Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cells

Journal of Nanoparticle Research

Volumn 11, Issue 1, 2009, Pages 25-39

  Lin, Weisheng ^a   Xu, Yi ^a   Huang, Chuan Chin ^a   Ma, Yinfa ^a   Shannon, Katie B ^a   Chen, Da Ren ^b   Huang, Yue Wern ^a  

^a MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

EHS; Human bronchoalveolar carcinoma derived cell (A549); Lipid peroxidation; Nanotechnology; Occupational health; Oxidative DNA damage; Oxidative stress; Particles; ZnO

Indexed keywords

EHS; HUMAN BRONCHOALVEOLAR CARCINOMA-DERIVED CELL (A549); LIPID PEROXIDATION; OCCUPATIONAL HEALTH; OXIDATIVE DNA DAMAGE; PARTICLES; ZNO;

ANIMAL CELL CULTURE; CELL CULTURE; CELL MEMBRANES; CYTOLOGY; DNA; DOSIMETERS; DOSIMETRY; GENES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMPURITIES; INDUSTRIAL HYGIENE; LEAKAGE (FLUID); MASS SPECTROMETRY; METAL ANALYSIS; METALS; NANOTECHNOLOGY; NUCLEIC ACIDS; OCCUPATIONAL RISKS; ORGANIC ACIDS; OXIDATION; OXIDATIVE STRESS; OXYGEN; PULMONARY DISEASES; SEMICONDUCTING ZINC COMPOUNDS; SULFUR COMPOUNDS; TOXICITY; ZINC; ZINC OXIDE;

CYTOTOXICITY;

ACETYLCYSTEINE; NANOPARTICLE; REACTIVE OXYGEN METABOLITE; ZINC; ZINC OXIDE;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DNA DAMAGE; DOSIMETRY; HUMAN; HUMAN CELL; HYDRODYNAMICS; LUNG ALVEOLUS EPITHELIUM; MEMBRANE LEAFLET; OXIDATIVE STRESS; PARTICLE SIZE; PRIORITY JOURNAL; TOXICITY;

EID: 58149185440     PISSN: 13880764     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11051-008-9419-7     Document Type: Article

References (46)

1. 2+ over the nonzwitterionic ones J Chem Phys 118 24 10973 10985
2. T Anish EM Michael JH Craig VH Brooke 2005 Effect of ideal, organic nanoparticles on the flow properties of linear polymers: non-Einstein-like behavior Macromolecules 38 19 8000 8011
3. SY Bae HW Seo 2004 Vertically aligned sulfur-doped ZnO nanowires synthesized via chemical vapor deposition J Phys Chem B 108 17 5206 5210
4. XD Bai PX Gao ZL Wang EG Wang 2003 Dual-mode mechanical resonance of individual ZnO nanobelts Appl Phys Lett 82 26 4806 4808
5. WS Beckett DF Chalupa A Pauly-Brown DM Speers JC Stewart MW Frampton MJ Utell LS Huang C Cox W Zareba G Oberdörster 2005 Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study Am J Respir Crit Care Med 171 10 1129 1135
6. MM Bradford 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254
7. DM Brown MR Wilson W MacNee V Stone K Donaldson 2001 Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines Toxicol Appl Pharmacol 175 3 191 199
8. E Comini G Faglia G Sberveglieri Z Pan ZL Wang 2002 Stable and highly sensitive gas sensors based on semiconducting oxide nanobelts Appl Phys Lett 81 10 1869 1871
9. MW Conner WH Flood AE Rogers MO Amdur 1988 Lung injury in guinea pigs caused by multiple exposures to ultrafine zinc oxide: changes in pulmonary lavage fluid J Toxicol Environ Health 25 1 57 69
10. G Cosma H Fulton T DeFeo T Gordon 1992 Rat lung metallothionein and heme oxygenase gene expression following ozone and zinc oxide exposure Toxicol Appl Pharmacol 117 1 75 80
11. IA Cotgreave 1997 N-acetylcysteine: pharmacological considerations and experimental and clinical applications Adv Pharmacol 38 205 227
12. Y Ding ZL Wang 2004 Structure analysis of nanowires and nanobelts by transmission electron microscopy J Phys Chem B 108 33 12280 12291
13. 2 formation from photocatalytic processes at the ZnO/water interface Environ Sci Pollut Res Int 8 4 285 287
14. K Donaldson CL Tran 2002 Inflammation caused by particles and fibers Inhal Toxicol 14 1 5 27
15. KL Dreher 2004 Health and environmental impact of nanotechnology: toxicological assessment of manufactured nanoparticles Toxicol Sci 77 1 3 5
16. R Dunford A Salinaro L Cai N Serpone S Horikoshi H Hidaka J Knowland 1997 Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients FEBS Lett 418 1-2 87 90
17. JM Fine T Gordon LC Chen P Kinney G Falcone WS Beckett 1997 Metal fume fever: characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value J Occup Environ Med 39 8 722 726
18. JR Gurr AS Wang CH Chen KY Jan 2005 Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells Toxicology 213 1-2 66 73
19. S Hirano S Higo N Tsukamoto E Kobayashi KT Suzuki 1989 Pulmonary clearance and toxicity of zinc oxide instilled into the rat lung Arch Toxicol 63 4 336 342
20. M Huang E Khor LY Lim 2004 Uptake and cytotoxicity of chitosan molecules and nanoparticles: effects of molecular weight and degree of deacetylation Pharm Res 21 2 344 353
21. GG Huang CT Wang HT Tang YS Huang J Yang 2006 ZnO nanoparticle-modified infrared internal reflection elements for selective detection of volatile organic compounds Anal Chem 78 7 2397 2404
22. HA Jeng J Swanson 2006 Toxicity of metal oxide nanoparticles in mammalian cells J Environ Sci Health Part A 41 2699 2711
23. HM Kipen DL Laskin 2005 Smaller is not always better: nanotechnology yields nanotoxicology Am J Physiol Lung Cell Mol Physiol 289 L696 L697
24. HF Lam MW Conner AE Rogers S Fitzgerald MO Amdur 1985 Functional and morphologic changes in the lungs of guinea pigs exposed to freshly generated ultrafine zinc oxide Toxicol Appl Pharmacol 78 1 29 38
25. HF Lam LC Chen D Ainsworth S Peoples MO Amdur 1988 Pulmonary function of guinea pigs exposed to freshly generated ultrafine zinc oxide with and without spike concentrations Am Ind Hyg Assoc J 49 7 333 341
26. W Lin YW Huang XD Zhou Y Ma 2006 In vitro toxicity of silica nanoparticles in human lung cancer cells Toxicol Appl Pharmacol 217 3 252 259
27. W Lin YW Huang XD Zhou Y Ma 2006 Toxicity of cerium oxide nanoparticles in human lung cancer cells Int J Toxicol 25 6 451 457
28. M Lindahl P Leanderson C Tagesson 1998 Novel aspect on metal fume fever: zinc stimulates oxygen radical formation in human neutrophils Hum Exp Toxicol 17 2 105 110
29. A Nel T Xia L Madler N Li 2006 Toxic potential of materials at the nanolevel Science 311 5767 622 627
30. G Oberdorster 2000 Toxicology of ultrafine particles: in vivo studies Trans R Soc Lond A 358 1175 2719 2740
31. G Oberdorster E Oberdorster J Oberdorster 2005 Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles Environ Health Perspect 113 7 823 839
32. G Ramakrishna HN Ghosh 2003 Effect of particle size on the reactivity of quantum size ZnO nanoparticles and charge-transfer dynamics with adsorbed catechols Langmuir 19 7 3006 3012
33. J Russell J Ness M Chopra J McMurray WE Smith 1994 The assessment of the HO scavenging action of therapeutic agents J Pharm Biomed Anal 12 7 863 866
34. X Shi Z Dong C Huang W Ma K Liu J Ye F Chen SS Leonard M Ding V Castranova V Vallyathan 1999 The role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NF-kappaB Mol Cell Biochem 194 1-2 63 70
35. P Skehan R Storeng D Scudiero A Monks J McMahon D Vistica JT Warren H Bokesch S Kenney MR Boyd 1990 New colorimetric cytotoxicity assay for anticancer-drug screening J Natl Cancer Inst 82 13 1107 1112
36. EF Straube NH Schuster AJ Sinclair 1980 Zinc toxicity in the ferret J Comp Pathol 90 3 355 361
37. D Upadhyay V Panduri A Ghio D Kamp 2003 Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria Am J Respir Cell Mol Biol 29 2 180 187
38. H Wang JA Joseph 1999 Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader Free Radic Biol Med 27 5-6 612 616
39. 2 rods and dots in rats: toxicity is not dependent upon particle size and surface area Toxicol Sci 91 1 227 236
40. SC Wesselkamper LC Chen T Gordon 2001 Development of pulmonary tolerance in mice exposed to zinc oxide fumes Toxicol Sci 60 1 144 151
41. SC Wesselkamper LC Chen T Gordon 2005 Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice Respir Res 6 73
42. RA Winters J Zukowski N Ercal RH Matthews DR Spitz 1995 Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide Anal Biochem 227 1 14 21
43. R Wottrich S Diabate HF Krug 2004 Biological effects of ultrafine model particles in human macrophages and epithelial cells in mono- and co-culture Int J Hyg Environ Health 207 4 353 361
44. Y Yamamoto N Imai R Mashima R Konaka M Inoue WC Dunlap 2000 Singlet oxygen from irradiated titanium dioxide and zinc oxide Methods Enzymol 319 29 37
45. Z Zhang HM Shen QF Zhang CN Ong 1999 Critical role of GSH in silica-induced oxidative stress, cytotoxicity, and genotoxicity in alveolar macrophages Am J Physiol 277 4 Pt 1 L743 L748
46. BL Zhu CS Xie DW Zeng WL Song AH Wang 2005 Investigation of gas sensitivity of Sb-doped ZnO nanoparticles Materials Chem Phys 89 1 148 153