Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles

Toxicological Sciences

Volumn 124, Issue 1, 2011, Pages 138-148

  Pietruska, Jodie R ^a   Liu, Xinyuan ^a   Smith, Ashley ^a   McNeil, Kevin ^a   Weston, Paula ^a   Zhitkovich, Anatoly ^a,b   Hurt, Robert ^b,c   Kane, Agnes B ^a,b  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

^c Brown University   (United States)

Author keywords

Apoptosis; Cancer; Cytotoxicity; HIF 1 ; Nanoparticles; Nickel

Indexed keywords

BETA ACTIN; CASPASE; CELL PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NANOPARTICLE; NICKEL; NICKEL MONOXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN NRDG1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOAVAILABILITY; BRONCHUS MUCOSA; CARCINOGENICITY; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOTOXICITY; DOSE TIME EFFECT RELATION; FLUORESCENCE; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LUNG ALVEOLUS EPITHELIUM; NUCLEAR LOCALIZATION SIGNAL; PHYSICAL CHEMISTRY; PROTEIN CLEAVAGE; TUMOR GROWTH; UPREGULATION;

APOPTOSIS; BIOLOGICAL AVAILABILITY; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; EPITHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; NICKEL; PARTICLE SIZE;

EID: 84155179303     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr206     Document Type: Article

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