The genotoxicity of physiological concentrations of chromium (Cr(III) and Cr(VI)) and cobalt (Co(II)): An in vitro study

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 688, Issue 1-2, 2010, Pages 53-61

  Figgitt, Martin ^a   Newson, Roger ^b   Leslie, Ian J ^c   Fisher, John ^c   Ingham, Eileen ^c   Case, Charles P ^a  

^a SOUTHMEAD HOSPITAL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Aneuploidy; Chromium; Cobalt; Genotoxicity; M FISH; Mutagenicity

Indexed keywords

CHROMIUM; COBALT;

ANEUPLOIDY; ARTICLE; CHROMOSOME LOSS; CHROMOSOME NUMBER; CHROMOSOME TRANSLOCATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPAIR; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC GAIN; GENOMIC INSTABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LONG TERM EXPOSURE; MUTAGENICITY; NUMERICAL CHROMOSOME ABERRATION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

ANEUGENS; CELLS, CULTURED; CHROMIUM; CHROMOSOME ABERRATIONS; COBALT; DNA DAMAGE; DNA REPAIR; FIBROBLASTS; GENOMIC INSTABILITY; HUMANS;

EID: 77952881649     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2010.03.008     Document Type: Article

References (51)

1. Keegan G.M., Learmonth I.D., Case C.P. A systematic comparison of the actual, potential, and theoretical health effects of cobalt and chromium exposures from industry and surgical implants. Crit. Rev. Toxicol. 2008, 38:645-674.
2. Doherty A.T, Howell R.T., Ellis L.A., Bisbinas I., Learmonth I.D., Newson R., Case C.P. Increased chromosome translocations and aneuploidy in peripheral blood lymphocytes of patients having revision arthroplasty of the hip. J. Bone Joint Surg. Br. 2001, 83:1075-1081.
3. Ladon D., Doherty A., Newson R., Turner J., Bhamra M., Case C.P. Changes in metal levels and chromosome aberrations in the peripheral blood of patients after metal-on-metal hip arthroplasty. J. Arthroplasty 2004, 19(Suppl. 3):78-83.
4. Davies A.P., Sood A., Lewis A.C., Newson R., Learmonth I.D., Case C.P. Metal-specific differences in levelsof DNA damage caused by synovial fluid recovered at revision arthroplasty. J Bone Joint Surg Br. 2005, 87:1439-1444. http://www.ncbi.nlm.nih.gov/pubmed/16189324.
5. Papageorgiou I., Brown C., Schins R., Singh S., Newson R., Davis S., Fisher J., Ingham E., Case C.P. The effect of nano- and micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitro. Biomaterials 2007, 28:2946-2958.
6. Papageorgiou I., Yin Z., Ladon D., Baird D., Lewis A.C., Sood A., Newson R., Learmonth I.D., Case C.P. Genotoxic effects of particles of surgical cobalt chrome alloy on human cells of different age in vitro. Mutat. Res. 2007, 619:45-58.
7. The Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COM) COM/06/S1 Hip Replacements (2006), Statement on biological effects of wear debris generated from metal on metal bearing surfaces: evidence for genotoxicitycom/06/S1, July 2006, http://www.iacom.org.uk/statements/COM06S1.htm.
8. Heisel C., Silva M., Skipor A.K., Jacobs J.J., Schmalzried T.P. The relationship between activity and ions in patients with metal-on-metal bearing hip prostheses. J. Bone Joint Surg. Am. 2005, 87:781-787.
9. Skipor A.K., Campbell P.A., Patterson L.M., Anstutz H.C., Schmalzried T.P., Jacobs J.J. Serum and urine metal levels in patients with metal-on-metal surface arthroplasty. J. Mater. Sci. Mater. Med. 2002, 13:1227-1234.
10. Brodner W., Grübl A., Jankovsky R., Meisinger V., Lehr S., Gottsauner-Wolf F. Cup inclination and serum concentration of cobalt and chromium after metal-on-metal total hip arthroplasty. J. Arthroplasty 2004, 19(Suppl 3):66-70.
11. Dunstan E., Sanghrajka A.P., Tilley S., Unwin P., Blunn G., Cannon S.R., Briggs T.W. Metal ion levels after metal-on-metal proximal femoral replacements: a 30-year follow-up. J. Bone Joint Surg. Br. 2005, 87:628-631.
12. O'Brien T.J., Ceryak S., Patierno S.R. Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms. Mutat. Res. 2003, 533:3-36.
13. Wise S.S, Holmes A.L., Wise J.P. Particulate and soluble hexavalent chromium are cytotoxic and genotoxic to human lung epithelial cells. Mutat. Res. 2006, 610:2-7.
14. Zhitkovich A. Importance of chromium-DNA adducts in mutagenicity and toxicity of chromium (VI). Chem. Res. Toxicol. 2005, 18:3-11.
15. Reynolds M.F., Peterson-Roth E.C., Bespalov I.A., Johnston T., Gurel V.M., Menard H.L., Zhitkovich A. Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross links by both MutS dimmers. Cancer Res. 2009, 69:1-9.
16. Holmes A.L., Wise S.S., Wise J.P. Carcinogenicity of hexavalent chromium. Indian J. Med. Res. 2008, 128:353-372.
17. IARC Monographs on the Evaluation of Carcinogenic risks to Humans: Chromium, Nickel and Welding 1990, vol. 49. International Agency for Cancer Research, Lyons, France.
18. Eastmond D.A., MacGregor J.T., Slesinski R.S. Trivalent chromium: assessing the genotoxic risk of an essential trace element and widely used human and animal nutritional supplement. Crit. Rev. Toxicol. 2008, 38:173-190.
19. Coogan T.P., Squibb K.S., Motz J., Kinney P.L., Costa M. Distribution of chromium within cells of the blood. Toxicol. Appl. Pharmacol. 1991, 108:157-166.
20. Merritt K., Brown S.A. Release of hexavalent chromium from corrosion of stainless steel and cobalt-chromium alloys. J. Biomed. Mater. Res. 1995, 29:627-633.
21. Sipowicz M.A., Anderson L.M., Utermahlen W.E., Issaq H.J., Kaprzak K.S. Uptake and tissue distribution of chromium (III) in mice after a single intraperitoneal or subcutaneous administration. Toxicol. Lett. 1997, 93:9-14.
22. Rudolf E., Cervinka M. Trivalent chromium activates Rac-1 and Src and induces switch in the cell death mode in human dermal fibroblasts. Toxicol. Lett. 2009, 188:236-242.
23. Cohen M.D., Kargacin B., Klein C.B., Costa M. Mechanisms of chromium carcinogenicity and toxicity. Crit. Rev. Toxicol. 1993, 23:255-281.
24. Seoane A.I., Dulout F.N. Genotoxic ability of cadmium, chromium and nickel salts studied by kinetochore staining in the cytokinesis-blocked micronucleus assay. Mutat. Res. 2001, 490:99-106.
25. Shrivastava H.Y, Ravikumar T., Shanmugasundaram N., Babu M., Nair B.U. Cytotoxicity studies of chromium(III) complexes on human dermal fibroblasts. Free Radic. Biol. Med. 2005, 38:58-69.
26. Levina A., Lay P.A. Chemical properties and toxicity of chromium(III) nutritional supplements. Chem. Res. Toxicol. 2008, 21:563-571.
27. Lloyd D.R., Carmichael P.L., Phillips D.H. Comparison of the formation of 8-hydroxy-2'-deoxyguanosine and single- and double-strand breaks in DNA mediated by fenton reactions. Chem. Res. Toxicol. 1998, 11:420-427.
28. Baldwin E.L., Byl J.A., Osheroff N. Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry 2004, 43:728-735.
29. Kaston U., Mullenders L.H., Hartwig A. Cobalt(II) inhibits the incision and the polymerization step of nucleotide excision repair in human fibroblasts. Mutat. Res. 1997, 383:81-89.
30. Beyersmann D., Hartwig A. The genetic toxicology of cobalt. Toxicol. Appl. Pharmacol. 1992, 115:137-145.
31. International Agency for Research on Cancer (IARC) Cobalt in hard metals and cobalt sulphate, gallium arsenide, indium phosphide and vanadium pentoxide. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 2003, vol. 86. IARC, Lyon, France.
32. Glaviano A., Nayak V., Cabuy E., Baird D.M., Yin Z., Newson R., Ladon D., Rubio M.A., Slijepcevic P., Lyng F., Mothersill C., Case C.P. Effects of hTERT on metal ion-induced genomic instability. Oncogene 2006, 25:3424-3435.
33. Wise S.S., Holmes A.L., Xie H., Thompson W.D., Wise J.P. Chronic exposure to particulate chromate induces spindle assembly checkpoint bypass in human lung cells. Chem. Res. Toxicol. 2006, 19:1492-1498.
34. Holmes A.L., Wise S.S., Sandwick S.J., Lingle W.L., Negron V.C., Thompson W.D., Wise J.P. Chronic exposure to lead chromate causes centrosome abnormalities and aneuploidy in human lung cells. Cancer Res. 2006, 66:4041-4048.
35. StataCorp. Stata Statistical Software: Release 10 2007, StataCorp LP, College Station, TX.
36. Newson R. Confidence intervals for rank statistics: Somers' D and extensions. Stata J. 2006, 6:309-334.
37. Satterthwaite F.E. An approximate distribution of estimates of variance components. Biometrics Bull. 1946, 2:110-114.
38. Hardin J.W., Hilbe J.M. Generalized Linear Models and Extensions 2007, Stata Press, College Station, TX. second ed.
39. Keegan G.M., Learmonth I.D., Case C.P. Orthopaedic metals and their potential toxicity in the orthroplasty patient. J. Bone Joint Surg. [Br.] 2007, 89:567-573.
40. Case C.P., Langkamer V.G., James C., Palmer M.R., Kemp A.J., Heap P.F., Solomon L. Widespread dissemination of metal debris from implants. J. Bone Joint Surg. [Br.] 1994, 76:701-712.
41. Rowbotham A.L., Levy L.S., Shuker L.K. Chromium in the environment: an evaluation of the exposure of the UK general population and possible adverse health effects. J. Toxicol. Environ. Health B: Crit. Rev. 2000, 3:145-178.
42. De Flora S., D'Agostini F., Balansky R., Micale R., Baluce B., Izzotti A. Lack of genotoxic effects in hematopoietic and gastrointestinal cells of mice receiving chromium(VI) with the drinking water. Mutat. Res. 2008, 659:60-67.
43. Zhang M., Chen Z., Chen Q., Zou H., Lou J., He J. Investigating DNA damage in tannery workers occupationally exposed to trivalent chromium using comet assay. Mutat. Res. 2008, 654:45-51.
44. Maeng S.H., Chung H.W., Kim K.J., Lee B.M., Shin Y.C., Kim S.J., Yu I.J. Chromosome aberrations and lipid peroxidation in chromium-exposed workers. Biomarkers 2004, 9:418-434.
45. Wise J.P., Payne R., Wise S.S., LaCerte C., Wise J., Gianios C., Thompson W.D., Perkins C., Zheng T., Zhu C., Benedict L., Kerr I. A global assessment of chromium pollution using sperm whales (Physeter macrocephalus) as an indicator species. Chemosphere 2009, 75:1461-1467.
46. Wise S.S., Shaffiey F., LaCerte C., Goertz C.E., Dunn J.L., Gulland F.M., Aboueissa A.M., Zheng T., Wise J.P. Particulate and soluble hexavalent chromium are cytotoxic and genotoxic to Steller sea lion lung cells. Aquat. Toxicol. 2009, 91:329-333.
47. Benova D., Hadjidekova V., Hristova R., Nikolova T., Boulanova M., Georgieva I., Grigorova M., Popov T., Panev T., Georgieva R., Natarajan A.T., Darroudi F., Nisson R. Cytogenetic effects of hexavalent chromium in Bulgarian chromium platers. Mutat. Res. 2002, 514:29-38.
48. Sarto F., Cominato I., Bianchi V., Levis A.G. Increased incidence of chromosomal aberrations and sister chromatid exchanges in workers exposed to chromic acid (Cro3) in electroplating factories. Carcinogenesis 1982, 3:1011-1016.
49. Hartwig A., Snyder R.D., Schiepegrell R., Beyersmann D. Modulation by Co (II) of UV-induced DNA repair, mutagenesis and sister-chromatid exchanges in mammalian cells. Mutat. Res. 1991, 248:177-185.
50. S.L. Thompson, D.A. Compton, Examining the link between chromosomal instability and aneuploidy in human cells, 180 (2008) 665-672.
51. Williams B.R., Prabhu V.R., Hunter K.E., Glazier C.M., Whittaker C.A., Housman D.E., Amon A. Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science 2008, 322:703-709.