Cellular toxicity of various inhalable metal nanoparticles on human alveolar epithelial cells

Inhalation Toxicology

Volumn 19, Issue SUPPL. 1, 2007, Pages 59-65

  Park, Seoyoung ^a   Lee, Yong Kwon ^b   Jung, Moonju ^b   Kim, Ki Heon ^b   Chung, Namhyun ^b   Ahn, Eun Kyung ^c   Lim, Young ^c   Lee, Kweon Haeng ^c  

^a Seoul National University Hospital   (South Korea)

^b Korea University   (South Korea)

^c The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM; DNA FRAGMENT; NANOPARTICLE; NICKEL; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; SILVER; TITANIUM DIOXIDE; ZINC;

AIR POLLUTION; APOPTOSIS; CELL COMPOSITION; CELL DAMAGE; CELL SIZE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL;

APOPTOSIS; CELL LINE; CELL SIZE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; HUMANS; METAL NANOPARTICLES; REACTIVE OXYGEN SPECIES; RESPIRATORY MUCOSA;

EID: 34548832559     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370701493282     Document Type: Conference Paper

References (21)

1. Bönnemann, H., and Richards, R. M. 2001. Nanoscopic metal particles - Synthetic methods and potential applications. Eur. J. Inorg. Chem. 2001:2455-2480.
2. Brown, D. M., Donaldson, K., Borm, P. J., Schins, R. P., Dehnhardt, M., Gilmour, P., Jimenez, L. A., and Stone, V. 2004. Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. Am. J. Physiol. Lung Cell Mol. Physiol. 286:L344-L353.
3. 2 in a tracheal explant system. Am. J. Physiol. Lung. Cell Mol. Physiol. 274:L81-L86.
4. Donaldson, K., Stone, V., Tran, C. L., Kreyling, W., and Brom, P. J. A. 2004. Nanotechnology. Occup. Environ. Med. 61:727-728.
5. Donaldson, K., and Tran, C. L. 2002. Inflammation caused by particles and fibers. Inhal. Toxicol. 14:5-27.
6. Donaldson, K., Tran, C. L., and MacNee, W. 2002. Deposition and effects of fine and ultrafine particles in the respiratory tract. Eur. Respir. Mon. 7:77-92.
7. 2, carbon black, and coal dust and the influence of poly-2-vinylpyridine-Noxide (PVNO). Exp. Toxicol. Pathol. 54:109-126.
8. Gradon, L., Orlicki, D., and Podgorski A. 2000. Deposition and retention of ultrafine aerosol particles in the human respiratory system. Normal and pathological cases. Int. J. Occup. Saf. Ergon. 6:189-207.
9. Hillery, A. M., Jani, P. U., and Florence, A. T. 1994. Comparative, quantitative study of lymphoid and non-lymphoid uptake of 60 nm polystyrene particles. J. Drug Target 2:151-156.
10. Hiura, T. S., Kaszubowski, M. P., Li, N., and Nel, A. E. 1999. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J. Immunol. 163:5582-5591.
11. Jani, P., Halbert, G. W., and Langridge, J. 1990. Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency. J. Pharm. Pharmacol. 42:821-826.
12. Kim, Y.-M., William, R., Anke, G. L., Ilona, J., Robert, S., Harry, S. N., and James, M. S. 2005. Ultrafine carbon particles induce interleukin-8 gene transcription and p38 MAPK activation in normal human bronchial epithelial cells. AJP - Lung 288:432-441.
13. Kruter, J., Shamenkov, D., and Petrov, V. 2002. Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier. J. Drug Target 10:317-325.
14. Nemmar, A., Hoet, P. H. M., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M. F., Vanbilloen, H., Mortelmans, L., and Nemery, B. 2002. Passage of inhaled particles into the blood circulation in humans. Circulation 105:411-414.
15. Oberdörster, G., Oberdörster, E., and Oberdörster, J. 2005. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113:823-839.
16. Oberdörster, G., Sharp, Z., and Elder, A. P. 2004. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol. 16:437-445.
17. Ralf, W., Silvia, D., and Harald, F. K. 2004. Biological effects of ultrafine model particles in human macrophage and epithelial cells in mono- and co-culture. Int. J. Environ. Health 207:353-361.
18. Renwick, L. C., Brown, D., Clouter, A., and Donaldson, K. 2004. Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup. Environ. Med. 61:442-447.
19. Shukla, A., Timblin, C., BeruBe, K., Gordon, T., McKinney, W., Driscoll, K., Vacek, P., and Mossman, B. T. 2000. Inhaled particulate matter causes expression of nuclear factor (NF)-κB-related genes and oxidant-dependent NF-κB activation in vitro. Am. J. Respir. Cell Mol. Biol. 23:182-187.
20. Stohs, S. J., and Bagchi, D. 1995. Oxidative mechanisms in the toxicity of metal ions. Free Radical Biol. Med., 18:321-336.
21. Tao, F., AND Kobzik, L. 2002. Lung macrophage-epithelial cell interactions amplify particle-mediated cytokine release. Am. J. Respir. Cell Mol. Biol. 26:499-505.