메뉴 건너뛰기




Volumn 355, Issue , 2012, Pages 119-133

JAK-mutant myeloproliferative neoplasms

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLORO N2 [1 (5 FLUORO 2 PYRIMIDINYL)ETHYL] N4 (5 METHYL 1H PYRAZOL 3 YL) 2,4 PYRIMIDINEDIAMINE; CYT 787; EXL 019; GUANINE; JANUS KINASE; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; JANUS KINASE 3; JANUS KINASE INHIBITOR; N TERT BUTYL 3 [5 METHYL 2 [4 [2 (1 PYRROLIDINYL)ETHOXY]PHENYLAMINO] 4 PYRIMIDINYLAMINO]BENZENESULFONAMIDE; PROTEIN KINASE TYK2; PROTEIN TYROSINE KINASE INHIBITOR; RUXOLITINIB; STAT PROTEIN; THYMIDINE; UNCLASSIFIED DRUG;

EID: 84865202724     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82-2011-170     Document Type: Article
Times cited : (21)

References (81)
  • 1
    • 76549109434 scopus 로고    scopus 로고
    • Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
    • Abdel-Wahab O et al (2010) Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res 70:447-452
    • (2010) Cancer Res , vol.70 , pp. 447-452
    • Abdel-Wahab, O.1
  • 2
    • 84905956633 scopus 로고    scopus 로고
    • Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
    • Abdel-Wahab O et al (2011a) Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms. Leukemia 19(5):769-780
    • (2011) Leukemia , vol.19 , Issue.5 , pp. 769-780
    • Abdel-Wahab, O.1
  • 3
    • 79960248721 scopus 로고    scopus 로고
    • DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms
    • Abdel-Wahab O et al (2011b) DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms. Leukemia 25:1219-1220
    • (2011) Leukemia , vol.25 , pp. 1219-1220
    • Abdel-Wahab, O.1
  • 4
    • 77951759127 scopus 로고    scopus 로고
    • Conditional expression of heterozygous or homozygous JAK2V617F from its endogenous promoter induces a polycythemia vera-like disease
    • Akada H et al (2010) Conditional expression of heterozygous or homozygous JAK2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood 115(17):3589-3597
    • (2010) Blood , vol.115 , Issue.17 , pp. 3589-3597
    • Akada, H.1
  • 5
    • 0027179365 scopus 로고
    • Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase
    • Argetsinger LS et al (1993) Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74:237-244
    • (1993) Cell , vol.74 , pp. 237-244
    • Argetsinger, L.S.1
  • 6
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ et al (2005) Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365:1054-1061
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1
  • 7
    • 60649096136 scopus 로고    scopus 로고
    • Clonal diversity in the myeloproliferative neoplasms: Independent origins of genetically distinct clones
    • Beer PA et al (2009) Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones. Br J Haematol 144:904-908
    • (2009) Br J Haematol , vol.144 , pp. 904-908
    • Beer, P.A.1
  • 8
    • 54349086521 scopus 로고    scopus 로고
    • Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
    • Bercovich D et al (2008) Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet 372:1484-1492
    • (2008) Lancet , vol.372 , pp. 1484-1492
    • Bercovich, D.1
  • 9
    • 23044495944 scopus 로고    scopus 로고
    • Crystal structure of the JAK3 kinase domain in complex with a staurosporine analog
    • Boggon TJ, Li Y, Manley PW, Eck MJ (2005) Crystal structure of the JAK3 kinase domain in complex with a staurosporine analog. Blood 106:996-1002
    • (2005) Blood , vol.106 , pp. 996-1002
    • Boggon, T.J.1    Li, Y.2    Manley, P.W.3    Eck, M.J.4
  • 10
    • 33845798378 scopus 로고    scopus 로고
    • Characterization of murine JAK2V617F-positive myeloproliferative disease
    • Bumm TG et al (2006) Characterization of murine JAK2V617F-positive myeloproliferative disease. Cancer Res 66:11156-11165
    • (2006) Cancer Res , vol.66 , pp. 11156-11165
    • Bumm, T.G.1
  • 11
    • 28244442441 scopus 로고    scopus 로고
    • Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: A prospective study
    • Campbell PJ et al (2005) Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study. Lancet 366:1945-1953
    • (2005) Lancet , vol.366 , pp. 1945-1953
    • Campbell, P.J.1
  • 12
    • 33749434271 scopus 로고    scopus 로고
    • Mutation of JAK2 in the myeloproliferative disorders: Timing, clonality studies, cytogenetic associations, and role in leukemic transformation
    • Campbell PJ et al (2006) Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation. Blood 108:3548-3555
    • (2006) Blood , vol.108 , pp. 3548-3555
    • Campbell, P.J.1
  • 13
    • 76749084667 scopus 로고    scopus 로고
    • Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias
    • Carbuccia N et al (2009a) Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. Leukemia 24(2):469-473
    • (2009) Leukemia , vol.24 , Issue.2 , pp. 469-473
    • Carbuccia, N.1
  • 14
    • 70450239681 scopus 로고    scopus 로고
    • Mutations of ASXL1 gene in myeloproliferative neoplasms
    • Carbuccia N et al (2009b) Mutations of ASXL1 gene in myeloproliferative neoplasms. Leukemia 23:2183-2186
    • (2009) Leukemia , vol.23 , pp. 2183-2186
    • Carbuccia, N.1
  • 15
    • 78249256979 scopus 로고    scopus 로고
    • Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling
    • Chen E et al (2010) Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling. Cancer Cell 18:524-535
    • (2010) Cancer Cell , vol.18 , pp. 524-535
    • Chen, E.1
  • 16
    • 33745842538 scopus 로고    scopus 로고
    • Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor
    • Cho YS, Kim EJ, Park UH, Sin HS, Um SJ (2006) Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor. J Biol Chem 281:17588-17598
    • (2006) J Biol Chem , vol.281 , pp. 17588-17598
    • Cho, Y.S.1    Kim, E.J.2    Park, U.H.3    Sin, H.S.4    Um, S.J.5
  • 17
    • 66249137734 scopus 로고    scopus 로고
    • Mutation in TET2 in myeloid cancers
    • Delhommeau F et al (2009) Mutation in TET2 in myeloid cancers. N Engl J Med 360:2289-2301
    • (2009) N Engl J Med , vol.360 , pp. 2289-2301
    • Delhommeau, F.1
  • 18
    • 2542502506 scopus 로고    scopus 로고
    • Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin
    • Ding J et al (2004) Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin. Blood 103:4198-4200
    • (2004) Blood , vol.103 , pp. 4198-4200
    • Ding, J.1
  • 19
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ et al (2001) Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344:1031-1037
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1
  • 20
    • 45149097975 scopus 로고    scopus 로고
    • Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2
    • Dusa A et al (2008) Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2. J Biol Chem 283:12941-12948
    • (2008) J Biol Chem , vol.283 , pp. 12941-12948
    • Dusa, A.1
  • 21
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T et al (2010) Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 42:722-726
    • (2010) Nat Genet , vol.42 , pp. 722-726
    • Ernst, T.1
  • 22
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME et al (2010) Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18:553-567
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1
  • 23
    • 70450277268 scopus 로고    scopus 로고
    • Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice
    • Fisher CL et al (2010) Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. Dev Biol 337:9-15
    • (2010) Dev Biol , vol.337 , pp. 9-15
    • Fisher, C.L.1
  • 24
    • 42249091014 scopus 로고    scopus 로고
    • Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
    • Flex E et al (2008) Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia. J Exp Med 205:751-758
    • (2008) J Exp Med , vol.205 , pp. 751-758
    • Flex, E.1
  • 25
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao SP et al (2007) Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 117:3846-3856
    • (2007) J Clin Invest , vol.117 , pp. 3846-3856
    • Gao, S.P.1
  • 26
    • 66849124925 scopus 로고    scopus 로고
    • Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
    • Gelsi-Boyer V et al (2009) Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia. Br J Haematol 145:788-800
    • (2009) Br J Haematol , vol.145 , pp. 788-800
    • Gelsi-Boyer, V.1
  • 27
    • 77149134353 scopus 로고    scopus 로고
    • Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
    • Gross S et al (2010) Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med 207:339-344
    • (2010) J Exp Med , vol.207 , pp. 339-344
    • Gross, S.1
  • 29
    • 70949094349 scopus 로고    scopus 로고
    • The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors
    • Hedvat M et al (2009) The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell 16:487-497
    • (2009) Cancer Cell , vol.16 , pp. 487-497
    • Hedvat, M.1
  • 30
    • 47049098437 scopus 로고    scopus 로고
    • Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders
    • Hexner EO et al (2008) Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders. Blood 111:5663-5671
    • (2008) Blood , vol.111 , pp. 5663-5671
    • Hexner, E.O.1
  • 31
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C et al (2005) A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434:1144-1148
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1
  • 32
    • 63449099560 scopus 로고    scopus 로고
    • JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms
    • Jones AV et al (2009) JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms. Nat Genet 41:446-449
    • (2009) Nat Genet , vol.41 , pp. 446-449
    • Jones, A.V.1
  • 33
    • 63449127583 scopus 로고    scopus 로고
    • A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms
    • Kilpivaara O et al (2009) A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms. Nat Genet 41:455-459
    • (2009) Nat Genet , vol.41 , pp. 455-459
    • Kilpivaara, O.1
  • 34
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M et al (2010) Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 468:839-843
    • (2010) Nature , vol.468 , pp. 839-843
    • Ko, M.1
  • 35
    • 77951031498 scopus 로고    scopus 로고
    • Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis
    • Koppikar P et al (2010) Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis. Blood 115(14):2919-2927
    • (2010) Blood , vol.115 , Issue.14 , pp. 2919-2927
    • Koppikar, P.1
  • 36
    • 0036191941 scopus 로고    scopus 로고
    • Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera
    • Kralovics R, Guan Y, Prchal JT (2002) Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera. Exp Hematol 30:229-236
    • (2002) Exp Hematol , vol.30 , pp. 229-236
    • Kralovics, R.1    Guan, Y.2    Prchal, J.T.3
  • 37
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • Kralovics R et al (2005) A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 352:1779-1790
    • (2005) N Engl J Med , vol.352 , pp. 1779-1790
    • Kralovics, R.1
  • 38
    • 33745721197 scopus 로고    scopus 로고
    • JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
    • Lacout C et al (2006) JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood 108:1652-1660
    • (2006) Blood , vol.108 , pp. 1652-1660
    • Lacout, C.1
  • 39
    • 54049129782 scopus 로고    scopus 로고
    • Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24, 577 first-degree relatives of 11, 039 patients with myeloproliferative neoplasms in Sweden
    • Landgren O et al (2008) Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24, 577 first-degree relatives of 11, 039 patients with myeloproliferative neoplasms in Sweden. Blood 112:2199-2204
    • (2008) Blood , vol.112 , pp. 2199-2204
    • Landgren, O.1
  • 40
    • 67649876132 scopus 로고    scopus 로고
    • Acquired mutations in TET2 are common in myelodysplastic syndromes
    • Langemeijer SM et al (2009) Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet 41:838-842
    • (2009) Nat Genet , vol.41 , pp. 838-842
    • Langemeijer, S.M.1
  • 41
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine RL et al (2005) Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7:387-397
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1
  • 42
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ et al (2010) DNMT3A mutations in acute myeloid leukemia. N Engl J Med 363:2424-2433
    • (2010) N Engl J Med , vol.363 , pp. 2424-2433
    • Ley, T.J.1
  • 43
    • 84905943881 scopus 로고    scopus 로고
    • JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia
    • Li J et al (2010) JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood 30(24):5741-5751
    • (2010) Blood , vol.30 , Issue.24 , pp. 5741-5751
    • Li, J.1
  • 44
    • 30144436273 scopus 로고    scopus 로고
    • The structural basis of janus kinase 2 inhibition by a potent and specific panjanus kinase inhibitor
    • Lucet IS et al (2006) The structural basis of janus kinase 2 inhibition by a potent and specific panjanus kinase inhibitor. Blood 107:176-183
    • (2006) Blood , vol.107 , pp. 176-183
    • Lucet, I.S.1
  • 45
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A cancer and leukemia group B study
    • Marcucci G et al (2010) IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 28:2348-2355
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1
  • 46
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER et al (2009) Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 361:1058-1066
    • (2009) N Engl J Med , vol.361 , pp. 1058-1066
    • Mardis, E.R.1
  • 47
    • 77956280929 scopus 로고    scopus 로고
    • Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice
    • Marty C et al (2010) Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice. Blood 116:783-787
    • (2010) Blood , vol.116 , pp. 783-787
    • Marty, C.1
  • 48
    • 77957854088 scopus 로고    scopus 로고
    • HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans
    • Marubayashi S et al (2010) HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans. J Clin Invest 120:3578-3593
    • (2010) J Clin Invest , vol.120 , pp. 3578-3593
    • Marubayashi, S.1
  • 49
    • 12844284481 scopus 로고    scopus 로고
    • Leukemic transformation in myelofibrosis with myeloid metaplasia: A single-institution experience with 91 cases
    • Mesa RA et al (2005) Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases. Blood 105:973-977
    • (2005) Blood , vol.105 , pp. 973-977
    • Mesa, R.A.1
  • 50
    • 79960064353 scopus 로고    scopus 로고
    • Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
    • Moran-Crusio K et al (2011) Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 20(1):11-24
    • (2011) Cancer Cell , vol.20 , Issue.1 , pp. 11-24
    • Moran-Crusio, K.1
  • 51
    • 77953274727 scopus 로고    scopus 로고
    • Physiological JAK2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
    • Mullally A et al (2010) Physiological JAK2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell 17:584-596
    • (2010) Cancer Cell , vol.17 , pp. 584-596
    • Mullally, A.1
  • 52
    • 67249146555 scopus 로고    scopus 로고
    • JAK mutations in high-risk childhood acute lymphoblastic leukemia
    • Mullighan CG et al (2009) JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 106:9414-9418
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9414-9418
    • Mullighan, C.G.1
  • 53
    • 77955087290 scopus 로고    scopus 로고
    • Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
    • Nikoloski G et al (2010) Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet 42:665-667
    • (2010) Nat Genet , vol.42 , pp. 665-667
    • Nikoloski, G.1
  • 54
    • 77953485892 scopus 로고    scopus 로고
    • Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
    • Oh ST et al (2010) Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood 116:988-992
    • (2010) Blood , vol.116 , pp. 988-992
    • Oh, S.T.1
  • 55
    • 63449134208 scopus 로고    scopus 로고
    • A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms
    • Olcaydu D et al (2009) A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms. Nat Genet 41:450-454
    • (2009) Nat Genet , vol.41 , pp. 450-454
    • Olcaydu, D.1
  • 56
    • 33750534561 scopus 로고    scopus 로고
    • MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1,182 patients
    • Pardanani AD et al (2006) MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1,182 patients. Blood 108:3472-3476
    • (2006) Blood , vol.108 , pp. 3472-3476
    • Pardanani, A.D.1
  • 57
    • 34447627350 scopus 로고    scopus 로고
    • TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations
    • Pardanani A et al (2007) TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia 21:1658-1668
    • (2007) Leukemia , vol.21 , pp. 1658-1668
    • Pardanani, A.1
  • 58
    • 79952333359 scopus 로고    scopus 로고
    • Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis
    • Pardanani A et al (2011) Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis. J Clin Oncol 29(7):789-796
    • (2011) J Clin Oncol , vol.29 , Issue.7 , pp. 789-796
    • Pardanani, A.1
  • 59
    • 0032076542 scopus 로고    scopus 로고
    • JAK2 is essential for signaling through a variety of cytokine receptors
    • Parganas E et al (1998) JAK2 is essential for signaling through a variety of cytokine receptors. Cell 93:385-395
    • (1998) Cell , vol.93 , pp. 385-395
    • Parganas, E.1
  • 60
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y et al (2006) MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med 3:e270
    • (2006) PLoS Med , vol.3
    • Pikman, Y.1
  • 61
    • 84905928975 scopus 로고    scopus 로고
    • TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
    • Quivoron C et al (2011) TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell 19(6):805-813
    • (2011) Cancer Cell , vol.19 , Issue.6 , pp. 805-813
    • Quivoron, C.1
  • 62
    • 58149326854 scopus 로고    scopus 로고
    • Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
    • Rebouissou S et al (2009) Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature 457:200-204
    • (2009) Nature , vol.457 , pp. 200-204
    • Rebouissou, S.1
  • 63
    • 0037033012 scopus 로고    scopus 로고
    • The pseudokinase domain is required for suppression of basal activity of JAK2 and JAK3 tyrosine kinases and for cytokine-inducible activation of signal transduction
    • Saharinen P, Silvennoinen O (2002) The pseudokinase domain is required for suppression of basal activity of JAK2 and JAK3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem 277:47954-47963
    • (2002) J Biol Chem , vol.277 , pp. 47954-47963
    • Saharinen, P.1    Silvennoinen, O.2
  • 64
    • 33749358349 scopus 로고    scopus 로고
    • Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia
    • Scott LM, Scott MA, Campbell PJ, Green AR (2006) Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia. Blood 108:2435-2437
    • (2006) Blood , vol.108 , pp. 2435-2437
    • Scott, L.M.1    Scott, M.A.2    Campbell, P.J.3    Green, A.R.4
  • 65
    • 33846660947 scopus 로고    scopus 로고
    • JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
    • Scott LM et al (2007) JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med 356:459-468
    • (2007) N Engl J Med , vol.356 , pp. 459-468
    • Scott, L.M.1
  • 66
    • 79956108320 scopus 로고    scopus 로고
    • Gain-of-function mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias
    • Shochat C et al (2011) Gain-of-function mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias. J Exp Med 208:901-908
    • (2011) J Exp Med , vol.208 , pp. 901-908
    • Shochat, C.1
  • 67
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M et al (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324:930-935
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1
  • 68
    • 34347394712 scopus 로고    scopus 로고
    • Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation
    • Theocharides A et al (2007) Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation. Blood 110: 375-379
    • (2007) Blood , vol.110 , pp. 375-379
    • Theocharides, A.1
  • 69
    • 43249084493 scopus 로고    scopus 로고
    • Ratio of mutant JAK2-V617F to wild-type JAK2 determines the MPD phenotypes in transgenic mice
    • Tiedt R et al (2008) Ratio of mutant JAK2-V617F to wild-type JAK2 determines the MPD phenotypes in transgenic mice. Blood 111:3931-3940
    • (2008) Blood , vol.111 , pp. 3931-3940
    • Tiedt, R.1
  • 70
    • 47149087181 scopus 로고    scopus 로고
    • Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia
    • Tomasson MH et al (2008) Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood 111:4797-4808
    • (2008) Blood , vol.111 , pp. 4797-4808
    • Tomasson, M.H.1
  • 71
    • 77956696835 scopus 로고    scopus 로고
    • Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
    • Verstovsek S et al (2010) Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med 363:1117-1127
    • (2010) N Engl J Med , vol.363 , pp. 1117-1127
    • Verstovsek, S.1
  • 72
    • 73949136283 scopus 로고    scopus 로고
    • Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells
    • Wang Y et al (2009) Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells. Blood 114:5024-5033
    • (2009) Blood , vol.114 , pp. 5024-5033
    • Wang, Y.1
  • 73
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward PS et al (2010) The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 17:225-234
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1
  • 74
    • 33744490974 scopus 로고    scopus 로고
    • Expression of JAK2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
    • Wernig G et al (2006) Expression of JAK2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood 107:4274-4281
    • (2006) Blood , vol.107 , pp. 4274-4281
    • Wernig, G.1
  • 75
    • 41249099841 scopus 로고    scopus 로고
    • Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera
    • Wernig G et al (2008) Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell 13:311-320
    • (2008) Cancer Cell , vol.13 , pp. 311-320
    • Wernig, G.1
  • 76
    • 0027327484 scopus 로고
    • JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    • Witthuhn BA et al (1993) JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74:227-236
    • (1993) Cell , vol.74 , pp. 227-236
    • Witthuhn, B.A.1
  • 77
    • 46749137278 scopus 로고    scopus 로고
    • Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice
    • Xing S et al (2008) Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood 111:5109-5117
    • (2008) Blood , vol.111 , pp. 5109-5117
    • Xing, S.1
  • 78
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan XJ et al (2011) Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 43(4):309-315
    • (2011) Nat Genet , vol.43 , Issue.4 , pp. 309-315
    • Yan, X.J.1
  • 79
    • 76249096219 scopus 로고    scopus 로고
    • Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia
    • Yoda A et al (2009) Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. Proc Natl Acad Sci USA 107(1):252-257
    • (2009) Proc Natl Acad Sci USA , vol.107 , Issue.1 , pp. 252-257
    • Yoda, A.1
  • 80
    • 34447642422 scopus 로고    scopus 로고
    • Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F
    • Zaleskas VM et al (2006) Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. PLoS ONE 1:e18
    • (2006) PLoS ONE , vol.1
    • Zaleskas, V.M.1
  • 81
    • 20744460045 scopus 로고    scopus 로고
    • Identification of an acquired JAK2 mutation in polycythemia vera
    • Zhao R et al (2005) Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem 280:22788-22792
    • (2005) J Biol Chem , vol.280 , pp. 22788-22792
    • Zhao, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.