Size-dependent effects of tungsten carbide-cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells

Toxicology and Applied Pharmacology

Volumn 241, Issue 3, 2009, Pages 260-268

  Ding, M ^a   Kisin, E R ^a   Zhao, J ^a   Bowman, L ^a   Lu, Y ^a   Jiang, B ^b   Leonard, S ^a   Vallyathan, V ^a   Castranova, V ^a   Murray, A R ^a,c   Fadeel, B ^d   Shvedova, A A ^a,c  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cancer; Nanoparticles; Signaling pathway; Skin; Transcription factor; Tungsten carbide cobalt

Indexed keywords

ACETYLCYSTEINE; CATALASE; COBALT; DEFEROXAMINE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR AP 1; TUNGSTEN CARBIDE; TUNGSTEN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMIS CELL; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SURFACE PROPERTY;

ANIMALS; CELL LINE; CELL PROLIFERATION; COBALT; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ACTIVATION; EPIDERMIS; GLUTATHIONE; IMMUNOHISTOCHEMISTRY; INDICATORS AND REAGENTS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASES; NANOPARTICLES; NF-KAPPA B; PARTICLE SIZE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SULFHYDRYL COMPOUNDS; TRANSCRIPTION FACTOR AP-1; TUNGSTEN COMPOUNDS;

MURINAE; MUS MUSCULUS;

EID: 70350605488     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.09.004     Document Type: Article

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