosomes of mice in vivo. Mutat Res 243: 1-6, 1990.
114. Meng H, Chen Z, Xing GM, Yuan H, Chen CY, Zhao F, ZhangCC, Wang Y and Zhao YL: Ultra high reactivity and grave nanotoxicity of copper nanoparticles. Journal of Radioanalytical and Nuclear Chemistry 272: 595-598, 2007.
115. Jose GP, Santra S, Mandal SK and Sengupta TK: Singlet oxygen mediated DNA degradation by copper nanoparticles: potential towards cytotoxic effect on cancer cells. J Nanobiotechnology9: 9, 2011.
116. Dolmans DE, Fukumura D and Jain RK: Photodynamic therapy for cancer. Nat Rev Cancer 3: 380-387, 2003.
117. Petersen EJ and Nelson BC: Mechanisms and measurements of nanomaterial-induced oxidative damage to DNA. Anal Bioanal Chem 398: 613-650, 2010.
118. Yu M, Mo Y, Wan R, Chien S, Zhang X and Zhang Q: Regulation of plasminogen activator inhibitor-1 expression in endothelial cells with exposure to metal nanoparticles. Toxicol Lett 195: 82-89, 2010.
119. Karlsson HL, Cronholm P, Gustafsson J and Möller L: Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes. Chem Res Toxicol 21: 1726-1732, 2008.
120. Karlsson HL, Gustafsson J, Cronholm P and MollerL: Size-dependent toxicity of metal oxide particles-a comparison between nano-and micrometer size. Toxicol Lett 188: 112-118, 2009.
121. Prabhu BM, Ali SF, Murdock RC, HussainSM and SrivatsanM: Copper nanoparticles exert size and concentration dependent toxicity on somatosensory neurons of rat. Nanotoxicology 4: 150-160, 2010.
122. Pettibone JM, Adamcakova-Dodd A, ThornePS, O'ShaughnessyPT, Weydert JA and Grassian VH: Inflammatory response of mice following inhalation exposure to iron and copper nanoparticles. Nanotoxicology 2: 189-204, 2008.
123. Yang B, Wang Q, Lei R, Wu C, Shi C, Wang Q, YaunY, WangY, Luo Y, Hu Z, Ma H and Liao M: Systems toxicology used in nanotoxicology: mechanistic insights into the hepatotoxicity of nano-copper particles from toxicogenomics. J Nanosci Nanotechnol 10: 8527-8537, 2010.
124. Liu Y, Gao Y, Zhang L, Wang T, Wang J, Jiao F, LiW, LiuY, LiY, Li B, Chai Z, Wu G and Chen C: Potential health impact on mice after nasal instillation of nano-sized copper particles and their translocation in mice. J Nanosci Nanotechnol 9: 6335-6343, 2009.
125. Sharma HS, Ali SF, Hussain S, Schlager JJ and SharmaA: Influence of engineered nanoparticles from metals on the blood-brain barrier permeability, cerebral blood flow, brain edema and neurotoxicity. An experimental study in the rat and mice using biochemical and morphological approaches. J Nanosci Nanotechnol 9: 5055-5072, 2009.
126. Martindale JL and Holbrook NJ: Cellular response to oxidative stress: signaling for suicide and rvival. J Cell Physiol 192: 1-15, 2002.
127. Huang YW, Wu CH and Aronstam RS: Toxicity of transition metal oxide nanoparticles: recent insights from in vitro studies. Materials 3: 4842-4859, 2010.