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Volumn 18, Issue 2, 2012, Pages 138-149

Yin and yang - the gastric X/A-like cell as possible dual regulator of food intake

Author keywords

Desacyl ghrelin; Eating; Ghrelin; Nucleobindin; Obesity; Obestatin; Stomach

Indexed keywords

CELL PROTEIN; DESACYL GHRELIN; GHRELIN; N DECANOYL GHRELIN; NESFATIN 1; NUCLEOBINDIN 2; OBESTATIN; UNCLASSIFIED DRUG;

EID: 84865104374     PISSN: 20930879     EISSN: 20930887     Source Type: Journal    
DOI: 10.5056/jnm.2012.18.2.138     Document Type: Review
Times cited : (22)

References (165)
  • 1
    • 2342606044 scopus 로고    scopus 로고
    • The " normal" endocrine cell of the gut: changing concepts and new evidences
    • Rindi G, Leiter AB, Kopin AS, Bordi C, Solcia E. The " normal" endocrine cell of the gut: changing concepts and new evidences. Ann N Y Acad Sci 2004;1014:1-12.
    • (2004) Ann N Y Acad Sci , vol.1014 , pp. 1-12
    • Rindi, G.1    Leiter, A.B.2    Kopin, A.S.3    Bordi, C.4    Solcia, E.5
  • 2
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y, Kojima M, Hosoda H, et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000;141:4255-4261.
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3
  • 3
    • 72249112599 scopus 로고    scopus 로고
    • Localization of acyl ghrelin- and des-acyl ghrelin-immunoreactive cells in the rat stomach and their responses to intragastric pH
    • Mizutani M, Atsuchi K, Asakawa A, et al. Localization of acyl ghrelin- and des-acyl ghrelin-immunoreactive cells in the rat stomach and their responses to intragastric pH. Am J Physiol Gastrointest Liver Physiol 2009;297:G974-G980.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297
    • Mizutani, M.1    Atsuchi, K.2    Asakawa, A.3
  • 4
    • 0036171253 scopus 로고    scopus 로고
    • Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract
    • Sakata I, Nakamura K, Yamazaki M, et al. Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract. Peptides 2002;23:531-536.
    • (2002) Peptides , vol.23 , pp. 531-536
    • Sakata, I.1    Nakamura, K.2    Yamazaki, M.3
  • 5
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 6
    • 0036085711 scopus 로고    scopus 로고
    • Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues
    • Rindi G, Necchi V, Savio A, et al. Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Histochem Cell Biol 2002;117:511-519.
    • (2002) Histochem Cell Biol , vol.117 , pp. 511-519
    • Rindi, G.1    Necchi, V.2    Savio, A.3
  • 7
    • 67449164331 scopus 로고    scopus 로고
    • Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents
    • Hiejima H, Nishi Y, Hosoda H, et al. Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents. Regul Pept 2009;156:47-56.
    • (2009) Regul Pept , vol.156 , pp. 47-56
    • Hiejima, H.1    Nishi, Y.2    Hosoda, H.3
  • 8
    • 27744600963 scopus 로고    scopus 로고
    • Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • Zhang JV, Ren PG, Avsian-Kretchmer O, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005;310:996-999.
    • (2005) Science , vol.310 , pp. 996-999
    • Zhang, J.V.1    Ren, P.G.2    Avsian-Kretchmer, O.3
  • 9
    • 58149466993 scopus 로고    scopus 로고
    • Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa
    • Stengel A, Goebel M, Yakubov I, et al. Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology 2009;150:232-238.
    • (2009) Endocrinology , vol.150 , pp. 232-238
    • Stengel, A.1    Goebel, M.2    Yakubov, I.3
  • 10
    • 81755173376 scopus 로고    scopus 로고
    • The discovery of ghrelin: with a little luck and great passion
    • Kojima M, Kangawa K. The discovery of ghrelin: with a little luck and great passion. Preface. Peptides 2011;32:2153-2154.
    • (2011) Preface. Peptides , vol.32 , pp. 2153-2154
    • Kojima, M.1    Kangawa, K.2
  • 11
    • 29844444877 scopus 로고    scopus 로고
    • International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function
    • Davenport AP, Bonner TI, Foord SM, et al. International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function. Pharmacol Rev 2005;57:541-546.
    • (2005) Pharmacol Rev , vol.57 , pp. 541-546
    • Davenport, A.P.1    Bonner, T.I.2    Foord, S.M.3
  • 12
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: structure and function
    • Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev 2005;85:495-522.
    • (2005) Physiol Rev , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 13
    • 20244366719 scopus 로고    scopus 로고
    • Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin
    • Nishi Y, Hiejima H, Hosoda H, et al. Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. Endocrinology 2005;146:2255-2264.
    • (2005) Endocrinology , vol.146 , pp. 2255-2264
    • Nishi, Y.1    Hiejima, H.2    Hosoda, H.3
  • 14
    • 0034676324 scopus 로고    scopus 로고
    • Structure-function studies on the new growth hormone-releasing peptide, ghrelin: min imal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
    • Bednarek MA, Feighner SD, Pong SS, et al. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: min imal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem 2000;43:4370-4376.
    • (2000) J Med Chem , vol.43 , pp. 4370-4376
    • Bednarek, M.A.1    Feighner, S.D.2    Pong, S.S.3
  • 15
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008;132:387-396.
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 16
  • 17
    • 67649207827 scopus 로고    scopus 로고
    • Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells
    • Sakata I, Yang J, Lee CE, et al. Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. Am J Physiol Endocrinol Metab 2009;297:E134-E141.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Sakata, I.1    Yang, J.2    Lee, C.E.3
  • 18
    • 75049085779 scopus 로고    scopus 로고
    • Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa
    • Stengel A, Goebel M, Wang L, Taché Y, Sachs G, Lambrecht NW. Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa. Biochem Biophys Res Commun 2010;392:67-71.
    • (2010) Biochem Biophys Res Commun , vol.392 , pp. 67-71
    • Stengel, A.1    Goebel, M.2    Wang, L.3    Taché, Y.4    Sachs, G.5    Lambrecht, N.W.6
  • 19
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue
    • Hosoda H, Kojima M, Matsuo H, Kangawa K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 2000;279:909-913.
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 20
    • 0042205288 scopus 로고    scopus 로고
    • Total and active ghrelin in developing rats during hypoxia
    • Raff H. Total and active ghrelin in developing rats during hypoxia. Endocrine 2003;21:159-161.
    • (2003) Endocrine , vol.21 , pp. 159-161
    • Raff, H.1
  • 21
    • 70350266819 scopus 로고    scopus 로고
    • The RAPID method for blood processing yields new insight in plasma concentrations and molecular forms of circulating gut peptides
    • Stengel A, Keire D, Goebel M, et al. The RAPID method for blood processing yields new insight in plasma concentrations and molecular forms of circulating gut peptides. Endocrinology 2009;150: 5113-5118.
    • (2009) Endocrinology , vol.150 , pp. 5113-5118
    • Stengel, A.1    Keire, D.2    Goebel, M.3
  • 22
    • 44649098808 scopus 로고    scopus 로고
    • Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle
    • Soares JB, Leite-Moreira AF. Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides 2008;29:1255-1270.
    • (2008) Peptides , vol.29 , pp. 1255-1270
    • Soares, J.B.1    Leite-Moreira, A.F.2
  • 23
    • 49749084909 scopus 로고    scopus 로고
    • Distribution of obestatin and ghrelin in human tissues: immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands
    • Grönberg M, Tsolakis AV, Magnusson L, Janson ET, Saras J. Distribution of obestatin and ghrelin in human tissues: immunoreactive cells in the gastrointestinal tract, pancreas, and mammary glands. J Histochem Cytochem 2008;56:793-801.
    • (2008) J Histochem Cytochem , vol.56 , pp. 793-801
    • Grönberg, M.1    Tsolakis, A.V.2    Magnusson, L.3    Janson, E.T.4    Saras, J.5
  • 24
    • 66149153002 scopus 로고    scopus 로고
    • Obestatin/ghrelin cells in normal mucosa and endocrine tumours of the stomach
    • Tsolakis AV, Grimelius L, Stridsberg M, et al. Obestatin/ghrelin cells in normal mucosa and endocrine tumours of the stomach. Eur J Endocrinol 2009;160:941-949.
    • (2009) Eur J Endocrinol , vol.160 , pp. 941-949
    • Tsolakis, A.V.1    Grimelius, L.2    Stridsberg, M.3
  • 25
    • 39149138127 scopus 로고    scopus 로고
    • Characterization of obestatin- and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: an immunohistochemical and electron-microscopic study
    • Zhao CM, Furnes MW, Stenström B, Kulseng B, Chen D. Characterization of obestatin- and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: an immunohistochemical and electron-microscopic study. Cell Tissue Res 2008;331:575-587.
    • (2008) Cell Tissue Res , vol.331 , pp. 575-587
    • Zhao, C.M.1    Furnes, M.W.2    Stenström, B.3    Kulseng, B.4    Chen, D.5
  • 26
    • 33749859790 scopus 로고    scopus 로고
    • Identification of nesfatin-1 as a satiety molecule in the hypothalamus
    • Oh IS, Shimizu H, Satoh T, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006;443:709-712.
    • (2006) Nature , vol.443 , pp. 709-712
    • Oh, I.S.1    Shimizu, H.2    Satoh, T.3
  • 27
    • 34748902793 scopus 로고    scopus 로고
    • Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain
    • Brailoiu GC, Dun SL, Brailoiu E, et al. Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain. Endocrinology 2007;148:5088-5094.
    • (2007) Endocrinology , vol.148 , pp. 5088-5094
    • Brailoiu, G.C.1    Dun, S.L.2    Brailoiu, E.3
  • 28
    • 53249107183 scopus 로고    scopus 로고
    • Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS
    • Foo K, Brismar H, Broberger C. Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS. Neuroscience 2008;156:563-579.
    • (2008) Neuroscience , vol.156 , pp. 563-579
    • Foo, K.1    Brismar, H.2    Broberger, C.3
  • 29
    • 40849142341 scopus 로고    scopus 로고
    • Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding
    • Kohno D, Nakata M, Maejima Y, et al. Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology 2008;149:1295-1301.
    • (2008) Endocrinology , vol.149 , pp. 1295-1301
    • Kohno, D.1    Nakata, M.2    Maejima, Y.3
  • 30
    • 68449094576 scopus 로고    scopus 로고
    • Nesfatin-1: an overview and future clinical application
    • Shimizu H, Oh-I S, Okada S, Mori M. Nesfatin-1: an overview and future clinical application. Endocr J 2009;56:537-543.
    • (2009) Endocr J , vol.56 , pp. 537-543
    • Shimizu, H.1    Okada, O.-I.2    Mori, S.M.3
  • 31
    • 17944379112 scopus 로고    scopus 로고
    • Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans
    • Ariyasu H, Takaya K, Tagami T, et al. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 2001; 86:4753-4758.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4753-4758
    • Ariyasu, H.1    Takaya, K.2    Tagami, T.3
  • 32
    • 8744303926 scopus 로고    scopus 로고
    • Changes in plasma ghrelin concentration immediately after gastrectomy in patients with early gastric cancer
    • Jeon TY, Lee S, Kim HH, et al. Changes in plasma ghrelin concentration immediately after gastrectomy in patients with early gastric cancer. J Clin Endocrinol Metab 2004;89:5392-5396.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5392-5396
    • Jeon, T.Y.1    Lee, S.2    Kim, H.H.3
  • 33
    • 0036097362 scopus 로고    scopus 로고
    • Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion
    • Date Y, Nakazato M, Hashiguchi S, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 2002;51:124-129.
    • (2002) Diabetes , vol.51 , pp. 124-129
    • Date, Y.1    Nakazato, M.2    Hashiguchi, S.3
  • 34
    • 3042735648 scopus 로고    scopus 로고
    • The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
    • Gnanapavan S, Kola B, Bustin SA, et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002;87:2988.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2988
    • Gnanapavan, S.1    Kola, B.2    Bustin, S.A.3
  • 35
    • 0036892268 scopus 로고    scopus 로고
    • Cellular location and hormonal regulation of ghrelin expression in rat testis
    • Barreiro ML, Gaytán F, Caminos JE, et al. Cellular location and hormonal regulation of ghrelin expression in rat testis. Biol Reprod 2002;67:1768-1776.
    • (2002) Biol Reprod , vol.67 , pp. 1768-1776
    • Barreiro, M.L.1    Gaytán, F.2    Caminos, J.E.3
  • 37
    • 0034970034 scopus 로고    scopus 로고
    • Post-prandial decrease of circulating human ghrelin levels
    • Tschöp M, Wawarta R, Riepl RL, et al. Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest 2001;24: RC19-RC21.
    • (2001) J Endocrinol Invest , vol.24
    • Tschöp, M.1    Wawarta, R.2    Riepl, R.L.3
  • 38
    • 67651177691 scopus 로고    scopus 로고
    • Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake
    • Xu G, Li Y, An W, et al. Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake. Endocrinology 2009;150:3637-3644.
    • (2009) Endocrinology , vol.150 , pp. 3637-3644
    • Xu, G.1    Li, Y.2    An, W.3
  • 39
    • 0034809159 scopus 로고    scopus 로고
    • Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration
    • Toshinai K, Mondal MS, Nakazato M, et al. Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun 2001;281:1220-1225.
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 1220-1225
    • Toshinai, K.1    Mondal, M.S.2    Nakazato, M.3
  • 40
    • 0042200265 scopus 로고    scopus 로고
    • Changes in ghrelin and ghrelin receptor expression according to feeding status
    • Kim MS, Yoon CY, Park KH, et al. Changes in ghrelin and ghrelin receptor expression according to feeding status. Neuroreport 2003; 14:1317-1320.
    • (2003) Neuroreport , vol.14 , pp. 1317-1320
    • Kim, M.S.1    Yoon, C.Y.2    Park, K.H.3
  • 41
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000;407:908-913.
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschöp, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 42
    • 0037162116 scopus 로고    scopus 로고
    • Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery
    • Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002;346:1623-1630.
    • (2002) N Engl J Med , vol.346 , pp. 1623-1630
    • Cummings, D.E.1    Weigle, D.S.2    Frayo, R.S.3
  • 44
    • 57749084282 scopus 로고    scopus 로고
    • Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa
    • González CR, Vázquez MJ, López M, Diéguez C. Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa. J Mol Endocrinol 2008;41:415-421.
    • (2008) J Mol Endocrinol , vol.41 , pp. 415-421
    • González, C.R.1    Vázquez, M.J.2    López, M.3    Diéguez, C.4
  • 45
    • 34547652457 scopus 로고    scopus 로고
    • Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: a microdialysis study
    • de la Cour CD, Norlén P, Håkanson R. Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: a microdialysis study. Regul Pept 2007;143:118-126.
    • (2007) Regul Pept , vol.143 , pp. 118-126
    • de la Cour, C.D.1    Norlén, P.2    Håkanson, R.3
  • 46
    • 79959406869 scopus 로고    scopus 로고
    • Oxytocin and dopamine stimulate ghrelin secretion by the ghrelin-producing cell line
    • Iwakura H, Ariyasu H, Hosoda H, et al. Oxytocin and dopamine stimulate ghrelin secretion by the ghrelin-producing cell line, MGN3-1 in vitro. Endocrinology 2011;152:2619-2625.
    • (2011) MGN3-1 in vitro. Endocrinology , vol.152 , pp. 2619-2625
    • Iwakura, H.1    Ariyasu, H.2    Hosoda, H.3
  • 47
    • 0242669971 scopus 로고    scopus 로고
    • Somatostatin suppresses ghrelin secretion from the rat stomach
    • Shimada M, Date Y, Mondal MS, et al. Somatostatin suppresses ghrelin secretion from the rat stomach. Biochem Biophys Res Commun 2003;302:520-525.
    • (2003) Biochem Biophys Res Commun , vol.302 , pp. 520-525
    • Shimada, M.1    Date, Y.2    Mondal, M.S.3
  • 48
    • 79960005949 scopus 로고    scopus 로고
    • Abdominal surgery inhibits circulating acyl ghrelin and ghrelin-O-acyltransferase levels in rats: role of the somatostatin receptor subtype 2
    • Stengel A, Goebel-Stengel M, Wang L, et al. Abdominal surgery inhibits circulating acyl ghrelin and ghrelin-O-acyltransferase levels in rats: role of the somatostatin receptor subtype 2. Am J Physiol Gastrointest Liver Physiol 2011;301:G239-G248.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301
    • Stengel, A.1    Goebel-Stengel, M.2    Wang, L.3
  • 49
    • 57349142534 scopus 로고    scopus 로고
    • Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1
    • Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab 2008;93:4519-4524.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4519-4524
    • Fischer, T.1    Doll, C.2    Jacobs, S.3    Kolodziej, A.4    Stumm, R.5    Schulz, S.6
  • 50
    • 39749130253 scopus 로고    scopus 로고
    • Prostacyclin signaling regulates circulating ghrelin during acute inflammation
    • Madison LD, Scarlett JM, Levasseur P, et al. Prostacyclin signaling regulates circulating ghrelin during acute inflammation. J Endocrinol 2008;196:263-273.
    • (2008) J Endocrinol , vol.196 , pp. 263-273
    • Madison, L.D.1    Scarlett, J.M.2    Levasseur, P.3
  • 51
    • 34547650656 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion
    • Hagemann D, Holst JJ, Gethmann A, Banasch M, Schmidt WE, Meier JJ. Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion. Regul Pept 2007;143: 64-68.
    • (2007) Regul Pept , vol.143 , pp. 64-68
    • Hagemann, D.1    Holst, J.J.2    Gethmann, A.3    Banasch, M.4    Schmidt, W.E.5    Meier, J.J.6
  • 52
    • 1842735215 scopus 로고    scopus 로고
    • Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach
    • Lippl F, Kircher F, Erdmann J, Allescher HD, Schusdziarra V. Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach. Regul Pept 2004;119:93-98.
    • (2004) Regul Pept , vol.119 , pp. 93-98
    • Lippl, F.1    Kircher, F.2    Erdmann, J.3    Allescher, H.D.4    Schusdziarra, V.5
  • 53
  • 54
    • 33846828652 scopus 로고    scopus 로고
    • Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men
    • Brennan IM, Otto B, Feltrin KL, Meyer JH, Horowitz M, Feinle-Bisset C. Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men. Peptides 2007;28:607-611.
    • (2007) Peptides , vol.28 , pp. 607-611
    • Brennan, I.M.1    Otto, B.2    Feltrin, K.L.3    Meyer, J.H.4    Horowitz, M.5    Feinle-Bisset, C.6
  • 55
    • 0036347936 scopus 로고    scopus 로고
    • Insulin regulates plasma ghrelin concentration
    • Saad MF, Bernaba B, Hwu CM, et al. Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 2002;87:3997-4000.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3997-4000
    • Saad, M.F.1    Bernaba, B.2    Hwu, C.M.3
  • 56
    • 33751547729 scopus 로고    scopus 로고
    • Brainstem thyrotropin-releasing hormone regulates food intake through vagal-dependent cholinergic stimulation of ghrelin secretion
    • Ao Y, Go VL, Toy N, et al. Brainstem thyrotropin-releasing hormone regulates food intake through vagal-dependent cholinergic stimulation of ghrelin secretion. Endocrinology 2006;147:6004-6010.
    • (2006) Endocrinology , vol.147 , pp. 6004-6010
    • Ao, Y.1    Go, V.L.2    Toy, N.3
  • 57
    • 78049457734 scopus 로고    scopus 로고
    • Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats
    • Stengel A, Goebel M, Luckey A, Yuan PQ, Wang L, Taché Y. Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats. Peptides 2010;31:2229-2235.
    • (2010) Peptides , vol.31 , pp. 2229-2235
    • Stengel, A.1    Goebel, M.2    Luckey, A.3    Yuan, P.Q.4    Wang, L.5    Taché, Y.6
  • 58
    • 33646769934 scopus 로고    scopus 로고
    • Direct stimulation of ghrelin secretion by sympathetic nerves
    • Mundinger TO, Cummings DE, Taborsky GJ Jr. Direct stimulation of ghrelin secretion by sympathetic nerves. Endocrinology 2006;147:2893-2901.
    • (2006) Endocrinology , vol.147 , pp. 2893-2901
    • Mundinger, T.O.1    Cummings, D.E.2    Taborsky Jr., G.J.3
  • 61
    • 70449688125 scopus 로고    scopus 로고
    • Endogenous ghrelin released in response to endothelin stimulates growth hormone secretion in cattle
    • Thanthan S, Mekaru C, Seki N, et al. Endogenous ghrelin released in response to endothelin stimulates growth hormone secretion in cattle. Domest Anim Endocrinol 2010;38:1-12.
    • (2010) Domest Anim Endocrinol , vol.38 , pp. 1-12
    • Thanthan, S.1    Mekaru, C.2    Seki, N.3
  • 62
    • 37349009036 scopus 로고    scopus 로고
    • Visualization of ghrelin-producing neurons in the hypothalamic arcuate nucleus using ghrelin-EGFP transgenic mice
    • Kageyama H, Kitamura Y, Hosono T, et al. Visualization of ghrelin-producing neurons in the hypothalamic arcuate nucleus using ghrelin-EGFP transgenic mice. Regul Pept 2008;145:116-121.
    • (2008) Regul Pept , vol.145 , pp. 116-121
    • Kageyama, H.1    Kitamura, Y.2    Hosono, T.3
  • 63
    • 77955654331 scopus 로고    scopus 로고
    • Lipopolysaccharide differentially decreases plasma acyl and desacyl ghrelin levels in rats: potential role of the circulating ghrelin-acylating enzyme GOAT
    • Stengel A, Goebel M, Wang L, Reeve JR Jr, Taché Y, Lambrecht NW. Lipopolysaccharide differentially decreases plasma acyl and desacyl ghrelin levels in rats: potential role of the circulating ghrelin-acylating enzyme GOAT. Peptides 2010;31:1689-1696.
    • (2010) Peptides , vol.31 , pp. 1689-1696
    • Stengel, A.1    Goebel, M.2    Wang, L.3    Reeve Jr., J.R.4    Taché, Y.5    Lambrecht, N.W.6
  • 64
    • 0034841199 scopus 로고    scopus 로고
    • G.H, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils
    • Hattori N, Saito T, Yagyu T, Jiang BH, Kitagawa K, Inagaki C. GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils. J Clin Endocrinol Metab 2001;86:4284-4291.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4284-4291
    • Hattori, N.1    Saito, T.2    Yagyu, T.3    Jiang, B.H.4    Kitagawa, K.5    Inagaki, C.6
  • 65
    • 71849109389 scopus 로고    scopus 로고
    • Lean mean fat reducing " ghrelin" machine: hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity
    • Schellekens H, Dinan TG, Cryan JF. Lean mean fat reducing " ghrelin" machine: hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity. Neuropharmacology 2010;58:2-16.
    • (2010) Neuropharmacology , vol.58 , pp. 2-16
    • Schellekens, H.1    Dinan, T.G.2    Cryan, J.F.3
  • 66
    • 8444226059 scopus 로고    scopus 로고
    • Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus
    • Xu L, Depoortere I, Tomasetto C, et al. Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus. Regul Pept 2005;124:119-125.
    • (2005) Regul Pept , vol.124 , pp. 119-125
    • Xu, L.1    Depoortere, I.2    Tomasetto, C.3
  • 67
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist
    • Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW. High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist. Mol Endocrinol 2003;17:2201-2210.
    • (2003) Mol Endocrinol , vol.17 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 68
    • 78049490903 scopus 로고    scopus 로고
    • Ghrelin receptor: high constitutive activity and methods for developing inverse agonists
    • Els S, Beck-Sickinger AG, Chollet C. Ghrelin receptor: high constitutive activity and methods for developing inverse agonists. Methods Enzymol 2010;485:103-121.
    • (2010) Methods Enzymol , vol.485 , pp. 103-121
    • Els, S.1    Beck-Sickinger, A.G.2    Chollet, C.3
  • 69
    • 33746583963 scopus 로고    scopus 로고
    • Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers
    • Jiang H, Betancourt L, Smith RG. Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers. Mol Endocrinol 2006;20:1772-1785.
    • (2006) Mol Endocrinol , vol.20 , pp. 1772-1785
    • Jiang, H.1    Betancourt, L.2    Smith, R.G.3
  • 71
    • 17744396454 scopus 로고    scopus 로고
    • Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines
    • Cassoni P, Papotti M, Ghè C, et al. Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. J Clin Endocrinol Metab 2001;86: 1738-1745.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1738-1745
    • Cassoni, P.1    Papotti, M.2    Ghè, C.3
  • 72
    • 12144290080 scopus 로고    scopus 로고
    • Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines
    • Cassoni P, Ghè C, Marrocco T, et al. Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur J Endocrinol 2004;150:173-184.
    • (2004) Eur J Endocrinol , vol.150 , pp. 173-184
    • Cassoni, P.1    Ghè, C.2    Marrocco, T.3
  • 73
    • 33646582986 scopus 로고    scopus 로고
    • Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor
    • Gauna C, Delhanty PJ, van Aken MO, et al. Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor. Mol Cell Endocrinol 2006;251:103-111.
    • (2006) Mol Cell Endocrinol , vol.251 , pp. 103-111
    • Gauna, C.1    Delhanty, P.J.2    van Aken, M.O.3
  • 74
    • 33846935917 scopus 로고    scopus 로고
    • Obestatin- a ghrelin-associated peptide that does not hold its promise to suppress food intake and motility
    • Gourcerol G, Taché Y. Obestatin - a ghrelin-associated peptide that does not hold its promise to suppress food intake and motility. Neurogastroenterol Motil 2007;19:161-165.
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 161-165
    • Gourcerol, G.1    Taché, Y.2
  • 75
    • 33846904900 scopus 로고    scopus 로고
    • Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents
    • Zizzari P, Longchamps R, Epelbaum J, Bluet-Pajot MT. Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology 2007;148:1648-1653.
    • (2007) Endocrinology , vol.148 , pp. 1648-1653
    • Zizzari, P.1    Longchamps, R.2    Epelbaum, J.3    Bluet-Pajot, M.T.4
  • 78
    • 33845883349 scopus 로고    scopus 로고
    • GPR39 signaling is stimulated by zinc ions but not by obestatin
    • Holst B, Egerod KL, Schild E, et al. GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology 2007;148:13-20.
    • (2007) Endocrinology , vol.148 , pp. 13-20
    • Holst, B.1    Egerod, K.L.2    Schild, E.3
  • 79
    • 33846995594 scopus 로고    scopus 로고
    • Comment on " Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake"
    • 766; author reply
    • Chartrel N, Alvear-Perez R, Leprince J, et al. Comment on " Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake" . Science 2007;315:766; author reply 766.
    • (2007) Science , vol.315 , pp. 766
    • Chartrel, N.1    Alvear-Perez, R.2    Leprince, J.3
  • 80
    • 33846995594 scopus 로고    scopus 로고
    • Response to Comment on " Obestatin, a Peptide Encoded by the Ghrelin Gene Opposes Ghrelin's Effects on Food Intake"
    • Zhang JV, Klein C, Ren P-G, et al. Response to Comment on " Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake" . Science 2007;315:766d.
    • (2007) Science , vol.315
    • Zhang, J.V.1    Klein, C.2    Ren, P.-G.3
  • 81
    • 44649103391 scopus 로고    scopus 로고
    • Obestatin induction of early-re sponse gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor GPR39
    • Zhang JV, Jahr H, Luo CW, et al. Obestatin induction of early-re sponse gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39. Mol Endocrinol 2008;22:1464-1475.
    • (2008) Mol Endocrinol , vol.22 , pp. 1464-1475
    • Zhang, J.V.1    Jahr, H.2    Luo, C.W.3
  • 82
    • 11144225093 scopus 로고    scopus 로고
    • Common structural basis for constitutive activity of the ghrelin receptor family
    • Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW. Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem 2004;279:53806-53817.
    • (2004) J Biol Chem , vol.279 , pp. 53806-53817
    • Holst, B.1    Holliday, N.D.2    Bach, A.3    Elling, C.E.4    Cox, H.M.5    Schwartz, T.W.6
  • 83
    • 77957036661 scopus 로고    scopus 로고
    • Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males
    • Tsuchiya T, Shimizu H, Yamada M, et al. Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males. Clin Endocrinol (Oxf) 2010;73:484-490.
    • (2010) Clin Endocrinol (Oxf) , vol.73 , pp. 484-490
    • Tsuchiya, T.1    Shimizu, H.2    Yamada, M.3
  • 84
    • 71349086261 scopus 로고    scopus 로고
    • Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans
    • Li QC, Wang HY, Chen X, Guan HZ, Jiang ZY. Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans. Regul Pept 2010;159:72-77.
    • (2010) Regul Pept , vol.159 , pp. 72-77
    • Li, Q.C.1    Wang, H.Y.2    Chen, X.3    Guan, H.Z.4    Jiang, Z.Y.5
  • 85
    • 78650520206 scopus 로고    scopus 로고
    • Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa
    • Ogiso K, Asakawa A, Amitani H, et al. Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa. Peptides 2011;32:150-153.
    • (2011) Peptides , vol.32 , pp. 150-153
    • Ogiso, K.1    Asakawa, A.2    Amitani, H.3
  • 86
    • 77954615466 scopus 로고    scopus 로고
    • Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity
    • Ramanjaneya M, Chen J, Brown JE, et al. Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology 2010;151: 3169-3180.
    • (2010) Endocrinology , vol.151 , pp. 3169-3180
    • Ramanjaneya, M.1    Chen, J.2    Brown, J.E.3
  • 87
    • 79953858161 scopus 로고    scopus 로고
    • Decreased cerebrospinal fluid/plasma ratio of the novel satiety molecule, nesfatin-1/NUCB-2, in obese humans: evidence of nesfatin-1/NUCB-2 resistance and implications for obesity treatment
    • Tan BK, Hallschmid M, Kern W, Lehnert H, Randeva HS. Decreased cerebrospinal fluid/plasma ratio of the novel satiety molecule, nesfatin-1/NUCB-2, in obese humans: evidence of nesfatin-1/NUCB-2 resistance and implications for obesity treatment. J Clin Endocrinol Metab 2011;96:E669-E673.
    • (2011) J Clin Endocrinol Metab , vol.96
    • Tan, B.K.1    Hallschmid, M.2    Kern, W.3    Lehnert, H.4    Randeva, H.S.5
  • 88
    • 78649972777 scopus 로고    scopus 로고
    • Molecular, cellular and physiological evidences for the anorexigenic actions of nesfatin-1 in goldfish
    • Gonzalez R, Kerbel B, Chun A, Unniappan S. Molecular, cellular and physiological evidences for the anorexigenic actions of nesfatin-1 in goldfish. PLoS One 2010;5:e15201.
    • (2010) PLoS One , vol.5
    • Gonzalez, R.1    Kerbel, B.2    Chun, A.3    Unniappan, S.4
  • 89
    • 77953525385 scopus 로고    scopus 로고
    • The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat
    • García-Galiano D, Navarro VM, Roa J, et al. The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat. J Neurosci 2010;30:7783-7792.
    • (2010) J Neurosci , vol.30 , pp. 7783-7792
    • García-Galiano, D.1    Navarro, V.M.2    Roa, J.3
  • 90
    • 72549108065 scopus 로고    scopus 로고
    • Continued controversy on obestatin as a gut hormone influencing food intake and gastrointestinal motility
    • Goebel M, Stengel A, Taché Y. Continued controversy on obestatin as a gut hormone influencing food intake and gastrointestinal motility. Obes Metab 2008;4:143-148.
    • (2008) Obes Metab , vol.4 , pp. 143-148
    • Goebel, M.1    Stengel, A.2    Taché, Y.3
  • 91
    • 73449090824 scopus 로고    scopus 로고
    • Ghrelin gene products and the regulation of food intake and gut motility
    • Chen CY, Asakawa A, Fujimiya M, Lee SD, Inui A. Ghrelin gene products and the regulation of food intake and gut motility. Pharmacol Rev 2009;61:430-481.
    • (2009) Pharmacol Rev , vol.61 , pp. 430-481
    • Chen, C.Y.1    Asakawa, A.2    Fujimiya, M.3    Lee, S.D.4    Inui, A.5
  • 93
    • 84865068238 scopus 로고    scopus 로고
    • The gut hormones in appetite regulation
    • Suzuki K, Jayasena CN, Bloom SR. The gut hormones in appetite regulation. J Obes 2011;2011:528401.
    • (2011) J Obes , vol.2011 , pp. 528401
    • Suzuki, K.1    Jayasena, C.N.2    Bloom, S.R.3
  • 94
    • 0033711116 scopus 로고    scopus 로고
    • The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion
    • Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000;141:4325-4328.
    • (2000) Endocrinology , vol.141 , pp. 4325-4328
    • Wren, A.M.1    Small, C.J.2    Ward, H.L.3
  • 95
    • 4644274876 scopus 로고    scopus 로고
    • Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats
    • Tang-Christensen M, Vrang N, Ortmann S, Bidlingmaier M, Horvath TL, Tschöp M. Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology 2004;145: 4645-4652.
    • (2004) Endocrinology , vol.145 , pp. 4645-4652
    • Tang-Christensen, M.1    Vrang, N.2    Ortmann, S.3    Bidlingmaier, M.4    Horvath, T.L.5    Tschöp, M.6
  • 96
    • 23944474572 scopus 로고    scopus 로고
    • Ghrelin increases food intake in obese as well as lean subjects
    • Druce MR, Wren AM, Park AJ, et al. Ghrelin increases food intake in obese as well as lean subjects. Int J Obes (Lond) 2005;29: 1130-1136.
    • (2005) Int J Obes (Lond) , vol.29 , pp. 1130-1136
    • Druce, M.R.1    Wren, A.M.2    Park, A.J.3
  • 97
    • 65549152532 scopus 로고    scopus 로고
    • Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats
    • Salome N, Haage D, Perrissoud D, et al. Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats. Eur J Pharmacol 2009;612:167-173.
    • (2009) Eur J Pharmacol , vol.612 , pp. 167-173
    • Salome, N.1    Haage, D.2    Perrissoud, D.3
  • 98
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • Sun Y, Wang P, Zheng H, Smith RG. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci USA 2004;101:4679-4684.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3    Smith, R.G.4
  • 99
    • 31044451759 scopus 로고    scopus 로고
    • Mice lacking ghrelin receptors resist the development of diet-induced obesity
    • Zigman JM, Nakano Y, Coppari R, et al. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 2005;115:3564-3572.
    • (2005) J Clin Invest , vol.115 , pp. 3564-3572
    • Zigman, J.M.1    Nakano, Y.2    Coppari, R.3
  • 100
    • 0036073405 scopus 로고    scopus 로고
    • Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure
    • Banks WA, Tschöp M, Robinson SM, Heiman ML. Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 2002;302:822-827.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 822-827
    • Banks, W.A.1    Tschöp, M.2    Robinson, S.M.3    Heiman, M.L.4
  • 101
    • 33645420927 scopus 로고    scopus 로고
    • Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin
    • Pan W, Tu H, Kastin AJ. Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides 2006; 27:911-916.
    • (2006) Peptides , vol.27 , pp. 911-916
    • Pan, W.1    Tu, H.2    Kastin, A.J.3
  • 102
    • 0036787457 scopus 로고    scopus 로고
    • The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
    • Date Y, Murakami N, Toshinai K, et al. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 2002;123:1120-1128.
    • (2002) Gastroenterology , vol.123 , pp. 1120-1128
    • Date, Y.1    Murakami, N.2    Toshinai, K.3
  • 103
    • 0038031634 scopus 로고    scopus 로고
    • Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion
    • Sakata I, Yamazaki M, Inoue K, Hayashi Y, Kangawa K, Sakai T. Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion. Neurosci Lett 2003;342:183-186.
    • (2003) Neurosci Lett , vol.342 , pp. 183-186
    • Sakata, I.1    Yamazaki, M.2    Inoue, K.3    Hayashi, Y.4    Kangawa, K.5    Sakai, T.6
  • 104
    • 33751120393 scopus 로고    scopus 로고
    • Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat
    • Arnold M, Mura A, Langhans W, Geary N. Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat. J Neurosci 2006;26:11052-11060.
    • (2006) J Neurosci , vol.26 , pp. 11052-11060
    • Arnold, M.1    Mura, A.2    Langhans, W.3    Geary, N.4
  • 105
    • 66449098274 scopus 로고    scopus 로고
    • Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention
    • Davies JS, Kotokorpi P, Eccles SR, et al. Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention. Mol Endocrinol 2009;23:914-924.
    • (2009) Mol Endocrinol , vol.23 , pp. 914-924
    • Davies, J.S.1    Kotokorpi, P.2    Eccles, S.R.3
  • 106
    • 50349090968 scopus 로고    scopus 로고
    • Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats
    • Strassburg S, Anker S, Castaneda T, et al. Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats. Am J Physiol Endocrinol Metab 2008;295:E78-E84.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Strassburg, S.1    Anker, S.2    Castaneda, T.3
  • 107
    • 41549110998 scopus 로고    scopus 로고
    • Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure
    • Pfluger PT, Kirchner H, Günnel S, et al. Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am J Physiol Gastrointest Liver Physiol 2008;294:G610-G618.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294
    • Pfluger, P.T.1    Kirchner, H.2    Günnel, S.3
  • 108
    • 0242580169 scopus 로고    scopus 로고
    • Deletion of ghrelin impairs neither growth nor appetite
    • Sun Y, Ahmed S, Smith RG. Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 2003;23:7973-7981.
    • (2003) Mol Cell Biol , vol.23 , pp. 7973-7981
    • Sun, Y.1    Ahmed, S.2    Smith, R.G.3
  • 109
    • 33745834734 scopus 로고    scopus 로고
    • Ghrelin action in the brain controls adipocyte metabolism
    • Theander-Carrillo C, Wiedmer P, Cettour-Rose P, et al. Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest 2006;116:1983-1993.
    • (2006) J Clin Invest , vol.116 , pp. 1983-1993
    • Theander-Carrillo, C.1    Wiedmer, P.2    Cettour-Rose, P.3
  • 110
    • 67650423944 scopus 로고    scopus 로고
    • GOAT links dietary lipids with the endocrine control of energy balance
    • Kirchner H, Gutierrez JA, Solenberg PJ, et al. GOAT links dietary lipids with the endocrine control of energy balance. Nat Med 2009; 15:741-745.
    • (2009) Nat Med , vol.15 , pp. 741-745
    • Kirchner, H.1    Gutierrez, J.A.2    Solenberg, P.J.3
  • 111
    • 0037155558 scopus 로고    scopus 로고
    • Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus
    • Lu S, Guan JL, Wang QP, et al. Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus. Neurosci Lett 2002;321:157-160.
    • (2002) Neurosci Lett , vol.321 , pp. 157-160
    • Lu, S.1    Guan, J.L.2    Wang, Q.P.3
  • 112
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • Cowley MA, Smith RG, Diano S, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003;37: 649-661.
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3
  • 114
    • 48849107624 scopus 로고    scopus 로고
    • Brain circuits regulating energy homeostasis
    • Abizaid A, Horvath TL. Brain circuits regulating energy homeostasis. Regul Pept 2008;149:3-10.
    • (2008) Regul Pept , vol.149 , pp. 3-10
    • Abizaid, A.1    Horvath, T.L.2
  • 115
    • 0842330725 scopus 로고    scopus 로고
    • Synaptic interactions between ghrelin- and neuropeptide Y-containing neurons in the rat arcuate nucleus
    • Guan JL, Wang QP, Kageyama H, Takenoya F, et al. Synaptic interactions between ghrelin- and neuropeptide Y-containing neurons in the rat arcuate nucleus. Peptides 2003;24:1921-1928.
    • (2003) Peptides , vol.24 , pp. 1921-1928
    • Guan, J.L.1    Wang, Q.P.2    Kageyama, H.3    Takenoya, F.4
  • 116
    • 0037204861 scopus 로고    scopus 로고
    • Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus
    • Wang L, Saint-Pierre DH, Taché Y. Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus. Neurosci Lett 2002;325: 47-51.
    • (2002) Neurosci Lett , vol.325 , pp. 47-51
    • Wang, L.1    Saint-Pierre, D.H.2    Taché, Y.3
  • 117
    • 0035513696 scopus 로고    scopus 로고
    • Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
    • Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes 2001;50:2438-2443.
    • (2001) Diabetes , vol.50 , pp. 2438-2443
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Wakabayashi, I.6
  • 118
    • 0035843183 scopus 로고    scopus 로고
    • A role for ghrelin in the central regulation of feeding
    • Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-198.
    • (2001) Nature , vol.409 , pp. 194-198
    • Nakazato, M.1    Murakami, N.2    Date, Y.3
  • 119
    • 2542475178 scopus 로고    scopus 로고
    • Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
    • Chen HY, Trumbauer ME, Chen AS, et al. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 2004;145:2607-2612.
    • (2004) Endocrinology , vol.145 , pp. 2607-2612
    • Chen, H.Y.1    Trumbauer, M.E.2    Chen, A.S.3
  • 120
    • 49649122302 scopus 로고    scopus 로고
    • UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
    • Andrews ZB, Liu ZW, Walllingford N, et al. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 2008;454:846-851.
    • (2008) Nature , vol.454 , pp. 846-851
    • Andrews, Z.B.1    Liu, Z.W.2    Walllingford, N.3
  • 121
    • 42949146633 scopus 로고    scopus 로고
    • Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin
    • López M, Lage R, Saha AK, et al. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab 2008;7: 389-399.
    • (2008) Cell Metab , vol.7 , pp. 389-399
    • López, M.1    Lage, R.2    Saha, A.K.3
  • 124
    • 22344435662 scopus 로고    scopus 로고
    • Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats
    • Chen CY, Inui A, Asakawa A, et al. Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology 2005;129:8-25.
    • (2005) Gastroenterology , vol.129 , pp. 8-25
    • Chen, C.Y.1    Inui, A.2    Asakawa, A.3
  • 125
    • 10844287775 scopus 로고    scopus 로고
    • Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin
    • Asakawa A, Inui A, Fujimiya M, et al. Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut 2005;54:18-24.
    • (2005) Gut , vol.54 , pp. 18-24
    • Asakawa, A.1    Inui, A.2    Fujimiya, M.3
  • 126
    • 56149100976 scopus 로고    scopus 로고
    • Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats
    • Inhoff T, Mönnikes H, Noetzel S, et al. Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats. Peptides 2008;29:2159-2168.
    • (2008) Peptides , vol.29 , pp. 2159-2168
    • Inhoff, T.1    Mönnikes, H.2    Noetzel, S.3
  • 127
    • 29244486778 scopus 로고    scopus 로고
    • Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect
    • Neary NM, Druce MR, Small CJ, Bloom SR. Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect. Gut 2006;55:135.
    • (2006) Gut , vol.55 , pp. 135
    • Neary, N.M.1    Druce, M.R.2    Small, C.J.3    Bloom, S.R.4
  • 128
    • 33645857375 scopus 로고    scopus 로고
    • Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor
    • Toshinai K, Yamaguchi H, Sun Y, et al. Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology 2006;147:2306-2314.
    • (2006) Endocrinology , vol.147 , pp. 2306-2314
    • Toshinai, K.1    Yamaguchi, H.2    Sun, Y.3
  • 129
    • 69049113063 scopus 로고    scopus 로고
    • A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance
    • Iwakura H, Ariyasu H, Li Y, et al. A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance. Am J Physiol Endocrinol Metab 2009;297: E802-E811.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Iwakura, H.1    Ariyasu, H.2    Li, Y.3
  • 130
    • 11144226216 scopus 로고    scopus 로고
    • Transgenic mice overexpressing des-acyl ghrelin show small phenotype
    • Ariyasu H, Takaya K, Iwakura H, et al. Transgenic mice overexpressing des-acyl ghrelin show small phenotype. Endocrinology 2005;146:355-364.
    • (2005) Endocrinology , vol.146 , pp. 355-364
    • Ariyasu, H.1    Takaya, K.2    Iwakura, H.3
  • 131
    • 50449085374 scopus 로고    scopus 로고
    • Effect of des-acyl ghrelin on adiposity and glucose metabolism
    • Zhang W, Chai B, Li JY, Wang H, Mulholland MW. Effect of des-acyl ghrelin on adiposity and glucose metabolism. Endocrinology 2008;149:4710-4716.
    • (2008) Endocrinology , vol.149 , pp. 4710-4716
    • Zhang, W.1    Chai, B.2    Li, J.Y.3    Wang, H.4    Mulholland, M.W.5
  • 132
    • 67349175270 scopus 로고    scopus 로고
    • Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes
    • Rodriguez A, Gómez-Ambrosi J, Catalán V, et al. Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. Int J Obes (Lond) 2009;33:541-552.
    • (2009) Int J Obes (Lond) , vol.33 , pp. 541-552
    • Rodriguez, A.1    Gómez-Ambrosi, J.2    Catalán, V.3
  • 133
    • 33751037202 scopus 로고    scopus 로고
    • Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat
    • Bresciani E, Rapetti D, Donà F, et al. Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. J Endocrinol Invest 2006;29:RC16-RC18.
    • (2006) J Endocrinol Invest , vol.29
    • Bresciani, E.1    Rapetti, D.2    Donà, F.3
  • 134
    • 33845415562 scopus 로고    scopus 로고
    • Obestatin improves memory performance and causes anxiolytic effects in rats
    • Carlini VP, Schiöth HB, Debarioglio SR. Obestatin improves memory performance and causes anxiolytic effects in rats. Biochem Biophys Res Commun 2007;352:907-912.
    • (2007) Biochem Biophys Res Commun , vol.352 , pp. 907-912
    • Carlini, V.P.1    Schiöth, H.B.2    Debarioglio, S.R.3
  • 135
    • 37549054328 scopus 로고    scopus 로고
    • Fragments of obestatin as modulators of feed intake, circulating lipids, and stored fat
    • Nagaraj S, Peddha MS, Manjappara UV. Fragments of obestatin as modulators of feed intake, circulating lipids, and stored fat. Biochem Biophys Res Commun 2008;366:731-737.
    • (2008) Biochem Biophys Res Commun , vol.366 , pp. 731-737
    • Nagaraj, S.1    Peddha, M.S.2    Manjappara, U.V.3
  • 137
    • 33751062773 scopus 로고    scopus 로고
    • Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats
    • Seoane LM, Al-Massadi O, Pazos Y, Pagotto U, Casanueva FF. Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats. J Endocrinol Invest 2006; 29:RC13-RC15.
    • (2006) J Endocrinol Invest , vol.29
    • Seoane, L.M.1    Al-Massadi, O.2    Pazos, Y.3    Pagotto, U.4    Casanueva, F.F.5
  • 138
    • 33749343484 scopus 로고    scopus 로고
    • Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse
    • Moechars D, Depoortere I, Moreaux B, et al. Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse. Gastroenterology 2006;131:1131-1141.
    • (2006) Gastroenterology , vol.131 , pp. 1131-1141
    • Moechars, D.1    Depoortere, I.2    Moreaux, B.3
  • 139
    • 33751019166 scopus 로고    scopus 로고
    • Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents
    • Gourcerol G, Million M, Adelson DW, et al. Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents. Peptides 2006;27:2811-2819.
    • (2006) Peptides , vol.27 , pp. 2811-2819
    • Gourcerol, G.1    Million, M.2    Adelson, D.W.3
  • 141
    • 33846008423 scopus 로고    scopus 로고
    • Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL
    • Yamamoto D, Ikeshita N, Daito R, et al. Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats. Regul Pept 2007;138: 141-144.
    • (2007) TSH and ACTH in rats. Regul Pept , vol.138 , pp. 141-144
    • Yamamoto, D.1    Ikeshita, N.2    Daito, R.3
  • 142
    • 33845911774 scopus 로고    scopus 로고
    • Effects of obestatin on energy balance and growth hormone secretion in rodents
    • Nogueiras R, Pfluger P, Tovar S, et al. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology 2007;148:21-26.
    • (2007) Endocrinology , vol.148 , pp. 21-26
    • Nogueiras, R.1    Pfluger, P.2    Tovar, S.3
  • 143
    • 51349166631 scopus 로고    scopus 로고
    • Characterization of obestatin in rat and human stomach and plasma, and its lack of acute effect on feeding behavior in rodents
    • Mondal M, Toshinai K, Ueno H, Koshinaka K, Nakazato M. Characterization of obestatin in rat and human stomach and plasma, and its lack of acute effect on feeding behavior in rodents. J Endocrinol 2008;198:339-346.
    • (2008) J Endocrinol , vol.198 , pp. 339-346
    • Mondal, M.1    Toshinai, K.2    Ueno, H.3    Koshinaka, K.4    Nakazato, M.5
  • 144
    • 43049159720 scopus 로고    scopus 로고
    • Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents
    • Kobelt P, Wisser AS, Stengel A, et al. Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents. Peptides 2008;29:1018-1027.
    • (2008) Peptides , vol.29 , pp. 1018-1027
    • Kobelt, P.1    Wisser, A.S.2    Stengel, A.3
  • 145
  • 146
    • 67649103527 scopus 로고    scopus 로고
    • Central administration of obestatin fails to show inhibitory effects on food and water intake in mice
    • Annemie VD, Debby VD, Valentijn V, et al. Central administration of obestatin fails to show inhibitory effects on food and water intake in mice. Regul Pept 2009;156:77-82.
    • (2009) Regul Pept , vol.156 , pp. 77-82
    • Annemie, V.D.1    Debby, V.D.2    Valentijn, V.3
  • 147
    • 67349197266 scopus 로고    scopus 로고
    • Effects of obestatin on feeding and body weight after standard or cafeteria diet in the rat
    • Brunetti L, Leone S, Orlando G, et al. Effects of obestatin on feeding and body weight after standard or cafeteria diet in the rat. Peptides 2009;30:1323-1327.
    • (2009) Peptides , vol.30 , pp. 1323-1327
    • Brunetti, L.1    Leone, S.2    Orlando, G.3
  • 148
    • 47649126847 scopus 로고    scopus 로고
    • Metabolic effects of chronic obestatin infusion in rats
    • Unniappan S, Speck M, Kieffer TJ. Metabolic effects of chronic obestatin infusion in rats. Peptides 2008;29:1354-1361.
    • (2008) Peptides , vol.29 , pp. 1354-1361
    • Unniappan, S.1    Speck, M.2    Kieffer, T.J.3
  • 150
    • 70350371308 scopus 로고    scopus 로고
    • Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway
    • Maejima Y, Sedbazar U, Suyama S, et al. Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab 2009;10:355-365.
    • (2009) Cell Metab , vol.10 , pp. 355-365
    • Maejima, Y.1    Sedbazar, U.2    Suyama, S.3
  • 151
    • 79952785186 scopus 로고    scopus 로고
    • Nesfatin-1: a novel inhibitory regulator of food intake and body weight
    • Stengel A, Goebel M, Taché Y. Nesfatin-1: a novel inhibitory regulator of food intake and body weight. Obes Rev 2011;12:261-271.
    • (2011) Obes Rev , vol.12 , pp. 261-271
    • Stengel, A.1    Goebel, M.2    Taché, Y.3
  • 152
    • 78650522318 scopus 로고    scopus 로고
    • Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervals
    • Goebel M, Stengel A, Wang L, Taché Y. Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervals. Peptides 2011;32:36-43.
    • (2011) Peptides , vol.32 , pp. 36-43
    • Goebel, M.1    Stengel, A.2    Wang, L.3    Taché, Y.4
  • 153
    • 70350319523 scopus 로고    scopus 로고
    • Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor
    • Stengel A, Goebel M, Wang L, et al. Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor. Endocrinology 2009; 150:4911-4919.
    • (2009) Endocrinology , vol.150 , pp. 4911-4919
    • Stengel, A.1    Goebel, M.2    Wang, L.3
  • 154
    • 77952694240 scopus 로고    scopus 로고
    • The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist
    • Yosten GL, Samson WK. The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist. Am J Physiol Regul Integr Comp Physiol 2010; 298:R1642-R1647.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.298
    • Yosten, G.L.1    Samson, W.K.2
  • 155
    • 77957596611 scopus 로고    scopus 로고
    • Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice
    • Atsuchi K, Asakawa A, Ushikai M, et al. Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice. Neuroreport 2010;21:1008-1011.
    • (2010) Neuroreport , vol.21 , pp. 1008-1011
    • Atsuchi, K.1    Asakawa, A.2    Ushikai, M.3
  • 156
    • 0042661175 scopus 로고    scopus 로고
    • Nibbling at CRF receptor control of feeding and gastrocolonic motility
    • Zorrilla EP, Taché Y, Koob GF. Nibbling at CRF receptor control of feeding and gastrocolonic motility. Trends Pharmacol Sci 2003; 24:421-427.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 421-427
    • Zorrilla, E.P.1    Taché, Y.2    Koob, G.F.3
  • 157
    • 35448953387 scopus 로고    scopus 로고
    • Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis
    • Tabarin A, Diz-Chaves Y, Consoli D, et al. Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis. Eur J Neurosci 2007;26:2303-2314.
    • (2007) Eur J Neurosci , vol.26 , pp. 2303-2314
    • Tabarin, A.1    Diz-Chaves, Y.2    Consoli, D.3
  • 158
    • 68049085867 scopus 로고    scopus 로고
    • Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system
    • Yosten GL, Samson WK. Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system. Am J Physiol Regul Integr Comp Physiol 2009;297:R330-R336.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297
    • Yosten, G.L.1    Samson, W.K.2
  • 159
    • 44649171554 scopus 로고    scopus 로고
    • Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice
    • Nonogaki K, Ohba Y, Sumii M, Oka Y. Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice. Biochem Biophys Res Commun 2008;372:186-190.
    • (2008) Biochem Biophys Res Commun , vol.372 , pp. 186-190
    • Nonogaki, K.1    Ohba, Y.2    Sumii, M.3    Oka, Y.4
  • 160
    • 54049126084 scopus 로고    scopus 로고
    • Nesfatin-1 inhibits NPY neurons in the arcuate nucleus
    • Price CJ, Samson WK, Ferguson AV. Nesfatin-1 inhibits NPY neurons in the arcuate nucleus. Brain Res 2008;1230:99-106.
    • (2008) Brain Res , vol.1230 , pp. 99-106
    • Price, C.J.1    Samson, W.K.2    Ferguson, A.V.3
  • 161
    • 0033278997 scopus 로고    scopus 로고
    • Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: effects of food restriction
    • Xu B, Kalra PS, Farmerie WG, Kalra SP. Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: effects of food restriction. Endocrinology 1999;140:2868-2875.
    • (1999) Endocrinology , vol.140 , pp. 2868-2875
    • Xu, B.1    Kalra, P.S.2    Farmerie, W.G.3    Kalra, S.P.4
  • 162
    • 0033972880 scopus 로고    scopus 로고
    • Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system
    • Taheri S, Sunter D, Dakin C, et al. Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system. Neurosci Lett 2000;279:109-112.
    • (2000) Neurosci Lett , vol.279 , pp. 109-112
    • Taheri, S.1    Sunter, D.2    Dakin, C.3
  • 163
    • 0036772364 scopus 로고    scopus 로고
    • Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake
    • Lu XY, Shieh KR, Kabbaj M, Barsh GS, Akil H, Watson SJ. Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake. Endocrinology 2002;143:3905-3915.
    • (2002) Endocrinology , vol.143 , pp. 3905-3915
    • Lu, X.Y.1    Shieh, K.R.2    Kabbaj, M.3    Barsh, G.S.4    Akil, H.5    Watson, S.J.6
  • 164
    • 59649122740 scopus 로고    scopus 로고
    • Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism
    • Shimizu H, Oh-I S, Hashimoto K, et al. Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology 2009;150:662-671.
    • (2009) Endocrinology , vol.150 , pp. 662-671
    • Shimizu, H.1    Hashimoto, K.2    Oh, I.S.3


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