Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion

Regulatory Peptides

Volumn 143, Issue 1-3, 2007, Pages 64-68

  Hagemann, Dirk ^a   Holst, Jens J ^b   Gethmann, Arnica ^a   Banasch, Matthias ^a   Schmidt, Wolfgang E ^a   Meier, Juris J ^a  

^a ST JOSEF HOSPITAL   (Germany)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Appetite; Energy homeostasis; Ghrelin; GLP 1; Glucagon like peptide 1

Indexed keywords

C PEPTIDE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN;

ADULT; ARTICLE; CONTROLLED STUDY; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN LIKE ACTIVITY; INSULIN RELEASE; MALE; NORMAL HUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; STOMACH EMPTYING; TEST MEAL;

ADULT; BLOOD GLUCOSE; ENERGY METABOLISM; GHRELIN; GLUCAGON-LIKE PEPTIDE 1; HUMANS; INFUSIONS, INTRAVENOUS; INSULIN; MALE; PEPTIDE HORMONES; RADIOIMMUNOASSAY;

EID: 34547650656     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2007.03.002     Document Type: Article

References (30)

1. Horvath T.L. The hardship of obesity: a soft-wired hypothalamus. Nat Neurosci 8 (2005) 561-565
2. Schwartz M.W., Woods S.C., Porte D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
3. Meier J.J., Gallwitz B., Schmidt W.E., and Nauck M.A. Glucagon-like peptide 1 (GLP-1) as a regulator of food intake and body weight: therapeutic perspectives. Eur J Pharmacol 440 (2002) 269-279
4. van der Lely A.J., Tschop M., Heiman M.L., and Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25 (2004) 426-457
5. Flint A., Raben A., Astrup A., and Holst J.J. Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans. J Clin Invest 101 (1998) 515-520
6. Gutzwiller J.-P., Göke B., Drewe J., et al. Glucagon-like peptide-1: a potent regulator of food intake in humans. Gut 44 (1999) 81-86
7. Meier J.J., Gallwitz B., Salmen S., et al. Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. J Clin Endocrinol Metab 88 (2003) 2719-2725
8. Zander M., Madsbad S., Madsen J.L., and Holst J.J. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 359 (2002) 824-830
9. Defronzo R.A., Ratner R.E., Han J., et al. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 28 (2005) 1092-1100
10. Kendall D.M., Riddle M.C., Rosenstock J., et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 28 (2005) 1083-1091
11. Buse J.B., Henry R.R., Han J., et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 27 (2004) 2628-2635
12. Tschop M., Smiley D.L., and Heiman M.L. Ghrelin induces adiposity in rodents. Nature 407 (2000) 908-913
13. Nakazato M., Murakami N., Date Y., et al. A role for ghrelin in the central regulation of feeding. Nature 409 (2001) 194-198
14. Cummings D.E., Purnell J.Q., Frayo R.S., et al. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50 (2001) 1714-1719
15. Cummings D.E., Weigle D.S., Frayo R.S., et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346 (2002) 1623-1630
16. Sugino T., Yamaura J., Yamagishi M., et al. Involvement of cholinergic neurons in the regulation of the ghrelin secretory response to feeding in sheep. Biochem Biophys Res Commun 304 (2003) 308-312
17. Nakagawa E., Nagaya N., Okumura H., et al. Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose. Clin Sci (Lond) 103 (2002) 325-328
18. Saad M.F., Bernaba B., Hwu C.M., et al. Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 87 (2002) 3997-4000
19. Mohlig M., Spranger J., Otto B., et al. Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J Endocrinol Investig 25 (2002) RC36-RC38
20. Djurhuus C.B., Hansen T.K., Gravholt C., et al. Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion. Horm Metab Res 34 (2002) 411-413
21. Perez-Tilve D., Gonzalez-Matias L., Alvarez-Crespo M., et al. Exendin-4 potently decreases ghrelin levels in fasting rats. Diabetes 56 (2007) 143-151
22. Rudovich N.N., Dick D., Moehlig M., et al. Ghrelin is not suppressed in hyperglycemic clamps by gastric inhibitory polypeptide and arginine. Regul Pept 127 (2005) 95-99
23. Djurhuus C.B., Hansen T.K., Holst J.J., and Schmitz O. Feast or famine - are GLP-1 and ghrelin secretion intertwined. Horm Metab Res 34 (2002) 353-354
24. Meier J.J., Gethmann A., Goetze O., et al. Glucagon-like peptide 1 (GLP-1) abolishes the postprandial rise in triglyceride concentrations and lowers free fatty acid levels in humans. Diabetologia 49 (2006) 452-458
25. Meier J.J., Gethmann A., Nauck M.A., et al. The glucagon-like peptide 1 metabolite GLP-1 (9-36)amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans. Am J Physiol Endocrinol Metabol Gastrointest Physiol 290 (2006) E1118-E1123
26. 2-terminus in type 2-diabetic patients and in healthy subjects. Diabetes 44 (1995) 1126-1131
27. Banasch M., Bulut K., Hagemann D., et al. Glucagon-like peptide 2 inhibits ghrelin secretion in humans. Regul Pept 137 (2007) 173-178
28. Kojima M., Hosoda H., Date Y., et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
29. Barkan A.L., Dimaraki E.V., Jessup S.K., et al. Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. J Clin Endocrinol Metab 88 (2003) 2180-2184
30. Turton M.D., D O.S., Gunn I., et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 (1996) 69-72